Skip to main content
SpringerLink
Log in

Lung Morphology in ARDS: How it Impacts Therapy

  • Conference paper
Mechanical Ventilation

Part of the book series: Update in Intensive Care Medicine ((UICMSOFT))

  • 932 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gattinoni L, Pelosi P, Pesenti A, et al (1991) CT scan in ARDS; clinical and physiopathological insights. Acta Anaesthesiol Scand 35 (Suppl 95):87–96

    Google Scholar 

  2. Gattinoni L, Caironi P, Pelosi P, Goodman LR (2001) What has computed tomography taught us about the acute respiratory distress syndrome? Am J Respir Crit Care Med 164:1701–1711

    PubMed  CAS  Google Scholar 

  3. Pelosi P, Goldner M, McKibben A, et al (2001) Recruitment and derecruitment during acute respiratory failure: an experimental study. Am J Respir Crit Care Med 164:122–130

    PubMed  CAS  Google Scholar 

  4. Muscedere JG, Mullen JB, Gan K, Slutsky AS (1994) Tidal ventilation at low airway pressures can augment lung injury. Am J Respir Crit Care Med 149:1327–1334

    PubMed  CAS  Google Scholar 

  5. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS (1997) Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 99:944–952

    Article  PubMed  CAS  Google Scholar 

  6. Slutsky AS (2001) Basic science in ventilator-induced lung injury: implications for the bedside. Am J Respir Crit Care Med 163:599–600

    PubMed  CAS  Google Scholar 

  7. Lachmann B (1992) Open up the lung and keep the lung open. Intensive Care Med 18:319–321

    Article  PubMed  CAS  Google Scholar 

  8. Dreyfuss D, Saumon G (1998) Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 157:294–323

    PubMed  CAS  Google Scholar 

  9. Martynowicz MA, Walters BJ, Hubmayr RD (2001) Mechanisms of recruitment in oleic acid-injured lungs. J Appl Physiol 90:1744–1753

    PubMed  CAS  Google Scholar 

  10. Martynowicz MA, Minor TA, Walters BJ, Hubmayr RD (1999) Regional expansion of oleic acid-injured lungs. Am J Respir Crit Care Med 160:250–258

    PubMed  CAS  Google Scholar 

  11. Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334–1349

    Article  PubMed  CAS  Google Scholar 

  12. Hubmayr RD (2002) Perspective on lung injury and recruitment: a skeptical look at the opening and collapse story. Am J Respir Crit Care Med 165:1647–1653

    Article  PubMed  Google Scholar 

  13. Rouby JJ, Lherm T, Martin de Lassale E, et al (1993) Histologic aspects of pulmonary barotrauma in critically ill patients with acute respiratory failure. Intensive Care Med 19:383–389

    Article  PubMed  CAS  Google Scholar 

  14. Goldstein I, Bughalo MT, Marquette CH, Lenaour G, Lu Q, Rouby JJ (2001) Mechanical ventilation-induced air-space enlargement during experimental pneumonia in piglets. Am J Respir Crit Care Med 163:958–964

    PubMed  CAS  Google Scholar 

  15. Gattinoni L, Pesenti A, Torresin A, et al (1986) Adult respiratoy distress syndrome profiles by computed tomography. J Thorac Imag 1:25–30

    Article  CAS  Google Scholar 

  16. Puybasset L, Cluzel P, Gusman P, Grenier P, Preteux F, Rouby JJ (2000) Regional distribution of gas and tissue in acute respiratory distress syndrome. I. Consequences for lung morphology. CT Scan ARDS Study Group. Intensive Care Med 26:857–869

    PubMed  CAS  Google Scholar 

  17. Malbouisson LM, Preteux F, Puybasset L, Grenier P, Coriat P, Rouby JJ (2001) Validation of a software designed for computed tomographic (CT) measurement of lung water. Intensive Care Med 27:602–608

    Article  PubMed  CAS  Google Scholar 

  18. Malbouisson LM, Muller JC, Constantin JM, Lu Q, Puybasset L, Rouby JJ (2001) Computed tomography assessment of positive end-expiratory pressure-induced alveolar recruitment in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 163:1444–1450

