Skip to main content
SpringerLink
Log in

The Relationship between Protein C Activity and the Endogenous Thrombin Potential in Controls and Septic Patients

  • Conference paper
34th Hemophilia Symposium

  • 576 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bernard GR et al. and the PROWESS Study Group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001, 344:699–709.

    Article  PubMed  CAS  Google Scholar 

  2. De Kleijn ED et al. Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, doubleblinded, placebo-controlled, dose finding study. Crit Care Med. 2003, 31:1839–47.

    PubMed  Google Scholar 

  3. Fourier F et al. Combined antithrombin and protein c supplementation in meningococcal purpura fulminans: a pharmacokinetic study. Intensive Care Med. 2003, 29: 1081–7.

    Google Scholar 

  4. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RMH, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. Chest 1992;101:1644–1655.

    PubMed  CAS  Google Scholar 

  5. Siegemund T, Petros S, Siegemund A, Scholz U, Engelmann L. Thrombin generation in severe haemophilia A and B: The endogenous thrombin potential in platelet-rich plasma. Thromb Haemost 2003; 90:781–6.

    PubMed  CAS  Google Scholar 

  6. Conrad Conard J, Bauer KA, Gruber A, Griffin JH, Schwarz HP, Horellou MH, Samama MM, Rosenberg RD. Normalization of markers of coagulation activation with a purified Protein C concentrate in adults with homozygous protein C deficiency. Blood 1993; 82: 1159–64.

    Google Scholar 

  7. Yan B, Dhainaut JF. Activated protein C versus protein C in severe sepsis. Crit Care Med 2001; 29(Suppl.): 69–74.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Klinische Chemie. Gerinnungslabor Innere Medizin, Universität Leipzig, D-Leipzig, Germany

    Frau Dr. A. Siegemund

  2. Hämostaseologische Ambulanz,Hämophiliezentrum, Universitätklinikum Leipzig, D-Leipzig, Germany

    Frau Dr. U. Scholz

Authors
  1. Frau Dr. A. Siegemund
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Siegemund
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Frau Dr. U. Scholz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Petros
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. Engelmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hemophilia Center, Dept. of Internal Medicine, University Hospital, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    I. Scharrer

  2. Dept. of Hemostaseology, University Hospital, Ziemssenstr. 1a, D-80336, München, Germany

    W. Schramm

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Medizin Verlag Heidelberg

About this paper

Cite this paper

Siegemund, A., Siegemund, T., Scholz, U., Petros, S., Engelmann, L. (2005). The Relationship between Protein C Activity and the Endogenous Thrombin Potential in Controls and Septic Patients. In: Scharrer, I., Schramm, W. (eds) 34th Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27022-1_15

Download citation

  • DOI: https://doi.org/10.1007/3-540-27022-1_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-22886-8

  • Online ISBN: 978-3-540-27022-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation