Skip to main content

Management of Neurologic Complications

  • Chapter
Neuroblastoma

Part of the book series: Pediatric Oncology ((PEDIATRICO))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 159.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Antunes NL (2000) Acute neurologic complications in children with systemic cancer. J Child Neurol 15:705–716

    PubMed  Google Scholar 

  • Antunes NL, Khakoo Y, Matthay KK et al. (2000) Antineuronal antibodies in patients with neuroblastoma and paraneoplastic opsoclonus-myoclonus. J Pediatr Hematol Oncol 22:315–320

    Article  PubMed  Google Scholar 

  • Banerjee S, Marwaha RK, Bajwa RPS (1995) Primary pelvic neuroblastoma with central nervous system metastases. Pediatr Hematol Oncol 12:309–312

    PubMed  Google Scholar 

  • Bataller L, Rosenfeld MR, Graus F et al. (2003) Autoantigen diversity in the opsoclonus-myoclonus syndrome. Ann Neurol 53:347–353

    Article  PubMed  Google Scholar 

  • Bergman I, Barmada MA, Heller G, Griffin JA, Cheung NKV (1999) Treatment of neoplastic meningeal xenografts by intraventricular administration of an anti-ganglioside monoclonal antibody 3F8. Int J Cancer 82:538–548

    Article  PubMed  Google Scholar 

  • Bigner DD, Brown MT, Friedman AH (1998) Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas:phase I trial results. J Clin Oncol 16:2202–2212

    PubMed  Google Scholar 

  • Blaes F (2002) Immunotherapeutic approaches to paraneoplastic neurological disorders. Exp Opin Biol Ther 2:419–430

    Article  Google Scholar 

  • Blatt J, Fitz C, Mirro J (1997) Recognition of central nervous system metastases in children with metastatic primary extracranial neuroblastoma. Pediatr Hematol Oncol 14:233–241

    PubMed  Google Scholar 

  • Cheung IY, Cheung NKV (2001) Quantitation of marrow disease in neuroblastoma by real-time reverse transcription-PCR. Clin Can Res 7:1698–1705

    Google Scholar 

  • Cheung NK, Kushner BH, Kramer K (2001) Monoclonal antibody-based therapy of neuroblastoma. Hematol Oncol Clin North Am 15:853–866

    Article  PubMed  Google Scholar 

  • Clerico A, Tenore A, Bartolozzi S et al. (1993) Adrenocorticotropic hormone-secreting ganglioneuroblastoma associated with opsomyoclonic encephalopathy: a case report with immunohistochemical study. Med Pediatr Oncol 21:690–694

    PubMed  Google Scholar 

  • Connolly AM, Pestronk A, Shobhna M et al. (1997) Serum autoantibodies in childhood opsoclonus-myoclonus syndrome: an analysis of antigenic targets in neural tissues. J Pediatr 130:878–884

    PubMed  Google Scholar 

  • Conrad E, Olsewski AD, Berger M et al. (1992) Pediatric spine tumors with spinal cord compression. J Pediatr Orthop 12:454–460

    PubMed  Google Scholar 

  • Cooper R, Khakoo Y, Matthay KK et al. (2001) Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: histopathologic features — a report from the children's cancer group. Med Pediatr Oncol 36:623–629

    Article  PubMed  Google Scholar 

  • De Bernardi B, Pianca C, Pistamiglio P et al. (2001) Neuroblastoma with symptomatic spinal cord compression at diagnosis: treatment and results with 76 cases. J Clin Oncol 19:183–190

    PubMed  Google Scholar 

  • DuBois SG, Kalika Y, Lukens JN et al. (1999) Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival. J Pediatr Hematol Oncol 21:181–189

    Google Scholar 

  • Everson TC, Cole WH (1956) Spontaneous regression of neuroblastoma. In: Everson TC, Cole WH (eds) Spontaneous regression of cancer. Saunders, Philadephia

    Google Scholar 

  • Fisher PG, Wechsler DS, Singer HS (1994) Anti-Hu antibody in a neuroblastoma-associated paraneoplastic syndrome. Pediatr Neurol 10:309–312

    Article  PubMed  Google Scholar 

  • Flickinger JC (2001) Radiotherapy and radiosurgical management of brain metastases. Curr Oncol Rep 3:484–489

    PubMed  Google Scholar 

  • Fuchs AF, Kaneko CRS, Seudder CA (1985) Brainstem control of saccadic eye movements. Annu Rev Neurosci 8:307–337

    PubMed  Google Scholar 

  • Gambini C, Conte M, Bernini G et al. (2003) Neuroblastic tumors associated with opsoclonus-myoclonus syndrome: histological, immunohistochemical and molecular features of 15 Italian cases. Virchows Arch 442:555–562

    PubMed  Google Scholar 

  • Gutierrez FA, Oi S, McLone DG (1983) Intraspinal tumors in children: clinical review, surgical results and follow-up in 51 cases. Concepts Pediatr Neurosurg 4:291–405

    Google Scholar 

  • Hayes FA, Green AA, O'Connor DM (1989) Chemotherapeutic management of epidural neuroblastoma. Med Pediatr Oncol 17:6–8

    PubMed  Google Scholar 

  • Hayward K, Jeremy RJ, Jenkins S et al. (2001) Long-term neurobehavioral outcomes in children with neuroblastoma and opsoclonus-myoclonus-ataxia syndrome: relationship to MRI findings and anti-neuronal antibodies. J Pediatr 139:552–559

    Article  PubMed  Google Scholar 

  • Hoover M, Bowman LC, Crawford SE et al. (1999) Long-term outcome of patients with intraspinal neuroblastoma. Med Pediatr Oncol 32:353–359

    Article  PubMed  Google Scholar 

  • Yu AL, Uttenreuther-Fischer M, Huang C-S et al. (1998) Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch 14.18 in patients with refractory neuroblastoma and osteosarcoma. J Clin Oncol 16:2169–2180

    PubMed  Google Scholar 

  • Katzenstein HM, Kent PM, London WB, Cohn SL (2001) Treatment and outcome of 83 children with intraspinal neuroblastoma: the Pediatric Oncology Group experience. J Clin Oncol 19:1047–1055

    PubMed  Google Scholar 

  • Kellie JJ, Hayes A, Bowman L et al. (1991) Primary extracranial neuroblastoma with central nervous system metastases: characterization by clinicopathologic findings and neuroimaging. Cancer 68:1999–2006

    PubMed  Google Scholar 

  • Koh PS, Raffensperger JG, Berry S et al. (1994) Long-term outcome in children with opsoclonus-myoclonus and ataxia and coincident neuroblastoma. J Pediatr 125:712–716

    PubMed  Google Scholar 

  • Kramer K, Cheung NKV, Humm JL et al. (2000) Targeted radioimmunotherapy for leptomeningeal cancer using 131-I-3F8: patient imaging and dosimetry. Med Ped Oncol 35:716–718

    Article  Google Scholar 

  • Kramer K, Kushner BH, Cheung NKV (2001) Neuroblastoma metastatic to the central nervous system: the Memorial Sloan-Kettering Cancer Center experience and a literature review. Cancer 91:1510–1519

    Article  PubMed  Google Scholar 

  • Lassman AB, DeAngelis LM (2003) Brain metastases. Neurol Clin 21:1–15

    Article  PubMed  Google Scholar 

  • Lieberman P (2002) On the nature and evolution of the neural bases of human language. Am J Phys Anthropol 35(Suppl):36–62

    Article  PubMed  Google Scholar 

  • LoPiccolo MS, Cheung NK, Cheung IY (2001) GD2 synthase: a new molecular marker for detecting neuroblastoma. Cancer 92:924–931

    Article  PubMed  Google Scholar 

  • Martin EF, Beckwith JB (1968) Lymphoid infiltrates in neuroblastoma: their occurrence and prognostic significance. J Pediatr Surg 3:161–164

    Article  PubMed  Google Scholar 

  • Massad M, Haddad F, Slim M et al. (1985) Spinal cord compression in neuroblastoma. Surg Neurol 23:567–572

    Article  PubMed  Google Scholar 

  • Matthay KK, Brisse H, Couanet D et al. (2003) Central nervous system metastases in neuroblastoma: radiologic, clinical, and biologic features in 23 patients. Cancer 98:155–165

    Article  PubMed  Google Scholar 

  • Mitchell WG, Davalos-Gonzalez Y, Brumm VL et al. (2002) Opsoclonus-ataxia caused by childhood neuroblastoma: developmental and neurologic sequelae. Pediatrics 109:86–98

    Article  PubMed  Google Scholar 

  • Papero PH, Pranzatelli MR, Margolis CJ et al. (1995) Neurobehavioral and psychosocial functioning of children with opsoclonus-myoclonus syndrome. Dev Med Child Neurol 37:915–932

    PubMed  Google Scholar 

  • Plantaz D, Hartmann O, Kalifa C, Sainte-Rose C, Lemoine G, Lemerle J (1993) Localized dumbbell neuroblastoma: a study of 25 cases treated between 1982 and 1987 using the same protocol. Med Pediatr Oncol 21:249–253

    PubMed  Google Scholar 

  • Plantaz D, Rubie H, Michon J et al. (1996) The treatment of neuroblastoma with intraspinal extension with chemotherapy followed by surgical removal of residual disease. Cancer 78:311–319

    Article  PubMed  Google Scholar 

  • Posner JB (1995) Neurologic complications of cancer. Davis, Philadelphia

    Google Scholar 

  • Pranzatelli MR (1992) The neurobiology of opsoclonus-myoclonus. Clin Neuropharmacol 15:186–228

    PubMed  Google Scholar 

  • Pranzatelli MR (1994) On the molecular mechanism of adrenocorticotrophic hormone: neurotransmitters and receptors. Exp Neurol 125:142–161

    Article  PubMed  Google Scholar 

  • Pranzatelli MR (1996) The immunopharmacology of the opsoclonus-myoclonus syndrome. Clin Neuropharmacol 19:1–47

    PubMed  Google Scholar 

  • Pranzatelli MR (2000) Friendly fire. Discover April:35–36

    Google Scholar 

  • Pranzatelli MR, Huang Y, Tate E et al. (1998a) Effect of high dose corticotropin on cerebrospinal fluid monoaminergic neurotransmitters or metabolites in corticotropin-responsive pediatric opsoclonus-myoclonus. Mov Disord 13:522–528

    Article  PubMed  Google Scholar 

  • Pranzatelli MR, Hanin I, Tate E et al. (1998b) Cerebrospinal fluid free choline in movement disorders of pediatric onset. Eur J Pediatr Neurol 1:33–39

    Article  Google Scholar 

  • Pranzatelli MR, Tate ED, Kinsbourne M et al. (2002a) Forty-one year follow-up of childhood-onset opsoclonus-myoclonus: cerebellar atrophy, multiphasic relapses, response to IVIG. Mov Disord 17:1387–1390

    PubMed  Google Scholar 

  • Pranzatelli MR, Tate ED, Wheeler A et al. (2002b) Screening for autoantibodies in children with opsoclonus-myoclonus-ataxia. Pediatr Neurol 27:384–387

    Article  PubMed  Google Scholar 

  • Punt J, Pritchard J, Pincott JR et al. (1980) Neuroblastoma: a review of 21 cases presenting with intra-spinal extension. Cancer 45:3095–3101

    PubMed  Google Scholar 

  • Reddy AT, Witek K (2003) Neurologic complications of chemotherapy for children with cancer. Curr Neurol Neurosci Rep 3:137–142

    PubMed  Google Scholar 

  • Rohrlich P, Hartmann O, Couanet D et al. (1989) Localisations neuro-meninges metastaques secondaires dans les neuroblastomes de l'enfant. Arch Fr Pediatric 46:5–10

    Google Scholar 

  • Rudnick E, Khakoo Y, Antunes N, Seeger RC, Brodeur GM, Shimada H, Gerbing RB, Stram DO, Matthay KK (2001a) Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: clinical outcome and anti-neuronal antibodies: a Children's Cancer Group study. Med Pediatr Oncol 36:612–622

    Article  PubMed  Google Scholar 

  • Rudnick E, Khakoo Y, Antunes NL et al. (2001b) Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: clinical outcome and antineuronal antibodies — a report from the Children's Cancer Group Study. Med Pediatr Oncol 36:612–622

    Article  PubMed  Google Scholar 

  • Russo C, Cohn SL, Petruzzi MJ, de Alarcon PA (1997) Long-term neurologic outcome in children with opsoclonus-myoclonus associated with neuroblastoma: a report from the Pediatric Oncology Group. Med Pediatr Oncol 28:284–288

    Article  PubMed  Google Scholar 

  • Sandberg DI, Bilsky M, Kushner BH et al. (2003) Treatment of spinal involvement in neuroblastoma patients. Pediatr Neurosurg 39:291–298

    Article  PubMed  Google Scholar 

  • Shaw PJ (1992) Neuroblastoma with intracranial involvement: an ENSG Study. Med Pediatr Oncol 20:149–155

    PubMed  Google Scholar 

  • Stubbs EB Jr, Lawlor MW, Richards MP et al. (2003) Anti-neurofilament antibodies in neuropathy with monoclonal gammopathy of undetermined significance produce experimental motor nerve conduction block. Acta Neuropathol (Berl) 105:109–116

    PubMed  Google Scholar 

  • Tasdemiroglu E, Patchell RA (1997) Neurologic examinations of the primary pediatric extracranial neuroblastomas. Neurol Res 19:45–50

    PubMed  Google Scholar 

  • Tasdemiroglu E, Ayan I, Kebudi R (1998) Extracranial neuroblastomas and neurologic complications. Child Nerv Syst 14:713–718

    Article  Google Scholar 

  • Tate ED, Pranzatelli MR, Huang Y et al. (1994) An innovative approach to the problem of sedating children with opsoclonus-myoclonus syndrome: effects of myoclonus and CSF monoamine metabolites. Ann Neurol 36:543–544

    Google Scholar 

  • Vines EF, Le Pechoux C, Arriagada R (2003) Prophylactic cranial irradiation in small cell lung cancer. Semin Oncol 30:38–46

    Article  Google Scholar 

  • Weinberg JS, Lang FF, Sawaya R (2001) Surgical management of brain metastases. Curr Oncol Rep 3:476–483

    PubMed  Google Scholar 

  • Wilberg JE, Muceniece R, Mandrika I et al. (2000) New aspects on the melanocortins and their receptors. Pharmacol Res 42:393–420

    Article  PubMed  Google Scholar 

  • Yu AL, Uttenreuther-Fischer M, Huang C-S et al. (1998) Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch 14.18 in patients with refractory neuroblastoma and osteosarcoma. J Clin Oncol 16:2169–2180

    PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kramer, K., Pranzatelli, M.R. (2005). Management of Neurologic Complications. In: Cheung, NK.V., Cohn, S.L. (eds) Neuroblastoma. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26616-X_13

Download citation

  • DOI: https://doi.org/10.1007/3-540-26616-X_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40841-3

  • Online ISBN: 978-3-540-26616-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics