Towards Understanding the Neurobiology of Mammalian Puberty: Genetic, Genomic and Proteomic Approaches

  • Sergio R. Ojeda
  • Alejandro Lomniczi
  • Alison Mungenast
  • Claudio Mastronardi
  • Anne-Simone Parent
  • Christian Roth
  • Vincent Prevot
  • Sabine Hegeir
  • Heike Jung
Conference paper
Part of the Research and Perspectives in Endocrine Interactions book series (RPEI)


The pubertal activation of gonadotropin hormone-releasing hormone (GnRH) release in rodents and primates is brought about by coordinated changes in excitatory and inhibitory inputs to GnRH neurons. These inputs include both transsynaptic and glia-to-neuron communication pathways. Using cellular and molecular approaches in combination with transgenic animal models and high throughput procedures for gene discovery, we are beginning to gain insights into the basic mechanisms underlying this dual transsynaptic/glial control of GnRH secretion, and hence, the initiation of mammalian puberty. The results thus far obtained suggest that the initiation of puberty requires reciprocal neuron-glia communication involving excitatory amino acids and growth factors, changes in synaptic make-up and glia-neuron adhesiveness, and the transcriptional regulation of genes required for the normal function of both neurons and glial cells involved in the control of GnRH secretion.


GnRH Neuron Transform Growth Factor Alpha GnRH Secretion GnRH Release Hypothalamic Hamartomas 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Sergio R. Ojeda
    • 1
  • Alejandro Lomniczi
    • 1
  • Alison Mungenast
    • 1
  • Claudio Mastronardi
    • 1
  • Anne-Simone Parent
    • 1
  • Christian Roth
    • 1
  • Vincent Prevot
    • 1
    • 2
  • Sabine Hegeir
    • 1
    • 3
  • Heike Jung
    • 1
    • 4
  1. 1.Division of NeuroscienceOregon National Primate Research Center/Oregon Health & Science UniversityBeaverton
  2. 2.INSERM U422Lille cedexFrance
  3. 3.Department of Pediatrics, Division of Pediatric EndocrinologyUniversity Children’s HospitalKielGermany
  4. 4.Lilly Deutschland GmvbHNiederlassung Bad HomburgBad HomburgGermany

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