Abstract
In the early years of molecular biology—over 50 years ago—we were faced with many unknowns. A significant one at the time was the relationship between DNA and RNA, both in terms of structure and function. Function is often a reflection of structure. Here I outline some of the early research in this area, especially for RNA structure, which was completely unknown when we started.
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References
Anonymous (1973) News and views. Nature 243:114
Arnott S, Wilkins MHF, Hamilton LD, Langridge R (1965) Fourier synthesis studies of lithium DNA. III. Hoogsteen models. J Mol Biol 11:391–402
Day RO, Seeman NC, Rosenberg JM, Rich A (1973) A crystalline fragment of the double helix: the structure of the dinucleoside phosphate guanylyl-3′, 5″-cytidine. Proc Natl Acad Sci USA 70:849–853
Egli M, Usman N, Zhang S, Rich A (1992) Crystal structure of an Okazaki fragment at 2-Å resolution. Proc Natl Acad Sci USA 89:534–538
Felsenfeld G, Davies DR, Rich A (1957) Formation of a three-stranded polynucleotide molecule. J Am Chem Soc 79:2023–2024
Franklin RE, Gosling RG (1953) Molecular configuration in sodium thymonucleate. Nature 171:740–741
Furth JJ, Hurwitz J, Goldmann M (1961) The directing role of DNA in RNA synthesis. Biochem Biophys Res Commun 4:362–367
Hoogsteen K (1959) The crystal and molecular structure of a hydrogen-bonded complex between 1-methylthymine and 9-methyladenine. Acta Crystallogr 12:822–823
Kim S-H, Quigley G, Suddath FL, Rich A (1971) High resolution X-ray diffraction patterns of tRNA crystals showing helical regions of the molecule. Proc Natl Acad Sci USA 68:841–845
Kim S-H, Quigley GJ, Suddath FL, McPherson A, Sneden D, Kim JJ, Weinzierl J, Rich A (1973) Three-dimensional structure of yeast phenylalanine transfer RNA: folding of the polynucleotide chain. Science 179:285–288
Kim SH, Suddath FL, Quigley GJ, McPherson A, Sussman JL, Wang AH, Seeman NC, Rich A (1974) Three-dimensional tertiary structure of yeast phenylalanine transfer RNA. Science 185:435–439
Rich A (1960) A hybrid helix containing both deoxyribose and ribose polynucleotides and its relation to the transfer of information between the nucleic acids. Proc Natl Acad Sci USA 46:1044–1053
Rich A (1962) On the problems of evolution and biochemical information transfer. In: Kasha M, Pullman B (eds) Horizons in biochemistry. Academic Press, New York, pp 103–126
Rich A, Davies DR (1956) A new two-stranded helical structure: polyadenylic acid and polyuridylic acid. J Am Chem Soc 78:3548
Rich A, Watson JD (1954) Some relations between DNA and RNA. Proc Natl Acad Sci USA 40:759–764
Rich A, Wang AHJ, Quigley GJ (1980) Diversity of sugar pucker in the nucleic acids. In: Ananchenko SN (ed) Frontiers of bioorganic chemistry and molecular biology (International Union of Pure and Applied Chemistry). Pergamon Press, Oxford, pp 327–343
Robertus JD, Ladner JE, Finch JT, Rhodes D, Brown RS, Clark BF, Klug A (1974) A structure of yeast phenylalanine tRNA at 3 Å resolution. Nature 250:546–551
Rosenberg JM, Seeman NC, Kim JJP, Suddath FL, Nicholas HB, Rich A (1973) Double helix at atomic resolution. Nature 243:150–154
Tener GM, Khorana HG, Markham R, Pol EH (1958) Studies on polynucleotides. II. The synthesis and characterization of linear and cyclic thymidine oligonucleotides. J Am Chem Soc 80:6223–6230
Voet D, Rich A (1970) The crystal structures of purine, pyrimidines and their intermolecular complexes. Prog Nucleic Acid Res Mol Biol 10:183–265
Wang AH, Fujii S, van Boom JH, van der Marel GA, van Boeckel SA, Rich A (1982) Molecular structure of r(GCG)d(TATACGC): aDNA-RNA hybrid helix joined to double helical DNA. Nature 299:601–604
Watson JD, Crick FHC (1953) A structure for deoxyribose nucleic acid. Nature 171:737–738
Wilkins MHF, Randall JT (1953) Molecular structure of deoxypentose nucleic acids. Nature 171:738–740
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Rich, A. (2006). Why RNA and DNA Have Different Structures. In: Erdmann, V., Barciszewski, J., Brosius, J. (eds) RNA Towards Medicine. Handbook of Experimental Pharmacology, vol 173. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27262-3_1
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DOI: https://doi.org/10.1007/3-540-27262-3_1
Publisher Name: Springer, Berlin, Heidelberg
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