Skip to main content
SpringerLink
Log in

White Matter Pathology in Systemic Immune-Mediated Diseases

  • Chapter
MR Imaging in White Matter Diseases of the Brain and Spinal Cord

Part of the book series: Medical Radiology Diagnostic Imaging ((Med Radiol Diagn Imaging))

  • 1652 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Akman-Demir G, Serdaroglu P, Tasçi B and the Neuro-Behçet Study Group (1999) Clinical patterns of neurological involvement in Behçet’s disease: evaluation of 200 patients. Brain 122:2171–2181

    Article  PubMed  Google Scholar 

  • Barkhof F, Filippi M, Miller DH et al (1997) Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 120:2059–2069

    Article  PubMed  Google Scholar 

  • Basser PJ, Pierpaoli C (1996) Microstructural features measured using diffusion tensor imaging. J Magn Reson B 111:209–219

    PubMed  CAS  Google Scholar 

  • Basser PJ, Mattiello J, Le Bihan D (1994) Estimation of the effective self-diffusion tensor from the NMR spin-echo. J Magn Reson B 103:247–254

    PubMed  CAS  Google Scholar 

  • Bell CL, Partington C, Robbins M et al (1991) Magnetic resonance imaging of central nervous system lesions in patients with lupus erythematosus. Correlation with clinical remission and antineurofilament and anticardiolipin antibody titers. Arthritis Rheum 34:432–441

    PubMed  CAS  Google Scholar 

  • Bosma GPT, Rood MJ, Zwinderman AH et al (2000a) Evidence of central nervous system damage in patients with neuropsychiatric systemic lupus erythematosus, demonstrated by magnetization transfer imaging. Arthr Reum 43:48–54

    CAS  Google Scholar 

  • Bosma GPT, Rood MJ, Huizinga TWJ et al (2000b) Detection of cerebral involvement in patients with active neuropsychiatric systemic lupus erythematosus by the use of volumetric magnetization transfer imaging. Arthr Reum 43:428–2436

    Google Scholar 

  • Bosma GPT, Middelkoop HAM, Rood MJ et al (2002) Association of global brain damage and clinical functioning in neuropsychiatric systemic lupus erythematosus. Arthr Reum 46:2665–2672

    Google Scholar 

  • Bosma GPT, Huizinga TWJ, Mooijaart SP et al (2003) Abnormal brain diffusivity in patients with neuropsychiatric systemic lupus erythematosus. AJNR Am J Neuroradiol 24:850–854

    PubMed  Google Scholar 

  • Bot JCJ, Barkhof F, Lycklama à Nijeholt G et al (2002) Differentiation of multiple sclerosis from other inflammatory disorders and cerebrovascular disease: value of spinal MR imaging. Radiology 223:46–56

    PubMed  Google Scholar 

  • Boumpas DT, Patronas NJ, Dalakas MC et al (1990) Acute transverse myelitis in systemic lupus erythematosus: magnetic resonance imaging and review of the literature. J Rheumatol 17:89–92

    PubMed  CAS  Google Scholar 

  • Brochet B, Dousset V (1999) Pathological correlates of magnetization transfer imaging abnormalities in animal models and humans with multiple sclerosis. Neurology 53[Suppl 3]:S12–S17

    PubMed  CAS  Google Scholar 

  • Calabrese LH, Duna GF, Lie T (1997) Vasculitis in the central nervous system. Arthritis Rheum 40:1189–1201

    PubMed  CAS  Google Scholar 

  • Campi A, Filippi M, Gerevini S et al (1996) Multiple white matter lesions of the brain. Magnetization transfer ratios in systemic lupus erythematosus and multiple sclerosis. Int J Neuroradiol 2:134–140

    Google Scholar 

  • Cellerini M, Bartolucci M, Mortilla M et al (2003) MR imaging and proton MR spectroscopy of the brain in Behçet’s disease. Rivista di Neuroradiologia 16:267–274

    Google Scholar 

  • Chinn RJS, Wilkinson ID, Hall-Craggs MA et al (1997) Magnetic resonance imaging of the brain and cerebral proton spectroscopy in patients with systemic lupus erythematosus. Arthritis Rheum 40:36–46

    PubMed  CAS  Google Scholar 

  • Coban O, Bahar S, Akman-Demir G et al (1996) A controlled study of reliability and validity of MRI findings in neuro-Behçet disease. Neuroradiology 38:312–316

    PubMed  CAS  Google Scholar 

  • Csépàny T, Bereczki D, Kollar J et al (2003) MRI findings in central nervous system systemic lupus erythematosus are associated with immunoserological parameters and hypertension. J Neurol 250:1348–1354

