Towards Understanding the Neurobiology of Mammalian Puberty: Genetic, Genomic and Proteomic Approaches
- 824 Downloads
The pubertal activation of gonadotropin hormone-releasing hormone (GnRH) release in rodents and primates is brought about by coordinated changes in excitatory and inhibitory inputs to GnRH neurons. These inputs include both transsynaptic and glia-to-neuron communication pathways. Using cellular and molecular approaches in combination with transgenic animal models and high throughput procedures for gene discovery, we are beginning to gain insights into the basic mechanisms underlying this dual transsynaptic/glial control of GnRH secretion, and hence, the initiation of mammalian puberty. The results thus far obtained suggest that the initiation of puberty requires reciprocal neuron-glia communication involving excitatory amino acids and growth factors, changes in synaptic make-up and glia-neuron adhesiveness, and the transcriptional regulation of genes required for the normal function of both neurons and glial cells involved in the control of GnRH secretion.
KeywordsGnRH Neuron Transform Growth Factor Alpha GnRH Secretion GnRH Release Hypothalamic Hamartomas
Unable to display preview. Download preview PDF.
- Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M (1999) A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2. Genomics 62: 139–146CrossRefPubMedGoogle Scholar
- Jung H, Carmel P, Schwartz MS, Witkin JW, Bentele KHP, Westphal M, Piatt JH, Costa ME, Cornea A, Ma YJ, Ojeda SR (1999) Some hypothalamic hamartomas contain transforming growth factor alpha, a puberty-inducing growth factor, but not luteinizing hormone-releasing hormone neurons. J Clin Endocrinol Metab 84:4695–4701CrossRefPubMedGoogle Scholar
- Lee BJ, Cho GJ, Norgren R, Junier M-P, Hill DF, Tapia V, Costa ME, Ojeda SR (2001) TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci 17: 107–126CrossRefPubMedGoogle Scholar
- Lomniczi A, Ojeda SR (2003) Hypothalamic tumor necrosis factor-a converting enzyme (TACE) activity is involved in the control of female sexual development. Program No 709 7, 2003 Abstract Viewer Washington, DC: Society for Neuroscience, 2003 OnlineGoogle Scholar
- Mungenast AE, Parent A, Chen SS, Goodlett D, Aebersold R, Corfas G, Ojeda SR (2003) The synaptic adhesion molecule SynCAM is associated with ERBB4 dysregulation in the hypothalamus of mice with a delayed onset of puberty. Program No 281 20, 2003 Abstract Viewer Washington, DC: Society for Neuroscience, 2003 OnlineGoogle Scholar
- Ojeda SR, Terasawa E (2002) Neuroendocrine regulation of puberty. In: Pfaff D, Arnold A, Etgen A, Fahrbach, S, Moss R, Rubin R (eds) Hormones, brain and behavior. Vol. 4. Elsevier, New York, pp 589–659Google Scholar
- Ojeda SR, Urbanski HF (1994) Puberty in the rat. In: Knobil E, Neill JD (eds) The physiology of reproduction. 2nd Edition, Vol. 2. Raven Press, New York, pp 363–409Google Scholar
- Ottem EN, Godwin JG, Petersen SL (2002) Glutamatergic signaling through the N-methyl-D-aspartate receptor directly activates medial subpopulations of luteinizing hormone-releasing hormone (LHRH) neurons, but does not appear to mediate the effects of estradiol on LHRH gene expression. Endocrinology 143: 4837–4845CrossRefPubMedGoogle Scholar
- Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Koslosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, Black RA (1998) An essential role for ectodomain shedding in mammalian development. Science 282: 1281–1284CrossRefPubMedGoogle Scholar
- Plant TM (1994) Pubertyin primates. In: Knobil E, Neill J (eds) The physiology of reproduction. 2nd Edition, Vol. 2. Raven Press, New York, pp 453–485Google Scholar
- Weiner RI, Findell PR, Kordon C (1988) Role of classic and peptide neuromediators in the neuroendocrine regulation of LH and prolactin. In: Knobil E Neill JD (eds) The physiology of reproduction. Vol. 1. Raven Press, New York, pp 1235–1281Google Scholar