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34th Hemophilia Symposium pp 153–155Cite as

Frequency and Inhibitor Risk of the Intron-1-Inversion Mutation in the German Hemophilia Population

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Conclusion

Compared to published data, our study revealed a significantly lower frequency of the intron 1 inversion mutation (2.4% vs 4–5%). The inhibitor prevalence of 30% clearly indicates a high risk for inhibitor formation which agrees with other null mutations.

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References

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Author information

Authors and Affiliations

  1. Institut für Humangenetik, Ernst-Moritz-Arndt-Universität, D-Greifswald, Germany

    Dr. J. Schröder

  2. GSF Forschungszentrum für Umwelt und Gesundheit, D-Neuherberg, Germany

    Prof. Dr. J. Graw

  3. Institut für Experimentelle Hämatologie und Transfusionsmedizin der Universität, D-Bonn, Germany

    Dr. H. -H. Brackmann

  4. Abteilung Hämostaseologie, Medizinische Klinik Innenstadt der Ludwig-Maximilians-Universität, D-Munchen

    Prof. Dr. W. Schramm

  5. Blutspendedienst Frankfurt/M., D-Frankfurt/Main, Germany

    Dr. J. Oldenburg

Authors
  1. Dr. J. Schröder
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  2. Prof. Dr. J. Graw
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  3. Dr. H. -H. Brackmann
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  4. B. Kellner
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  5. S. Löffler
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  6. Prof. Dr. W. Schramm
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  7. R. Schwabb
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  8. C. Müller-Reible
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  9. Dr. J. Oldenburg
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Editor information

Editors and Affiliations

  1. Hemophilia Center, Dept. of Internal Medicine, University Hospital, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    I. Scharrer

  2. Dept. of Hemostaseology, University Hospital, Ziemssenstr. 1a, D-80336, München, Germany

    W. Schramm

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© 2005 Springer Medizin Verlag Heidelberg

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Schröder, J. et al. (2005). Frequency and Inhibitor Risk of the Intron-1-Inversion Mutation in the German Hemophilia Population. In: Scharrer, I., Schramm, W. (eds) 34th Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27022-1_23

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  • DOI: https://doi.org/10.1007/3-540-27022-1_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-22886-8

  • Online ISBN: 978-3-540-27022-5

  • eBook Packages: MedicineMedicine (R0)

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