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Role of EBAF/Lefty in Implantation and Uterine Bleeding

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Book cover New Mechanisms for Tissue-Selective Estrogen-Free Contraception

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 52))

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References

  • Affandi B (1998) An integrated analysis of vaginal bleeding patterns in clinical trials of Implanon. Contraception 58(6 Suppl):99S–107S

    Article  PubMed  CAS  Google Scholar 

  • Alexander CM, Hansell EJ, Behrendtsen O, Flannery ML, Kishnani NS, Hawkes SP, Werb Z (1996) Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation. Development 122:1723–1736

    PubMed  CAS  Google Scholar 

  • Alvarez-Sanchez F, Brache V, Thevenin F, Cochon L, Faundes (1996) A Hormonal treatment for bleeding irregularities in Norplant implant users. Am J Obstet Gynecol 174:919–922

    Article  PubMed  CAS  Google Scholar 

  • Ando N, Hirahara F, Fukushima J, Kawamoto S, Okuda K, Funabashi T, Gorai I, Minaguchi H (1998) Differential gene expression of TGF-beta isoforms and TGF-beta receptors during the first trimester of pregnancy at the human maternal-fetal interface. Am J Reprod Immunol 40:48–56

    PubMed  CAS  Google Scholar 

  • Archer DF, Pickar JH, Bottiglioni F (1994) Bleeding patterns in postmenopausal women taking continuous combined or sequential regimens of conjugated estrogens with medroxyprogesterone acetate. Obstet Gynecol 83:686–692

    PubMed  CAS  Google Scholar 

  • Arumugam K, Lim JM (1997) Menstrual characteristics associated with endometriosis. Br J Obstet Gynaecol 104:948–950

    PubMed  CAS  Google Scholar 

  • Baird DD, Weinberg CR, Wilcox AJ, McConnaughey DR, Musey PI, Collins DC (1991) Hormonal profiles of natural conception cycles ending in early, unrecognized pregnancy loss. J Clin Endocrinol Metab 72:793–800

    PubMed  CAS  Google Scholar 

  • Bany BM, Harvey MB, Schultz GA (2000) Expression of matrix metalloproteinases 2 and 9 in the mouse uterus during implantation and oil-induced decidualization. J Reprod Fertil 120:125–134

    Article  PubMed  CAS  Google Scholar 

  • Barbieri RL (1996) Medical treatment of infertility associated with minimal to mild endometriosis. Int J Fertil Menopausal Stud 41:393–395

    PubMed  CAS  Google Scholar 

  • Barnhart KT, Furman I, Pommer R, Coutinho E, Devoto L (1997) Changes in the menstrual bleeding of users of a subdermal contraceptive implant of nomegestrol acetate (Uniplant) do not influence sexual frequency, sexual desire, or sexual enjoyment. Fertil Steril 67:244–249

    Article  PubMed  CAS  Google Scholar 

  • Bayer SR, DeCherney AH (1993) Clinical manifestations and treatment of dysfunctional uterine bleeding. JAMA 14:1823–1828

    Article  Google Scholar 

  • Behrendtsen O, Alexander CM, Werb Z (1992) Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths. Development 114:447–456

    PubMed  CAS  Google Scholar 

  • Benagiano G, Pera A, Primiero FM (2000) The endometrium and hormonal contraceptives. Hum Reprod 15(Suppl l):101–118

    PubMed  CAS  Google Scholar 

  • Bischof P, Meisser A, Campana A (2000) Paracrine and autocrine regulators of trophoblast invasion — a review. Placenta 21(Suppl A):S55–S60

    Article  PubMed  Google Scholar 

  • Biswas A, Leong WP, Ratnam SS, Viegas OA (1996) Menstrual bleeding patterns in Norplant-2 implant users. Contraception 54:91–95

    Article  PubMed  CAS  Google Scholar 

  • Bruner KL, Rodgers WH, Gold LI, Korc M, Hargrove JT, Matrisian LM, Osteen KG (1995) Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium. Proc Natl Acad Sci USA 92: 7362–7366

    Article  PubMed  CAS  Google Scholar 

  • Bulletti C, Flamigni C, Giacomucci E (1996) Reproductive failure due to spontaneous abortion and recurrent miscarriage. Hum Reprod Update 2:118–136

