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Functional MRI

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MR Imaging in White Matter Diseases of the Brain and Spinal Cord

Part of the book series: Medical Radiology Diagnostic Imaging ((Med Radiol Diagn Imaging))

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References

  • Andreasen NC (1995) Symptoms, signs, and diagnosis of schizophrenia. Lancet. 346(8973):477–481

    Article  PubMed  CAS  Google Scholar 

  • Andreasen NC (1997) The role of the thalamus in schizophrenia. Can J Psychiatry 42(1):27–33

    PubMed  CAS  Google Scholar 

  • Bandettini PA, Wong EC, Hinks RS, Tikofsky RS, Hyde JS (1992) Time course EPI of human brain function during task activation. Magn Reson Med 25(2):390–397

    PubMed  CAS  Google Scholar 

  • Barch DM, Carter CS, Braver TS, Sabb FW, MacDonald A III, Noll DC, Cohen JD (2001) Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Arch Gen Psychiatry 58(3):280–288

    PubMed  CAS  Google Scholar 

  • Barch DM, Csernansky JG, Conturo T, Snyder AZ (2002) Working and long-term memory deficits in schizophrenia: is there a common prefrontal mechanism? J Abnorm Psychol 111(3):478–494

    Article  PubMed  Google Scholar 

  • Belliveau JW, Kennedy DN Jr, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR (1991) Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254:716–719

    PubMed  CAS  Google Scholar 

  • Buckner RL (1998) Event-related fMRI and the hemodynamic response. Human Brain Mapping 6:373–377

    Article  PubMed  CAS  Google Scholar 

  • Buxton RB, Frank LR (1997) A model for the coupling between cerebral blood fl ow and oxygen metabolism during neural stimulation. J Cereb Blood Flow Metab 17(1):64–72

    PubMed  CAS  Google Scholar 

  • Buxton RB, Wong EC, Frank LR (1998) Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 39(6):855–864

    PubMed  CAS  Google Scholar 

  • Callicott JH, Bertolino A, Mattay VS, Langheim FJ, Duyn J, Coppola R, Goldberg TE, Weinberger DR (2000) Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex 10(11):1078–1092

    Article  PubMed  CAS  Google Scholar 

  • Chen W, Zhu XH (1997) Suppression of physiological eye movement artifacts in functional MRI using slab presaturation. Magn Reson Med 38(4):546–550

    PubMed  CAS  Google Scholar 

  • Daniel DG, Goldberg TE, Gibbons RD, Weinberger DR (1991) Lack of a bimodal distribution of ventricular size in schizophrenia: a Gaussian mixture analysis of 1056 cases and controls. Biol Psychiatry 30(9):887–903

    Article  PubMed  CAS  Google Scholar 

  • David AS, Woodruff PW, Howard R, Mellers JD, Brammer M, Bullmore E, Wright I, Andrew C, Williams SC (1996) Auditory hallucinations inhibit exogenous activation of auditory association cortex. Neuroreport 7(4):932–936

    PubMed  CAS  Google Scholar 

  • Davis TL, Kwong KK, Weisskoff RM, Rosen BR (1998) Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci U S A 95(4):1834–1839

    Article  PubMed  CAS  Google Scholar 

  • Duyn JH, Moonen CT, van Yperen GH, de Boer RW, Luyten PR (1994) Inflow versus deoxyhemoglobin effects in BOLD functional MRI using gradient echoes at 1.5 T. NMR Biomed 7(1-2):83–88

    PubMed  CAS  Google Scholar 

  • Ernst T, Hennig J (1994) Observation of a fast response in functional MR. Magn Reson Med 32(1):146–149

    Google Scholar 

  • Frackowiak RSJ, Friston KJ, Frith CD, Dolan RJ, Mazziotta JC (eds) (1997) Human brain function. Academic Press, San Diego

    Google Scholar 

  • Friston KJ (1998) The disconnection hypothesis. Schizophr Res 30(2):115–125

    Article  PubMed  CAS  Google Scholar 

  • Friston KJ, Frith CD (1995) Schizophrenia: a disconnection syndrome? Clin Neurosci 3(2):89–97

    PubMed  CAS  Google Scholar 

  • Friston KJ, Jezzard P, Turner R (1994) Analysis of functional MRI time series. Hum Brain Mapp 1:153–171

    Article  Google Scholar 

  • Friston K, Holmes A, Worsley K, Poline J-B, Frith C, Frackowiak R (1995) Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp 2:189–210

    Google Scholar 

  • Gaser C, Volz HP, Kiebel S, Riehemann S, Sauer H (1999) Detecting structural changes in whole brain based on nonlinear deformations—application to schizophrenia research. Neuroimage 10(2):107–113

    Article  PubMed  CAS  Google Scholar 

  • Gati JS, Menon RS, Ugurbil K, Rutt BK (1997) Experimental determination of the BOLD field strength dependence in vessels and tissue. Magn Reson Med 38(2):296–302

    PubMed  CAS  Google Scholar 

  • Golay X, Silvennoinen MJ, Zhou J, Clingman CS, Kauppinen RA, Pekar JJ, van Zijl PC (2001) Measurement of tissue oxygen extraction ratios from venous blood T2: increased precision and validation of principle. Magn Reson Med 46(2):282–291

    Article  PubMed  CAS  Google Scholar 

  • Grafman J, Litvan I (1999) Evidence for four forms of neuroplasticity. In: Grafman J, Christen Y (eds) Neuronal plasticity: building a bridge from the laboratory to the clinic (research and perspectives in neurosciences). Springer, Berlin Heidelberg New York, pp 131–139

    Google Scholar 

  • Grubb RL Jr, Raichle ME, Eichling JO, Ter-Pogossian MM (1974) The effects of changes in PaCO2 on cerebral blood volume, blood fl ow, and vascular mean transit time. Stroke 5(5):630–639

    PubMed  Google Scholar 

  • Haase A, Frahm J, Matthaei D, Hanicke W Merboldt KD (1986) FLASH imaging: rapid NMR imaging using low fl ip angles. J Magn Reson 67:217–222

    Google Scholar 

  • Hennig J, Hodapp M (1993) Burst imaging. MAGMA 1:39–48

    Google Scholar 

  • Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB (1999) Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci U S A 96(16):9403–9408

    Article  PubMed  CAS  Google Scholar 

  • Honey GD, Bullmore ET, Sharma T (2002) De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia. Schizophr Res 53(1-2):45–56

    Article  PubMed  Google Scholar 

  • Horner PJ, Gage FH (2000) Regenerating the damaged central nervous system. Nature 407(6807):963–970

    PubMed  CAS  Google Scholar 

  • Hulshoff Pol HE, Schnack HG, Mandl RC, van Haren NE, Koning H, Collins DL, Evans AC, Kahn RS (2001) Focal gray matter density changes in schizophrenia. Arch Gen Psychiatry 58(12):1118–1125

    Google Scholar 

  • Hulshoff Pol HE, Schnack HG, Mandl RC, Cahn W, Collins DL, Evans AC, Kahn RS (2004) Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity. Neuroimage 21(1):27–35

    Google Scholar 

  • Jacobs KM, Donoghue JP (1991) Reshaping the cortical motor map by unmasking latent intracortical connections. Science 251(4996):944–947

    PubMed  CAS  Google Scholar 

  • Jakob PM, Schlaug G, Griswold M, Lovblad KO, Thomas R, Ives JR, Matheson JK, Edelman RR (1998) Functional BURST imaging. Magn Reson Med 40(4):614–621

    PubMed  CAS  Google Scholar 

  • Jezzard P, Balaban RS (1995) Correction for geometric distortion in echo planar images from B0 field variations. Magn Reson Med 34:65–73

    PubMed  CAS  Google Scholar 

  • Jezzard P, Matthews PM, Smith SM (Eds) (2001) Functional magnetic resonance imaging: an introductory guide. Oxford University Press, Oxford

    Google Scholar 

  • Jones TA, Schallert T (1992) Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage. Brain Res 581(1):156–160

    Article  PubMed  CAS  Google Scholar 

  • Kim SG, Tsekos NV, Ashe J (1997) Multi-slice perfusion-based functional MRI using the FAIR technique: comparison of CBF and BOLD effects. NMR Biomed 10(4-5):191–196

    PubMed  CAS  Google Scholar 

  • Kruger G, Glover GH (2001) Physiological noise in oxygenation-sensitive magnetic resonance imaging. Magn Reson Med 46(4):631–637

    PubMed  CAS  Google Scholar 

  • Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, et al (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci U S A 89(12):5675–5679

    PubMed  CAS  Google Scholar 

  • Lawrie SM, Abukmeil SS (1998) Brain abnormality in schizophrenia: a systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry 172:110–120

    Article  PubMed  CAS  Google Scholar 

  • Liu G, Sobering G, Duyn J, Moonen CTW (1993) A functional MRI technique combining principles of echo-shifting with a train of observations (PRESTO). Magn Reson Med 30:764–768

    PubMed  CAS  Google Scholar 

  • Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A (2001) Neurophysiological investigation of the basis of the fMRI signal. Nature 412(6843):150–157

    Article  PubMed  CAS  Google Scholar 

  • Lotze M, Flor H, Grodd W, Larbig W, Birbaumer N (2001) Phantom movements and pain: an fMRI study in upper limb amputees. Brain 124(11):2268–2277

    Article  PubMed  CAS  Google Scholar 

  • Lowe IJ, Wysong RE (1993) DANTE ultrafast imaging sequence (DUFIS). J Magn Reson 101:106–109

    CAS  Google Scholar 

  • Luh WM, Wong EC, Bandettini PA, Ward BD, Hyde JS (2000) Comparison of simultaneously measured perfusion and BOLD signal increases during brain activation with T(1)-based tissue identification. Magn Reson Med 44(1):137–143

    Article  PubMed  CAS  Google Scholar 

  • MacDonald AW III, Carter CS (2003) Event-related FMRI study of context processing in dorsolateral prefrontal cortex of patients with schizophrenia. J Abnorm Psychol 112(4):689–697

    Article  PubMed  Google Scholar 

  • Mandeville JB, Marota JJ, Kosofsky BE, Keltner JR, Weissleder R, Rosen BR, Weisskoff RM (1998) Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn Reson Med 39(4):615–624

    PubMed  CAS  Google Scholar 

  • Mandeville JB, Marota JJ, Ayata C, Zaharchuk G, Moskowitz MA, Rosen BR, Weisskoff RM (1999) Evidence of a cerebrovascular postarteriole windkessel with delayed compliance. J Cereb Blood Flow Metab 19(6):679–689

    PubMed  CAS  Google Scholar 

  • Manoach DS, Gollub RL, Benson ES, Searl MM, Goff DC, Halpern E, Saper CB, Rauch SL (2000) Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol Psychiatry 48(2):99–109

    Article  PubMed  CAS  Google Scholar 

  • Mansfield P (1977) Multi-planar image formation using NMR spin echoes. J Phys C 10:L55–L58

    Article  CAS  Google Scholar 

  • McKinnon GC (1993) Ultrafast interleaved gradient-echoplanar imaging on a standard scanner. Magn Reson Med 30(5):609–616

    PubMed  CAS  Google Scholar 

  • Menon RS, Ogawa S, Hu X, Strupp JP, Anderson P, Ugurbil K (1995) BOLD based functional MRI at 4 Tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals. Magn Reson Med 33(3):453–459

    PubMed  CAS  Google Scholar 

  • Meyer CH, Macovski A (1987) Square spiral fast imaging: interleaving and off-resonance effects. Proceedings 6th Society for Magnetic Resonance in Medicine 1:230

    Google Scholar 

  • Moonen CT, Liu G, van Gelderen P, Sobering G (1992) A fast gradient-recalled MRI technique with increased sensitivity to dynamic susceptibility effects. Magn Reson Med 26(1):184–189

