Conclusion
The very benign course of our case report shows that early substitution in a premature infant with hemophilia A can prevent bleeding complications despite low post partum factor levels. Obviously this observation is limited by the fortunate lack of common complications in premature infants below 1500 g, such as the often necessary operations. In concordance with the publication by Gale et al. we report good recovery (96%) but shortened half-life (6 hrs) of the factor VIII concentrate, but both swayed considerably particularly at the beginning of the therapy. The low post partum factor VIII levels increased during the first year of life. Close cooperation between obstetricians, neonatologists and the pediatric hemophilia centre was essential for the successful treatment of our patient.
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Giangrande, PLF. Pregnancy in Women with inherited bleeding disorders in: Treatment of Haemopilia, No. 29, Feb 2003
Kulkarni R, Lusher J. Perinatal management of newborns with hemophilia, B J Haematol (2001) 112:264–2743. Gale, RF. et al. Management of a premature infant with moderate haemophilia A using recombinant factor VIII, Haemophilia. (1998), 4:850–853
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© 2005 Springer Medizin Verlag Heidelberg
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Bidlingmaier, C., Garhammer, A., Jenkins, S., Deml, M., Kurnik, K. (2005). Management of a Premature Infant below 1500 g with Hemophilia A. In: Scharrer, I., Schramm, W. (eds) 34th Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27022-1_18
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DOI: https://doi.org/10.1007/3-540-27022-1_18
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