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Protection of Endothelial Function

  • Chapter
Atherosclerosis: Diet and Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 170))

Abstract

The vascular endothelium synthesizes and releases a spectrum of vasoactive substances and therefore plays a fundamental role in the basal and dynamic regulation of the circulation. Nitric oxide (NO)—originally described as endothelium-derived relaxing factor—is released from endothelial cells in response to shear stress produced by blood flow, and in response to activation of a variety of receptors. After diffusion from endothelial to vascular smooth muscle cells, NO increases intracellular cyclic guanosine-monophosphat concentrations by activation of the enzyme guanylate cyclase leading to relaxation of the smooth muscle cells. NO has also antithrombogenic, antiproliferative, leukocyte-adhesion inhibiting effects, and influences myocardial contractility. Endothelium-derived NO-mediated vascular relaxation is impaired in spontaneously hypertensive animals. NO decomposition by free oxygen radicals is a major mechanism of impaired NO bioavailability. The resulting imbalance of endothelium-derived relaxing and contracting substances disturbs the normal function of the vascular endothelium. Endothelin acts as the natural counterpart to endothelium-derived NO. In man, besides its effect of increasing arterial blood pressure, ET-1 induces vascular and myocardial hypertrophy, which are independent risk factors for cardiovascular morbidity and mortality. Current therapeutic strategies concentrate mainly on lowering of low-density lipoprotein cholesterol and an impressive reduction in the risk for cardiovascular morbidity and mortality has been achieved. Inflammatory mechanisms play an important role in vascular disease and inflammatory plasma markers correlate with prognosis. Novel therapeutic strategies specifically targeting inflammation thus bear great potential for the prevention and treatment of atherosclerotic vascular disease.

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References

  • Anderson EA, Mark AL (1989) Flow-mediated and reflex changes in large peripheral artery tone in humans. Circulation 79:93–100

    PubMed  Google Scholar 

  • Anderson TJ, Elstein E, Haber H, Charbonneau F (2000) Comparative study of ACE-inhibition, angiotensin II antagonism, and calcium channel blockade on flow-mediated vasodilation in patients with coronary disease (BANFF study). J Am Coll Cardiol 35:60–66

    Article  PubMed  Google Scholar 

  • Andre P, Nannizzi-Alaimo L, Prasad SK, Phillips DR (2002) Platelet-derived CD40L: the switch-hitting player of cardiovascular disease. Circulation 106:896–899

    Article  PubMed  Google Scholar 

  • Anonymous (1982) The MRFIT research group. Multiple Risk Factor Intervention Trial. Risk factor changes and mortality results. JAMA 248:1465–1477

    Google Scholar 

  • Anonymous (1994) The Scandinavian Simvastatin Survival Study group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344:1383–1389

    Google Scholar 

  • Anonymous (1995) The West of Scotland Coronary Prevention Study group. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med 333:1301–1307

    Google Scholar 

  • Anonymous (1998) The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 339:1349–1355

    Google Scholar 

  • Anonymous (2000) Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. Circulation 102:21–27

    Google Scholar 

  • Anonymous (2002) MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360:7–22

    Google Scholar 

  • Aukrust P, Muller F, Ueland T, Berget T, Aaser E, Brunsvig A, Solum NO, Forfang K, Froland SS, Gullestad L (1999) Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes. Circulation 100:614–620

    PubMed  Google Scholar 

  • Badimon JJ, Badimon L, Fuster V (1990) Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit. J Clin Invest 85:1234–1241

    PubMed  Google Scholar 

  • Barton M, d'Uscio LV, Shaw S, Meyer P, Moreau P, Luscher TF (1998) ET(A) receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension. Hypertension 31:499–504

    PubMed  Google Scholar 

  • Bhagat K, Moss R, Collier J, Vallance P (1996) Endothelial 'stunning’ following a brief exposure to endotoxin: a mechanism to link infection and infarction? Cardiovasc Res 32:822–829

    Article  PubMed  Google Scholar 

  • Bhagat K, Vallance P (1997) Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo. Circulation 96:3042–3047

    PubMed  Google Scholar 

  • Blankenberg S, Rupprecht HJ, Bickel C, Peetz D, Hafner G, Tiret L, Meyer J, et al. (2001) Circulating cell adhesion molecules and death in patients with coronary artery disease. Circulation 104:1336–1342

    PubMed  Google Scholar 

  • Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE et al. (1997) Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 96:1432–1437

    PubMed  Google Scholar 

  • Boulanger C, Lüscher TF (1990) Release of endothelin from the porcine aorta. Inhibition of endothelium-derived nitric oxide. J Clin Invest 85:587–590

    PubMed  Google Scholar 

  • Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Albers JJ (2001) Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 345:1583–1592

    PubMed  Google Scholar 

  • Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340:1111–1115

    Article  PubMed  Google Scholar 

  • Chenevard R, Hurlimann D, Bechir M, Enseleit F, Spieker L, Hermann M, Riesen W, Gay S, Gay RE, Neidhart M, Michel B, Luscher TF, Noll G, Ruschitzka F (2003) Selective COX-2 inhibition improves endothelial function in coronary artery disease. Circulation 107:405–409

    PubMed  Google Scholar 

  • Cipollone F, Mezzetti A, Porreca E, Di Febbo C, Nutini M, Fazia M, Falco A, Cuccurullo F, Davi G (2002) Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy. Circulation 106:399–402

    Article  PubMed  Google Scholar 

  • Cockcroft JR, Chowienczyk PJ, Brett SE, Chen CP, Dupont AG, Van Nueten L, Wooding SJ, Ritter JM (1995) Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J Pharmacol Exp Ther 274:1067–1071

    PubMed  Google Scholar 

  • Cockerill GW, Huehns TY, Weerasinghe A, Stocker C, Lerch PG, Miller NE, Haskard DO (2001) Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selectin in an in vivo model of acute inflammation. Circulation 103:108–112

    PubMed  Google Scholar 

  • Cohen RA, Zitnay KM, Haudenschild CC, Cunningham LD (1988) Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. Circ Res 63:903–910

    PubMed  Google Scholar 

  • De Caterina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone Jr MA, Shin WS, Liao JK (1995) Nitric oxide decreases cytokine induced endothelial activation: nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 96:60–68

    PubMed  Google Scholar 

  • Downs JR, Clearfield M, Weis S, Whitney E, Shapiro DR, Beere PA, Langendorfer A, Stein EA, Kruyer W, Gotto AM, Jr. (1998) Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 279:1615–1622

    PubMed  Google Scholar 

  • Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney JFJ, Vita JA (1999) Treatment of hypertension with ascorbic acid. Lancet 354

    Google Scholar 

  • Dupuis J, Tardif JC, Cernacek P, Theroux P (1999) Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (Reduction of cholesterol in ischemia and function of the endothelium) trial. Circulation 99:3227–3233

    PubMed  Google Scholar 

  • Egashira K, Hirooka Y, Kai H, Sugimachi M, Suzuki S, Inou T, Takeshita A (1994) Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia. Circulation 89:2519–2524

    PubMed  Google Scholar 

  • Eriksson M, Carlson LA, Miettinen TA, Angelin B (1999) Stimulation of fecal steroid excretion after infusion of recombinant proapolipoprotein A-I. Potential reverse cholesterol transport in humans. Circulation 100:594–598

    PubMed  Google Scholar 

  • Fichtlscherer S, Rosenberger G, Walter G, Breuer S, Dimmeler S, Zeiher AM (2000) Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 102:1000–1006

    PubMed  Google Scholar 

  • Frick MH, Elo O, Haapa K, Heinonen OP, Heinsalmi P, Helo P, Huttunen JK, Kaitaniemi P, Koskinen P, Manninen V, et al. (1987) Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 317:1237–1245

    PubMed  Google Scholar 

  • Furchgott RF (1983) Role of endothelium in responses of vascular smooth muscle. Circ Res 53:557–573

    PubMed  Google Scholar 

  • Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373–376

    Article  PubMed  Google Scholar 

  • Fuster V, Fayad ZA, Badimon JJ (1999) Acute coronary syndromes: biology. Lancet 353(suppl II):5–9

    Article  Google Scholar 

  • Garlichs CD, John S, Schmeisser A, Eskafi S, Stumpf C, Karl M, Goppelt-Struebe M, Schmieder R, Daniel WG (2001) Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia. Circulation 104:2395–2400

    PubMed  Google Scholar 

  • Genest J, Jr., McNamara JR, Ordovas JM, Jenner JL, Silberman SR, Anderson KM, Wilson PW, Salem DN, Schaefer EJ (1992) Lipoprotein cholesterol, apolipoprotein A-I and B and lipoprotein (a) abnormalities in men with premature coronary artery disease. J Am Coll Cardiol 19:792–802

    PubMed  Google Scholar 

  • Ghiadoni, L, S Taddei, Virdis A, Sudano I, Di Legge V, Meola M, Di Venanzio L, Salvetti A (1998) Endothelial function and common carotid artery wall thickening in patients with essential hypertension. Hypertension 32:25–32

    PubMed  Google Scholar 

  • Ghiadoni L, Virdis A, Magagna A, Taddei S, Salvetti A (2000) Effect of the angiotensin II type 1 receptor blocker candesartan on endothelial function in patients with essential hypertension. Hypertension 35:501–506

    PubMed  Google Scholar 

  • Griffin JH, Kojima K, Banka CL, Curtiss LK, Fernandez JA (1999) High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C. J Clin Invest 103:219–227

    PubMed  Google Scholar 

  • Henn V, Slupsky JR, Grafe M, Anagnostopoulos I, Forster R, Muller-Berghaus G, Kroczek RA (1998) CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391:591–594

    Article  PubMed  Google Scholar 

  • Hickey KA, Rubanyi G, Paul RJ, Highsmith RF (1985) Characterization of a coronary vaso-constrictor produced by cultured endothelial cells. Am J Physiol 248: C550–C556

    PubMed  Google Scholar 

  • Hingorani AD, Cross J, Kharbanda RK, Mullen MJ, Bhagat K, Taylor M, Donald AE, Palacios M, Griffin GE, Deanfield JE, MacAllister RJ, Vallance P (2000) Acute systemic inflammation impairs endothelium-dependent dilatation in humans. Circulation 102:994–999

    PubMed  Google Scholar 

  • Ito H, Hirata Y, Hiroe M, Tsujino M, Adachi S, Takamoto T, Nitta M, Taniguchi K, Marumo F (1991) ET-1 induces hypertrophy with enhanced expression of muscle specific genes in cultured neonatal rat cardiomyocytes. Circ Res 69:209–215

    PubMed  Google Scholar 

  • Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, Lüscher TF (1995a) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91:1314–1319

    PubMed  Google Scholar 

  • Joannides R, Richard V, Haefeli WE, Linder L, Lüscher TF, Thuillez C (1995b) Role of basal and stimulated release of nitric oxide in the regulation of radial artery caliber in humans. Hypertension 26:327–331

    PubMed  Google Scholar 

  • John S, Schlaich M, Langenfeld M, Weihprecht H, Schmitz G, Weidinger G, Schmieder RE (1998) Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients: a randomized, placebo-controlled, double-blind study. Circulation 98:211–216

    PubMed  Google Scholar 

  • Kannel WB, Gordon T, Offutt D (1969) Left ventricular hypertrophy by electrocardiogram. Prevalence, incidence, and mortality in the Framingham study. Ann Intern Med 71:89–105

    PubMed  Google Scholar 

  • Katusic ZS, Vanhoutte PM (1989) Superoxide anion is an endothelium-derived contracting factor. Am J Physiol 257:H33–H37

    PubMed  Google Scholar 

  • Kiely DG, Cargill RI, Struthers AD, Lipworth BJ (1997) Cardiopulmonary effects of endothelin-1 in man. Cardiovasc Res 33:378–386

    Article  PubMed  Google Scholar 

  • Laufs U, La Fata V, Plutzky J, Liao JK (1998) Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 97:1129–1135

    PubMed  Google Scholar 

  • Lerman A, Edwards BS, Hallett JW, Heublein DM, Sandberg SM, Burnett JJ (1991) Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med 325:997–1001

    PubMed  Google Scholar 

  • Leung W-H, Lau C-P, Wong C-K (1993) Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolemic patients. Lancet 341:1496–1500

    Article  PubMed  Google Scholar 

  • Li D, Weng S, Yang B, Zander DS, Saldeen T, Nichols WW, Khan S, Mehta JL (1999) Inhibition of arterial thrombus formation by ApoA1 Milano. Arterioscler ThrombVasc Biol 19:378–383

    Google Scholar 

  • Libby P (2001) Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 104:365–372

    PubMed  Google Scholar 

  • Lichtlen PR, Hugenholtz PG, Rafflenbeul W, Hecker H, Jost S, Deckers JW (1990) Retardation of angiographic progression of coronary artery disease by nifedipine. Results of the International Nifedipine Trial on Antiatherosclerotic Therapy (INTACT). INTACT Group Investigators. Lancet 335:1109–1113

    PubMed  Google Scholar 

  • Lindmark E, Tenno T, Siegbahn A (2000) Role of platelet P-selectin and CD40 ligand in the induction of monocytic tissue factor expression. Arterioscler Thromb Vasc Biol 20:2322–2328

    PubMed  Google Scholar 

  • Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB, Maseri A (1994) The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med 331:417–424

    Article  PubMed  Google Scholar 

  • Lüscher TF, Yang Z, Tschudi M, Von SL, Stulz P, Boulanger C, Siebenmann R, Turina M, Bühler FR (1990) Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins. Circ Res 66:1088–1094

    PubMed  Google Scholar 

  • Mach F, Schonbeck U, Sukhova GK, Atkinson E, Libby P (1998) Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature 394:200–203

    Article  PubMed  Google Scholar 

  • Mancini GB, Henry GC, Macaya C, O'Neill BJ, Pucillo AL, Carere RG, Wargovich TJ, Mudra H, Luscher TF, Klibaner MI, Haber HE, Uprichard AC, Pepine CJ, Pitt B (1996) Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (Trial on Reversing ENdothelial Dysfunction) Study [published erratum appears in Circulation 1996; 94:1490]. Circulation 94:258–265

    PubMed  Google Scholar 

  • May AE, Kälsch T, Massberg S, Herouy Y, Schmidt R, Gawaz M (2002) Engagement of glycoprotein IIb/IIIa (αIIbβ3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells. Circulation 106:2111–2117

    Article  PubMed  Google Scholar 

  • Murray CJ, Lopez AD (1997) Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 349:1269–1276

    Article  PubMed  Google Scholar 

  • Naqvi TZ, Shah PK, Ivey PA, Molloy MD, Thomas AM, Panicker S, Ahmed A, Cercek B, Kaul S (1999) Evidence that high-density lipoprotein cholesterol is an independent predictor of acute platelet-dependent thrombus formation. Am J Cardiol 84:1011–1017

    PubMed  Google Scholar 

  • Nofer, JR, Kehrel B, Fobker M, Levkau B, Assmann G, von Eckardstein A (2002) HDL and arteriosclerosis: beyond reverse cholesterol transport. Atherosclerosis 161:1–16

    Article  PubMed  Google Scholar 

  • O'Driscoll G, Green D, Taylor RR (1997) Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation 95:1126–1131

    PubMed  Google Scholar 

  • O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK, Jr. (1999) Carotidartery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340:14–22

    Article  PubMed  Google Scholar 

  • Oemar BS, Tschudi MR, Godoy N, Brovkovich V, Malinski T, Luscher TF (1998) Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis. Circulation 97:2494–2498

    PubMed  Google Scholar 

  • Palmer RM, Ashton DS, Moncada S (1988a) Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333:664–666

    Article  PubMed  Google Scholar 

  • Palmer RM, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524–526

    PubMed  Google Scholar 

  • Palmer RMJ, Rees DD, Ashton DS, Moncada S (1988b) L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 153:1251–1256

    PubMed  Google Scholar 

  • Perticone F, Maio R, Ceravolo R, Cosco C, Cloro C, Mattioli PL (1999) Relationship between left ventricular mass and endothelium-dependent vasodilation in never-treated hypertensive patients. Circulation 99:1991–1996

    PubMed  Google Scholar 

  • Pitt B, Waters D, Brown WV, van Boven AJ, Schwartz L, Title LM, Eisenberg D, Shurzinske L, McCormick LS (1999) Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. Atorvastatin versus Revascularization Treatment Investigators. N Engl J Med 341:70–76

    Article  PubMed  Google Scholar 

  • Ridker PM, Buring JE, Shih J, Matias M, Hennekens CH (1998a) Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 98:731–733

    PubMed  Google Scholar 

  • Ridker PM, Glynn RJ, Hennekens CH (1998b) C-Reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial Infarction. Circulation 97:2007–2011

    PubMed  Google Scholar 

  • Ridker PM, Hennekens CH, Roitman-Johnson B, Stampfer MJ, Allen J (1998c) Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet 351:88–92

    Article  PubMed  Google Scholar 

  • Ridker PM, Rifai N, Clearfield M, Downs JR, Weis SE, Miles JS, Gotto AMJ (2001) Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N Engl J Med 344:1959–1965

    Article  PubMed  Google Scholar 

  • Ridker PM, Rifai N, Pfeffer MA, Sacks FM, Moye LA, Goldman S, Flaker GC, Braunwald E (1998d) Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators. Circulation 98:839–844

    PubMed  Google Scholar 

  • Ross R (1999) Atherosclerosis—an inflammatory disease. N Engl J Med 340:115–126

    Article  PubMed  Google Scholar 

  • Rossi GP, Colonna S, Pavan E, Albertin G, Della Rocca F, Gerosa G, Casarotto D, Sartore S, Pauletto P, Pessina AC (1999) Endothelin-1 and its mRNA in the wall layers of human arteries ex vivo. Circulation 99:1147–1155

    PubMed  Google Scholar 

  • Rubanyi GM, JC Romero, Vanhoutte PM (1986) Flow-induced release of endothelium-derived relaxing factor. Am J Physiol 250: H1145–H1149

    PubMed  Google Scholar 

  • Rubanyi GM, Vanhoutte PM (1986) Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol 250: H822–H827

    PubMed  Google Scholar 

  • Rubins, HB, SJ Robins, Collins D, Fye CL, Anderson JW, Elam MB, Faas FH, Linares E, Schaefer EJ, Schectman G, Wilt TJ, Wittes J (1999) Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 341:410–418

    Article  PubMed  Google Scholar 

  • Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG, Brown L, Warnica JW, Arnold JMO, Wun C-C, Davis BR, Braunwald E (1996) The effects of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 335:1001–1009

    Article  PubMed  Google Scholar 

  • Saito Y, Nakao K, Mukoyama M, Imura H (1990) Increased plasma endothelin level in patients with essential hypertension [letter]. N Engl J Med 322:205

    Google Scholar 

  • Saku K, Ahmad M, Glas-Greenwalt P, Kashyap ML (1985) Activation of fibrinolysis by apolipoproteins of high density lipoproteins in man. Thromb Res 39:1–8

    PubMed  Google Scholar 

  • Schieffer B, Schieffer E, Hilfiker-Kleiner D, Hilfiker A, Kovanen PT, Kaartinen M, Nussberger J, Harringer W, Drexler H (2000) Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability. Circulation 101:1372–1378

    PubMed  Google Scholar 

  • Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, Zeiher A, Chaitman BR, Leslie S, Stern T (2001) Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. Jama 285:1711–1718

    PubMed  Google Scholar 

  • Serruys PW, de Feyter P, Macaya C, Kokott N, Puel J, Vrolix M, Branzi A, Bertolami MC, Jackson G, Strauss B, Meier B (2002) Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: a randomized controlled trial. JAMA 287:3215–3222