    PubMed  Google Scholar 

  • Davie CA, Fenstein A, Kartsounis LD et al (1995) Proton magnetic resonance spectroscopy of systemic lupus erythematosus involving the central nervous system. J Neurol 242:522–528

    Article  PubMed  CAS  Google Scholar 

  • Dehmeshki J, van Buchem MA, Bosma GPT et al (2002) Systemic lupus erythematosus: diagnostic application of magnetization transfer ratio histograms in patients with neuropsychiatric symptoms — initial results. Radiology 222:722–728

    PubMed  Google Scholar 

  • Deodhar AA, Hochenedel T, Bennett RM (1999) Longitudinal involvement of the spinal cord in a patient with lupus related transverse myelitis. J Rheumatol 26:446–449

    PubMed  CAS  Google Scholar 

  • De Stefano N Federico A (2001) Overview of magnetic resonance spectroscopy studies in white matter diseases other than multiple sclerosis. In: Filippi M, Arnold DL, Comi G (eds) Magnetic resonance spectroscopy in multiple sclerosis. Springer, Milan, pp 121–133

    Google Scholar 

  • Fazekas F, Barkhof F, Filippi M et al (1999) The contribution of magnetic resonance imaging to the diagnosis of multiple sclerosis. Neurology 53:448–456

    PubMed  CAS  Google Scholar 

  • Fieschi C, Rasura M, Anzini A et al (1998) Central nervous system vasculitis. J Neurol Sci 153:159–171

    Article  PubMed  CAS  Google Scholar 

  • Friedman SD, Stidley CA, Brooks WM et al (1998) Brain injury and neurometabolic abnormalities in systemic lupus erythematosus. Radiology 209:79–84

    PubMed  CAS  Google Scholar 

  • Gerber S, Biondi A, Dormont D et al (1996) Long-term MR follow-up of cerebral lesions in neuro-Behçet disease. Neuroradiology 38:761–768

    Article  PubMed  CAS  Google Scholar 

  • Gumà A, Aguileira C, Acebes J et al (1998) Meningeal involvement in Behçet disease: MRI. Neuroradiology 40:512–515

    PubMed  Google Scholar 

  • Hachulla E, Michon Pasturel U, Leys D et al (1998) Cerebral magnetic resonance imaging in patients with or without antiphospholipid antibodies. Lupus 7:124–131

    Article  PubMed  CAS  Google Scholar 

  • Handa R, Sahota P, Kumar M et al (2003) In vivo proton magnetic resonance spectroscopy (MRS) and single photon emission computerized tomography (SPECT) in systemic lupus erythematosus (SLE). Magn Reson Imaging 21:1033–1037

    PubMed  CAS  Google Scholar 

  • Hiwatashi A, Garber T, Moritani T et al (2003) Diffusionweighted MR imaging of neuro-Behçet’s disease: case report. Neuroradiology 45:468–471

    Article  PubMed  Google Scholar 

  • Ijdo JW, Conti-Kelly AM, Greco P et al (1999) Anti-phospholipid antibodies in patients with multiple sclerosis and MS-like illnesses: MS or APS? Lupus 8:109–115

    Article  PubMed  CAS  Google Scholar 

  • Jennings JE, Sundgren PC, Attwood J et al (2004) Value of MRI of the brain in patients with systemic lupus erythematosus and neurologic disturbance. Neuroradiology 461:15–21

    Google Scholar 

  • Karussis D, Leker RR, Ashkenazi A et al (1998) A subgroup of multiple sclerosis patients with anticardiolipin antibodies and unusual clinical manifestations: do they represent a new nosological entity? Ann Neurol 44:629–634

    Article  PubMed  CAS  Google Scholar 

  • Kozora E, West SG, Kotzin BL et al (1998) Magnetic resonance imaging abnormalities and cognitive deficits in systemic lupus erythematosus patients without overt central nervous system disease. Arthritis Rheum 41:41–47

    Article  PubMed  CAS  Google Scholar 

  • Kunimatsu A, Abe O, Aoki S et al (2003) Neuro-Behçet’s disease: analysis of apparent diffusion coefficients. Neuroradiology 45:524–527

    PubMed  CAS  Google Scholar 

  • Le Bihan D, Breton E, Lallemand D et al (1986) MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 161:401–407

    PubMed  Google Scholar 

  • Le Bihan D, Turner R, Pekar J et al (1991) Diffusion and perfusion imaging by gradient sensitization: design, strategy and significance. J Magn Reson Imaging 1:7–8

    PubMed  Google Scholar 

  • Lee SH, Yoon PH, Park SJ et al (2001) MRI findings in neuro-Behçet’s disease. Clin Radiol 56:485–494

