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RNA Towards Medicine pp 9–43Cite as

Regulatory RNAs as Mediators of Virulence Gene Expression in Bacteria

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 173))

Abstract

Bacteria exploit functional diversity of RNAs in a wide range of regulatory mechanisms to control gene expression. In last few years, small RNA molecules have been discovered at a staggering rate in bacteria, mainly in Escherichia coli. While functions of many of these RNA molecules are still not known, several of them behave as key effectors of adaptive responses, such as environmental cue recognition, stress response, and virulence control. Most fascinating, perhaps, is the discovery that mRNAs behave as direct sensors of small molecules or of environmental cues. The astonishing diversity of RNA-dependent regulatory mechanisms is linked to the dynamic properties and versatility of the RNA structure. In this review, we relate several recent studies in different bacterial pathogens that illustrate the diverse roles of RNA to control virulence gene expression.

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Authors and Affiliations

  1. Institut de Biologie Moléculaire et Cellulaire, UPR 9002 CNRS, Université Louis Pasteur, 15 rue R. Descartes, 67084, Strasbourg cedex, France

    T. Geissmann, M. Possedko, E. Huntzinger, P. Fechter, C. Ehresmann & P. Romby

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  1. T. Geissmann
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  2. M. Possedko
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  3. E. Huntzinger
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  4. P. Fechter
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  5. C. Ehresmann
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  6. P. Romby
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Editors and Affiliations

  1. Institute of Chemistry/Biochemistry, Free University Berlin, Thielallee 63, 14195, Berlin, Germany

    Volker Erdmann

  2. Institute of Bioorganic Chemistry, Polish Academy of Scienes, Noskowskiego 12/14, 61-704, Poznan, Poland

    Jan Barciszewski

  3. Institute of Experimental Pathology, Molecular Neurobiology (ZMBE), University of Münster, Von-Esmarch-Str. 56, 48149, Münster, Germany

    Jürgen Brosius

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Geissmann, T., Possedko, M., Huntzinger, E., Fechter, P., Ehresmann, C., Romby, P. (2006). Regulatory RNAs as Mediators of Virulence Gene Expression in Bacteria. In: Erdmann, V., Barciszewski, J., Brosius, J. (eds) RNA Towards Medicine. Handbook of Experimental Pharmacology, vol 173. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27262-3_2

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