    Article  PubMed  CAS  Google Scholar 

  • Chard T (1991) Frequency of implantation and early pregnancy loss in natural cycles. Bailliere’s Clin Obstet Gynaecol 5:179–189

    Article  CAS  Google Scholar 

  • Chen HL, Yelavarthi KK, Hunt JS (1993) Identification of transforming growth factor-beta 1 mRNA in virgin and pregnant rat uteri by in situ hybridization. J Reprod Immunol 25:221–233

    Article  PubMed  CAS  Google Scholar 

  • Clark DE, Hurst PR, McLennan IS, Myers DB (1996) Immunolocalization of collagen type I and laminin in the uterus on days 5 to 8 of embryo implantation in the rat. Anat Rec 237:8–20

    Article  Google Scholar 

  • Coll Capdevila C (1997) Dysfunctional uterine bleeding and dysmenorrhea. Eur J Contracept Reprod Health Care 2:229–237

    Article  PubMed  CAS  Google Scholar 

  • Cornelli I, Brosens A, Marbaix E, Vael T, Baudhurin P, Courtoy PJ (1990) A biochemical study of lysosomal enzymes in control and levonorgestrel-treated human endometria: analysis of total activity and evidence of secretion. In: Aracangues C, Fraser JR, Newton JR, Odlind V (eds) Contraception and mechanisms of endometrial bleeding. Cambridge University Press, Cambridge, pp 383–410

    Google Scholar 

  • Cornet PB, Picquet C, Lemoine P, Osteen KG, Bruner-Tran KL, Tabibzadeh S, Courtoy PJ, Eeckhout Y, Marbaix E, Henriet P (2002) Regulation and function of LEFTY-A/EBAF in the human endometrium. mRNA expression during the menstrual cycle, control by progesterone, and effect on matrix metalloproteinases. J Biol Chem 277:42496–42504

    Article  PubMed  CAS  Google Scholar 

  • Cox KE, Sharpe-Timms KL, Kamiya N, Saraf M, Donnelly KM, Fazleabas AT (2000) Differential regulation of stromelysin-1 (matrix metalloprotein-ase-3) and matrilysin (matrix metalloproteinase-7) in baboon endometrium. J Soc Gynecol Investig 7:242–248

    Article  PubMed  CAS  Google Scholar 

  • Dahlen JR, Jean F, Thomas G, Foster DC, Kisiel W (1998) Inhibition of soluble recombinant Furin by human proteinase inhibitor 8. J Biol Chem 273:1851–1854

    Article  PubMed  CAS  Google Scholar 

  • Daopin S, Piez KA, Ogawa Y, Davies DR (1992) Crystal structure of transforming growth factor beta 2: an unusual fold in the superfamily. Science 257:369–373

    Article  PubMed  CAS  Google Scholar 

  • Das SK, Flanders KC, Andrews GK, Dey SK (1992) Expression of transforming growth factor-beta isoforms (beta 2 and beta 3) in the mouse uterus: analysis of the periimplantation period and effects of ovarian steroids. Endocrinology 130:3459–3466

    Article  PubMed  CAS  Google Scholar 

  • Das SK, Lim H, Wang J, Paria BC, BazDresch M, Dey SK (1997) Inappropriate expression of human transforming growth factor (TGF)-alpha in the uterus of transgenic mouse causes downregulation of TGF-beta receptors and delays the blastocyst-attachment reaction. J Mol Endocrinol 18:243–257

    Article  PubMed  CAS  Google Scholar 

  • Duncan MR, Frazier KS, Abramson S, Williams S, Klapper H, Huang X, Grotendorst GR (1999) Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J 13:1774–1786

    PubMed  CAS  Google Scholar 

  • Eeckhout Y (1990) In: D’Arcangues C, Fraser IS, Newton JR, Odlind V (eds) Contraception and mechanisms of endometrial bleeding. Cambridge University Press, Cambridge, pp 431–439

    Google Scholar 

  • Formigli LG, Formigli C, Roccio C (1987) Donation of fertilized uterine ova to infertile women. Fertil Steril 47:62–65

    Google Scholar 

  • Fraser IS (1990) Mechanisms of endometrial bleeding. Reprod Fertil Dev 2:193–198

