Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Abraham E et al (2003) Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis. A randomized controlled trial. JAMA 290: 238–247
Abraham E et al (2003) Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa grop lia secretory phospholipase A2, in patients with suspected sepsis and organ failure. Crit Care Med 31: 718–728
Abraham E et al. (1995) Efficacy and safety of monoclonal antibody to human tumor-necrosis factor αin patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-α Mab Sepsis Study Group. JAMA 273: 934–941
Abraham E (2001) Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: arandomized, double-blind, placebo-controlled, mulitcenter phase III trial with 1342 patients. Crit Care Med 29: 503–510
Alberti C et al. (2002) Epidemiology of sepsis and infection in ICU patients from an fnternational multicentre cohort study. Intensive Care Med 28: 108–121
Alberti C, Brun-Buisson C (2003) Epidemiology of inefction and sepsis: Areview. Advances in Sepsis 3: 45–55
Alejandria MMt et al (2001) Intravenous immuneglobuline for treating sepsis and septic shock. The Cochrane Library 2.; Oxford: Update Software
Angus DC et al (2001) Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 29: 1303–1310
Angus DC et al (2002) The effects of drotrecogin alfa (activated) on long-term survival after severe sepsis. Chest 122(Suppl.): 51S
Angus DC, Crowther MA (2003) Unraveling severe sepsis. Why did OPTIMIST fail and what’s next. JAMA 290: 256–258
Annane D (2002) Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients in septic shock. JAMA 288: 862–871
Annane D et al (2000) A3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 283: 1038–1045
Annane D, Cavaillon JM (2003) Corticosteroids in sepsis: From bench to bedside. Shock 20: 197–207
Arich C et al. (1987) Comparison of the efficacy of cefotaxime alone and the combination cefazolin-tobramycin in the treatment of enterobacterial septicemia. Pathol Biol (Paris) 35: 613–615
Barie PS, et al. (2003) Drortecogin alfa (activated) has a favorable benefit/risk profile in surgical patients with severe sepsis
Bernard GR et al. (2003) Safety assesment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis. Crit Care 7: 155–163
Bernard GR et al. (2001) Efficacy and safety of recombinant human activated protein C for sever sepsis. N Engl J Med 344: 699–709
Bilton BD et al. (1998) Aggressive surgical management of necrotizing fasciitis serves to decresemortality: a retrospective study. Am Surg 64: 397–400
Bochud PY, Glauser MP, Calandra T (2001) Antibiotics in sepsis. Intensive Care Med 27: S33–S48
Bodmann KF, Vogel F (2001) Antimikrobielle Therapie der Sepsis. Chemotherapie J 10: 43–56
Bollaert PE et al. (1998) Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 26: 645–650
Bone RC (1991) Critical evaluation of new agents for the treatment of sepsis. JAMA 266: 1686–1691
Bone RC et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101: 1644–1655
Bone RC, Fisher CJ, Clemmer TP (1987) A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 317: 653–658
Briegel J et al (1999) Stress doses of hydrocortison reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 27: 723–732
Brun-Buisson C et al. (1995) Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU group for severe sepsis. JAMA 274: 968–974
Cometta A, Baumgartner JD (1994) Prospective randomized comparison of imipenem monotherapy with imipenem plus netilmicinfortreatment of severe infections in non-neutropenic patients. Antimicrob Agents Chemother 38: 1309–1013
Cooper MS, Stewart PM (2003) Corticosteroid insufficiency in acutely ill patients. N Engl J Med 348: 727–734
Cronin L, Cook DJ, Carlet J (1995) Corticosteroid treatment for sepsis: A critical appraisal and meta-analysis of the literature. Crit Care Med 1995 23: 1430–1439
Dhainnaut JF et al. (2003) Drotrcogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial. Intensive Care Med 29: 894–903
Eichacker PQ et al. (2002) Riskand efficacy of antiinflammatory agents. Retrospective and confirmatory studies of sepsis. Am J Respir Crit Care Med 166: 1197–1205