    PubMed  CAS  Google Scholar 

  • Liem MD, Gzesh DJ, Flanders AE (1996) MRI and angiographic diagnosis of lupus cerebral vasculitis. Neuroradiology 38:134–136

    PubMed  CAS  Google Scholar 

  • Lim K, Suh CH, Kim HJ et al (2000) Systemic lupus erythematosus: brain MR imaging and single-voxel hydrogen 1 MR spectroscopy. Radiology 217:43–49

    PubMed  CAS  Google Scholar 

  • Lycklama à Nijeholt GJ, van Walderveen MAA, Castelijns JA et al (1998) Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms. Brain 121:687–697

    Google Scholar 

  • Mascalchi M, Cosottini M, Cellerini M et al (1998) MRI of spinal cord involvement in Behçet disease: case report. Neuroradiology 40:255–257

    Article  PubMed  CAS  Google Scholar 

  • Mattioli F, Capra R, Rovaris M et al (2002) Frequency and patterns of subclinical cognitive impairment in patients with ANCA-associated small vessel vasculitides. J Neurol Sci 195:161–166

    Article  PubMed  Google Scholar 

  • Maubon AJ, Pothin A, Ferru JM et al (1998) Unselected brain 0.5 T MR imaging: comparison of lesion detection and characterization with three T2-weighted sequences. Radiology 208:671–678

    PubMed  CAS  Google Scholar 

  • Miller DH, Ormerod IEC, Gibson A et al (1987) MR brain scanning in patients with vasculitis: differentiation from multiple sclerosis. Neuroradiology 29:226–231

    Article  PubMed  CAS  Google Scholar 

  • Miller DH, Grossman RI, Reingold SC et al (1998) The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain 121:3–24

    Article  PubMed  Google Scholar 

  • Miller DH, Thompson AJ, Filippi M (2003) Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosis. J Neurol 250:1407–1419

    Article  PubMed  CAS  Google Scholar 

  • Mok CC, Lau CS, Chan EY et al (1998) Acute transverse myelopathy in systemic lupus erythematosus: clinical presentation, treatment and outcome. J Rheumatol 25:467–473

    PubMed  CAS  Google Scholar 

  • Moritani T, Shrier DA, Nugamuchi Y et al (2001) Diffusionweighted echo-planar MR imaging of CNS involvement in systemic lupus erythematosus. Acad Radiol 8:741–753

    Article  PubMed  CAS  Google Scholar 

  • Morrissey SP, Miller DH, Hermaszawski R et al (1993) Magnetic resonance imaging in the central nervous system in Behçet’s disease. Eur Neurol 33:287–293

    PubMed  CAS  Google Scholar 

  • Mottershead JP, Schmierer K, Clemence M et al (2003) High field MRI correlates of myelin content and axonal density in multiple sclerosis. A post-mortem study of the spinal cord. J Neurol 250:1293–1301

    Article  PubMed  CAS  Google Scholar 

  • Nadeau SE (1997) Diagnostic approach to central and peripheral nervous system vasculitis. Neurol Clin 15:759–777

    Article  PubMed  CAS  Google Scholar 

  • Provenzale JM, Allen NB (1996) Wegener granulomatosis: CT and MR findings. AJNR Am J Neuroradiol 17:785–792

    PubMed  CAS  Google Scholar 

  • Provenzale JM, Barboriak DP, Gaensler EH et al (1994) Lupusrelated myelitis: serial MR findings. AJNR Am J Neuroradiol 15:1911–1917

    PubMed  CAS  Google Scholar 

  • Rovaris M, Filippi M (2003) Magnetization transfer imaging. In: Filippi M., Comi G (eds) New frontiers of MR-based techniques in multiple sclerosis. Springer, Milan, p 19

    Google Scholar 

  • Rocca MA, Mastronardo G, Horsfield MA et al (1999) Comparison of three MR sequences for the detection of cervical cord lesions in multiple sclerosis. AJNR Am J Neuroradiol 20:1710–1716

    PubMed  CAS  Google Scholar 

  • Rovaris M, Inglese M, Viti B et al (2000a) The contribution of fast-FLAIR MRI for lesion detection in the brain of patients with systemic autoimmune diseases. J Neurol 247:29–33

    PubMed  CAS  Google Scholar 

  • Rovaris M, Viti B, Ciboddo G et al (2000b) Brain involvement in systemic immune-mediated diseases: magnetic resonance and magnetisation transfer imaging study. J Neurol Neurosurg Psychiatry 68:170–177

    Article  PubMed  CAS  Google Scholar 

  • Rovaris M, Viti B, Ciboddo G et al (2000c) Cervical cord magnetic resonance imaging in systemic immune-mediated diseases. J Neurol Sci 176:128–130