    Article  PubMed  CAS  Google Scholar 

  • Frazier KS, Grotendorst GR (1997) Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors. Int J Biochem Cell Biol 29:153–161

    Article  PubMed  CAS  Google Scholar 

  • Galant C, Vekemans M, Lemoine P, Kokorine I, Twagirayezu P, Henriet P, Picquet C, Rigot V, Eeckhout Y, Courtoy PJ, Marbaix E (2000) Temporal and spatial association of matrix metalloproteinases with focal endometrial breakdown and bleeding upon progestin-only contraception. J Clin Endocrinol Metab 85:4827–4834

    Article  PubMed  CAS  Google Scholar 

  • Grotendorst GR (1997) Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 8:171–179

    Article  PubMed  CAS  Google Scholar 

  • Gurgan T, Urman B, Yarali H, Kisnisci HA (1995) The results of in vitro fertilization-embryo transfer in couples with unexplained infertility failing to conceive with superovulation and intrauterine insemination. Fertil Steril 64:93–97

    PubMed  CAS  Google Scholar 

  • Guttmacher AF (1956) Factors affecting normal expectancy of conception. JAMA 16:855–864

    Google Scholar 

  • Hallberg L, Hogdahl A, Nilsson L, Rybo G (1966) Menstrual blood loss — a population study. Acta Obstet Gynecol Scand 45:320–351

    PubMed  CAS  Google Scholar 

  • Harvey MB, Leco KJ, Arcellana-Panlilio MY, Zhang X, Edwards DR, Schultz GA (1995) Roles of growth factors during peri-implantation development. Hum Reprod 10:712–718

    PubMed  CAS  Google Scholar 

  • Henzl MR, Smith RE, Boost G, Tyler ET (1972) Lysosomal concept of menstrual bleeding in humans. J Clin Endocrinol Metab 34:860–875

    Article  PubMed  CAS  Google Scholar 

  • Hertig A, Rock J, Adams EC (1956) A description of 34 human ova within the first 17 days of development. Am J Anat 98:435–493

    Article  PubMed  Google Scholar 

  • Hickey M, Dwarte D, Fraser IS (2000) Superficial endometrial vascular fragility in Norplant users and in women with ovulatory dysfunctional uterine bleeding. Hum Reprod 15:1509–1514

    Article  PubMed  CAS  Google Scholar 

  • Hickey M, Simbar M, Markham R, Young L, Manconi F, Russell P, Fraser IS (1999) Changes in vascular basement membrane in the endometrium of Norplant users. Hum Reprod 14:716–721

    Article  PubMed  CAS  Google Scholar 

  • Hillard TC, Siddle NC, Whitehead MI, Fraser DI, Pryse-Davies J (1992) Continuous combined conjugated equine estrogen-progestogen therapy: Effects of medroxyprogesterone acetate and norethindrone acetate on bleeding patterns and endometrial histologic diagnosis. Am J Obstet Gynecol 167:1–7

    PubMed  CAS  Google Scholar 

  • Holmes A, Sa S, Shiwen X, Black CM, Abraham DJ, Leask A (2001) CTGF and SMADs: maintenance of scleroderma phenotype is independent of SMAD signalling. J Biol Chem 276:10594–10601

    Article  PubMed  CAS  Google Scholar 

  • Hurst PR, Gibbs RD, Clark DE, Myers DB (1994) Temporal changes to uterine collagen types I, III and V in relation to early pregnancy in the rat. Reprod Fertil Dev 6:669–677

    Article  PubMed  CAS  Google Scholar 

  • Hurst PR, Palmay RD (1999) Matrix metalloproteinases and their endogenous inhibitors during the implantation period in the rat uterus. Reprod Fertil Dev 11:395–402

    Article  PubMed  CAS  Google Scholar 

  • Irwin JC, Kirk D, Gwatkin RB, Navre M, Cannon P, Giudice LC (1996) Human endometrial matrix metalloproteinase-2, a putative menstrual proteinase. Hormonal regulation in cultured stromal cells and messenger RNA expression during the menstrual cycle. J Clin Invest 97:438–447