    PubMed  CAS  Google Scholar 

  • Ogawa S, Lee TM, Nayak AS, Glynn P (1990) Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14(1):68–78

    PubMed  CAS  Google Scholar 

  • Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A 89(13):5951–5955

    PubMed  CAS  Google Scholar 

  • Ogawa S, Menon RS, Tank DW, Kim SG, Merkle H, Ellermann JM, Ugurbil K (1993) Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J 64(3):803–812

    Article  PubMed  CAS  Google Scholar 

  • Oja JM, Gillen JS, Kauppinen RA, Kraut M, van Zijl PC (1999) Determination of oxygen extraction ratios by magnetic resonance imaging. J Cereb Blood Flow Metab 19(12):1289–1295

    PubMed  CAS  Google Scholar 

  • Ostergaard L, Weisskoff RM, Chesler DA, Gyldensted C, Rosen BR (1996) High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: Mathematical approach and statistical analysis. Magn Reson Med 36(5):715–725

    PubMed  CAS  Google Scholar 

  • Paillere-Martinot M, Caclin A, Artiges E, Poline JB, Joliot M, Mallet L, Recasens C, Attar-Levy D, Martinot JL (2001) Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia. Schizophr Res 50(1-2):19–26

    PubMed  CAS  Google Scholar 

  • Pauling L, Coryell C (1936) The magnetic properties and structure of hemoglobin, oxyhemoglobin and carbon monoxyhemoglobin. Proc Natl Acad Sci U S A 22:210–216

    CAS  PubMed  Google Scholar 

  • Perlstein WM, Carter CS, Noll DC, Cohen JD (2001) Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. Am J Psychiatry 158(7):1105–1113

    Article  PubMed  CAS  Google Scholar 

  • Ramsey NF, Koning HA, Welles P, Cahn W, van der Linden JA, Kahn RS (2002) Excessive recruitment of neural systems subserving logical reasoning in schizophrenia. Brain 125(8):1793–1807

    Article  PubMed  CAS  Google Scholar 

  • Riehemann S, Volz HP, Stutzer P, Smesny S, Gaser C, Sauer H (2001) Hypofrontality in neuroleptic-naive schizophrenic patients during the Wisconsin Card Sorting Test—a fMRI study. Eur Arch Psychiatry Clin Neurosci 251(2):66–71

    Article  PubMed  CAS  Google Scholar 

  • Rosen BR, Belliveau JW, Aronen HJ, Kennedy D, Buchbinder BR, Fischman A, Gruber M, Glas J, Weisskoff RM, Cohen MS, et al (1991) Susceptibility contrast imaging of cerebral blood volume: human experience. Magn Reson Med 22(2):293–299

    PubMed  CAS  Google Scholar 

  • Rubia K, Russell T, Bullmore ET, Soni W, Brammer MJ, Simmons A, Taylor E, Andrew C, Giampietro V, Sharma T (2001) An fMRI study of reduced left prefrontal activation in schizophrenia during normal inhibitory function. Schizophr Res 52(1-2):47–55

    Article  PubMed  CAS  Google Scholar 

  • Sharma T (2003) Insights and treatment options for psychiatric disorders guided by functional MRI. J Clin Invest 112(1):10–18

    Article  PubMed  CAS  Google Scholar 

  • Sharma T, Antonova L (2003) Cognitive function in schizophrenia. Deficits, functional consequences, and future treatment. Psychiatr Clin North Am 26(1):25–40

    Article  PubMed  Google Scholar 

  • Shergill SS, Brammer MJ, Williams SC, Murray RM, McGuire PK (2000) Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Arch Gen Psychiatry 57(11):1033–1038

    PubMed  CAS  Google Scholar 

  • Shergill SS, Brammer MJ, Fukuda R, Williams SC, Murray RM, McGuire PK (2003) Engagement of brain areas implicated in processing inner speech in people with auditory hallucinations. Br J Psychiatry 182:525–531

    PubMed  Google Scholar 

  • Sigmundsson T, Suckling J, Maier M, Williams S, Bullmore E, Greenwood K, Fukuda R, Ron M, Toone B (2001) Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am J Psychiatry 158(2):234–243