Eklund AE, Nord CE (1993) A randomized multicenter trial of piperacillin/tazobactam vs. imipenem/cilastatin in the treatment of severe intra-abdominal infections.Swedish Study Group. J Antimicrob Chemother [Suppl.A]: 79–85
Ely EW et al (2003) Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med 31: 12–19
Ely EW, Bernard GR, Vincent JL (2002) Activated protein C for severe sepsis.N Engl J Med 347: 1035–1036
Extermann M et al. (1995) Initial treatment of sepsis in non-neutropenic patients: ceftazidime alone vs. »best guess« combined antibiotic therapy. Chemotherapy 41:306–315
Freischlag JA, Ajalat G, Busuttil RW (1985) Treatment of necrotizing soft tissue infections. Aneed for a new approach. Am J Surg 149: 751–755
Friedman, G., Silva, E., and Vincent, J. L. Has the Mortality of Septic Shock Changed With Time. Crit Care Med. 1998;26(12): 2078–2086
Gatell J M (1988) Nosocomial Bacteremia in a Large Spanish Teaching Hospital: Analysis of Factors Influencing Prognosis. Rev Infect Dis 10: 203–210
Gerzof SG et al (1981) Percutaneous catheter drainage of abdominal abscesses. A five year experience. N Engl J Med 305: 653–657
Gerzof SG et al (1985) Expanded criteria for percutaneous abscess drainage. Arch Surg 120: 227–232
Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348: 138–150
Jaccard C et al. (1998) Prospective randomized comparison of imipenem/cilastatin and piperacillen/tazobactam in nosocomial pneumonia or peritonitis. Antimicrob Agents Chemother 42: 2966–2972
Joyce DE, Grinnell BW (2002) Recombinat human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kB. Crit Care Med 30[Suppl.]: S288–S293
Knaus WA et al. (1996) Use of predicted risk of mortality to evaluate the efficacy of anticytokine therapy in sepsis. The RhIL1-ra Phase IIISepsis Syndrome Study Group. Crit Care Med 24: 46–56
Krumpe PE et al. (1999) Intravenous and oral mono-or combination treament of severe infections: ciprofloxacin vs. standard antibiotic therapy.Ciprofloxacib Study Group. J Antimicrob Chemother [Suppl.A]: 117–128
Lefering R, Neugebauer EAM (1995) A steroid controversy in sepsis and septic shock: A meta-analysis. Crit Care Med 1995 23: 1294–1303
Leone M et al. (203) Empirical antibiotic therapyof sptic shock patients. Adequancy and impact on the outcome. Crit Care Med 31: 462–467
Malmberg K (1997) Prospective randomised study of intensive insulin treatment on lonf term survival after acute myocardial infarction in patients with diabetes mellitus. BMJ 314: 1512–1515
Marik PE, Zaloga GP (2003) Adrenal insufficiency inseptic shock. Crit Care Med 31: 141–145
Marshall JC (2001) Inflammation, coagulation, and the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 29[Suppl.]: S99–S106.863
Mc Cormick PA et al. (1997) A prospective randomized trial of ceftazidime vs. netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients. Hepathology 25: 833–836
Meehan TP et al (1997) Quality of care, process, ant outcomes in elderly patients with pneumonia. JAMA 278: 2080–2084
Mesotten D et al. (2004) Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 89: 219–226
Mier J et al (1997) Early vs. late necrosectomy in severe necrotizing pancreatitis. Am J Surg 173: 71–75
Miller JD (1983) The importance of early diagnosis and surgical treatment of necrotizing fasciitis. Surg Gynecol Obstet 157: 197–200
Mouton Y et al. (1990) Prospective randomized, controlled study of imipenem-cilastatin vs. cefotaxime-amikacin in the treatment of lower respiratory tract infection and septicemia at intensive care untis. Presse Méd 19: 607–612
Mouton Y, Beuscart C (1995) Empirical monotherapy with meropenem in seriousbacterial infections.Meropenem Study Group. J Antimicrob Chemother 36[Suppl. A]: 145–156
Muckart DJ et al. (1997) American college of chest physicians/society of critical care medicine consensus conference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients. Crit Care Med 25: 1789–95
Neilson AR et al. (2003) Cost-effectiveness of drotrecogin alfa (activated) for the treatment of severe sepsis in Germany. J Crit Care 18: 217–227
Niederman MS (2003) Appropriateuse of antmicrobial agents: Challenges and strategies for improvement. Crit Care Med 31: 608–616
Oblinger MJ et al (1982) Moxalactam therapy vs. standard antimicrobial therapy for selected serious infections. Rev Infect Dis 4[Suppl.]: S639–S649
Olak JO et al. (1986) Operative vs. precutaneous drainage of intra-abdominal abscesses. Arch Surg 121: 141–146
Pittet D et al (1993) Importance of pre-existing co-morbidities for prognosis of septicemia in critically ill patients. Intensive Care Med 19: 265–72
Pittet D et al. (1995) Systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock: Incidence, morbidities and outcomes in surgical ICU patients. Intensive Care Med 21: 302–9
Rangel-Frausto M S et al. (1995) The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 273: 117–23
Rea WJ, Wyrick WJ (1970) Necrotizing fasciitis. Ann Surg 172: 957–964
Reinhart K et al. (2001) Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study. Crit Care Med 29: 765–769
Rello J et al. (1994) Nosocomial bacteremia in a medicalsurgical intensive care unit: epidemiologic characteristics and factor influencing mortality in 111 episodes. Intensive Care Med 20: 94–98
Saini S et al (1983) Improvedlocalization and survival in patients with intra-abdominal abscesses. Am J Surg 145: 136–142
Salvo I et al (1995) The italian SEPSIS study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock. Intensive Care Med 21[Suppl 2]: S244–S249
Schumer W (1976) Steroids in the treatment of clinicalseptic shock. Ann Surg 184: 333–341
Siegel JP (2002)Assesing the use of activated protein Cin the treatment of severe sepsis. N Engl J Med 347: 1030–1034
Solberg CO, Sjursen H (1995) Safety and efficacy of meropenem in patients with septicaemia: a randomised comparison with ceftazidime,alone or combined with amikacin. J Antimicrob Chemother 36[Suppl. A]: 157–166
Sudarsky LA et al (1987) Improved results from standardized approach in treating patients with necrotizing fasciitis. Ann Surg 206: 661–665
The Veterans Administration Systemic Sepsis Cooperative Study Group (1987) Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of sepsis. N Engl J Med 317: 659–665
Van den Berghe G et al (1999) Reactivation of pituitary hormone release and metabolic improvement by infusion of growth hormone-releasing peptide and thyrotropin-releasing hormone in patientswith protracted critical illness. J Clin Endocrinol Metab 84: 1311–1323
Van den Berghe G et al (2001) Intensive insulin therapy in critically ill patients. N Engl J Med 345: 1359–1367
Van den Berghe G et al (2003) Outcome benefit of intensive insulin therapy in the criticallyill: Insulin dose vs. glcemic control. Crit Care Med 31: 359–366
Vincent JL et al (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/ failure. Intensive Care Med 22: 707–710
Vincent JL et al (2002) Reducing mortality in sepsis: new directions. Crit Care 6[Suppl.]: S1–S18
Vincent JL et al. (2003) Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 31: 834–840
Voros D et al (1993) Role of earlyand extensive surgery in the treatment of severe necrotizing soft tissue infections. Br J Surg 80: 1190–1191
Warren BL et al (2001) Caring for critical ill patient. Highdose antithrombin III in severe sepsis: a randomized controlled trial. JAMA 286: 1869–1878
Werdan K (2001) Intravenous immunoglobulinfor prophylais and therapy of sepsis. Curr Opin Crit Care 7: 354–361
White NJ et al. (1989) Halving of mortality of severe melioidosis by ceftazidime. Lancet II: 697–701
Wichmann WM et al. (2000) Incidence and mortality of severe sepsis in surgical sntensive care patients: the influence of patient gender on disease process and outcome. Intensive Care Med 26: 167–72
Yan SB, Dhainaut JF (2001) Activated protein C vs. protein C in severe sepsis. Crit Care Med 29[Suppl.]: S69–S74
Zeni F, Freeman B, Natanson C (1997) Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment. Crit Care Med 25: 1095–1100
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer Medizin Verlag Heidelberg
About this chapter
Cite this chapter
de Rossi, L. (2005). Therapie der Sepsis. In: Evidenzbasierte Medizin in Anästhesie und Intensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26858-8_4
Download citation
DOI: https://doi.org/10.1007/3-540-26858-8_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20042-0
Online ISBN: 978-3-540-26858-1
eBook Packages: Medicine (German Language)