    PubMed  CAS  Google Scholar 

  • Iwahashi M, Muragaki Y, Ooshima A, Yamoto M, Nakano R (1996) Alterations in distribution and composition of the extracellular matrix during decidualization of the human endometrium. J Reprod Fertil 108:147–155

    Article  PubMed  CAS  Google Scholar 

  • Jacobs A, Butler EB (1965) Menstrual blood loss in iron deficiency anaemia. Lancet 407–409

    Google Scholar 

  • Keller NR, Sierra-Rivera E, Eisenberg E, Osteen KG (2000) Progesterone exposure prevents matrix metalloproteinase-3 (MMP-3) stimulation by interleukin-1 alpha in human endometrial stromal cells. J Clin Endocrinol Metab 85:1611–1619

    Article  PubMed  CAS  Google Scholar 

  • Kingsley DM (1994) The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8:133–146

    PubMed  CAS  Google Scholar 

  • Kokorine I, Marbaix E, Henriet P, Okada Y, Donnez J, Eeckhout Y, Courtoy PJ (1996) Focal cellular origin and regulation of interstitial collagenase (matrix metalloproteinase-1) are related to menstrual breakdown in the human endometrium. J Cell Sci 109:2151–2160

    PubMed  CAS  Google Scholar 

  • Kosaki K, Bassi MT, Kosaki R, Lewin M, Belmont J, Schauer G, Casey B (1999) Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. Am J Hum Genet 64:712–721

    Article  PubMed  CAS  Google Scholar 

  • Kothapalli R, Buyuksal I, Wu S-Q, Chegini N, Tabibzadeh S (1997) Detection of TGF-beta a novel human gene of the TGF-beta superfamily; association of gene expression with endometrial bleeding. J Clin Invest 99:2342–2350

    PubMed  CAS  Google Scholar 

  • Kubo M, Kikuchi K, Nashiro K, Kakinuma T, Hayashi N, Nanko H, Tamaki K (1998) Expression of fibrogenic cytokines in desmoplastic malignant melanoma. Br J Dermatol 139:192–197

    Article  PubMed  CAS  Google Scholar 

  • Lennard SN, Stewart F, Allen WR (1995) Transforming growth factor beta 1 expression in the endometrium of the mare during placentation. Mol Reprod Dev 42:131–140

    Article  PubMed  CAS  Google Scholar 

  • Lessey BA, Castelbaum AJ, Buck CA, Lei Y, Yowell CW, Sun J (1994) Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil Steril 62:497–506

    PubMed  CAS  Google Scholar 

  • Lessey BA, Danjanovich L, Coutfaris C, Castelbaum A, Albelda SM, Buck CA (1992) Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. J Clin Invest 90:188–195

    Article  PubMed  CAS  Google Scholar 

  • Liotta LA (1996) Probing the depths of degradation: matrix metalloproteinase-2 and endometrial menstrual breakdown. J Clin Invest 97:273–274

    PubMed  CAS  Google Scholar 

  • Lockwood CJ, Runic R, Wan L, Krikun G, Demopolous R, Schatz F (2000) The role of tissue factor in regulating endometrial haemostasis: implications for progestin-only contraception. Hum Reprod 15(Suppl 3): 144–151

    PubMed  CAS  Google Scholar 

  • Lysiak JJ, Hunt J, Pringle GA, Lala PK (1995) Localization of transforming growth factor beta and its natural inhibitor decorin in the human placenta and decidua throughout gestation. Placenta 16:221–231

    Article  PubMed  CAS  Google Scholar 

  • Marbaix E, Kokorine I, Moulin P, Donnez J, Eeckhout Y, Courtoy PJ (1996) Menstrual breakdown of human endometrium can be mimicked in vitro and is selectively and reversibly blocked by inhibitors of matrix metalloproteinases. Proc Natl Acad Sci USA 93:9120–9125

    Article  PubMed  CAS  Google Scholar 

  • Marbaix E, Vekemans M, Galant C, Rigot V, Lemoine P, Dubois D, Picquet C, Henriet P, Twagirayezu P, Sufi S, Eeckhout Y, Courtoy PJ (2000) Circulating sex hormones and endometrial stromelysin-1 (matrix metalloproteinase-3) at the start of bleeding episodes in levonorgestrel-implant users. Hum Reprod 15(Suppl 3): 120–134

    PubMed  CAS  Google Scholar 

  • Markee JE (1940) Menstruation in intraocular endometrial transplants in the rhesus monkey. Contrib Embryol 28:219–308

    Google Scholar 

  • Mason J, Xu HP, Rao SK, Leask A, Barcia M, Shan J, Stephenson R, Tabibzadeh S (2002) Lefty contributes to the remodeling of extracellular matrix by inhibition of CTGF and collagen mRNA expression and increased proteolytic activity in a fibrosarcoma model. J Biol Chem 4:407–415

    Google Scholar 

  • Massague J (1990) The transforming growth factor-beta family. Annu Rev Cell Biol 6:597–641

    Article  PubMed  CAS  Google Scholar 

  • McDonald NQ, Hendrickson WA (1993) A structural superfamily of growth factors containing a cystine knot motif. Cell 73:421–424

    Article  PubMed  CAS  Google Scholar 

  • McPherron A, Lee S-J (1993) GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines. J Biol Chem 268:3444–3449

    PubMed  CAS  Google Scholar 

  • Meno C, Ito Y, Saijoh Y, Matsuda Y, Tashiro K, Kuhara S, Hamada H (1997) Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells 2:513–524

    Article  PubMed  CAS  Google Scholar 

  • Meno C, Saijoh Y, Fujii H, Ikeda M, Yokoyamas T, Yokoyamas M, Toyoda Y, Hamada H (1996) Left-right asymmetric expression of the TGF-beta family member lefty in mouse embryos. Nature 381:151–155

    Article  PubMed  CAS  Google Scholar 

  • Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, Noji S, Kondoh H, Hamada H (1998) Lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94:287–297

    Article  PubMed  CAS  Google Scholar 

  • Mosher WD, Pratt WF (1991) Fecundity and infertility in the United States: incidence and trends. Fertil Steril 56:192–193

    PubMed  CAS  Google Scholar 

  • Mosher WD, Pratt WF (1993) The demography of infertility in the United States. In: Asch RH, Studd JW (eds) Annual progress in reproductive medicine. Parthenon Publishing Group, Pearl River, New York, pp 37–43

    Google Scholar 

  • Moussad EE, Brigstock DR (2000) Connective tissue growth factor: what’s in a name? Mol Genet Metab 71:276–292

    Article  PubMed  CAS  Google Scholar 

  • Mulholland J, Aplin JD, Ayad S, Hong L, Glasser SR (1992) Loss of collagen type VI from rat endometrial stroma during decidualization. Biol Reprod 46:1136–1143

    Article  PubMed  CAS  Google Scholar 

  • Navot DM, Anderson TL, Droesh K, Scott RT, Kreiner D, Kreiner Z, Rosen-waks Z (1989) Hormonal manipulation of endometrial maturation. J Clin Endocrinol Metab 68:801–807

    Article  PubMed  CAS  Google Scholar 

  • Navot DM, Scott RT, Droesh K, Kreiner D, Veeck LL, Liu HC, Rosenwaks Z (1991) The window of embryo transfer and the efficiency of human conception in vitro. Fertil Steril 55:114–117

    PubMed  CAS  Google Scholar 

  • Nothnick WB, Edwards DR, Leco KJ, Curry TE Jr (1995) Expression and activity of ovarian tissue inhibitors of metalloproteinases during pseudopregnancy in the rat. Biol Reprod 53:684–691

    Article  PubMed  CAS  Google Scholar 

  • Ober WB (1977) Effects of oral and intrauterine administration of contraceptives on the uterus. Hum Pathol 8:513–526

    PubMed  CAS  Google Scholar 

  • Olive DL, Haney AF (1986) Endometriosis-associated infertility: a critical review of therapeutic approaches. Obstet Gynecol Surv 41:538–555

    PubMed  CAS  Google Scholar 

  • Osteen KG, Keller NR, Feltus FA, Melner MH (1999) Paracrine regulation of matrix metalloproteinase expression in the normal human endometrium. Gynecol Obstet Invest 48(Suppl 1):2–13

    Article  PubMed  CAS  Google Scholar 

  • Osteen KG, Rodgers WH, Gaire M, Hargrove JT, Gorstein F, Matrisian LM (1994) Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium. Proc Natl Acad Sci USA 91:10129–10133

    Article  PubMed  CAS  Google Scholar 

  • Palmer JA, Lau TM, Hickey M, Simbah M, Rogers PA (1996) Immunohistochemical study of endometrial microvascular basement membrane components in women using Norplant. Hum Reprod 11:2142–2150

    PubMed  CAS  Google Scholar 

  • Paradis V, Dargere D, Vidaud M, De Gouville AC, Huet S, Martinez V, Gauthier JM, Ba N, Sobesky R, Ratziu V, Bedossa P (1999) Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 30:968–976

    Article  PubMed  CAS  Google Scholar 

  • Polette M, Nawrocki B, Pintiaux A, Massenat C, Maquoi E, Volders L, Schaaps JP, Birembaut P, Foidart JM (1994) Expression of gelatinases A and B and their tissue inhibitors by cells of early and term human placenta and gestational endometrium. Lab Invest 71:838–846

    PubMed  CAS  Google Scholar 

  • Querfeld C, Sollberg S, Huerkamp C, Eckes B, Krieg T (2000) Pseudoscleroderma associated with lung cancer: correlation of collagen type I and connective tissue growth factor gene expression. Br J Dermatol 142: 1228–1233

    Article  PubMed  CAS  Google Scholar 

  • Rees MCP, Turnball AC (1989) Menstrual disorders: an overview. Bailliere’s Clin Obstet Gynaecol 3:217–226

    Article  CAS  Google Scholar 

  • Roberts DK, Parmley TH, Walker NJ, Horbelt DV (1992) infrastructure of the microvasculature in the human endometrium throughout the normal menstrual cycle. Am J Obstet Gynecol 166:1393–1406

    PubMed  CAS  Google Scholar 

  • Rodgers WH, Matrisian LM, Giudice LC, Dsupin B, Cannon P, Svitek C, Gorstein F, Osteen KG (1994) Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J Clin Invest 94:946–953

    PubMed  CAS  Google Scholar 

  • Rodgers WH, Osteen KG, Matrisian LM, Navre M, Giudice LC, Gorstein F (1993) Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle. Am J Obstet Gynecol 168:253–260

    PubMed  CAS  Google Scholar 

  • Rogers PA, Plunkett D, Affandi B (2000) Perivascular smooth muscle alphaactin is reduced in the endometrium of women with progestin-only contraceptive breakthrough bleeding. Hum Reprod 15(Suppl 3):78–84

    PubMed  CAS  Google Scholar 

  • Rogers PAW, Murphy CR (1989) Uterine receptivity for implantation: Human studies. In: Yoshiaga (ed) Blastocyst Implantation. Serono Symposia, USA, pp 231–238

    Google Scholar 

  • Rosenberg MJ, Waugh MS, Higgins JE (1996) The effect of desogestrel, gestodene, and other factors on spotting and bleeding. Contraception 53:85–90

    Article  PubMed  CAS  Google Scholar 

  • Rudolph-Owen LA, Slayden OD, Matrisian LM, Brenner RM (1998) Matrix metalloproteinase expression in Macaca mulatta endometrium: evidence for zone-specific regulatory tissue gradients. Biol Reprod 59:1349–1359

    Article  PubMed  CAS  Google Scholar 

  • Said S, Sadek W, Rocca M, Koetsawang S, Kirwat O, Piya-Anant M, Dusitsin N, Sethavanich S, Affandi B, Hadisaputra W, Kazi A, Ramos RM, d’Arcangues C, Belsey EM, Noonan E, Olayinka I, Pinol A (1996) Clinical evaluation of the therapeutic effectiveness of ethinyl oestradiol and oestrone sulphate on prolonged bleeding in women using depot medroxyprogesterone acetate for contraception. World Health Hum Reprod Suppl 2:1–13

    Google Scholar 

  • Salamonsen LA (1994) Matrix metalloproteinases and endometrial remodelling. Cell Biol Int 18:1139–1144

    Article  PubMed  CAS  Google Scholar 

  • Salamonsen LA, Nagase H, Woolley DE (1995) Matrix metalloproteinases and their tissue inhibitors at the ovine trophoblast-uterine interface. J Reprod Fertil Suppl 49:29–37

    PubMed  CAS  Google Scholar 

  • Salamonsen LA, Woolley DE (1999) Menstruation: induction by matrix metalloproteinases and inflammatory cells. J Reprod Immunol 44:1–27

    Article  PubMed  CAS  Google Scholar 

  • Schatz F, Papp C, Toth-Pal E, Lockwood CJ (1994) Ovarian steroid-modulated stromelysin-1 expression in human endometrial stromal and decidual cells. J Clin Endocrinol Metab 78:1467–1472

    Article  PubMed  CAS  Google Scholar 

  • Schier AF, Shen MM (2000) Nodal signalling in vertebrate development. Nature 403:385–389

    Article  PubMed  CAS  Google Scholar 

  • Skinner JL, Riley SC, Gebbie AE, Glasier AF, Critchley HO (1999) Regulation of matrix metalloproteinase-9 in endometrium during the menstrual cycle and following administration of intrauterine levonorgestrel. Hum Reprod 14:793–799

    Article  PubMed  CAS  Google Scholar 

  • Slack JL, Liska DJ, Bornstein P (1993) Regulation of expression of the type I collagen genes. Am J Med Genet 45:140–151

    Article  PubMed  CAS  Google Scholar 

  • Stenback F (1989) Collagen type III formation and distribution in the uterus: effects of hormones and neoplasm development. Oncology 46:326–334

    Article  PubMed  CAS  Google Scholar 

  • Stirrat GM (1999) Choice of treatment for menorrhagia. Lancet 353:2175–2176

    Article  PubMed  CAS  Google Scholar 

  • Tabibzadeh S (2002) Decoding implantation and menstruation: the tale of two opposing signals. Front Biosci 7:1475–1486

    Google Scholar 

  • Tabibzadeh S, Babaknia A (1995) The signals and molecular pathways involved in implantation, a symbiotic interaction between blastocyst and endometrium involving adhesion and tissue destruction. Mol Hum Reprod 10:1579–1602

    CAS  Google Scholar 

  • Tabibzadeh S, Kothapalli R, Buyuksal I (1997) Distinct tumor specific expression of ebaf, a novel human gene of the TGF-beta superfamily. Front Biosci 2:18–25

    Google Scholar 

  • Tabibzadeh S, Mason JM, Shea W, Cai Y, Murray MJ, Lessey B (2000) Dysregulated expression of ebaf, a novel molecular defect in the endometria of patients with infertility. J Clin Endocrinol Metab 85:2526–2536

    Article  PubMed  CAS  Google Scholar 

  • Tabibzadeh S, Satyaswaroop PG (1988) Temporal and site specific expression of ebaf in human endometrium. Mol Hum Reprod 4:595–602

    Article  Google Scholar 

  • Tamada H, McMaster MT, Flanders KC, Andrews GK, Dey SK (1990) Cell type-specific expression of transforming growth factor-beta 1 in the mouse uterus during the periimplantation period. Mol Endocrinol 4:965–972

    Article  PubMed  CAS  Google Scholar 

  • Thisse B, Wright CV, Thisse C (2000) Activin-and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Nature 403: 425 28

    Article  PubMed  CAS  Google Scholar 

  • Thisse C, Thisse B (1999) Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction. Development 126:229–240

    PubMed  CAS  Google Scholar 

  • Ulloa L, Creemers JWM, Liu S, Mason J, Pergolizzi R, Broome J, Tabibzadeh S (2001) Lefty proteins exhibit unique processing, and activate the MAP kinase pathway. J Biol Chem 276:21387–21396

    Article  PubMed  CAS  Google Scholar 

  • Ulloa L, Tabibzadeh S (2001) Lefty inhibits R-Smad phosphorylation induced by activated TGF-beta receptor. J Biol Chem 276:21397–21404

    Article  PubMed  CAS  Google Scholar 

  • Uzumcu M, Homsi MF, Ball DK, Coskun S, Jaroudi K, Hollanders JM, Brigstock DR (2000) Localization of connective tissue growth factor in human uterine tissues. Mol Hum Reprod 6:1093–1098

    Article  PubMed  CAS  Google Scholar 

  • Vercellini P, De Giorgi O, Aimi G, Panazza S, Uglietti A, Crosignani PG (1997) Menstrual characteristics in women with and without endometriosis. Obstet Gynecol 90:264–268

    Article  PubMed  CAS  Google Scholar 

  • Vincent AJ, Salamonsen LA (2000) The role of matrix metalloproteinases and leukocytes in abnormal uterine bleeding associated with progestin-only contraceptives. Hum Reprod 15(Suppl 3):135–143

    PubMed  CAS  Google Scholar 

  • Vincent AJ, Zhang J, Ostor A, Rogers PA, Affandi B, Kovacs G, Salamonsen LA (2000) Matrix metalloproteinase-1 and-3 and mast cells are present in the endometrium of women using progestin-only contraceptives. Hum Reprod 15:123–130

    Article  PubMed  CAS  Google Scholar 

  • Wathen PI, Henderson MC, Witz CA (1995) Abnormal uterine bleeding. Med Clin North Am 79:329–342

    PubMed  CAS  Google Scholar 

  • Weitlauf HM, Suda-Hartman M (1988) Changes in secreted uterine proteins associated with embryo implantation in the mouse. J Reprod Fertil 84: 539–549

    Article  PubMed  CAS  Google Scholar 

  • Wenger C, Ellenrieder V, Alber B, Lacher U, Menke A, Hameister H, Wilda M, Iwamura T, Beger HG, Adler G, Gress TM (1999) Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells. Oncogene 18:1073–1080

    Article  PubMed  CAS  Google Scholar 

  • Wilcox AJ, Weinberg CR, Wehmann RE, Armstrong EG, Canfield RE, Nisula BC (1985) Measuring early pregnancy loss: laboratory and field methods. Fertil Steril 44:366–374

    PubMed  CAS  Google Scholar 

  • Woessner JF Jr (1991) Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5:2145–2154

    PubMed  CAS  Google Scholar 

  • Wood JC, Williams AE, Barley VL, Codwell RH (1969) The activity of hydrolytic enzymes in the human endometrium during the menstrual cycle. J Obstet Gynecol Br Commonw 76:724–728

    CAS  Google Scholar 

  • Ye RD, Ahern SM, Le Beau MM, Lebo RV, Sadler JE (1989) Structure of the gene for human plasminogen activator inhibitor-2. The nearest mammalian homologue of chicken ovalbumin. J Biol Chem 264:5495–5502

    PubMed  CAS  Google Scholar 

  • Yochim JM, Blahna DG (1976) Effects of oestrone and progesterone on collagen and ascorbic acid content in the endometrium and myometrium of the rat. J Reprod Fertil 47:79–82

    Article  PubMed  CAS  Google Scholar 

  • Zhang J, Hampton AL, Nie G, Salamonsen LA (1996) Progesterone inhibits activation of latent matrix metalloproteinase (MMP)-2 by membrane-type 1 MMP: enzymes coordinately expressed in human endometrium. Biol Reprod 62:85–94

    Article  Google Scholar 

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Authors and Affiliations

  1. Departments of Obstetrics and Gynecology and Fetomaternal Medicine, Stony Brook University, Stony Brook, NY, 11794, USA

    S. Tabibzadeh

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  1. S. Tabibzadeh
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Editors and Affiliations

  1. Instituto Chileno de Medicina Reproductive (ICMER), José Ramon Gutierrez 295, Santiago de Chile, Chile

    H. B. Croxatto

  2. Strategic Business Unit, Gynecology and Andrology, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    R. Schürmann  & I. Schellschmidt  & 

  3. CRBA, Gynecology and Andrology, Female Health Care, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    U. Fuhrmann

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© 2005 Springer-Verlag Berlin Heidelberg

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Tabibzadeh, S. (2005). Role of EBAF/Lefty in Implantation and Uterine Bleeding. In: Croxatto, H.B., Schürmann, R., Fuhrmann, U., Schellschmidt, I. (eds) New Mechanisms for Tissue-Selective Estrogen-Free Contraception. Ernst Schering Research Foundation Workshop, vol 52. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-27147-3_8

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  • DOI: https://doi.org/10.1007/3-540-27147-3_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-23089-2

  • Online ISBN: 978-3-540-27147-5

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