    PubMed  Google Scholar 

  • Spieker LE, Sudano I, Hurlimann D, Lerch PG, Lang MG, Binggeli C, Corti R, Ruschitzka F, Luscher TF, Noll G (2002) High-density lipoprotein restores endothelial function in hypercholesterolemic men. Circulation 105:1399–1402

    Article  PubMed  Google Scholar 

  • Stamler JS, Loh E, Roddy MA, Currie KE, Creager MA (1994) Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 89:2035–2040

    PubMed  Google Scholar 

  • Stamler JS, Singel DJ, Loscalzo J (1992) Biochemistry of nitric oxide and its redox-activated forms. Science 258:1898–1902

    PubMed  Google Scholar 

  • Stroes ES, Koomans HA, de Bruin TW, Rabelink TJ (1995) Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet 346:467–471

    Article  PubMed  Google Scholar 

  • Taddei S, Virdis A, Ghiadoni L, Uleri S, Magagna A, Salvetti A (1997) Lacidipine restores endothelium-dependent vasodilation in essential hypertensive patients. Hypertension 30:1606–1612

    PubMed  Google Scholar 

  • Treasure CB, Klein JL, Weintraub WS, Talley JD, Stillabower ME, Kosinski AS, Zhang J, Boccuzzi SJ, Cedarholm JC, Alexander RW et al. (1995) Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 332:481–487

    Article  PubMed  Google Scholar 

  • Vallance P, Collier J, Moncada S (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2:997–1000

    Article  PubMed  Google Scholar 

  • van Boven AJ, Jukema JW, Zwinderman AH, Crijns HJ, Lie KI, Bruschke AV (1996) Reduction of transient myocardial ischemia with pravastatin in addition to the conventional treatment in patients with angina pectoris. REGRESS Study Group [see comments]. Circulation 94:1503–1505

    PubMed  Google Scholar 

  • Van Lenten B, Wagner AC, Nayak DP, Hama S, Navab M, Fogelman A (2001) High-density lipoprotein loses its anti-inflammatory properties during acute influenza a infection. Circulation 103:2283–2288

    PubMed  Google Scholar 

  • Verhaar MC, Honing ML, van Dam T, Zwart M, Koomans HA, Kastelein JJ, Rabelink TJ (1999) Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids. Cardiovasc Res 42:752–760

    Article  PubMed  Google Scholar 

  • Verhaar MC, Wever RM, Kastelein JJ, van Dam T, Koomans HA, Rabelink TJ (1998) 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 97:237–241

    PubMed  Google Scholar 

  • Vierhapper H, Wagner O, Nowotny P, Waldhausl W (1990) Effect of endothelin-1 in man. Circulation 81:1415–1418

    PubMed  Google Scholar 

  • Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411–415

    PubMed  Google Scholar 

  • Yang Z, Krasnici N, Lüscher TF (1999) Endothelin-1 potentiates smooth muscle cell growth to PDGF: role of ETA and ETB receptor blockade. Circulation 100:5–8

    PubMed  Google Scholar 

  • Zeiher AM, Schachlinger V, Hohnloser SH, Saurbier B, Just H (1994) Coronary atherosclerotic wall thickening and vascular reactivity in humans. Elevated high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis. Circulation 89:2525–2532

    PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Cardiology, University Hospital, 8091, Zürich, Switzerland

    L.E. Spieker & T.F. Lüscher

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  1. L.E. Spieker
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  2. T.F. Lüscher
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Editors and Affiliations

  1. Institute of Clinical Chemistry, University Hospital of Zurich, Rämistrasse 100, 8091, Zürich, Switzerland

    Arnold von Eckardstein

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© 2005 Springer-Verlag Berlin Heidelberg

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Spieker, L., Lüscher, T. (2005). Protection of Endothelial Function. In: von Eckardstein, A. (eds) Atherosclerosis: Diet and Drugs. Handbook of Experimental Pharmacology, vol 170. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27661-0_23

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