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Applied Scanning Probe Methods III pp 1–26Cite as

Atomic Force Microscopy in Nanomedicine

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Part of the book series: NanoScience and Technology ((NANO))

12.6 Summary

The combination of AFM with conventional techniques, as well as AFM itself, allows answering biomedical questions of high interest. We could show this clearly for CFTR with single molecule imaging and observation of structural dynamics in native cell membranes. AFM also allows identification and determination of CFTR at single molecule level. The observation that the lack of CFTR influences the mechanical and, therefore, rheological properties of RBC could lead to a novel therapeutic approach for CF treatment. Regarding the fact that the defect of a single protein causes lethal diseases, research at the single molecule level would become vital in the future.

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Author information

Authors and Affiliations

  1. Institute of Physiology II, Robert-Koch Str. 27b, 48149, Muenster, Germany

    Dessy Nikova, Tobias Lange, Hans Oberleithner & Hermann Schillers

  2. Institute for Biophysics, J. Kepler University, Altenbergerstr. 69, A-4040, Linz, Austria

    Andreas Ebner & Peter Hinterdorfer

Authors
  1. Dessy Nikova
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  2. Tobias Lange
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  3. Hans Oberleithner
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  4. Hermann Schillers
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  5. Andreas Ebner
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  6. Peter Hinterdorfer
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Editor information

Editors and Affiliations

  1. Nanotribology Laboratory for Information Storage and MEMS/NEMS (NLIM), The Ohio State University, 650 Ackerman Road, Suite 255, Columbus, OH, 43202-1107, USA

    Bharat Bhushan

  2. Center for Nanotechnology (CeNTech) and Institute of Physics, University of Münster, Gievenbecker Weg 11, 48149, Münster, Germany

    Harald Fuchs

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© 2006 Springer-Verlag Berlin Heidelberg

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Nikova, D., Lange, T., Oberleithner, H., Schillers, H., Ebner, A., Hinterdorfer, P. (2006). Atomic Force Microscopy in Nanomedicine. In: Bhushan, B., Fuchs, H. (eds) Applied Scanning Probe Methods III. NanoScience and Technology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26910-X_1

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