This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Editorial Committee of the Manual of the Japanese Pharmacopoeia (ed) (1996) Manual of Japanese Pharmacopoeia, 13th edn. Hirokawa Publishing Co., Tokyo, pp C556–C559 (in Japanese)
Hawks RL, Kopin IJ, Colburn RW et al. (1974) A pharmacologically active metabolite of cocaine found in brain. Life Sci 15:2189–2195
Baselt RC (1983) Stability of cocaine in biological fluids. J Chromatogr 268:502–505
Isenschmid DS, Levine BS, Caplan YH (1989) A comprehensive study of the stability of cocaine and its metabolites. J Anal Toxicol 13:250–256
Matsubara K, Maseda C, Fukui Y (1984) Quantitation of cocaine, benzoylecgonine and ecgonine methyl ester by GC-CI-MS after Extrelut extraction. Forensic Sci Int 26:181–192
Varian’s Bond Elut Certify Instruction Manual. Harbor City, CA, USA
Abusada GM, Abukhalaf IK, Alford DD et al. (1993) Solid-phase extraction and GC/MS quantitation of cocaine, ecgonine methyl ester, benzoyl-ecgonine, and cocaethylene from meconium, whole blood, and plasma. J Anal Toxicol 17:353–358
Crouch DJ, Alburges ME, Spanbauer AC et al. (1995) Analysis of cocaine and its metabolites from biological specimens using solid-phase extraction and positive ion chemical ionization mass spectrometry. J Anal Toxicol 19:352–358
Ueki M (1999) Significance and problems of doping tests and toxin analysis. Nipponrinsho 57:361–363 (in Japanese)
Sander R, Ryser MA, Lamoreaux TC et al. (1985) An epidemic of cocaine associated deaths in Utah. J Forensic Sci 30:478–484
Spiehler VR, Reed D (1985) Brain concentrations of cocaine and benzoylecgonine in fatal cases. J Forensic Sci 30:1003–1011
Karch SB, Stephens B, Ho C-H (1998) Relating cocaine blood concentrations to toxicity-an autopsy study of 99 cases. J Forensic Sci 43:41–45
Jenkins AJ, Levine B, Titus J et al. (1999) The interpretation of cocaine and benzoylecgonine concentrations in postmortem cases. Forensic Sci Int 101:17–25
Hamilton HE, Wallace JE, Shimek EL et al. (1977) Cocaine and benzoylecgonine excretion in humans. J Forensic Sci 22:697–707
Amber J (1985) The urinary excretion of cocaine and metabolites in humans: a kinetic analysis of published data. J Anal Toxicol 9:241–245
Moffat AC, Jackson JV, Moss MS et al. (eds) (1986) Clark’s Isolation and Identification of Drugs, 2nd edn. The Pharmaceutical Press, London, pp 489–490
Vitti TG, Boni RL (1985) Metabolism of cocaine. In: Barnett G, Chiang CN (eds) Pharmacokinetics and Pharmacodynamics of Psychoactive Drugs. Biomedical Publications, Foster City, CA, pp 427–440
Amber J, Fischman M, Ruo T-I (1984) Urinary excretion of ecgonine methyl ester, a major metabolite of cocaine in humans. J Anal Toxicol 8:23–25
Amber J, Ruo TI, Nelson J et al. (1988) Urinary excretion of cocaine, benzoylecgonine, and ecgonine methyl ester in humans. J Anal Toxicol 12:301–306
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Takekawa, K. (2005). Cocaine and its metabolites. In: Drugs and Poisons in Humans. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27579-7_22
Download citation
DOI: https://doi.org/10.1007/3-540-27579-7_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-22277-4
Online ISBN: 978-3-540-27579-4
eBook Packages: MedicineMedicine (R0)