    Article  PubMed  CAS  Google Scholar 

  • Sowell ER, Levitt J, Thompson PM, Holmes CJ, Blanton RE, Kornsand DS, Caplan R, McCracken J, Asarnow R, Toga AW (2000) Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance images. Am J Psychiatry 157(9):1475–1484

    Article  PubMed  CAS  Google Scholar 

  • Springer CS (1994) Bulk magnetic susceptibility frequency shifts in cell suspensions. NMR Biomed 7:198–202

    Google Scholar 

  • Stroman PW, Ryner LN (2001) Functional MRI of motor and sensory activation in the human spinal cord. Magn Reson Imaging 19(1):27–32

    PubMed  CAS  Google Scholar 

  • Stroman PW, Nance PW, Ryner LN (1999) BOLD MRI of the human cervical spinal cord at 3 Tesla. Magn Reson Med 42(3):571–576

    Article  PubMed  CAS  Google Scholar 

  • Stroman PW, Krause V, Frankenstein UN, Malisza KL, Tomanek B (2001a) Spin-echo versus gradient-echo fMRI with short echo times. Magn Reson Imaging 19(6):827–831

    PubMed  CAS  Google Scholar 

  • Stroman PW, Krause V, Malisza KL, Frankenstein UN, Tomanek B (2001b) Characterization of contrast changes in functional MRI of the human spinal cord at 1.5 T. Magn Reson Imaging 19(6):833–838

    PubMed  CAS  Google Scholar 

  • Stroman PW, Krause V, Malisza KL, Frankenstein UN, Tomanek B (2002a) Extravascular proton-density changes as a non-BOLD component of contrast in fMRI of the human spinal cord. Magn Reson Med 48(1):122–127

    Article  PubMed  CAS  Google Scholar 

  • Stroman PW, Krause V, Malisza KL, Frankenstein UN, Tomanek B (2002b) Functional magnetic resonance imaging of the human cervical spinal cord with stimulation of different sensory dermatomes. Magn Reson Imaging 20(1):1–6

    PubMed  CAS  Google Scholar 

  • Stroman PW, Tomanek B, Krause V, Frankenstein UN, Malisza KL (2002c) Mapping of neuronal function in the healthy and injured human spinal cord with spinal fMRI. Neuroimage 17(4):1854–1860

    Article  PubMed  CAS  Google Scholar 

  • Stroman PW, Tomanek B, Krause V, Frankenstein UN, Malisza KL (2003) Functional magnetic resonance imaging of the human brain based on signal enhancement by extravascular protons (SEEP fMRI). Magn Reson Med 49(3):433–439

    Article  PubMed  CAS  Google Scholar 

  • Stroman PW, Kornelsen J, Bergman A, Krause V, Ethans K, Malisza KL, Tomanek B (2004) Noninvasive assessment of the injured human spinal cord by means of functional magnetic resonance imaging. Spinal Cord 42(2):59–66

    Article  PubMed  CAS  Google Scholar 

  • Surguladze SA, Calvert GA, Brammer MJ, Campbell R, Bullmore ET, Giampietro V, David AS (2001) Audio-visual speech perception in schizophrenia: an fMRI study. Psychiatry Res 106(1):1–14

    PubMed  CAS  Google Scholar 

  • Thulborn KR, Gisbert A (2001) Clinical applications of mapping neurocognitive processes in the human brain with functional MRI. In: Jezzard P, Matthews PM, Smith SM (eds) Functional magnetic resonance imaging: an introductory guide. Oxford University Press, Oxford, pp 353–382

    Google Scholar 

  • Thulborn KR, Waterton JC, Matthews PM, Radda GK (1982) Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 714(2):265–270

    PubMed  CAS  Google Scholar 

  • Toosy AT, Ciccarelli O, Parker GJ, Wheeler-Kingshott CA, Miller DH, Thompson AJ (2004) Characterising function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging. Neuroimage 21(4):1452–1463

