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MR Imaging in White Matter Diseases of the Brain and Spinal Cord pp 377–388Cite as

Neurodegenerative Diseases with Associated White Matter Pathology

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Part of the book series: Medical Radiology Diagnostic Imaging ((Med Radiol Diagn Imaging))

Conclusions

Conventional MR imaging can show macroscopic white matter signal changes in degenerative diseases of the CNS which are a useful diagnostic tool for FTD, OPCA, SA, and PLS/ALS.

Non-conventional MR, including DTI, MT and 1H-MRS, demonstrates abnormalities of the white matter in almost every degenerative disease of the CNS. These white matter changes are variably correlated to the severity of the clinical deficit and are currently evaluated as markers of disease progression and possible surrogate markers in pharmacological trials.

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Authors and Affiliations

  1. Sezione di Radiodiagnostica, Dipartimento di Fisiopatologia Clinica, Università di Firenze, Viale Morgagni, 85, 50134, Firenze, Italy

    Mario Mascalchi MD (Professor)

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  1. Mario Mascalchi MD
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Editors and Affiliations

  1. Neuroimaging Research Unit Department of Neurology Scientific Institute, University Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy

    Massimo Filippi MD (Director) (Director)

  2. Department of Neurology & Behavioral Sciences, University of Siena, Viale Bracci 2, 53100, Siena, Italy

    Nicola De Stefano MD PhD (Associate Professor) (Associate Professor)

  3. Service de Neuroradiologie Diagnostique et Thérapeutique CHU Bordeaux Pellegrin and Laboratoire de Neurobiologie des Affections de la Myéline, Université Victor Segalen, Bourdeaux 2, 33076, Bordeaux, France

    Vincent Dousset MD, PhD (Professor) (Professor)

  4. Department of Electrical Engineering, United States Naval Academy, Maury Hall 227, Annapolis, MD, 21402-5025, USA

    Joseph C. McGowan PhD (Associate Professor of Electrical Engineering) (Associate Professor of Electrical Engineering)

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Mascalchi, M. (2005). Neurodegenerative Diseases with Associated White Matter Pathology. In: Filippi, M., De Stefano, N., Dousset, V., McGowan, J.C. (eds) MR Imaging in White Matter Diseases of the Brain and Spinal Cord. Medical Radiology Diagnostic Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27644-0_26

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  • DOI: https://doi.org/10.1007/3-540-27644-0_26

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  • Online ISBN: 978-3-540-27644-9

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