    Article  PubMed  CAS  Google Scholar 

  • Rovaris M, Holtmannspotter M, Rocca MA et al (2002) Contribution of cervical cord MRI and brain magnetization transfer imaging to the assessment of individual patients with multiple sclerosis: a preliminary study. Mult Scler 8:52–58

    Article  PubMed  CAS  Google Scholar 

  • Sabet A, Sibbitt WL Jr, Stidley CA, Danska J, Brooks WM (1998) Neurometabolite markers of cerebral injury in the antiphospholipid antibody syndrome of systemic lupus erythematosus. Stroke 29:2254–2260

    PubMed  CAS  Google Scholar 

  • Sailer M, Burchert W, Ehrenheim C et al (1997) Positron emission tomography and magnetic resonance imaging for cerebral involvement in patients with systemic lupus erythematosus. J Neurol 244:186–193

    Article  PubMed  CAS  Google Scholar 

  • Salmaggi A, Lamperti E, Eoli M et al (1994) Spinal cord involvement and systemic lupus erythematosus: clinical and magnetic resonance findings in 5 patients. Clin Exp Rheumatol 12:389–394

    PubMed  CAS  Google Scholar 

  • Sibbit WL, Haseler LJ, Griffey RR et al (1997) Neurometabolism of active neuropsychiatric lupus determined with proton MR Spectroscopy. AJNR Am J Neuroradiol 18:1271–1277

    Google Scholar 

  • Triulzi F, Scotti G (1998) Differential diagnosis of multiple sclerosis: contribution of magnetic resonance techniques. J Neurol Neurosurg Psychiatry 64[Suppl 1]:S6–S14

    PubMed  Google Scholar 

  • Trysberg E, Nylen K, Rosengren LE et al (2003) Neuronal and astrocytic damage in systemic lupus erythematosus patients with central nervous system involvement. Arthr Reum 48:2710–2712

    Google Scholar 

  • van Buchem MA, McGowan JC, Kolson DL et al (1996) Quantitative volumetric magnetization transfer analysis in multiple sclerosis: estimation of macroscopic and microscopic disease burden. Magn Reson Med 36:632–636

    PubMed  Google Scholar 

  • Waterloo K, Omdal R, Sjoholm H et al (2001) Neuropsychological dysfunction in systemic lupus erythematosus is not associated with changes in cerebral blood flow. J Neurol 248:595–602

    Article  PubMed  CAS  Google Scholar 

  • Weingarten K, Filippi C, Barbut D et al (1997) The neuroimaging features of the cardiolipin antibody syndrome. Clin Imaging 21:6–12

    Article  PubMed  CAS  Google Scholar 

  • West SG, Emlen W, Wener MH et al (1995) Neuropsychiatric lupus erythematosus: a 10-year prospective study on the value of diagnostic tests. Am J Med 99:153–163

    Article  PubMed  CAS  Google Scholar 

  • Yoshioka H, Matsubara T, Miyanomae Y et al (1996) Spinal cord MRI in neuro-Behçet disease. Neuroradiology 38:661–662

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy

    Marco Rovaris MD & Massimo Filippi MD (Director)

Authors
  1. Marco Rovaris MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Massimo Filippi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Neuroimaging Research Unit Department of Neurology Scientific Institute, University Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy

    Massimo Filippi MD (Director) (Director)

  2. Department of Neurology & Behavioral Sciences, University of Siena, Viale Bracci 2, 53100, Siena, Italy

    Nicola De Stefano MD PhD (Associate Professor) (Associate Professor)

  3. Service de Neuroradiologie Diagnostique et Thérapeutique CHU Bordeaux Pellegrin and Laboratoire de Neurobiologie des Affections de la Myéline, Université Victor Segalen, Bourdeaux 2, 33076, Bordeaux, France

    Vincent Dousset MD, PhD (Professor) (Professor)

  4. Department of Electrical Engineering, United States Naval Academy, Maury Hall 227, Annapolis, MD, 21402-5025, USA

    Joseph C. McGowan PhD (Associate Professor of Electrical Engineering) (Associate Professor of Electrical Engineering)

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rovaris, M., Filippi, M. (2005). White Matter Pathology in Systemic Immune-Mediated Diseases. In: Filippi, M., De Stefano, N., Dousset, V., McGowan, J.C. (eds) MR Imaging in White Matter Diseases of the Brain and Spinal Cord. Medical Radiology Diagnostic Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27644-0_23

Download citation

  • DOI: https://doi.org/10.1007/3-540-27644-0_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40230-5

  • Online ISBN: 978-3-540-27644-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation