Advertisement

Sialorrhoe und Xerostomie

Ursachen und therapeutische Optionen
  • J. Zenk
  • P. Leins
  • A. Bozzato
Chapter
  • 686 Downloads
Part of the HNO Praxis heute book series (HNO, volume 24)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    AL-Hashimi I, Taylor SE (2001) A new medication for treatment of dry mouth in Sjögren’s syndrome. Tex Dent J 118: 262–266PubMedGoogle Scholar
  2. 2.
    Allaire JH (2000) Saliva Assessment Instrument. Paper presented at the AACPDM Annual Meeting, TorontoGoogle Scholar
  3. 3.
    Anaya JM, Ogawa N, Talal N (1995) Sjogren’s syndrome in childhood. J Rheumatol 22: 1152–1158PubMedGoogle Scholar
  4. 4.
    Anaya JM, Talal N (1999) Sjogren’s syndrome comes of age. Semin Arthritis Rheum 28: 355–359CrossRefPubMedGoogle Scholar
  5. 5.
    Bachrach SJ, Walter RS, Trzcinski K (1998) Use of glycopyrrolate and other anticholinergic medications for sialorrhea in children with cerebral palsy. Clin Pediatr 37: 485–90Google Scholar
  6. 6.
    Bassichis BA, Maple BF (2002) Dry mouth and nose in the older patient — What every PCP should know. Geriatrics 57: 22–24, 29, 32PubMedGoogle Scholar
  7. 7.
    Bertram U (1967) Xerostomia. Clinical aspects, pathology and pathogenesis. Acta Odont Scand 25:Suppl 49: 1–126PubMedGoogle Scholar
  8. 8.
    Blasco PA Allaire J & Participants of the consortium of Drooling (2002) Management of drooling: 10 years after the Consortium on Drooling, 1990. Dev Med Child Neurol 44(11): 778–781CrossRefPubMedGoogle Scholar
  9. 9.
    Bohlender J, Rauh M, Zenk J, Gröschl M (2003) Differential distribution and expression of leptin and the functional leptin receptor in major salivary glands of humans. J Endocrinol 178: 217–223CrossRefPubMedGoogle Scholar
  10. 10.
    Bothwell JE, Clarke K, Dooley JM, Gordon KE, Anderson R, Wood EP, Camfield CS, Camfield PR (2002) Botulinum toxin A as a treatment for excessive drooling in children. Pediatr Neurol 27: 18–22CrossRefPubMedGoogle Scholar
  11. 11.
    Brody GS (1977) Control of drooling by translocation of parotid duct and extirpation of mandibular gland. Dev Med Child Neurol 19: 514–517PubMedGoogle Scholar
  12. 12.
    Brown C, Allaire JH (2000) Technological Approaches. Presentation, Symposium on Sialorrhea. Paper presented at the AACPDM Annual Meeting, Toronto, 20th September 2000Google Scholar
  13. 13.
    Chang C-J, Wong AM-K (2001) Intraductal laser photocoagulation of the bilateral parotid ducts for reduction of drooling in patients with cerebral palsy. Plastic and Reconstr Surg 107: 907–913Google Scholar
  14. 14.
    Cherry-Peppers G, Sorkin J, Andres R, Baum BJ, Ship JA (1992) Salivary gland function and glucose metabolic status. J Gerontol 47: 130–134Google Scholar
  15. 15.
    Chilla R (1982) Klinik, Diagnostik und Therapie der Xerostomie. HNO 30: 201–207PubMedGoogle Scholar
  16. 16.
    Crysdale WS, White A (1989) Submandibular duct relocation for drooling: a 10-year experience with 194 patients. Otolaryngol Head Neck Surg 101: 87–92PubMedGoogle Scholar
  17. 17.
    Crysdale WS, Raveh E, McCann C, Roske L, Kotler A (2001) Management of drooling in individuals with neurodisability: a surgical experience. Dev Med Child Neurol 43: 379–83CrossRefPubMedGoogle Scholar
  18. 18.
    Davies AN (2000) A comparison of artificial saliva and chewing gum in the management of xerostomia in patients with advanced cancer. Palliat Med: 197–203Google Scholar
  19. 19.
    Davies AN, Daniels C, Pugh R, Sharma K (1998) A comparison of artificial salive and pilocarpine in the management of xerostomia in patients with advanced cancer. Palliat Med 12: 105–111CrossRefPubMedGoogle Scholar
  20. 20.
    Dawes C, Wood CM (1973) The contribution of oral minor mucous gland secretions to the volume of whole saliva in man. Arch Oral Biol 18: 337–342PubMedGoogle Scholar
  21. 21.
    Dettman CE (1984) Suppression of salivation in wind-instrument players with scopolamine. N Engl J Med 310: 1396PubMedGoogle Scholar
  22. 22.
    Dundas DF, Peterson RA (1979) Surgical treatment of drooling by bilateral parotid duct ligation and submandibular gland resection. Plast Reconstr Surg. 64: 47–51PubMedGoogle Scholar
  23. 23.
    Ekedahl C (1974). Surgical treatment of drooling. Acta Otalaryng (Stockholm) 77: 215–220Google Scholar
  24. 24.
    Ellies M, Rohrbach-Volland S, Arglebe C, Wilken B, Laskawi R, Hanefeld F (2002) Successful management of drooling with botulinum toxin A in neurologically disabled children. Neuropediatrics 33: 327–330CrossRefPubMedGoogle Scholar
  25. 25.
    Ellies M, Laskawi R, Rohrbach-Volland S, Arglebe C, Beuche W (2002) Botulinum toxin to reduce saliva flow: selected indications for ultrasound-guided toxin application into salivary glands. The Laryngoscope; 112: 82–86, 2002PubMedGoogle Scholar
  26. 26.
    Ellies M, Laskawi R, Rohrbach-Volland S, Rödel R, Beuche W (2001) Sekretionshemmung exokriner Drüsen des Kopf-Hals-Bereiches durch Applikation von Botulinum Toxin A. HNO 49: 807–813CrossRefPubMedGoogle Scholar
  27. 27.
    Faulconbridge RV L, Tranter RM, Moffat V, Green E (2001) Review of management of drooling problems in neurologically impaired children: a review of methods and results over 6 years at Chailey Heritage Clinical Services. Clin Otolaryngol 26: 76–81Google Scholar
  28. 28.
    Fischer-BrandisHm Avalle C, Limbrock CJ (1987) Therapy of orofacial dysfunctions in cerebral palsy according to Castillo-Morales. First Results of a new treatment concept. Eur J Orthodont 9: 139Google Scholar
  29. 29.
    Fischer RB, Eichhorn M (2001) Was tun bei neuroleptikainduzierter Hypersalivation? / What to do in Neuroleptic-Induced Sialorrhea. Psychiat. Praxis 28: 249–50Google Scholar
  30. 30.
    Fox PC (1997) Management of dry mouth. Dent Clin North Am 41: 863–75PubMedGoogle Scholar
  31. 31.
    Giess R, Naumann M, Werner E, Riemann R, Beck M, Puls I, Reiners C, Toyka KV (2000) Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 69: 121–123CrossRefPubMedGoogle Scholar
  32. 32.
    Glatz-Noll E, Berg R (1991) Oral Dysfunction in children with Down’s-Syndrome: an evaluation of treatment effects by means of video-registration. Eur J Orthod 13: 446–451PubMedGoogle Scholar
  33. 33.
    Grdina DJ, Murley JS, Kataoka Y (2002) Radioprotectants: current status and new directions. Oncology 63Suppl 2: 2–10PubMedGoogle Scholar
  34. 34.
    Greenspan D (1996) Xerostomia: Diagnosis and management. Suppl. Oncology, 10: 7–11Google Scholar
  35. 35.
    Harriman M, Morrison M, Hay J, Revonta M, Eisen A, Lentle B (2001) Use of radiotherapy for control of sialorrhea in patients with amyotrophic lateral sclerosis. J Otolaryngol 30: 242–45PubMedGoogle Scholar
  36. 36.
    Harris MM, Dignam PF (1980) A non-surgical method of reducing drooling in cerebral-palsied children. Dev Med Child Neurol 22: 293–299PubMedGoogle Scholar
  37. 37.
    Heft MW, Baum BJ (1984) Unstimulated and stimulated parotid salivary flow rate in individuals of different ages. J Dent Res 63: 1182–1185PubMedGoogle Scholar
  38. 38.
    Hillel AD, Miller R (1989) Bulbar amyotrophic lateral sclerosis: patterns of progression and clinical management. Head Neck 11: 51–59PubMedGoogle Scholar
  39. 39.
    Holmes S. (1998) Xerostomia: aetiology and management in cancer patients. Support Care Cancer 6: 348–355CrossRefPubMedGoogle Scholar
  40. 40.
    Hoon AH Jr, Freese PO, Reinhardt EM, Wilson MA, Lawrie WT Jr, Harryman SE, Pidcock FS, Johnston MV (2001) Agedependent effects of trihexyphenidyl in extrapyramidal cerebral palsy. Pediatr Neurol 25: 55–58CrossRefPubMedGoogle Scholar
  41. 41.
    Hyson CH, Johnson AM, Jog MS (2002) Sublingual atropine for sialorrhea seconday to parkinsonism: A pilot study. Movement Disorders Society 17: 1318–1320Google Scholar
  42. 42.
    Iro H, Uttenweiler V, Zenk J (2000) Kopf-Hals-Sonographie. Springer Verlag Berlin Heidelberg New YorkGoogle Scholar
  43. 43.
    Jha N, Seikaly H, McGaw T, Coulter L (2000) Submandibular salivary gland transfer prevents radiation-induced xerotomia. Int J Radiat Oncol Biol Phys 46: 7–11CrossRefPubMedGoogle Scholar
  44. 44.
    Jha N, Seikaly H, Harris J, Williams D, Liu R, McGaw T, Hofmann H, Robinson D, Hanson J, Barnaby P (2003) Prevention of radiation induced xerostomia by surgical transfer of submandibular salivary gland into the submental space. Radiother Oncol 66: 283–289CrossRefPubMedGoogle Scholar
  45. 45.
    Johnson H, King J, Reddihough DS (2001) Children with sialorrhea in the absence of neurological abnormalities. Child Care Health Dev 27: 591–602CrossRefPubMedGoogle Scholar
  46. 46.
    Jongerius PH, Joosten F, Hoogen JA, Gabreels FJM, Rotteveel JJ (2003) The treatment of drooling by ultrasound-guided intraGl.r injections of botulium toxin type A into the salivary glands. Laryngoscope 113: 107–111PubMedGoogle Scholar
  47. 47.
    Koheil R, Sochaniwskyj AE, Bablich K, Kenny DJ, Milner M (1987) Biofeedback techniques and behaviour modification in the conservative remediation of drooling by children with cerebral palsy. Dev Med Child Neurol 29: 19–26PubMedGoogle Scholar
  48. 48.
    Lavelle CLB (1988) Applied Oral Physiology, 2nd edn. Wright (Butterworth), Bristol.Google Scholar
  49. 49.
    Lespargot A, Langevin MF, Muller S, Guillemont S (1993) Swallowing disturbances associated with drooling in cerebral-palsied children. Dev Med Child Neurol 35: 298–304PubMedGoogle Scholar
  50. 50.
    Limbrock GJ, Hoyer H, Scheying H (1990) Regulation therapy by Castillo-Morales in children with Down syndrome: primary and secondary orofacial pathology. ASDC J Dent Child 57: 437–41PubMedGoogle Scholar
  51. 51.
    Limbrock GJ, Hoyer H & Scheyling H (1990) Drooling, chewing and swallowing dysfunctions in children with cerebral palsy: treatment according to Castillo-Morales. J ASDC J Dent Child 57: 445–51Google Scholar
  52. 52.
    Massengill R (1979) A follow-up investigation of patients who have had parotid duct transplantation surgery to control drooling Ann Plast Surg 2: 205–8PubMedGoogle Scholar
  53. 53.
    McCracken A (1978) Drool control and tongue thrust therapy for the mentally retarded. Am J Occup Ther 32: 79–85PubMedGoogle Scholar
  54. 54.
    Meurman JH, Laine P, Keinanen S, Pyrhonen S, Teerenhovi L, Lindqvist Cn (1997) Five-year follow-up of saliva in patients treated for lymphomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 83: 447–52CrossRefPubMedGoogle Scholar
  55. 55.
    Meurman JH, Collin HL, Niskanen L, Toyry J, Alakuijala P, Keinanen S, Uusitupa M (1998) Saliva in non-insulin-dependent diabetic patients and control subjects: The role of the autonomic nervous system. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86: 69–76CrossRefPubMedGoogle Scholar
  56. 56.
    Meyer-Lueckel H, Kielbassa AM (2002) Die Verwendung von Speichelsersatzmitteln bei Patienten mit Xerostomie. Schweiz Monatsschr Zahnmed 112: 1037–1058PubMedGoogle Scholar
  57. 57.
    Michel RG, Johnson KA, Patterson CN (1977) Parasympathetic nerve section for control of sialorrhea. Arch Otolaryngol 103: 94–97PubMedGoogle Scholar
  58. 58.
    Myer CM (1989) Sialorrhea. Pediatr Clin North Am 36: 1495–500PubMedGoogle Scholar
  59. 59.
    Närhi TO, Meurman JH, Ainamo A (1999) Xerotomia and hyposalivation — Causes, consequences and teatment in the elderly. Drugs Aging 15: 103–116PubMedGoogle Scholar
  60. 60.
    Neverlien PO, Sorumshagen L, Eriksen T, Grinna T, Kvalshaugen H, Lind A-B (2000) Glycopyrrolate treatment of drooling in an adult male patient with cerebral palsy. Clin Exp Pharmacol Physiol 27: 320–322CrossRefPubMedGoogle Scholar
  61. 61.
    Nunn JH (2000) Drooling: review of the literature an proposals for management. J Oral Rehabil 27: 735–743CrossRefPubMedGoogle Scholar
  62. 62.
    O’Connell AC, Baccaglini L, Fox PC, O’Connell BC, Kenshalo D, Oweisy H, Hoque AT, Sun D, Herscher LL, Braddon VR, Delporte C, Baum BJ (1999) Safety and efficacy of adenovirus-mediated transfer of the human aquaporin-1 cDNA to irradiated parotid glands of nonhuman primates. Cancer Gene Ther 6: 505–513PubMedGoogle Scholar
  63. 63.
    Özgenel GY, Özcan M (2002) Bilateral parotid-duct diversion using autologous vein grafts for the management of chronic drooling in cerebral palsy. Br J Plastic Surg 55: 490–493Google Scholar
  64. 64.
    Panarese A, Ghosh S, Hodgson J, McEwan J, Bull PD (2001) Outcomes of submandibular duct re-implantation for siolorroea. Clin Otolaryngol 26: 143–146CrossRefPubMedGoogle Scholar
  65. 65.
    Prause JU, Frost-Larsen K, Hoj L, Isager H, Manthorpe R (1984) Lacrimal and salivary secretion in Sjogren’s syndrome: the effect of systemic treatment with bromhexine. Acta Ophthalmol (Copenh) 62: 489–497Google Scholar
  66. 66.
    Rapp D (1980) Drool control: long term follow-up. Dev Med Child Neurol 22: 448–453PubMedGoogle Scholar
  67. 67.
    Rauch S (1959) Die Speicheldrüsen des Menschen. Thieme, StuttgartGoogle Scholar
  68. 68.
    Ross JA (1970) The function of the tympanic plexus as related to Frey’s syndrome. Laryngoscope. 1970 Dec; 80(12): 1816–1833PubMedGoogle Scholar
  69. 69.
