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Molekularmedizinische Grundlagen von fetalen und neonatalen Erkrankungen pp 231–264Cite as

Umweltbedingte vorgeburtliche Entwicklungsschäden

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3.1.22 Literatur

  • Abbott BD, Birnbaum LS (1990) TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD. Toxicol Appl Pharmacol 106:418–432

    Article  PubMed  CAS  Google Scholar 

  • Abbott BD, Probst MR, Perdew GH, Buckalew AR (1998) AH receptor, ARNT, glucocorticoid receptor, EGF receptor, EGF, TGF alpha, TGF beta 1, TGF beta 2, and TGF beta 3 expression in human embryonic palate, and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Teratology 58:30–43

    Article  PubMed  CAS  Google Scholar 

  • Abbott BD, Held GA, Wood CR et al (1999a) AhR, ARNT, and CYP1A1 mRNA quantitation in cultured human embryonic palates exposed to TCDD and comparison with mouse palate in vivo and in culture. Toxicol Sci 47:62–75

    PubMed  CAS  Google Scholar 

  • Abbott BD, Schmid JE, Brown JG et al (1999b) RT-PCR quantitation of AHR, ARNT, GR, and CYP1A1 mRNA in craniofacial tissues of embryonic mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and hydrocortisone. Toxicol Sci 47:76–85

    PubMed  CAS  Google Scholar 

  • Abel EL (1995) An update on the incidence of FAS: FAS is not an equal opportunity birth defect. Neurotoxicol Teratol 17:437–443

    PubMed  CAS  Google Scholar 

  • Abel EL (1999) What really causes FAS? Teratology 59:4–6

    Article  PubMed  CAS  Google Scholar 

  • Adams J, Lammer EJ (1991) Relationship between dysmorphology and neuropsychological funetions in children exposed to isotretinoin (in utero). In: Fujii T, Boer GJ (eds) Functional neuroteratology of short term exposure to drugs. Teiko University Press, Tokyo, pp 159–168

    Google Scholar 

  • Alles AJ, Sulik KK (1990) Retinoid acid-indueed spina bifida: evidence for a pathogenetic mechanism. Development: 108:73–81

    PubMed  CAS  Google Scholar 

  • Baghurst PA, McMichael AJ, Wigg N et al (1992) Environmental exposure to lead and children’s intelligence at the age of seven years. N Engl J Med 327:1279–1284

    Article  PubMed  CAS  Google Scholar 

  • Barker DJ (1998) Mothers, babies and health in later life, 2nd edn. Livingston, Edinburgh

    Google Scholar 

  • Bellinger D et al (1987) Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. N Engl J Med 316:1037–1043

    Article  PubMed  CAS  Google Scholar 

  • Bjerregard P, Hansen JC (2000) Organochlorines and heavy metals in pregnant women from the disco bay area in Greenland. Science Total Environ 245:195–202

    Google Scholar 

  • BgVV — Bundesinstitut für gesundheitlichen Verbraucherschutz und Veterinärmedizin (1999) Während der Schwangerschaft verzehr bestimmter Fischarten einschränken. Berliner Ärzte 7/99:10

    Google Scholar 

  • BgVV — Bundesinstitut für gesundheitlichen Verbraucherschutz und Veterinärmedizin (2000) Belastung der Bevölkerung mit Dioxinen und anderen unerwünschten Stoffen in Deutschland deutlich zurückgegangen. Trends der Rückstandsgehalte in Frauenmilch der Bundesrepublik Deutschland — Aufbau der Frauenmilch-und Dioxin-Humandatenbank am BgVV. BgVV-Pressedienst 15, 2000

    Google Scholar 

  • Briggs GG, Nageotte MP (2001) Fatal fetal outcome with the combined use of valsartan and atenolol. Ann Pharmacother 35:859–861

    Article  PubMed  CAS  Google Scholar 

  • Briggs GG, Freeman RK, Yaffe SJ (1998) Drugs in pregnancy and lactation, 5th edn: Williams & Wilkins, Baltimore

    Google Scholar 

  • Buehler BA, Conover B (1993) Prenatal diagnosis of the fetal hydantoin syndrome: practical considerations. Reprod Toxicol 7:161–162

    Google Scholar 

  • Chan WS, Anand S, Ginsberg JS (2000) Anticoagulation of pregnant women with mechanical heart valves. Arch Intern Med 160:191–196

    Article  PubMed  CAS  Google Scholar 

  • Chernoff GF, Jones KL (1983) Malformations in structural development. Semin Perinatol 7:244–246

    PubMed  CAS  Google Scholar 

  • Cohen LS, Friedman JM, Jefferson JW, Johnson EM, Weiner ML (1994) A reevaluation of risk of in utero exposure to lithium. JAMA 271:146–150

    Article  PubMed  CAS  Google Scholar 

  • Collins MD, Mao GE (1999) Teratology of retinoids. Ann Rev Pharmacol Toxicol 39:399–430

    CAS  Google Scholar 

  • Committee on Developmental Toxicology, National Research Council (2000) Scientific frontiers in developmental toxicology and risk assessment. Mechanisms of developmental toxicity. National Academy Press, Washington, pp 58–87

    Google Scholar 

  • Cox C, Breazna A, Davidson PW et al (1999) Prenatal and postnatal methylmercury exposure and neurodevelopmental outcomes. JAMA 282:1333–1334

    Article  PubMed  CAS  Google Scholar 

  • Crabb DW (1990) Biological markers for increased risk of alcoholism and for quantitation of alcohol consumption. J Clin Invest 85:311–315

    PubMed  CAS  Google Scholar 

  • Croen LA, Shaw GM, Sanbonmatsu L, Selvin L, Buffler PA (1997) Maternal residential proximity to hazardous waste sites and risk for selected congenital malformations. Epidemiology 8:347–354

    PubMed  CAS  Google Scholar 

  • Danielsson BR, Azarbayjani F, Skold A-C, Webster WS (1997) Initiation of phenytoin teratogenesis: pharmacologically induced embryonic bradycardia and arrhythmia resulting in hypoxia and possible free radical damage at reoxygenation. Teratology 56:271–281

    Article  PubMed  CAS  Google Scholar 

  • DeSesso JM, Jacobson CF, Scially AR et al (1998) An assessment of the developmental toxicity of inorganic arsenic. Reprod Toxicol 12:385–433

    Article  PubMed  CAS  Google Scholar 

  • Dewailly E, Bruneau S, Ayotte P, Lalibert C, Gingras S, Belanger D, Ferron L (1993) Health Status at birth of Inuit newborns prenatally exposed to organochlorines. Chemosphere 27:359–366

    Article  CAS  Google Scholar 

  • DFG (Deutsche Forschungsgemeinschaft) (2003) Maximale Arbeitsplatzkonzentrationen und Biologische Arbeitsstofftoleranzwerte. VCH, Weinheim

    Google Scholar 

  • Dietrich KN et al (1987) Low-level fetal lead exposure effect on neurobehavioral development in early infancy. Pediatrics 80:721–730

    PubMed  CAS  Google Scholar 

  • Dietrich KN, Berger OG, Succop PA, Hammond PB, Bornschein RL (1993) The developmental consequences of low to moderate prenatal and postnatal lead exposure: intellectual attainment in the Cincinnati lead study cohort following school entry. Neurotoxicol Teratol 15:37–44

    Article  PubMed  CAS  Google Scholar 

  • Dolk H, Vrijheid M, Armstariong B, Abramsky L, Bianchi F, Garne E, Nelen V et al (1997) Spontaneous abortion in dry cleaning workers potentially exposed to perchloroethylene. Occup Environ Med 54:848–853

    Google Scholar 

  • Enders G (1991) Infektionen und Impfungen in der Schwangerschaft, 2. Aufl. Urban & Schwarzenberg, München

    Google Scholar 

  • Fail PA, Chapin RE, Price CJ, Heindel JJ (1998) General, reproductive, developmental, and endocrine toxicity of boronated compounds. Reprod Toxicol 12:1–18

    PubMed  CAS  Google Scholar 

  • Fried S, Kozer E, Nulman I et al (2004) Malformation rates in children of women with untreated epilepsy. Drug Safety 27:197–202

    PubMed  Google Scholar 

  • Gelineau-van Waes J, Bennett GD, Finnell RH (1999) Phenytoin-induced alterations in craniofacial gene expression. Teratology 59:23–34

    Article  PubMed  CAS  Google Scholar 

  • Generoso WM, Rutledge JC, Cain KT et al (1987) Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutat Res 176:269–274

    PubMed  CAS  Google Scholar 

  • Gianantonio di E, Schaefer C, Mastroiacovo PP et al (2001) Adverse effects of prenatal methimazole exposure. Teratology 64:262–266

    PubMed  Google Scholar 

  • Grandjean P, Weihe P, White RF et al (1997) Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 19:417–428

    Article  PubMed  CAS  Google Scholar 

  • Gregg NM (1941) Congenital cataract following German measles in mother. Trans Ophthalmol Soc Aust 3:35–46

    Google Scholar 

  • Haie F (1933) Pigs born without eye balls. J Hered 24:105–106

    Google Scholar 

  • Hard M, Raha S, Robinson BH, Koren G (2000) The role of acetaldehyde. The Motherisk Newsletter, Hospital for Sick Children Toronto 12:5

    Google Scholar 

  • Helms JA, Kim CH, Hu D et al. (1997) Sonic hedgehog participates in craniofacial morphogenesis and is down-regulated by teratogenic doses of retinoid acid. Dev Biol 187:25–35

    Article  PubMed  CAS  Google Scholar 

  • Hernandez-Diaz S, Werler MM, Walker AM, Mitchell AA (2000) Folie acid antagonists and the risk of birth defects. N Engl J Med 343:1608–1614

    Article  PubMed  CAS  Google Scholar 

  • Hernandez-Diaz S, Werler MM, Walker AM, Mitchell AA (2001) Neural tube defects in relation to use of folic acid antagonists during pregnancy. Am J Epidemiol 153:961–968

    PubMed  CAS  Google Scholar 

  • Holmes LB, Harvey EA, Coull BA et al (2001) The teratogenicity of anticonvulsant drugs. N Engl J Med 344:1132–1138

    Article  PubMed  CAS  Google Scholar 

  • Honein MA, Paulozzi LJ (2000) Accutane®-exposed pregnancies. Teratology 61:442

    Google Scholar 

  • Hoogdalem van EJ (1998) Transdermal absorption of topical anti-aene agents in man; review of clinical pharmaeokinetic data. J Europ Acad Dermatol Venereol 11:13–19

    Google Scholar 

  • Howe AM, Oakes DJ, Woodman PD, Webster WS (1999) Prothrombin and PIVKA-II levels in cord blood from newborns exposed to anticonvulsants during pregnancy. Epilepsia 40:980–984

    PubMed  CAS  Google Scholar 

  • Hwang SJ, Beaty TH, Panny SR et al (1995) Association study of transforming growth factor alpha (TGF alpha) Taql polymorphism and oral clefts: indication of gene-environment interaction in a population-based sample of infants with birth defects. Am J Epidemiol 141:629–636

    PubMed  CAS  Google Scholar 

  • Hwang SJ, Beaty TH, Mclntosh I et al (1998) Association between homeobox-containing gene MSX1 and the occurrence of limb deficiency. Am J Med Genet 75:419–423

    Article  PubMed  CAS  Google Scholar 

  • Ingram JL, Rodier PM (1998) Valproic acid alters expression of HOX AI in rat embryos: A mechanism of teratogenesis? Teratology 57:191

    Google Scholar 

  • Jacobson JL, Jacobson SW (1996) Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 335:783–789

    Article  PubMed  CAS  Google Scholar 

  • Jacobson JL, Jacobson SW (1997) Teratogen update: polychlorinated biphenyls. Teratology 55:338–347

    Article  PubMed  CAS  Google Scholar 

  • Jones HE, Balster RL (1998) Inhalant abuse in pregnancy. Obstet Gynecol Clin N Am 25:153–167

    CAS  Google Scholar 

  • Jones KL, Smith DW (1973) Recognition of the fetal alcohol syndrome in early infancy. Lancet 2:999–1001

    PubMed  CAS  Google Scholar 

  • Jones KL, Lacro RV, Johnson KA, Adams J (1989) Pattern of malformations in the children of women treated with carbamazepine during pregnancy. N Engl J Med 320:1661–1666

    PubMed  CAS  Google Scholar 

  • Juchau MR (1989) Bioactivation in chemical teratogenesis. Ann Rev Pharmacol Toxicol 29:165–187

    CAS  Google Scholar 

  • Källén B, Robert E (2000) Drinking water chlorination and delivery outcome — a registry-based study in Sweden. Reprod Toxicol 14:303–309

    PubMed  Google Scholar 

  • Kaneko S, Battino D, Andermann E et al (1999) Congenital malformations due to antiepileptic drugs. Epilep Res 33:145–158

    CAS  Google Scholar 

  • Kavlock R, Boekelheide K, Chapin R et al (2002) NTP Center for the evaluation of risks to human reproduction: phthalates expert panel reports on the reproductive and developmental toxicity of phthalate. Reprod Toxicol 16:453–734

    PubMed  CAS  Google Scholar 

  • Koch S, Jäger-Roman E, Lösche G, Nau H, Rating D, Helge H (1996) Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome. Acta Paediatr 85:739–746

    PubMed  CAS  Google Scholar 

  • Koopman-Esseboom C, Morse DC, Weisglas-Kuperus N et al (1994) Effects of dioxins and polychlorinated biphenyls on thyroid hormone Status of pregnant women and their infants. Pediatr Res 36:468–473

    PubMed  CAS  Google Scholar 

  • Koopman-Esseboom C, Weisglas-Kuperus N, de Ridder MA, van der Paauw CG, Tuinstra LG, Sauer PJ (1996) Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants mental and psychomotor development. Pediatrics 97:700–706

    PubMed  CAS  Google Scholar 

  • Kozma C (2000) Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. Am J Med Genet 98:168–175

    Google Scholar 

  • Kyyrönen PK, Taskinen H, Lindholm ML, Hemminki K, Heinonen OP (1989) Spontaneous abortions and congenital malformations among women exposed to tetrachlorethylene in dry cleaning. J Epidem Comm Health 43:346–351

    Google Scholar 

  • Lammer EJ, Hayes AM, Schunior A, Holmes LB (1988) Unusually high risk for adverse outcomes of pregnancy following fetal isotretinoin exposure. Am J Hum Genet 43:A 58

    Google Scholar 

  • Laumont B, Martin JL, Bertucat I, Verney MP, Robert E (1996) Exposure to organic solvents during pregnancy and oral clefts: as case control study. Reprod Toxicol 10:15–19

    Google Scholar 

  • Lenz W (1961) Kindliche Fehlbildungen nach Medikament während der Gravidität? Dtsch Med Wochenschr 86:2555–2556

    Google Scholar 

  • Liberti di JH, Farndon PA, Dennis NR, Curry CJ (1984) The fetal valproate syndrome. Am J Med Genet 19:473–481

    Google Scholar 

  • Liebl B, Ehrenstorfer S (1993) Nitromoschusverbindungen in der Frauenmilch. Gesundh-Wes 55:527–532

    CAS  Google Scholar 

  • Llewellyn A, Stowe ZN, Strader JR (1998) The use of lithium and management of women with bipolar disorder during pregnancy and lactation. J Clin Psychiatry 59(Suppl 2):57–64

    PubMed  CAS  Google Scholar 

  • Loebstein R, Lalkin A, Koren G (1997) Pharmacokinetic changes during pregnancy and their clinical relevance. Clin Pharmacokinet; 33:328–343

    PubMed  CAS  Google Scholar 

  • Martinez-Frias ML, Rodriguez-Pinilla E (1999) First-trimester exposure to topical tretinoin: its safety is not warranted. Teratology 60:5

    PubMed  CAS  Google Scholar 

  • Matalon S, Schechtman S, Goldzweig G, Ornoy A (2002) The teratogenic effect of carbamazepine: a meta-analysis of 1255 exposures. Reprod Toxicol 16:9–17

    Article  PubMed  CAS  Google Scholar 

  • McMartin KI, Chu M, Kopecky E, Einarson TR, Koren G (1998) Pregnancy outcome following maternal organic solvent exposure: a meta-analysis of epidemiologic studies. Am J Ind Med 34:288–292

    Article  PubMed  CAS  Google Scholar 

  • Middaugh JP, Egeland GM (1997) Intellectual function of children exposed to polychlorinated biphenyls in utero. N Engl J Med 356:660–661

    Google Scholar 

  • Moore SJ, Turnpenny P, Quinn A, Glover S, Lloyd DJ, Montgomery T, Dean JC (2000) A clinical study of 57 children with fetal anticonvulsant syndrome. J Med Genet 37:489–497

    Article  PubMed  CAS  Google Scholar 

  • Musselman AC, Bennett GD, Greer KA et al (1994) Preliminary evidence of phenytoin-induced alteration in embryonic gene expression in a mouse model. Reprod Toxicol 8:383–395

    Article  PubMed  CAS  Google Scholar 

  • Nau H (1986) Species differences in pharmacokinetics and drug teratogenesis. Environ Health Perspect 70:113–129

    PubMed  CAS  Google Scholar 

  • Nau H, Zierer R, Spielmann H, Neubert D, Gansau C (1981) A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations. Life Sciences 29:2803–2914

    Article  PubMed  CAS  Google Scholar 

  • Navarre-Belhassen C, Blancehet P, Hillaire-Buys D, Sarda P, Blayac J-P (1998) Multiple congenital malformations associated with topical tretinoin. Ann Pharmacother 32:505–506

    PubMed  CAS  Google Scholar 

  • Nelson K, Holmes LB (1989) Malformations due to presumed spontaneous mutations in newborn infants. N Engl J Med 320:19–23

    Article  PubMed  CAS  Google Scholar 

  • Nieuwenhuijsen MJ, Toledano MB, Eaton NE et al (2000) Chlorination disinfection by products in water and their association with adverse reproductive outcomes: a review. Occup Environ Med 57:73–85

    Article  PubMed  CAS  Google Scholar 

  • Nulman I, Kennedy D, Rovet J, Wolpin J, Wasson C, Loebstein M, Gladstone J et al (2000) Neurodevelopment of children exposed in utero to maternal binge alcohol consumption: a prospective, controlled study. The Motherisk Newsletter, Hospital for Sick Children Toronto 12:2–3

    Google Scholar 

  • Ornoy A, Diav-Citrin O (2002) Teratogen update: antithyroid drugs. Methimazole and propylthiouracil. Teratology 65:38–44

    PubMed  Google Scholar 

  • Ornoy A, Cohen E (1996) Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy. Arch Dis Child 75:517–520

    Article  PubMed  CAS  Google Scholar 

  • Ornoy A, Shechtman S, Arnon J, Diav-Citrin O (2000) Is carbamazepine administration during pregnancy teratogenic? A prospective controlled study on pregnancy outcome in 229 exposed women (abstract). Teratology 61:440

    Article  Google Scholar 

  • Ou YC, Thompson SA, Ponce RA et al (1999) Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicol Appl Pharmacol 157:203–212

    Article  PubMed  CAS  Google Scholar 

  • Patandin S, Lanting CI, Mulder PG, Boersma ER, Sauer PJ, Weisglas-Kuperus N (1999) Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. Pediatr 134:33–41

    CAS  Google Scholar 

  • Phelan MC, Pellock MM, Nance WE (1982) Discordant expression of fetal hydantoin syndrome in heteropaternal dizygotic twins. N Engl J Med 307:99–102

    Article  PubMed  CAS  Google Scholar 

  • Polygenis D, Wharton S, Malmberg C et al (1998) Moderate alcohol consumption during pregnancy and the incidence of fetal malformations: A meta-analysis. Neurotoxicol Teratol 20:61–67

    Article  PubMed  CAS  Google Scholar 

  • Rasmussen SA, Lammer EJ, Shaw GM et al (2002) Integration of DNA sample collection into a multi-site birth defects case-control study. Teratology 66:177–184

    Article  PubMed  CAS  Google Scholar 

  • Raymond GV, Buehler BA, Finell RH et al (1995) Anticonvulsant teratogenesis: 3. Possible metabolic basis. Teratology 51:55–56

    PubMed  CAS  Google Scholar 

  • Rimkus G, Rimkus B, Wolf M (1994) Nitro musks in human adipose tissue and breast milk. Chemosphere 28:421–432

    Article  CAS  Google Scholar 

  • Ritz B, Yu F (1999) The effect of ambient carbon monoxide on low birth weight among children in Southern California between 1989 and 1993. Environ Health Perspect 107:17–25

    PubMed  CAS  Google Scholar 

  • Robert E (1999) Intrauterine effects of electromagnetic fields (low frequency, mid frequency RF, and microwave): review of epidemiologic studies. Teratology 59:292–298

    Article  PubMed  CAS  Google Scholar 

  • Robert E, Källén B (1994) In utero exposure to carbamazepine — effects on the fetus. Issues Rev Teratol 7:37–55

    Google Scholar 

  • Rodier PM (1998) Neuroteratology of autism. In: Slikker W, Chang L (eds) Handbook of developmental neurotoxicology. Academic Press, New York, pp 661–672

    Google Scholar 

  • Rodriguez-Pinella E, Arroyo I, Fondevilla J et al (2000) Prenatal exposure to valproic acid during pregnancy and limb deficiencies: a case-control study. Am J Med Genet 90:376–381

    Google Scholar 

  • Rogan WJ, Gladen BC, Leon Guo YL, Hsu CC (1999) Sex ratio after exposure to dioxin-like chemicals in Taiwan. Lancet 353:206–207

    Article  PubMed  CAS  Google Scholar 

  • Saji H, Yamanaka M, Hagiwara A, Ijiri R (2001) Losartan and fetal toxic effects. Lancet 357:363

    Article  PubMed  CAS  Google Scholar 

  • Savarirayan R (1999) Common phenotype and etiology in warfarin embryopathy and X-linked chondrodysplasia punctata (CDPX). Pediatr Radiol 29:322

    Article  PubMed  CAS  Google Scholar 

  • Schaefer C (2003) Angiotensin II-receptor-antagonists: further evidence of fetotoxicity but not teratogenicity. Birth Defects Research (Part A) 67:591–594

    Article  CAS  Google Scholar 

  • Schaefer C (2002) Coumarin derivates during pregnancy. Vortrag auf dem 13. Jahrestreffen des European Network of Teratology Information Service (ENTIS), Padua, 5.–7. April 2002

    Google Scholar 

  • Schaefer C, Spielmann H, unter Mitarb. von Vetter K (2001) Arzneiverordnung in Schwangerschaft und Stillzeit, 6. Aufl. Urban & Fischer, München

    Google Scholar 

  • Schardein JL (2000) Chemically induced birth defects, 4th edition. Dekker, New York

    Google Scholar 

  • Schiele R, Erler M, Dittineger EW (1999) Untersuchungen zur Quecksilberbelastung fetaler und frühkindlicher Organe infolge mütterlicher Exposition durch Zahnamalgam. Arbeitsmed Sozialmed Umweltmed 34:472–475

    Google Scholar 

  • Shaw GM, Wassermann CR, Lammer EJ et al (1996) Orofacial clefts, parental cigarette smoking and transforming growth factor-alpha gene variants. Am J Hum Genet 58:551–561

    PubMed  CAS  Google Scholar 

  • Shaw GM, Nelson V, Todoroff K, Wasserman CR, Neutra RR (1999) Maternal periconceptional use of electric bed-heating devices and risk for neural tube defects and orofacial clefts. Teratology 60:124–129

    Article  PubMed  CAS  Google Scholar 

  • Shepard TH (1994) Letter: „proof“ of teratogenicity. Teratology 50:97

    PubMed  CAS  Google Scholar 

  • Shepard TH (1995) Catalogue of teratogenic agents. John Hopkins University Press, Baltimore

    Google Scholar 

  • Shepard TH, Brent RL, Friedman JM et al (2002) Update on new developments in the study of human teratogens. Teratology 65:153–161

    PubMed  CAS  Google Scholar 

  • Siambani C, Westall CA, Koren G, Rovet JF (2000) Maternal occupational exposure to organic solvents during pregnancy and subsequent cognitive and visual functioning in the child: a prospective controlled study. Teratology 61:522

    Google Scholar 

  • Sikorski R et al (1987) Women in dental surgeries: reproductive hazards in environmental exposure to metallic mercury. Int Arch Occup Environ Health 59:551

    Article  PubMed  CAS  Google Scholar 

  • Spohr HL, Wülms J, Steinhausen HC (1995) Die Berliner Verlaufsstudie von Kindern mit einem fetalem Alkoholsyndrom (FAS). 1. Pädiatrische Befunde. Monatsschr Kinderheükd 143:149–156

    Google Scholar 

  • Steinhausen HC, Wülms J, Spohr HL (1995) Die Berliner Verlaufsstudie von Kindern mit einem fetalem Alkoholsyndrom (FAS). 2. Psychiatrische und psychologische Befunde. Monatsschr Kinderheilkd 143:157–164

    Google Scholar 

  • Stephens TD, Fillmore BJ (2000) Hypothesis: thalidomide embryopathy-proposed mechanism of action. Teratology 61:189–195

    Article  PubMed  CAS  Google Scholar 

  • Sterling TD, Arundel A (1986) Review of recent Vietnamese studies on the carcinogenic and teratogenic effects of phenoxy herbicide exposure. Int J Health Serv 16:265

    PubMed  CAS  Google Scholar 

  • Stewart P, Reihmann J, Lonky E, Darvill T, Pagano J (2000) Prenatal exposure and neonatal behavioral assessment scale (NBAS) Performance. Neurotoxicol Teratol 22:21–29

    Article  PubMed  CAS  Google Scholar 

  • Steuerwald U, Weihe P, Jorgensen PJ, Bjerve K, Brock J, Heinzow B, Budtz-Jorgensen E et al (2000) Maternal seafood diet, methylmercury exposure and neonatal neurologic function. Pediatrics 136:599–605

    CAS  Google Scholar 

  • Strömland K, Nordin V, Miller M et al. (1994) Autism in thalidomide embryopathy: a population study. Dev Med Chüd Neurol 36:351–356

    Google Scholar 

  • Streissguth AP, Dehaene P (1993) Fetal alcohol syndrome in twins of alcoholic mothers: concordance of diagnosis and IQ. Am J Med Genet 47:857–861

    Article  PubMed  CAS  Google Scholar 

  • Tenconi R (1998) Risk of congenital anomalies near hazardous-waste landfill sites in Europe: the EUROHAZCON study. Lancet 352:423–427

    PubMed  Google Scholar 

  • Teufel M, Nissen KH, Sartoris J et al (1990) Chlorinated hydrocarbons in fat tissue: analysis of residues in healthy children, tumor patients and malformed children. Arch Environ Contam Toxicol 19:646–652

    Article  PubMed  CAS  Google Scholar 

  • Tong SL, Baghurst P, McMichael A et al (1996) Lifetime exposure to environmental lead and children’s intelligence at 11-13 years — the Port Pirie cohort study. BMJ 312:1569–1575

    PubMed  CAS  Google Scholar 

  • Tzimas G, Thiel R, Chahoud I, Nau H (1997) The area under the concentration-time curve of all-trans-retinoic acid is the most suitable pharmacokinetic correlate to the embryotoxicity of this retinoid in the rat. Toxicol Appl Pharmacol 143:435–444

    Article  Google Scholar 

  • Vitale N, De Feo M, De Santo LS, Pollice A, Tedesco N, Cotrufo M (1999) Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves. J Am Coll Cardiol 33:1637–1641

    Article  PubMed  CAS  Google Scholar 

  • Warkany J, Nelson RC (1940) Appearance of skeletal abnssormalities in the offspring of rats retarded on a deficient diet. Science 92:383–384

    CAS  PubMed  Google Scholar 

  • Wasserman GA, Musabegovic A, Liu X et al (2000) Lead exposure and motor functioning in 4 1/2-year-old children: the Yugoslavia prospective study. J Pediatr 137:555–561

    PubMed  CAS  Google Scholar 

  • Wells PG, Kim PM, Nicol CJ et al (1997) Reactive intermediates. In: Kavlock RJ, Daston GP (eds) Drug toxicity in embryonic development. Handbook of experimental pharmacology, vol 124/1. Springer, Berlin Heidelberg New York Tokyo, pp 451–516

    Google Scholar 

  • Wilkins-Haug L (1997) Teratogen update: toluene. Teratology 55:145–151

    Article  PubMed  CAS  Google Scholar 

  • Williams G, King J, Cunningham M et al (2001) Fetal valproate syndrome and autism: additional evidence of an association. Dev Med Child Neurol 43:202–206

    Article  PubMed  CAS  Google Scholar 

  • Windham GC, Von Behren J, Fenster L, Schaefer C, Swan SH (1997) Moderate maternal alcohol consumption and risk of spontaneous abortion. Epidemiology 8:509–514

    PubMed  CAS  Google Scholar 

  • Wilson JD (1977) Embryotoxicity of drugs to man. In: Wilson JD, Frazer FC (eds) Handbook of teratology, vol 1. Plenum Press, New York, pp 309–355

    Google Scholar 

  • Yang QH, Witkiewicz BB, Olney RS et al (2000) Maternal alcohol consumption and intrauterine growth retardation: a population-based case-control study. Teratology 61:441

    Google Scholar 

  • Zielhuis GA, Gijsen R, van der Gulden JW (1989) Menstrual disorders among dry-cleaning workers. Scand J Work Environ Health 15:238

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben (BBGes), Spandauer Damm 130, Haus 10, 14050, Berlin

    Dr. med. Christof Schaefer

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  1. Dr. med. Christof Schaefer
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  1. Vorstandsvorsitzender Charité, Universitätsmedizin Berlin, Schumannstr. 20/21, 10117, Berlin

    Detlev Ganten

  2. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10, 13125, Berlin-Buch

    Klaus Ruckpaul

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© 2005 Springer-Verlag Berlin Heidelberg

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Schaefer, C. (2005). Umweltbedingte vorgeburtliche Entwicklungsschäden. In: Ganten, D., Ruckpaul, K. (eds) Molekularmedizinische Grundlagen von fetalen und neonatalen Erkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26524-4_10

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