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Multiple Distal Pseudotumours in a Patient with Severe Hemophilia A and High Titer Inhibitors

  • Conference paper
34th Hemophilia Symposium

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Conclusions

The described PTs had the characteristics of distal PTs, appeared most probably after intraosseous hemorrhage. The presented case of multiple distal PTs is extremely rare. The most important factors favoring the apparition of multiple PTs were: high inhibitors level, shortage of bypassing agents, and severe osteoporosis. The spontaneous evolution of PTs was characterized by repeated episodes of hemorrhage and infection, and progressive growth. The conservative surgical approach (evacuation, drainage) was almost always inefficient. PTs could be solved only by complete excision/amputation. Alternative approaches to radical surgery, in patients with distal PTs and inhibitors merit to be discussed (antiangiogenic therapy, long-term therapy with bypassing agents, early conservative surgery — percutaneous management).

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Author information

Authors and Affiliations

  1. Spitalul Clinic de copii, Louis Turcanu/Clin. Pediatrie III, Compartimentul de Onco-Hermatologie, R-Timişoara, Germany

    Frau Dr. C. A. Petrescu

  2. IIIrd Paediatric Clinic, University of Medicine, R-Timişoara, Germany

    Frau prof. Dr. M. Şerban

  3. Abteilung Hämostaseologie, Medizinische Klinik Innenstadt der Ludwig-Maximilians-Universität, D-Munchen

    Prof. Dr. W. Schramm

Authors
  1. Frau Dr. C. A. Petrescu
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  2. Frau prof. Dr. M. Şerban
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  3. P. Ţepeneu
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  4. Prof. Dr. W. Schramm
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  5. R. BĂdeŢi
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  6. B. Popescu
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Editor information

Editors and Affiliations

  1. Hemophilia Center, Dept. of Internal Medicine, University Hospital, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    I. Scharrer

  2. Dept. of Hemostaseology, University Hospital, Ziemssenstr. 1a, D-80336, München, Germany

    W. Schramm

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© 2005 Springer Medizin Verlag Heidelberg

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Petrescu, C.A., Şerban, M., Ţepeneu, P., Schramm, W., BĂdeŢi, R., Popescu, B. (2005). Multiple Distal Pseudotumours in a Patient with Severe Hemophilia A and High Titer Inhibitors. In: Scharrer, I., Schramm, W. (eds) 34th Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27022-1_26

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  • DOI: https://doi.org/10.1007/3-540-27022-1_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-22886-8

  • Online ISBN: 978-3-540-27022-5

  • eBook Packages: MedicineMedicine (R0)

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