    Article  PubMed  Google Scholar 

  • Turner R (2002) How much cortex can a vein drain? Downstream dilution of activation-related cerebral blood oxygenation changes. Neuroimage 16(4):1062–1067

    Article  PubMed  Google Scholar 

  • Turner R, Le Bihan D, Moonen CT, Despres D, Frank J (1991) Echo-planar time course MRI of cat brain oxygenation changes. Magn Reson Med 22(1):159–166

    PubMed  CAS  Google Scholar 

  • van Zijl PCM, Eleff SM, Ulatowski JA, Oja JME, Ulug AM, Traystman RJ, Kauppinen RA (1998) Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging. Nat Med 4(2):159–167

    PubMed  Google Scholar 

  • Waxman SG (2001) Acquired channelopathies in nerve injury and MS. Neurology 56(12):1621–1627

    PubMed  CAS  Google Scholar 

  • Weisskoff RM (1996) Simple measurement of scanner stability for functional NMR imaging of activation in the brain. Magn Reson Med 36:643–645

    PubMed  CAS  Google Scholar 

  • Williams DS, Detre JA, Leigh JS, Koretsky AP (1992) Magnetic resonance imaging of perfusion using spin inversion of arterial water. Proc Natl Acad Sci U S A 89(1):212–216

    PubMed  CAS  Google Scholar 

  • Wong EC, Buxton RB, Frank LR (1998) Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II). Magn Reson Med 39:702–708

    PubMed  CAS  Google Scholar 

  • Wong EC, Buxton RB, Frank LR (1999) Quantitative perfusion imaging using arterial spin labeling. Neuroimaging Clin N Am 9(2):333–342

    PubMed  CAS  Google Scholar 

  • Woodruff PW, Wright IC, Bullmore ET, Brammer M, Howard RJ, Williams SC, Shapleske J, Rossell S, David AS, McGuire PK, Murray RM (1997) Auditory hallucinations and the temporal cortical response to speech in schizophrenia: a functional magnetic resonance imaging study. Am J Psychiatry 154(12):1676–1682

    PubMed  CAS  Google Scholar 

  • Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET (2000) Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry 157(1):16–25

    PubMed  CAS  Google Scholar 

  • Ye FQ, Allen PS (1995) Relaxation enhancement of the transverse magnetization of water protons in paramagnetic suspensions of red blood cells. Magn Reson Med 34(5):713–720

    PubMed  CAS  Google Scholar 

  • Yoshizawa T, Nose T, Moore GJ, Sillerud LO (1996) Functional magnetic resonance imaging of motor activation in the human cervical spinal cord. Neuroimage 4(3):174–182

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. FMRIB Centre, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    P. Jezzard PhD

  2. Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK

    A. Toosy MD

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  1. P. Jezzard PhD
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  2. A. Toosy MD
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Editors and Affiliations

  1. Neuroimaging Research Unit Department of Neurology Scientific Institute, University Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy

    Massimo Filippi MD (Director) (Director)

  2. Department of Neurology & Behavioral Sciences, University of Siena, Viale Bracci 2, 53100, Siena, Italy

    Nicola De Stefano MD PhD (Associate Professor) (Associate Professor)

  3. Service de Neuroradiologie Diagnostique et Thérapeutique CHU Bordeaux Pellegrin and Laboratoire de Neurobiologie des Affections de la Myéline, Université Victor Segalen, Bourdeaux 2, 33076, Bordeaux, France

    Vincent Dousset MD, PhD (Professor) (Professor)

  4. Department of Electrical Engineering, United States Naval Academy, Maury Hall 227, Annapolis, MD, 21402-5025, USA

    Joseph C. McGowan PhD (Associate Professor of Electrical Engineering) (Associate Professor of Electrical Engineering)

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Jezzard, P., Toosy, A. (2005). Functional MRI. In: Filippi, M., De Stefano, N., Dousset, V., McGowan, J.C. (eds) MR Imaging in White Matter Diseases of the Brain and Spinal Cord. Medical Radiology Diagnostic Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27644-0_8

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