Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Summary of Clinical Trials of Mechanical Ventilation in ARDS

  • Conference paper
Mechanical Ventilation

Part of the book series: Update in Intensive Care Medicine ((UICMSOFT))

  • 933 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Webb HH, Tierney DF (1974) Experimental pulmonary edema due to intermittent positive pressure ventilation with high pressures. Am Rev Respir Dis 110:556–565

    PubMed  CAS  Google Scholar 

  2. Tsuno K, Prato P, Kolobow T (1990) Acute lung injury from mechanical ventilation at moderately high airway pressures. J Appl Physiol 69:956–961

    PubMed  CAS  Google Scholar 

  3. Parker JC, Hernandez LA, Longenecker GL, Peevy K, Johnson W (1990) Lung edema caused by high peak inspiratory pressuresin dogs. Am Rev Respir Dis 142:321–328

    PubMed  CAS  Google Scholar 

  4. Parker JC, Hernandez LA, Peevy KJ (1993) Mechanisms of ventilator-induced lung injury. Crit Care Med 21:131–143

    PubMed  CAS  Google Scholar 

  5. Dreyfuss D, Saumon G (1992) Barotrauma is volutrauma but which volume is the one responsible? Intensive Care Med 18:139–141

    Article  PubMed  CAS  Google Scholar 

  6. Dreyfuss D, Saumon G (1993) Role of tidal volume, FRC, end-inspiratory volume in the development of pulmonary edema following mechanical ventilation. Am Rev Respir Dis 136:730–736

    Google Scholar 

  7. Dreyfuss D, Saumon G (1998) State of the Art: Ventilator-induced lung injury; lessons from experimental studies. Am J Respir Crit Care Med 157:294–323

    PubMed  CAS  Google Scholar 

  8. Muscedere JG, Mullen JBM, Gan K, Slutsky AS (1994) Tidal ventilation at low airway pressures can augment lung injury. Am J Respir Crit Care Med 149:1327–1334

    PubMed  CAS  Google Scholar 

  9. Corbridge TC, Wood LDH, Crawford GP, Chudoba MJ, Yanos J, Sznajder JI (1990) Adverse effects of large tidal volume and low PEEP in canine acid aspiration. Am Rev Respir Dis 142:311–315

    PubMed  CAS  Google Scholar 

  10. Colice GL (1994) Historical perspective on the development of mechanical ventilation. In: Tobin M (ed) Principles and Practice of Mechanical Ventilation. McGraw-Hill, Inc, New York, pp 1–35

    Google Scholar 

  11. Benedixen HH, Hedley-Whyte J, Laver MB (1963) Impaired oxygenation in surgical patients during general anesthesia with controlled ventilation. N Engl J Med 269:991–997

    Google Scholar 

  12. Hedley-Whyte J, Laver MB, Benedixen HH (1964) Effect of changes in tidal ventilation on physiologic shunting. Am J Physiol 206:891–897

    PubMed  CAS  Google Scholar 

  13. Cheney FW, Burnham SC (1971) Effect of ventilatory pattern on oxygenation in pulmonary edema. J Appl Physiol 31:909–912

    PubMed  Google Scholar 

  14. Hedley-Whyte J, Pontoppidan H, Morris MJ (1966) The response of patients with respiratory failure and cardiopulmonary disease to different levels of constant volume ventilation. J Clin Invest 45:1543–1554

    Article  PubMed  CAS  Google Scholar 

  15. Maunder RJ, Shuman WP, McHugh JW, Marglin SI, Butler M (1986) Preservation of normal lung regions in the adult respiratory distress syndrome. JAMA 255:2463–2465

    Article  PubMed  CAS  Google Scholar 

  16. Gattinoni L, Pesenti A, Avalli L, Ross F, Bomino M (1987) Pressure-volume curve of total respiratory system in acute respiratory failure: computed tomographic scan study. Am Rev Respir Dis 136:730–736

    PubMed  CAS  Google Scholar 

  17. Tsuno K, Miura K, Takeya M, Kolobow T, Morioka T (1991) Histopathologic pulmonary changes from mechanical ventilation at high peak airway pressures. Am Rev Respir Dis 143:1115–1120

    PubMed  CAS  Google Scholar 

  18. Parker JC, Townsley MI, Rippe B, Taylor AE, Thigpen J (1984) Increased microvascular permeability in dog lungs due to high peak airway pressures. J Appl Physiol 57:1809–1816

    PubMed  CAS  Google Scholar 

  19. Hickling KG, Walsh J, Henderson S, Jackson R (1994) Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: a prospective study. Crit Care Med 22:1568–1578

    Article  PubMed  CAS  Google Scholar 

  20. Hickling KG, Henderson SJ, Jackson R (1990) Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome. Intensive Care Med 16:372–377

    PubMed  CAS  Google Scholar 

  21. Mead J, Takishima T, Leith D (1970) Stress distribution in lungs: A model of pulmonary elasticity. J Appl Physiol 28:596–608

    PubMed  CAS  Google Scholar 

  22. Martynowicz MA, Minor TA, Walters BJ, Hubmayr RD (1999) Regional expansion of oleic acid-injured lungs. Am J Respir Crit Care Med 160:250–258

    PubMed  CAS  Google Scholar 

  23. Hubmayr RD (2002) Perspective on lung injury and recruitment: A skeptical look at the opening and collapse story. Am J Respir Crit Care Med 165:1647–1653

    Article  PubMed  Google Scholar 

  24. Lachman B (1992) Open up the lung and keep the lung open. Intensive Care Med 18:319–321

    Google Scholar 

  25. Amato MBP, Barbas CSV, Medeiros DM, et al (1995) Beneficial effects of the “open lung approach” with low distending pressures in acute respiratory distress syndrome. Am J Respir Crit Care Med 152:1835–1846

    PubMed  CAS  Google Scholar 

  26. Pinsky MR (1993) Heart-lung interactions. In: Pinsky MR, Dhainaut JF (eds) Pathophysiologic Foundations of Critical Care. Williams & Wilkins, Baltimore, pp: 472–490

    Google Scholar 

  27. Scharf SM (1998) Mechanical cardiopulmonary interactions in critical care. In: Dantzker DR, Scharf SM (ed) Cardiopulmonary Critical Care. W.B. Saunders Company, Philadelphia, pp: 75–91

    Google Scholar 

  28. Carmichael LC, Dorinsky PM, Higgins SB, et al (1996) Diagnosis and therapy of acute respiratory distress syndrome in adults: an international survey. J Crit Care 11:9–18

    PubMed  CAS  Google Scholar 

  29. Esteban A, Anzueto A, Alia I, et al (2000) How is mechanical ventilation employed in the Intensive Care Unit? An international utilization review. Am J Respir Crit Care Med 161:1450–1458

    PubMed  CAS  Google Scholar 

  30. Esteban A, Anzueto A, Frutos F, et al (2002) A 28-day international study of the characteristics and outcomes in patients receiving mechanical ventilation. JAMA 287:345–355

    Article  PubMed  Google Scholar 

  31. Amato MBP, Barbas CSV, Medeiros DM, et al (1998) Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 338:347–354

    Article  PubMed  CAS  Google Scholar 

  32. Hudson LD (1998) Protective ventilation for patients with acute respiratory distress syndrome. N Engl J Med 338:385–387

    Article  PubMed  CAS  Google Scholar 

  33. Brochard L, Roudot-Thoraval F, Roupie E, et al (1998) Tidal volume reduction for prevention of ventilator-induced lung injury in the acute respiratory distress syndrome. Am J Respir Crit Care Med 158:1831–1838

    PubMed  CAS  Google Scholar 

  34. Brower RG, Shanholtz CB, Fessler HE, et al (1999) Prospective randomized, controlled clinical trial comparing traditional vs. reduced tidal volume ventilation in ARDS patients. Crit Care Med 27:1492–1498

    PubMed  CAS  Google Scholar 

  35. Stewart TE, Meade MO, Cook DJ, et al (1998) Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. N Engl J Med 338:355–361

    Article  PubMed  CAS  Google Scholar 

  36. Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308

    Google Scholar 

  37. Whitehead J (1986) On the bias of maximum likelihood estimation following a sequential test. Biometrika 73:573–581

    Google Scholar 

  38. Brower R (1990) Mechanical ventilation in acute lung injury and ARDS. Crit Care Clin 18:1–13

    Google Scholar 

  39. Walley KR, Lewis TH, Wood LDH (1990) Acute respiratory acidosis decreases left ventricular contracticility but increases cardiac output in dogs. Circ Res 67:628–635

    PubMed  CAS  Google Scholar 

  40. Manley ES, Nash CB, Woodbury RA (1964) Cardiovascular responses to severe hypercapnia of short duration. Am J Physiol 207:634–640

    PubMed  Google Scholar 

  41. Feihl F, Perret C (1994) Permissive hypercapnia-How permissive should we be? Am J Respir Crit Care Med 150:1722–1737

    PubMed  CAS  Google Scholar 

  42. Tang W, Weil MH, Gazmuri RJ, Bisera J, Rackow EC (1991) Reversible impairment of myocardial contractility due to hypercarbic acidosis in the isolated perfused rat heart. Crit Care Med 19:218

    PubMed  CAS  Google Scholar 

  43. Broccard AF, Hotchkiss JR, Vannay C, et al (2001) Protective effects of hypercapnic acidosis on ventilator-induced lung injury. Am J Respir Crit Care Med 164:802–806

    PubMed  CAS  Google Scholar 

  44. Laffey JG, Tanaka M, Engelberts D, et al (2000) Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion. Am J Respir Crit Care Med 162:2287–2294

    PubMed  CAS  Google Scholar 

  45. Chang HK (1984) Mechanisms of gas transport during ventilation by high frequency oscillation. J Appl Physiol 56:553–563

    PubMed  CAS  Google Scholar 

  46. Slutsky AS, Drazen JM, Kamm RD (1984) Alveolar ventilation at high frequencies using tidal volumes less than the anatomic dead space. In: Engel LA, Paiva M, Lenfant Ce (eds) Lung Biology in Health and Disease. Marcel Dekker, New York, pp: 137–176

    Google Scholar 

  47. Krishnan J, Brower R (2000) High-frequency ventilation for acute lung injury and ARDS. Chest 118:795–807

    Article  PubMed  CAS  Google Scholar 

  48. Carlon GC, Howland WS, Ray C, Miodownik S, Griffin JP, Groeger JS (1983) High-frequency jet ventilation: prospective, randomized evaluation. Chest 84:551–559

    PubMed  CAS  Google Scholar 

  49. Courtney SE, Durand DJ, Asselin JM, Hudak ML, Aschner JL, Shoemaker CT (2002) High-frequency oscillatory ventilation versus conventional mechanical ventilation for very-low-birthweight infants. N Engl J Med 347:643–652

    Article  PubMed  Google Scholar 

  50. Gerstmann DR, Minton SD, Stodard RA, et al (1996) The Provo multicenter early high-frequency oscillatory ventilation trial: Improved pulmonary and clinical outcomes in respiratory distress syndrome. Pediatrics 98:1044–1057

    PubMed  CAS  Google Scholar 

  51. Clark RH, Yoder BA, Sell MS (1994) Prospective, randomized comparison of high-frequency oscillation and conventional ventilation in candidates for extracorporeal membrane oxygenation. J Pediatr 124:447–454

    PubMed  CAS  Google Scholar 

  52. HiFO Study Group (1993) Randomized study of high-frequency oscillatory ventilation in infants with severe respiratory distress syndrome. J Pediatr 122:609–619

    Google Scholar 

  53. HIFI Study Group (1989) High-frequency oscillatory ventilation compared with conventional mechanical ventilation in the treatment of respiratory failure in preterm infants. N Engl J Med 320:88–93

    Google Scholar 

  54. Johnson AH, Peacock JL, Greenough A, et al (2002) High-frequency oscillatory ventilation for the prevention of chronic lung disease of prematurity. N Engl J Med 347:633–642

    Article  PubMed  Google Scholar 

  55. Derdak S, Mehta S, Stewart TE, et al (2002) High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults. Am J Respir Crit Care Med 166:801–808

    Article  PubMed  Google Scholar 

  56. Eichacker PQ, Gerstenberger EP, Banks SM, Cui X, Natanson C (2002) A metaanalysis of ALI and ARDS trials testing low tidal volumes. Am J Respir Crit Care Med 166:1510–1514

    PubMed  Google Scholar 

  57. Tobin M (2000) Culmination of an era in research on the acute respiratory distress syndrome. N Engl J Med 342:1360–1361

    Article  PubMed  CAS  Google Scholar 

  58. Brower R, Matthay MA, Schoenfeld DA (2002) Meta-analysis of acute lung injury and acute respiratory distress syndrome trials. Am J Respir Crit Care Med 166:1515–1516

    PubMed  Google Scholar 

Download references

Authors
  1. R. G. Brower
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. D. Rubenfeld
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Toronto, Queen Street Wing, Room 4-042, 30 Bond Street, Toronto, ON M5B 1W8, Canada

    Arthur S. Slutsky MD (Professor of Medicine, Surgery and Biomedical Engineering) (Professor of Medicine, Surgery and Biomedical Engineering)

  2. St. Michael’s Hospital, Queen Street Wing, Room 4-042, 30 Bond Street, Toronto, ON M5B 1W8, Canada

    Arthur S. Slutsky MD (Professor of Medicine, Surgery and Biomedical Engineering) (Professor of Medicine, Surgery and Biomedical Engineering)

  3. Department of Intensive Care, Hospital Henri Mondor, University Paris XII, 94010, Créteil, France

    Laurent Brochard

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Brower, R.G., Rubenfeld, G.D. (2005). Summary of Clinical Trials of Mechanical Ventilation in ARDS. In: Slutsky, A.S., Brochard, L. (eds) Mechanical Ventilation. Update in Intensive Care Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26791-3_28

Download citation

  • DOI: https://doi.org/10.1007/3-540-26791-3_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20267-7

  • Online ISBN: 978-3-540-26791-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation