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Skin Substitutes and Tissue-Engineered Skin Equivalents

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Wound Healing and Ulcers of the Skin

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References

  1. Bello YM, Falabella AF, Eaglstein WH: Tissue-Engineered Skin. Current status in wound healing. Am J Clin Dermatol 2001; 2:305–313

    PubMed  Google Scholar 

  2. Eaglstein WH, Falanga V: Tissue engineering for skin: an update. J Am Acad Dermatol 1998; 39:1007–1010

    PubMed  Google Scholar 

  3. Wainwright DJ: Use of an acellular allograft dermal matrix (AlloDerm) in the management of full thickness burns. Potential as a template for the reconstruction of viable dermis. Burns 1995; 21:243–248

    Article  PubMed  Google Scholar 

  4. Livesey SA, Herndon DN, Hollyoak MA, et al: Transplanted acellular allograft dermal matrix. Transplantation 1995; 60:1–9

    PubMed  Google Scholar 

  5. Gustafson CJ, Kratz G: Cultured autologous keratinocytes on a cell-free dermis in the treatment of full-thickness wounds. Burns 1999; 25:331–335

    Article  PubMed  Google Scholar 

  6. Hussmann J, Russell RC, Kucan JO, et al: Use of glycerolized human allografts as temporary and permanent cover in adults and children. Burns 1994; 20[Suppl 1]:S61–S66

    PubMed  Google Scholar 

  7. Abbott WM, Hembree JS: Absence of antigenicity in freeze-dried skin allografts. Cryobiology 1970; 6:416–418

    PubMed  Google Scholar 

  8. Chakrabarty KH, Dawson RA, Harris P, et al: Development of autologous human dermal-epidermal composites based on sterilized human allodermis for dinical use. Br J Dermatol 1999; 141:811–823

    Article  PubMed  Google Scholar 

  9. Phillips TJ: New skin for old: Developments in biological skin substitutes. Arch Dermatol 1998; 134:344–349

    Article  PubMed  Google Scholar 

  10. Herndon DN: Perspectives in the use of allograft. J Burn Care Rehabil 1997; 18:S6

    PubMed  Google Scholar 

  11. Greenleaf G, Hansbrough JF: Current trends in the use of allograft skin for patients with burns and reflections on the future of skin banking in the United States. J Burn Care Rehabil 1994; 15:428–431

    PubMed  Google Scholar 

  12. Balasubramani M, Kumar TR, Babu M: Skin substitutes: a review. Burns 2001; 27:534–544

    PubMed  Google Scholar 

  13. Snyder RJ, Simonson DA: Cadaveric allograft as adjunct therapy for nonhealing ulcers. J Foot Ankle Surg 1999; 38:93–101

    PubMed  Google Scholar 

  14. Ruszczak Z, Schwartz RA: Modern aspects of wound healing: an update. Dermatol Surg 2000; 26:219–229

    Article  PubMed  Google Scholar 

  15. Davis DA, Arpey CJ: Porcine heterografts in dermatologic surgery and reconstruction. Dermatol Surg 2000; 26:76–80

    Article  PubMed  Google Scholar 

  16. Bromberg BE, Song IC: Homograts and heterografts as skin substitutes. Am J Surg 1966; 112:28–33

    Article  PubMed  Google Scholar 

  17. Culliton P, Kwasnik RE, Novicki D, et al: The efficacy of porcine skin grafts for treating non-healing cutaneous ulcers. Part 1: dinical studies. J Am Podiatry Assoc 1978; 68:1–10

    PubMed  Google Scholar 

  18. Elliott RA Jr, Hoehn JG: Use of commercial porcine skin for wound dressings. Plast Reconstr Surg 1973; 52:401–405

    PubMed  Google Scholar 

  19. Ersek RA, Lorio J: The most indolent ulcers of the skin treated with porcine xenografts and silver ions. Surg Gynecol Obstet 1984; 158:431–436

    Google Scholar 

  20. Kaplan EG, Kaplan GS, Kaplan DM, et al: Superficial ulcer treatment utilizing hyperbaric oxygen and porcine skin grafts. J Foot Surg 1978; 17:144–149

    PubMed  Google Scholar 

  21. Kudo K, Yokota M, Fujioka Y: Immediate reconstruction using a scalp-forehead flap for the entire upper lip defect with the application of lyophilized porcine skin to surgical wounds. A case report of a malignant melanoma in the upper lip and oral mucosa. J Maxillofac Surg 1983; 11:275–278

    Article  PubMed  Google Scholar 

  22. Poskitt KR, James AH, Lloyd-Davies ER, et al: Pinch skin grafting or porcine dermis in venous ulcers: a randomised clinical trial. Br Med J 1987; 294:674–676

    Google Scholar 

  23. Piez KA: Structure and assembly of the native collagen fibril. Connect Tissue Res 1982; 10:25–36

    PubMed  Google Scholar 

  24. Dedhar S, Ruoslahti E, Pierschbacher MD: A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence. J Cell Biol 1987; 104:585–593

    Article  PubMed  Google Scholar 

  25. Burke JF, Yannas IV, Quinby WC Jr, et al: Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg 1981; 194:413–428

    PubMed  Google Scholar 

  26. Postlethwaite AE, Seyer JM, Kang AH: Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci USA 1978; 75:871–875

    PubMed  Google Scholar 

  27. Voytik-Harbin SL, Brightman AO, Kraine MR, et al: Identification of extractable growth factors from small intestinal submucosa. J Cell Biochem 1997; 67:478–491

    Article  PubMed  Google Scholar 

  28. Kolenik SA 3rd, McGovern TW, Leffell DJ: Use of a lyophilized bovine collagen matrix in postoperative wound healing. Dermatol Surg 1999; 25:303–307

    Article  PubMed  Google Scholar 

  29. Motta G, Ratto GB, De Barbieri A, et al: Can heterologous collagen enhance the granulation tissue growth? An experimental study. Ital J Surg Sci 1983; 13:101–108

    PubMed  Google Scholar 

  30. Leipziger LS, Glushko V, DiBernardo B, et al: Dermal wound repair: role of collagen matrix implants and synthetic polymer dressings. J Am Acad Dermatol 1985; 12:409–419

    PubMed  Google Scholar 

  31. Hodde JP, Badylak SF, Brightman AO, et al: Glycosaminoglycan content of small intestinal submucosa: A bioscaffold for tissue replacement. Tissue Engineering 1996; 2:209–217

    Google Scholar 

  32. McPherson TB, Badylak SF: Characterization of Fibronectin derived from porcine small intestinal submucosa. Tissue Engineering 1998; 4:75–83

    Google Scholar 

  33. Brown-Etris M, Punchello M, Shields D: Final report on a pilot study to evaluate porcine small intestinal submucosa as a covering for partial thickness wounds. WOCN 32nd Annual Conference. June 2000; Toronto

    Google Scholar 

  34. Mian E, Martini P, Beconcini D, et al: Healing of open skin surfaces with collagen foils. Int J Tissue React 1992; 14[Suppl]:27–34

    PubMed  Google Scholar 

  35. Lorenzetti OJ, Fortenberry B, Busby E, et al: Influence of microcrystalline collagen on wound healing. I. Wound closure of normal excised and burn excised wounds of rats, rabbits and pigs. Proc Soc Exp Biol Med 1972; 140:896–900

    PubMed  Google Scholar 

  36. Chvapil M: Considerations on manufacturing principles of a synthetic burn dressing: a review. J Biomed Mater Res 1982; 16:245–263

    Article  PubMed  Google Scholar 

  37. Phillips TJ, Dover JS: Leg Ulcers. J Am Acad Dermatol 1991; 25:965–987

    PubMed  Google Scholar 

  38. Zapata-Sirvent R, Hansbrough JF, Carroll W, et al: Comparison of Biobrane and Scarlet red dressings for treatment of donor site wounds. Arch Surg 1985; 120:743–745

    PubMed  Google Scholar 

  39. McHugh TP, Robson MC, Heggers JP, et al: Therapeutic efficacy of Biobrane in partial-and full-thickness thermal injury. Surgery 1986; 100:661–664

    PubMed  Google Scholar 

  40. Zachary L, Heggers JP, Robson MC, et al: The use of topical antimicrobials combined with Biobrane in burn wound infections. J Trauma 1982; 22:833–836

    PubMed  Google Scholar 

  41. Donaghue VM, Chrzan JS, Rosenblum BI, et al: Evaluation of a collagen-alginate wound dressing in the management of diabetic foot ulcers. Adv Wound Care 1998; 11:114–119

    PubMed  Google Scholar 

  42. Alvarez O, Fahey C, Papantonio C, et al: Experience with a collagen-alginate wound dressing in the management of chronic venous ulcers. Symposium on Advanced Wound Care and Medical research forum on Wound Repair. 1999

    Google Scholar 

  43. Ghatnekar O, Willis M, Persson U: Cost-effectiveness of treating deep diabetic foot ulcers with Promogran in four European countries. J Wound Care 2002; 11:70–74

    PubMed  Google Scholar 

  44. Veves A, Sheehan P, Pham HT: A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch Surg 2002; 137:822–827

    Article  PubMed  Google Scholar 

  45. Vin F, Teot L, Meaume S: The healing properties of Promogran in venous leg ulcers. J Wound Care 2002; 11:335–341

    PubMed  Google Scholar 

  46. Rheinwald JG, Green H: Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell 1975; 6:331–343

    Article  PubMed  Google Scholar 

  47. O'Connor NE, Mulliken JB, Banks-Schlegel S, et al: Grafting of burns with cultured epithelium prepared from autologous epidermal cells. Lancet 1981; 1:75–78

    Article  PubMed  Google Scholar 

  48. Gallico GG 3rd, O'Connor NE, Compton CC, et al: Permanent coverage of large burn wounds with autologous cultured human epithelium. N Engl J Med 1984; 311:448–451

    PubMed  Google Scholar 

  49. Teepe RG, Ponec M, Kreis RW, et al: Improved grafting method for the treatment of burns with autologous cultured human epithelium (letter). Lancet 1986; 1:385

    Article  PubMed  Google Scholar 

  50. Teepe RG, Ponec JA, Kempenaar B: Clinical, histological and ultrastructural aspects of cultured epithelium. In: Proceedings of the International Symposium on the clinical Use of Cultured Epithelium in Surgery and Dermatology. Leiden, March, 1987

    Google Scholar 

  51. De Luca M, Albanese E, Bondanza S, et al: Multicentre experience in the treatment of burns with autologous and allogenic cultured epithelium, fresh or preserved in a frozen state. Burns 1989; 15:303–309

    Article  PubMed  Google Scholar 

  52. Eldad A, Burt A, Clarke JA, et al: Cultured epithelium as a skin substitute. Burns Incl Therm Inj 1987; 13:173–180

    PubMed  Google Scholar 

  53. Bettex-Galland M, Slongo T, Hunziker T, et al: Use of cultured keratinocytes in the treatment of severe burns. Z Kinderchir 1988; 43:224–228

    PubMed  Google Scholar 

  54. Gao ZR, Hao ZQ, Nie LJ, et al: Coverage of full skin thickness burns with allograft inoculated with autogenous epithelial cells. Burns Inc Therm Inj 1986; 12:220–224

    Google Scholar 

  55. Hefton JM, Caldwell D, Biozes DG, et al: Grafting of skin ulcers with cultured autologous epidermal cells. J Am Acad Dermatol 1986; 14:399–405

    PubMed  Google Scholar 

  56. Leigh IM, Purkis PE: Culture grafted leg ulcers. Clin Exp Dermatol 1986; 11:650–652

    PubMed  Google Scholar 

  57. Teepe RG, Keobrugge EJ, Ponec M, et al: Fresh versus cryopreserved cultured allografts for the treatment of chronic skin ulcers. Br J Dermatol 1990; 122:81–89

    PubMed  Google Scholar 

  58. Leigh IM, Purkis PE, Navsaria HA, et al: Treatment of chronic venous ulcers with sheets of cultured allogeneic keratinocytes. Br J Dermatol 1987; 117:591–597

    PubMed  Google Scholar 

  59. Phillips TJ, Gilchrest BA: Cultured allogeneic keratinocyte grafts in the management of wound healing: prognostic factors. J Dermatol Surg Oncol 1989; 15:1169–1176

    PubMed  Google Scholar 

  60. Beele H, Naeyaert JM, Goeteyn M, et al: Repeated cultured epidermal allografts in the treatment of chronic leg ulcers of various origins. Dermatologica 1991; 183:31–35

    PubMed  Google Scholar 

  61. Marcusson JA, Lindgren C, Berghard A: Allogeneic cultured keratinocytes in the treatment of leg ulcers. Acta Derm Venereol (Stockh) 1992; 72:61–64

    Google Scholar 

  62. De Luca M, Albanese E, Cancedda R, et al: Treatment of leg ulcers with cryopreserved allogeneic cultured epithelium. A multicenter study. Arch Dermatol 1992; 128:633–638

    Article  PubMed  Google Scholar 

  63. Stanulis-Praeger BM, Gilchrest BA: Growth factor responsiveness dedines during adulthood for human skin-derived cells. Mech Ageing Dev 1986; 35:185–198

    Article  PubMed  Google Scholar 

  64. Sauder DN, Stanulis-Praeger BM, Gilchrest BA: Autocrine growth stimulation of human keratinocytes by epidermal cell-derived thymocyte activating factor: Implications for skin aging. Arch Dermatol Res 1988; 280:71–76

    Article  PubMed  Google Scholar 

  65. Jones JE, Nelson EA: Skin grafting for venous leg ulcers (Cochrane Review). In: The Cochrane Library, Issue 4, 2000. Oxford: Update Software

    Google Scholar 

  66. Limat A, Mauri D, Hunziker T: Successful treatment of chronic leg ulcers with epidermal equivalents generated from cultured autologous outer root sheath cells. J Invest Dermatol 1996; 107:128–135

    Article  PubMed  Google Scholar 

  67. Limat A, French LE, Blal L, et al: Organotypic cultures of autologous hair follicle keratinocytes for the treatment of recurrent leg ulcers. J Am Acad Dermatol 2003; 48:207–214

    Article  PubMed  Google Scholar 

  68. Bolivar-Flores YJ, Kuri-Harcuch W: Frozen allogeneic human epidermal cultured sheets for the cure of complicated leg ulcers. Dermatol Surg 1999; 25:610–617

    Article  PubMed  Google Scholar 

  69. Teepe RG, Roseeuw DI, Hermans J, et al: Randomized trial comparing cryopreserved cultured epidermal allografts with hydrocolloid dressings in healing chronic venous ulcers. J Am Acad Dermatol 1993; 29:982–988

    PubMed  Google Scholar 

  70. Lindgren C, Marcusson JA, Toftgard R: Treatment of venous leg ulcers with cryopreserved cultured allogeneic keratinocytes: a prospective open controlled study. Br J Dermatol 1998; 139:271–275

    Article  PubMed  Google Scholar 

  71. Duhra P, Blight A, Mountford E, et al: A randomized controlled trial of cultured keratinocyte allografts for chronic venous ulcers. J Dermatol Treat 1992; 3:189–191

    Google Scholar 

  72. Jones I, Currie L, Martin R: A guide to biological skin substitutes. Br J Plast Surg 2002; 55:185–193

    Article  PubMed  Google Scholar 

  73. Hansbrough JF, Morgan J, Greenleaf G, et al: Development of a temporary living skin replacement composed of human neonatal fibroblasts cultured in Biobrane, a synthetic dressing material. Surgery 1994; 115:633–644

    PubMed  Google Scholar 

  74. Gentzkow G, Iwasaki SD, Hershon KS, et al: Use of Dermagraft: a cultured human dermis to treat diabetic foot ulcers. Diabetes care 1996; 19:350–354

    PubMed  Google Scholar 

  75. Pollak RA, Edington H, Jensen JL, et al: A human dermal replacement for the treatment of diabetic foot ulcers. Wounds 1997; 9:175–183

    Google Scholar 

  76. Hanft JR, Surprenant MS: Healing of chronic foot ulcers in diabetic patients treated with a human fibroblast-derived dermis. J Foot Ankle Surg 2002; 41:291–299

    PubMed  Google Scholar 

  77. Hansbrough J: Status of cultured skin replacement. Wounds 1995; 7:130–136

    Google Scholar 

  78. Marston WA, Hanft J, Norwood P, et al: The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers. Diabetes Care 2003; 26:1701–1705

    PubMed  Google Scholar 

  79. Bell E, Ehrlich HP, Sher S, et al: Development and use of a living skin equivalent. Plast Reconstr Surg 1981; 67:386–392

    PubMed  Google Scholar 

  80. MacKenzie IC, Fusenig NE: Regeneration of organized epithelial structure. J Invest Dermatol 1983; 81:189S–194S

    Article  PubMed  Google Scholar 

  81. Cuono CB, Langdon R, Birchall N, et al: Composite autologous-allogeneic skin replacement: Development and clinical application. Plast Reconstr Surg 1987; 80:626–637

    PubMed  Google Scholar 

  82. Bell E, Ehrlich HP, Buttle DJ, et al: Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness. Science 1981; 211:1052–1054

    PubMed  Google Scholar 

  83. Krejci NC, Cuono CB, Langdon RC, et al: In vitro reconstitution of skin: Fibroblasts facilitate keratinocyte growth and differentiation on acellular reticular dermis. J Invest Dermatol 1991; 97:843–848

    Article  PubMed  Google Scholar 

  84. Mol MA, Nanninga PB, van Eendenburg JP, et al: Grafting of venous leg ulcers. An intraindividual comparison between cultured skin equivalents and full-thickness skin punch grafts. J Am Acad Dermatol 1991; 24:77–82

    PubMed  Google Scholar 

  85. Hansbrough JF, Dore C, Hansbrough WB: Clinical trials of a living dermal tissue replacement placed beneath meshed, split thickness skin grafts on excised burn wounds. J Burn Care Rehabil 1992; 13:519–529

    PubMed  Google Scholar 

  86. Boyce ST, Glatter R, Kitzmiller WJ: Case studies: Treatment of chronic wounds with cultured skin substitutes: a pilot study. Ostomy Wound Manage 1995; 41:26–28,30,32

    PubMed  Google Scholar 

  87. Harvima IT, Virnes S, Kauppinen L, et al: Cultured allogeneic skin cells are effective in the treatment of chronic diabetic leg and foot ulcers. Acta Derm Venereol (Stockh) 1999; 79:217–220

    Article  Google Scholar 

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(2005). Skin Substitutes and Tissue-Engineered Skin Equivalents. In: Wound Healing and Ulcers of the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26761-1_13

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  • DOI: https://doi.org/10.1007/3-540-26761-1_13

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