Abstract
Rho GTPases are molecular switches controlling a broad range of cellular processes including lymphocyte activation. Not surprisingly, Rho GTPases are now recognized as pivotal regulators of antigen-specific T cell activation by APCs and immunological synapse formation. This review summarizes recent advances in our understanding of how Rho GTPase-dependent pathways control T lymphocyte motility, polarization and activation.
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Deckert, M., Moon, C., Le Bras, S. (2005). The Immunological Synapse and Rho GTPases. In: Boquet, P., Lemichez, E. (eds) Bacterial Virulence Factors and Rho GTPases. Current Topics in Microbiology and Immunology, vol 291. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27511-8_5
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