    PubMed  CAS  Google Scholar 

  19. Vieira S, Puybasset L, Richecoeur J, et al (1998) A lung computed tomographic assessment of positive end-expiratory pressure-induced lung overdistension. Am J Respir Crit Care Med 158:1571–1577

    PubMed  CAS  Google Scholar 

  20. Puybasset L, Gusman P, Muller J-C, et al (2000) Regional distribution of gas and tissue in acute respiratory distress syndrome-part 3: Consequences for the effects of positive end expiratory pressure. Intensive Care Med 26:1215–1227

    PubMed  CAS  Google Scholar 

  21. Rouby JJ, Puybasset L, Cluzel P, Richecoeur J, Lu Q, Grenier P (2000) Regional distribution of gas and tissue in acute respiratory distress syndrome. II. Physiological correlations and definition of an ARDS Severity Score. CT Scan ARDS Study Group. Intensive Care Med 26:1046–1056

    Article  PubMed  CAS  Google Scholar 

  22. Gattinoni L, Pesenti A, Avalli L, Rossi F, Bombino M (1987) Pressure-volume curve of total respiratory system in acute respiratory failure. Computed tomographic scan study. Am Rev Respir Dis 136:730–736

    PubMed  CAS  Google Scholar 

  23. Gattinoni L, D’Andrea L, Pelosi P, Vitale G, Pesenti A, Fumagalli R (1993) Regional effects and mechanism of positive end-expiratory pressure in early adult respiratory distress syndrome. JAMA 269:2122–2127

    Article  PubMed  CAS  Google Scholar 

  24. Gattinoni L, Pesenti A, Bombino M, et al (1988) Relationships between lung computed tomographic density, gas exchange, and PEEP in acute respiratory failure. Anesthesiology 69:824–832

    PubMed  CAS  Google Scholar 

  25. Puybasset L, Cluzel P, Chao N, et al (1998) A computed tomography assessment of regional lung volume in acute lung injury. Am J Respir Crit Care Med 158:1644–1655

    PubMed  CAS  Google Scholar 

  26. Lu Q, Malbouisson LM, Mourgeon E, Goldstein I, Coriat P, Rouby JJ (2001) Assessment of PEEP-induced reopening of collapsed lung regions in acute lung injury: are one or three CT sections representative of the entire lung? Intensive Care Med 27:1504–1510

    PubMed  CAS  Google Scholar 

  27. Gevenois PA, Vuyst P, Maertelaer V, et al (1996) Comparison of computed density and microscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med 154:187–192

    PubMed  CAS  Google Scholar 

  28. Gould GA, Macnee W, Mclean A, et al (1988) CT measurements of lung density in life can quantitate distal airspace enlargement-An essential defining feature of human emphysema. Am Rev Respir Dis 137:380–392

    PubMed  CAS  Google Scholar 

  29. Mondor H (1940) Diagnostics urgents Abdomen. Masson Editeur, Paris

    Google Scholar 

  30. Malbouisson LM, Busch CJ, Puybasset L, Lu Q, Cluzel P, Rouby JJ (2000) Role of the heart in the loss of aeration characterizing lower lobes in acute respiratory distress syndrome. CT Scan ARDS Study Group. Am J Respir Crit Care Med 161:2005–2012

    PubMed  CAS  Google Scholar 

  31. Gattinoni L, Pelosi P, Vitale G, Pesenti A, D’andrea L, Mascheroni D (1991) Body position changes redistribute lung computed tomographic density in patients with acute respiratory failure. Anesthesiology 74:15–23

    PubMed  CAS  Google Scholar 

  32. Richard JC, Maggiore SM, Michard F, et al (1999) Upright positioning (UP) in patients with Acute Lung Injury (ALI). Am J Respir Crit Care Med 159:A 695 (abst)

    Google Scholar 

  33. Hickling KG (1998) The pressure-volume curve is greatly modified by recruitment. A mathematical model of ARDS lungs. Am J Respir Crit Care Med 158:194–202

    PubMed  CAS  Google Scholar 

  34. Suki B, Andrade JS, Jr., Coughlin MF, et al (1998) Mathematical modeling of the first inflation of degassed lungs. Ann Biomed Eng 26:608–617

    Article  PubMed  CAS  Google Scholar 

  35. Martin-Lefevre L, Ricard JD, Roupie E, Dreyfuss D, Saumon G (2001) Significance of the changes in the respiratory system pressure-volume curve during acute lung injury in rats. Am J Respir Crit Care Med 164:627–632

    PubMed  CAS  Google Scholar 

  36. Wilson TA, Anafi RC, Hubmayr RD (2001) Mechanics of edematous lungs. J Appl Physiol 90:2088–2093

    PubMed  CAS  Google Scholar 

  37. Jonson B, Richard JC, Straus C, Mancebo J, Lemaire F, Brochard L (1999) Pressure-volume curves and compliance in acute lung injury: evidence of recruitment above the lower inflection point. Am J Respir Crit Care Med 159:1172–1178

    PubMed  CAS  Google Scholar 

  38. Richard JC, Maggiore SM, Jonson B, Mancebo J, Lemaire F, Brochard L (2001) Influence of tidal volume on alveolar recruitment. Respective role of PEEP and a recruitment maneuver. Am J Respir Crit Care Med 163:1609–1613

    PubMed  CAS  Google Scholar 

  39. Gattinoni L, Pelosi P, Suter PM, Pedoto A, Vercesi P, Lissoni A (1998) Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease. Different syndromes? Am J Respir Crit Care Med 158:3–11

    PubMed  CAS  Google Scholar 

  40. Rialp G, Betbese AJ, Perez-Marquez M, Mancebo J (2001) Short-term effects of inhaled nitric oxide and prone position in pulmonary and extrapulmonary acute respiratory distress syndrome. Am J Respir Crit Care Med 164:243–249

    PubMed  CAS  Google Scholar 

  41. Vieira SR, Puybasset L, Lu Q, et al (1999) A scanographic assessment of pulmonary morphology in acute lung injury. Significance of the lower inflection point detected on the lung pressure-volume curve. Am J Respir Crit Care Med 159:1612–1623

    PubMed  CAS  Google Scholar 

  42. Dambrosio M, Roupie E, Mollet JJ, et al (1997) Effects of positive end-expiratory pressure and different tidal volumes on alveolar recruitment and hyperinflation. Anesthesiology 87:495–503

    PubMed  CAS  Google Scholar 

  43. Rouby JJ, Lu Q, Goldstein I (2002) Selecting the right level of positive end-expiratory pressure in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 165:1182–1186

    PubMed  Google Scholar 

  44. Pelosi P, Cadringher P, Bottino N, et al (1999) Sigh in acute respiratory distress syndrome. Am J Respir Crit Care Med 159:872–880

    PubMed  CAS  Google Scholar 

  45. Van Der Kloot TE, Blanch L, Youngblood AM, et al (2000) Recruitment maneuvers in three experimentals models of acute lung injury. Effects on lung volume and gas exchange. Am J Respir Crit Care Med 161:1485–1494

    PubMed  CAS  Google Scholar 

  46. Pelosi P, D’andrea L, Pesenti A, Gattinoni L (1994) Vertical gradient of regional lung inflation in adult respiratory distress syndrome. Am J Respir Crit Care Med 149:8–13

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. J. J. Rouby
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. R. de A Girardi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Toronto, Queen Street Wing, Room 4-042, 30 Bond Street, Toronto, ON M5B 1W8, Canada

    Arthur S. Slutsky MD (Professor of Medicine, Surgery and Biomedical Engineering) (Professor of Medicine, Surgery and Biomedical Engineering)

  2. St. Michael’s Hospital, Queen Street Wing, Room 4-042, 30 Bond Street, Toronto, ON M5B 1W8, Canada

    Arthur S. Slutsky MD (Professor of Medicine, Surgery and Biomedical Engineering) (Professor of Medicine, Surgery and Biomedical Engineering)

  3. Department of Intensive Care, Hospital Henri Mondor, University Paris XII, 94010, Créteil, France

    Laurent Brochard

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Rouby, J.J., de A Girardi, C.R. (2005). Lung Morphology in ARDS: How it Impacts Therapy. In: Slutsky, A.S., Brochard, L. (eds) Mechanical Ventilation. Update in Intensive Care Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26791-3_22

Download citation

  • DOI: https://doi.org/10.1007/3-540-26791-3_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20267-7

  • Online ISBN: 978-3-540-26791-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation