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Chirurgisches Forum 2005 pp 7–9Cite as

Signifikante Steigerung der Leberregeneration durch systemische Erythropoietingabe nach linkslateraler Hemihepatektomie

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Part of the book series: Deutsche Gesellschaft für Chirurgie ((FORUMBAND,volume 34))

Abstract

The aim of this study was to develop a way to improve liver regeneration. We studied the regeneration of hepatocytes in pigs after partial hepatectomy and treatment with erythropoietin (EPO).

Twenty-eight female pigs underwent laparoscopic hepatectomy. Pigs were allocated randomly into three groups. Group 1 (n = 16) received no EPO; group 2 (n = 6) received EPO topically to the resection surface, and group 3 (n = 6) received EPO topically and systemically. Pigs were sacrificed after 14 days. Liver volume and weight were measured and bone marrow samples were taken. For immunhistochemical examination, we used the antigenes Ki-67 and PCNA and CD117 for bone marrow tissues. Twenty-six pigs underwent successful left hepatic lobectomy.

Liver weight and volume were signifcantly increased in group 3 in comparison to group 2 and 1. Additionally, the immunhistochemical analysis revealed that the number of Ki-67 positive cells was significantly increased in group 3 and in group 2, when compared to group 1.

Our results indicate for the first time that EPO induces a regenerative effect on hepatocytes after liver resection.

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Literatur

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Author information

Authors and Affiliations

  1. Institut für Pathologie, Universität Leipzig, Leipzig

    A. Tannapfel

  2. Klinik für Anästhesiologie und Operative Intensivmedizin, Charité, Universitätsmedizin Berlin, Berlin

    B. Donaubauer

  3. Abteilung für Zelltechniken und angewandte Stammzellbiologie, Deutschland

    A. Baader

  4. Klinik für Visceral-, Transplantations-, Thorax- und Gefäßchirurgie, Universität Leipzig, Liebigstr. 20, 04103, Leipzig, Deutschland

    PD Dr. Michael R. Schön, E. Hogrebe, M. M. Spannbauer, M. v. Feilitzsch, J. Redlich & J. P. Hauss

Authors
  1. PD Dr. Michael R. Schön
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  2. E. Hogrebe
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  3. A. Tannapfel
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  4. B. Donaubauer
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  5. M. M. Spannbauer
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  6. M. v. Feilitzsch
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  7. A. Baader
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  8. J. Redlich
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  9. J. P. Hauss
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Editor information

Editors and Affiliations

  1. Thorax- und Gefäßchirurgie, Klinikum der Philipps Universität, Baldingerstraße, 35043, Marburg

    M. Rothmund (Präsident des 122. Kongresses der Deutschen Gesellschaft für Chirurgie) (Präsident des 122. Kongresses der Deutschen Gesellschaft für Chirurgie)

  2. Klinikum Großhadern, Marchioninistraße 15, 81366, München

    K.-W. Jauch (Vorsitzender der Sektion Chirurgische Forschung) (Vorsitzender der Sektion Chirurgische Forschung)

  3. Deutsche Gesellschaft für Chirurgie Geschäftsstelle, Luisenstraße 58/59, 10117, Berlin

    H. Bauer (Generalsekretär der Deutschen Gesellschaft für Chirurgie) (Generalsekretär der Deutschen Gesellschaft für Chirurgie)

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© 2005 Springer Medizin Verlag Heidelberg

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Cite this paper

Schön, M.R. et al. (2005). Signifikante Steigerung der Leberregeneration durch systemische Erythropoietingabe nach linkslateraler Hemihepatektomie. In: Rothmund, M., Jauch, KW., Bauer, H. (eds) Chirurgisches Forum 2005. Deutsche Gesellschaft für Chirurgie, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26560-0_3

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  • DOI: https://doi.org/10.1007/3-540-26560-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-24888-0

  • Online ISBN: 978-3-540-26560-3

  • eBook Packages: Medicine (German Language)

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