    Schiodt M, Oxholm P, Jacobsen A (1986) Treatment of xerostomia in patients with primary Sjogren’s syndrome with sulfarlem. Scand J Rheumatol Suppl 61: 250–252PubMedGoogle Scholar
  70. 70.
    Schubert MM, Izutsu KT (1987) Iatrogenic causes of salivary gland dysfunction. J Dent Res 66 Spec No: 680Google Scholar
  71. 71.
    Ship JA, Baum BJ (1990) Is reduced salivary flow normal in old people? Lancet 15;336: 1507Google Scholar
  72. 72.
    Spiegel JH, Zhang F, Levin DE, Singer MI, Buncke HJ (2000) Microvascular transplantation of the rat submandibular gland. Plast Reconstr Surg 106: 1326–1335PubMedGoogle Scholar
  73. 73.
    Spiegel JH, Deschler DG, Cheney ML (2001) Microvascular transplantation and replantation of the rabbit submandibular gland. Arch Otolaryngol Head Neck Surg 127: 991–996PubMedGoogle Scholar
  74. 74.
    Sreebny LM, Valdini A (1988) Xerostomia: Part I: Relationship to other oral symptoms and salivary gland hypofuncion. Oral Surg Oral Med Oral Pathol 66: 451–458PubMedGoogle Scholar
  75. 75.
    Sreebny LM, Schwartz SS (1997) A reference guide to drugs and dry mouth-2nd edition. Gerodontology 14: 33–47CrossRefPubMedGoogle Scholar
  76. 76.
    Stern Y, Feinmesser R, Collins M, Shott SR, Cotton RT (2002) Bilateral submandibular gland excision with parotid duct ligation for treatment of sialorrhea in children: long-term results. Arch Otolaryngol Head Neck Surg 128: 801–803PubMedGoogle Scholar
  77. 77.
    Talmi YP, Zohar Y, Finkelstein Y, Laurian N (1988) Reduction of salivary flow with scopoderm TTS. Ann Otol Rhinol Laryngol 97: 128–130PubMedGoogle Scholar
  78. 78.
    Valdez IH, Atkinson JC, Ship JA, Fox PC (1993) Major salivary gland function in patients with radiation-induced xerostomia: flow rates and sialochemistry. Int J Radiat Oncol Biol Phys 25: 41–47PubMedGoogle Scholar
  79. 79.
    Wilkie TF (1967) The problem of drooling in cerebral palsy: a surgical approach. Can J Surg. 1967 Jan; 10(1): 60–67PubMedGoogle Scholar
  80. 80.
    Wilkie TF, Brody GS (1977) The surgical treatment of drooling. A ten-year review. Plast Reconstr Surg 59: 791–797PubMedGoogle Scholar
  81. 81.
    Wilson SW, Henderson HP (1999) The surgical treatment of drooling in Leicester: 12 years experience. Br J Plastic Surg 52: 335–338CrossRefGoogle Scholar
  82. 82.
    Wong V, Sun JG, Wong W (2001) Traditional Chinese Medicine (tongue acupuncture) in children with drooling problems. Pediatr Neurol 25: 47–54CrossRefPubMedGoogle Scholar
  83. 83.
    Wu AJ, Atkinson JC, Fox PC, Baum BJ, Ship JA (1993) Cross-sectional and longitudinal analyses of stimulated parotid salivary constituents in healthy, different-ages subjects. J Gerontol 48: 219–224Google Scholar

Copyright information

© Springer Medizin Verlag Heidelberg 2005

Authors and Affiliations

  • J. Zenk
    • 1
  • P. Leins
    • 2
  • A. Bozzato
    • 3
  1. 1.HNO-KlinikUniversitätsklinikum ErlangenErlangenGermany
  2. 2.Abteilung für NuklearmedizinKrankenhaus KemnathKemnath
  3. 3.HNO-KlinikUniversitätsklinikum ErlangenErlangenGermany

Personalised recommendations