Skip to main content
SpringerLink
Log in

Photoreceptor Stability and Degeneration in Mammalian Retina: Lessons from the Edge

  • Chapter
Book cover Macular Degeneration

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adler R, Curcio C, Hicks D, Price D, Wong F (1999) Cell death in age-related macular degeneration. Mol Vis 5: 31

    PubMed  CAS  Google Scholar 

  • Ahnelt P (1998) The photoreceptor mosaic. Eye 2: 531–540

    Google Scholar 

  • Bateman J, Klisak I, Kojis T, Mohandas T, Sparkes R, Li T (1992) Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16. Genomics 12: 601–603

    Article  PubMed  CAS  Google Scholar 

  • Bowers F, Valter K, Chan S, Walsh N, Maslim J, Stone J (2001) Effects of oxygen and bFGF on the vulnerability of photoreceptors to light damage. Invest Ophthalmol Vis Sci 42: 804–815

    PubMed  CAS  Google Scholar 

  • Cao W, Li F, Steinberg RH, Lavail MM (2001) Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina. Exp Eye Res 72: 591–604

    Article  PubMed  CAS  Google Scholar 

  • Curcio C, Millican C, Allen K, Kalina R (1993) Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci 34: 3278–3296

    PubMed  CAS  Google Scholar 

  • Curcio C, Medeiros N, Millican C (1996) Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci 37: 1236–1249

    PubMed  CAS  Google Scholar 

  • Curcio CA, Owsley C, Jackson GR (2000) Spare the rods, save the cones in aging and age-related maculopathy. Invest Ophthalmol Vis Sci 41: 2015–2018

    PubMed  CAS  Google Scholar 

  • D’Cruz PM, Yasumura D, Weir J, Matthes MT, Abderrahim H, LaVail MM, Vollrath D (2000) Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 9: 645–651

    PubMed  CAS  Google Scholar 

  • Gao H, Hollyfield JG (1992) Aging of the human retina: differential loss of neurons and retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 33: 1–17

    PubMed  CAS  Google Scholar 

  • Gargini C, Belfiore M, Bisti S, Cervetto L, Valter K, Stone J (1999) The impact of bFGF on photoreceptor function and morphology. Invest Ophthalmol Vis Sci 40: 2088–2099

    PubMed  CAS  Google Scholar 

  • Gartner J (1975) Fine structural changes of peripheral cystoid degenerations during life. Mod Probl Ophthalmol 15: 98–102

    PubMed  CAS  Google Scholar 

  • Gartner S, Henkind P (1981) Lange’s folds: a meaningful ocular artifact. Ophthalmology 88: 1307–1310

    PubMed  CAS  Google Scholar 

  • Gresh J, Goletz PW, Crouch RK, Rohrer B (2003) Structure-function analysis of rods and cones in juvenile, adult, and aged C57bl/6 and Balb/c mice. Vis Neurosci 20: 211–220

    Article  PubMed  Google Scholar 

  • Jackson GR, Owsley C, McGwin G Jr (1999) Aging and dark adaptation. Vis Res 39: 3975–3982

    PubMed  CAS  Google Scholar 

  • Jackson GR, Owsley C, Curcio CA (2002) Photoreceptor degeneration and dysfunction in aging and age-related maculopathy. Ageing Res Rev 1: 381–396

    PubMed  Google Scholar 

  • LaVail MM (1981) Photoreceptor characteristics in congenic strains of RCS rats. Invest Ophthalmol Vis Sci 20: 671–675

    PubMed  CAS  Google Scholar 

  • LaVail M, Battelle B (1975) Influence of eye pigmentation and light deprivation on inherited retinal dystrophy on the rat. Exp Eye Res 21: 167–192

    Article  PubMed  CAS  Google Scholar 

  • LaVail MM, Li L, Turner JE, Yasumura D (1992) Retinal pigment epithelial cell transplantation in rcs rats: normal metabolism in rescued photoreceptors. Exp Eye Res 55: 555–562

    Article  PubMed  CAS  Google Scholar 

  • Li Y, Kljavin I, Milam A (1995) Rod photoreceptor neurite sprouting in retinitis pigmentosa. J Neurosci 15: 5429–5438

    PubMed  CAS  Google Scholar 

  • Liu C, Peng M, Laties A, Wen R (1998) Preconditioning with bright light evokes a protective response against light damage in the rat retina. J Neurosci: 1337–1344

    Google Scholar 

  • Maslim J, Valter K, Egensperger R, Hollander H, Stone J (1997) Tissue oxygen during a critical developmental period controls the death and survival of photoreceptors. Invest Ophthalmol Vis Sci 38: 1667–1677

    PubMed  CAS  Google Scholar 

  • Mervin K, Stone J (2002a) Developmental death of photoreceptors in the C57BL/6J mouse: association with retinal function and self-protection. Exp Eye Res 75: 703–713

    PubMed  CAS  Google Scholar 

  • Mervin K, Stone J (2002b) Regulation by oxygen of photoreceptor death in the developing and adult C57BL/6J mouse. Exp Eye Res 75: 715–722

    PubMed  CAS  Google Scholar 

  • Mohand-Said S, Deudon-Combe A, Hicks D, Simonutti M, Forster V, Fintz AC, Leveillard T, Dreyfus H, Sahel JA (1998) Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse. Proc Natl Acad Sci USA 95: 8357–8362

    Article  PubMed  CAS  Google Scholar 

  • Mollon J, Regan B, Bowmaker J (1998) What is the function of the cone-rich rim of the retina? Eye 12: 548–552

    PubMed  Google Scholar 

  • Nir I, Liu C, Wen R (1999) Light treatment enhances photoreceptor survival in dystrophic retinas of Royal College of Surgeons rats. Invest Ophthalmol Vis Sci 40: 2383–2390

    PubMed  CAS  Google Scholar 

  • Organisciak DT, Darrow RA, Darrow RA, Lininger LA (1998) Environmental light and age-related changes in retinal proteins. In: Photostasis and related phenomena. Plenum, New York, pp 79–92

    Google Scholar 

  • Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J (2003) Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 5: 741–747

    Article  PubMed  CAS  Google Scholar 

  • Penn J, Anderson R (1991) Effects of light history on the rat retina. Prog Retin Res 11: 75–98

    Google Scholar 

  • Steinberg RH (1994) Survival factors in retinal degenerations. Curr Opin Neurobiol 4: 515–524

    Article  PubMed  CAS  Google Scholar 

  • Stone J, Johnston E (1981) The topography of primate retina: a study of the human, bushbaby, and new and old-world monkeys. J Comp Neurol 196: 205–223

    Article  PubMed  CAS  Google Scholar 

  • Stone J, Maslim J, Valter-Kocsi K, Mervin K, Bowers F, Chu Y, Barnett N, Provis J, Lewis G, Fisher S, Bisti S, Gargini C, Cervetto L, Merin S, Pe’er J (1999) Mechanism of photoreceptor death and survival. Prog Retin Eye Res 18: 689–735

    Article  PubMed  CAS  Google Scholar 

  • Stone J, Maslim J, Fawsi A, Lancaster P, Heckenlively J (2001) The role of perinatal stress in retinitis pigmentosa: evidence from surveys in Australia and the USA. Can J Ophthalmol 36: 315–322

    PubMed  CAS  Google Scholar 

  • Valter K, Maslim J, Bowers F, Stone J (1998) Photoreceptor dystrophy in the RCS rat: roles of oxygen, debris and bFGF. Invest Ophthalmol Vis Sci 39: 2427–2442

    PubMed  CAS  Google Scholar 

  • Vrabec F (1967) Neurohistology of cystoid degeneration of the peripheral human retina. Am J Ophthalmol 64: 90–99

    PubMed  CAS  Google Scholar 

  • Walsh N, Stone J (2001) Timecourse of bFGF and CNTF expression in light-induced photoreceptor degeneration in the rat retina. In: New insights into retinal degenerative diseases. Kluwer, New York, pp 111–118

    Google Scholar 

  • Walsh N, Valter K, Stone J (2001) Cellular and subcellular patterns of expression of bFGF and CNTF in the normal and light stressed adult rat retina. Exp Eye Res 72: 495–501

    Article  PubMed  CAS  Google Scholar 

  • Wen R, Song Y, Cheng T, Matthes M, Yasamura D, LaVail M, Steinberg R (1995) Injury-induced upregulation of bFGF and CNTF mRNAs in the rat retina. J Neurosci 15: 7377–7385

    PubMed  CAS  Google Scholar 

  • Williams RW (1991) The human retina has a cone-enriched rim. Vis Neurosci 6: 403–406

    Article  PubMed  CAS  Google Scholar 

  • Yamada H, Yamada E, Hackett SF, Ozaki H, Okamoto N, Campochiaro PA (1999) Hyperoxia causes decreased expression of vascular endothelial growth factor and endothelial cell apoptosis in adult retina. J Cell Physiol 179: 149–156

    Article  PubMed  CAS  Google Scholar 

  • Yu DY, Cringle SJ, Su EN, Yu PK (2000) Intraretinal oxygen levels before and after photoreceptor loss in the RCS Rat. Invest Ophthalmol Vis Sci 41: 3999–4006

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Jonathan Stone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kyle Mervin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Natalie Walsh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Krisztina Valter
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jan M. Provis
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Philip L. Penfold
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Regenera Limited, PO Box 9, 2 Brindabella Circuit, Canberra Airport, ACT, 2609, Australia

    Philip L. Penfold (Chief Scientist) (Chief Scientist)

  2. Research School of Biological Sciences, The Australian National University, GPO Box 475, Canberra, ACT, 2601, Australia

    Jan M. Provis

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Stone, J., Mervin, K., Walsh, N., Valter, K., Provis, J.M., Penfold, P.L. (2005). Photoreceptor Stability and Degeneration in Mammalian Retina: Lessons from the Edge. In: Penfold, P.L., Provis, J.M. (eds) Macular Degeneration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26977-0_9

Download citation

  • DOI: https://doi.org/10.1007/3-540-26977-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20058-1

  • Online ISBN: 978-3-540-26977-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation