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1.1.3 Literatur

  • Adams GR, McCue SA (1998) Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. J Appl Physiol 84:1716–1722

    PubMed  CAS  Google Scholar 

  • Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W et al (1999) Roles of ephrin B ligands and ephB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev 13:295–306

    Article  PubMed  CAS  Google Scholar 

  • Acedo J, Ayenzon M, Von Ohlen T, Noll M, Hopper JE (1996) The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog Signal. Cell 86:221–232

    Article  Google Scholar 

  • Akitaya T, Bronner-Fraser M (1992) Expression of cell adhesion molecules during initiation and cessation of neural crest cell migration. Dev Dyn 194:12–20

    PubMed  CAS  Google Scholar 

  • Altmann J (1969) Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with Special reference to persisting neurogenesis in the olfactory bulb. J Comp Neurol 137:433–457

    Article  Google Scholar 

  • Altmann J, Das GD (1965) Autoradiographic and histologic evidence of postnatal neurogenesis in rats. J Comp Neurol 124:319–335

    Article  Google Scholar 

  • Amthor H, Christ B, Weil M, Patel K (1998) The importance of timing differentiation during limb muscle development. Curr Biol 8:642–652

    Article  PubMed  CAS  Google Scholar 

  • Amthor H, Christ B, Patel K (1999) A molecular mechanism enabling continuous embryonic muscle growth — a balance between proliferation and differentiation. Development 126:1041–1053

    PubMed  CAS  Google Scholar 

  • Arias AM, McBrown A, Brennan K (1999) Wnt signaling: pathway or network? Curr Opin Gen Dev 9:447–454

    Article  CAS  Google Scholar 

  • Aristotele: De anima. Generation of animals. In: Barnes J (ed) The complete works of Aristotle. Bollington series LXXI. Princeton University Press (revised Oxford translation)

    Google Scholar 

  • Armelin HA (1973) Pituitary extracts and steroid hormones in the control of 3T3 cell growth. Proc Natl Acad Sci 70:2702–2706

    Article  PubMed  CAS  Google Scholar 

  • Arnold HH, Braun T (2000) Genetics of muscle determination and development. Curr Top Dev Biol 48:129–164

    Article  PubMed  CAS  Google Scholar 

  • Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B et al (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964–967

    Article  PubMed  CAS  Google Scholar 

  • Assoian RK, Fleurdelys BE, Stevenson HC, Miller PJ, Madtes DK, Raines EW, Ross R et al (1987) Expression and secretion of type β transforming growth factor by activated human macrophages. Proc Natl Acad Sci USA 84:6020–6024

    Article  PubMed  CAS  Google Scholar 

  • Attisano L, Wrana JL (1998) Mads and smads in TGFβ signalling. Curr Opin Cell Biol 10:188–194

    Article  PubMed  CAS  Google Scholar 

  • Aulehla A, Johnson RL (1999) Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation. Dev Biol 207:49–61

    Article  PubMed  CAS  Google Scholar 

  • Awede B, Thissen J, Gailly P, Lebacq J (1999) Regulation of IGF-I, IGFBP-4 and IGFBP-5 gene expression stimulates skeletal muscle. FEBS Lett 461:263–267

    Article  PubMed  CAS  Google Scholar 

  • Baer von KE (1828) Über die Entwicklungsgeschichte der Thiere. Königsberg

    Google Scholar 

  • Baker J, Liu JP, Robertson EJ, Efstratiades A (1993) Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75:73–82

    Article  PubMed  CAS  Google Scholar 

  • Barrio del MG, Nieto MA (2002) Overexpression of snail family members highlights their ability to promote chick neural crest formation. Development 129:1583–1593

    PubMed  Google Scholar 

  • Barnes JD, Crosby JL, Jones CM, Wright CV, Hogan BL (1994) Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev Biol 161:168–178

    Article  PubMed  Google Scholar 

  • Battle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia de Herreros A (2000) The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2:84–89

    Article  CAS  Google Scholar 

  • Benninghoff B, Drenckhahn D (2003) Anatomie. Makroskopische Anatomie, Histologie, Embryology, Zellbiologie, Bd 1, 16. Aufl. Urban & Fischer, München

    Google Scholar 

  • Bergemann AD, Cheng HJ, Brambilla R, Klein R, Flanagan JG (1995) ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol Cell Biol 15:4921–4929

    PubMed  CAS  Google Scholar 

  • Birchmeier C, Birchmeier W, Brand-Saberi B (1996) Epithelial-mesenchymal transitions in cancer progression. Acta Anat 156:217–226

    Article  PubMed  CAS  Google Scholar 

  • Birling MC, Price J (1995) Influence of growth factors on neuronal differentiation. Curr Opin Cell Biol 7:878–884

    Article  PubMed  CAS  Google Scholar 

  • Blau HM (1989) How fixed is the differentiated State? Lessons from heterokaryons. Trends Genet 5:268–272

    Article  PubMed  CAS  Google Scholar 

  • Blau HM (2002) A twist of fate. Nature 419:437

    Article  PubMed  CAS  Google Scholar 

  • Blau HM, Baltimore D (1991) Differentiation requires continuous regulation. J Cell Biol 112:781–783

    Article  PubMed  CAS  Google Scholar 

  • Blechschmidt E (1961) Die vorgeburtlichen Entwicklungsstadien des Menschen. Eine Einführung in die Humanembryologie. Karger, Basel

    Google Scholar 

  • Boettger T, Wittler L, Kessel M (1999) Fgf8 funetions in the specification of the right body side of the chick. Curr Biol 9:277–280

    Article  PubMed  CAS  Google Scholar 

  • Bogdanovich S, Krag T, Barton E, Morris L, Whittemore L-A, Ahima R, Khurana T (2002) Functional improvement of dystrophic muscle by myostatin blockade. Nature 420:418–421

    Article  PubMed  CAS  Google Scholar 

  • Brand-Saberi B, Seifert R, Grim M, Wilting J, Kühlewein M, Christ B (1995) Blood vessel formation in the avian limb bud involves angioblastic and angiotrophic growth. Dev Dyn 202:181–194

    PubMed  CAS  Google Scholar 

  • Brand-Saberi B, Gamel A, Krenn V, Müller T, Wilting J, Christ B (1996 a) N-cadherin is involved in myoblast migration and muscle differentiation in the avian limb bud. Dev Biol 178:160–173

    Article  PubMed  CAS  Google Scholar 

  • Brand-Saberi B, Müller TS, Wilting J, Christ B, Birchmeier C (1996 b) Scatter factor/Hepatocyte growth factor (SF/HGF) induces emigration of myogenic cells at interlimb level in vivo. Dev Biol 179:303–308

    Article  PubMed  CAS  Google Scholar 

  • Briscoe J, Pierani A, Jessell TM, Ericson J (2000) A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 101:435–445

    Article  PubMed  CAS  Google Scholar 

  • Briscoe J, Chen Y, Jessell TM, Strahl G (2001) A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube. Mol Cell 7:1279–1291

    Article  PubMed  CAS  Google Scholar 

  • Britsch S, Li L, Kirchhoff S, Theuring F, Brinkmann V, Birchmeier C, Riethmacher D (1998) The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev 12:1825–1836

    Article  PubMed  CAS  Google Scholar 

  • Brown AM, Wildin RS, Prendergast TJ, Varmus HE (1986) A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell 46:1001–1009

    Article  PubMed  CAS  Google Scholar 

  • Bruno L, Schaniel C, Rolink A (2002) Plasticity of Pax-5(„-/-“) pre-B I cells. Cell Tiss Org 17:38–43

    Article  Google Scholar 

  • Burri PH, Tarek MR (1990) A novel mechanism of capillary growth in the rat pulmonary microcirculation. Anat Rec 228:35–45

    Article  PubMed  CAS  Google Scholar 

  • Cann GM, Lee JW, Stockdale FE (1999) Sonic hedgehog enhances somite cell viability and formation of primary slow muscle fibers in avian segmented mesoderm. Anat Embryol 200:239–252

    Article  PubMed  CAS  Google Scholar 

  • Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barro MG, Portillo F et al (2000) The transcription factor snail controls epithelial-mesenchymal transition by re-pressing E-cadherin expression. Nat Cell Biol 2:76–83

    Article  PubMed  CAS  Google Scholar 

  • Capdevila J, Tabin C, Johnson R (1998) Control of dorsoventral somite patterning by Wnt-1 and β-Catenin. Dev Biol 193:182–194

    Article  PubMed  CAS  Google Scholar 

  • Capdevila J, Vogan KJ, Tabin CJ, Ispisúa-Belmonte JC (2000) Mechanisms of left-right determination in vertebrates. Cell 101:9–21

    Article  PubMed  CAS  Google Scholar 

  • Carpenter G, Cohen S (1979) Epidermal growth factor. A Rev Biochem 48:193–216

    Article  CAS  Google Scholar 

  • Chan S, Karpf D, Fowlkes M, Hooks M, Bradley M, Vuong V, Bambino T et al (1992) Two homologs of the Drosophila polarity gene frizzled are widely expressed in mammalian tissues. J Biol Chem 267:25202–25207

    PubMed  CAS  Google Scholar 

  • Chen H, Lun Y, Ovchinnikov D, Kokubo H, Oberg KC, Pepicelli CV, Gan L et al (1998) Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat Genet 19:51–55

    Article  PubMed  Google Scholar 

  • Chenn A, McConnell SK (1995) Cleavage orientation and the asymmetric inheritance of Notch-1 immuno-reactivity in mammalian neurogenesis. Cell 82:631–641

    Article  PubMed  CAS  Google Scholar 

  • Chiang C, Litingtung K, Lee E, Young KE, Corden JL, Westphal H, Beachy PA (1996) Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407–413

    Article  PubMed  CAS  Google Scholar 

  • Christ B (1969) Die Knorpelentstehung in den Wirbelanlagen. Experimentelle Untersuchungen an Hühnerembryonen. Z Anat Entwickl-Gesch 129:177–194

    Article  CAS  Google Scholar 

  • Christ B, Ordahl CP (1995) Early stages of somite development. Anat Embryol 191:381–396

    Article  PubMed  CAS  Google Scholar 

  • Christ B, Wachtier F (1998) Medizinische Embryologie. Ullstein Medical, Wiesbaden

    Google Scholar 

  • Christ B, Jacob HJ, Jacob M (1977) Experimental analysis of the origin of the wing musculature in avian embryos. Anat Embryol 150:171–186

    Article  PubMed  CAS  Google Scholar 

  • Christ B, Schmidt C, Huang R, Wilting J, Brand-Saberi B (1998) Segmentation of the vertebrate body. Anat Embryol 197:1–8

    Article  PubMed  CAS  Google Scholar 

  • Christ B, Amthor H, Huang R, Wagner J, Patel K (2001) Control of muscle mass development. In: Sanders EJ et al (eds) The origin and fate of somites. IOS, Amsterdam, 124–131

    Google Scholar 

  • Claesson-Welsh L (1999) Vascular growth factors and angiogenesis. Springer, Berlin Heidelberg New York, Tokyo

    Google Scholar 

  • Coleman ME, De Mayo F, Yin KC, Lee HM, Geske R, Montgomery C, Schwartz RJ (1995) Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J Biol Chem 270:12109–12116

    Article  PubMed  CAS  Google Scholar 

  • Collignon J, Varlet I, Robertson EJ (1996) Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 381:155–158

    Article  PubMed  CAS  Google Scholar 

  • Dathe V, Gamel A, Männer J, Brand-Saberi B, Christ B (2002) Morphological left-right asymmetry of hensen’s node precedes the asymmetric expression of Shh and Fgf8 in the chick embryo. Anat Embryol 205:343–354

    Article  PubMed  CAS  Google Scholar 

  • Davies AM (1994) Neutrophic factors. Switching neurotrophin dependence. Curr Biol 4:273–276

    Article  PubMed  CAS  Google Scholar 

  • Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M et al (1994) Ligands for the ephrelated receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 266:816–819

    Article  PubMed  CAS  Google Scholar 

  • Dietz UH, Ziegelmeier G, Bittner K, Bruckner P, Balling R (1999) Spatio-temporal distribution of chondromodulin-I mRNA in the chicken embryo: expression during cartilage development and formation of the heart and eye. Dev Dyn 216:233–243

    Article  PubMed  CAS  Google Scholar 

  • Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD (1984) Close similarity of epidermal growth factor receptor and v-erb-B protein sequences. Nature 307:521–527

    Article  PubMed  CAS  Google Scholar 

  • Draetta G (1990) Cell cycle control in eukaryotes: molecular mechanisms of cfc2 activation. Trends Biochem Sci 15:378–383

    Article  PubMed  CAS  Google Scholar 

  • Dressler GR (1995) Transcription factors in renal development: the WT1 and Pax-2 story. Semin Nephrol 15:263–271

    PubMed  CAS  Google Scholar 

  • Dressler GR (1996) Pax-2, kidney development, and oncogenesis. Med Pediatr Oncol 27:440–444

    Article  PubMed  CAS  Google Scholar 

  • Dressler GR, Deutsch U, Chowdhury K, Nornes HO, Gruss P (1990) Pax2, a new murine paired box-containing gene and its expression in the developing excretory system. Development 109:787–795

    PubMed  CAS  Google Scholar 

  • Drossopoulou G, Lewis KE, Sanz-Ezquerro JJ, Nikbakht N, McMahon AP, Hofmann C, Tickle C (2000) A model for anterior-posterior patterning of the vertebrate limb based on sequential long-and short-range Shh signalling and Bmp signalling. Development 127:1337–1348

    PubMed  CAS  Google Scholar 

  • Duband JL, Dufour S, Hata K, Takeichi M, Edelman GM, Thiery JP (1987) Adhesion molecules during somitogenesis in the avian embryo. J Cell Biol 104:1361–1374

    Article  PubMed  CAS  Google Scholar 

  • Dudley AT, Ros MA, Tabin CF (2002) A re-examination of proximodistal patterning during vertebrate limb development. Nature 418:539–544

    Article  PubMed  CAS  Google Scholar 

  • Echelard Y, Epstein DJ, Jacques B, Shen L, Mohler J, McMahon JA (1993) Sonic hedgehog, a member of a family of putative signaling molecules is implicated in the regulation of CNS and limb polarity. Cell 75:1417–1430

    Article  PubMed  CAS  Google Scholar 

  • Eichele G, Tickle C, Alberts BM (1985) Studies on the mechanism of retinoid-induced pattern duplications in the early chick limb bud: temporal and spatial aspects. J Cell Biol 101:1913–1920

    Article  PubMed  CAS  Google Scholar 

  • Ericson J, Rashbass P, Schedl A, Brenner-Morton S, Kawakami A, van Heyningen V, Jessell TM et al (1997) Pax6 control progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90:169–180

    Article  PubMed  CAS  Google Scholar 

  • Erikkson PS, Perfilieva E, Bjork-Erikkson T, Alborn AM, Nordborg C, Peterson DA, Gage FH (1998) Neurogenesis in the adult human hippocampus. Nat Med 4:1313–1317

    Article  CAS  Google Scholar 

  • Esko JD (1991) Genetics analysis of proteoglycan strueture, funetion and metabolism. Curr Opin Cell Biol 3:806–816

    Article  Google Scholar 

  • Fan CM, Tessier-Lavigne M (1994) Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 79:1175–1186

    Article  PubMed  CAS  Google Scholar 

  • Fan CM, Lee C, Tessier-Lavigne M (1997) A role of Wnt proteins in induction of dermomyotome. Dev Biol 191:160–165

    Article  PubMed  CAS  Google Scholar 

  • Fantl WJ, Peters KG, Williams LT (1996) PDGF and FGF receptors in health and disease. In: Leroith D, Bondy C (ed) Growth factors and cytokines in health and disease. JAI, London, 170–228

    Google Scholar 

  • Ferrara N (1999) Vascular endothelial growth factor: molecular and biological aspects. In: Claesson-Welsh L (ed) Vascular growth factors and angiogenesis. Springer, Berlin Heidelberg New York Tokyo, 1–30

    Google Scholar 

  • Flake AW (2001) Fate mapping of stem cells. In: Marshak DR, Gottlieband D, Gardner RL (eds) Stemm cell biology. Cold Spring Harbor Laboratory Press, New York, 375–397

    Google Scholar 

  • Fournier M, Lewis MI (2000) Influences of IGF-I gene disruption on the cellular profile of the diaphragm. Am J Physiol Endocrinol Metab 278:E707–715

    PubMed  CAS  Google Scholar 

  • Frolik CA, Dart LL, Meyers CA, Smith DM, Sporn MB (1983) Purification and initial characterization of type β transforming growth factor from human placenta. Proc Natl Acad Sci USA 80:3676–3680

    Article  PubMed  CAS  Google Scholar 

  • Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M et al (1996) Eph receptors and ligands comprise two major specificity subclasses and are reciproeally compartmentalized during embryogenesis. Neuron 17:9–19

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Castro M, Vielmetter E, Bronner-Fraser M (2000) N-Cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry. Science 288:1047–1051

    Article  PubMed  CAS  Google Scholar 

  • Glücksmann A (1951) Cell death in normal vertebrate ontogeny. Biol Rev 26:59–86

    Article  Google Scholar 

  • Go V, Gardner J, Brooks F, Lebenthal E, DiMagno E, Scheele G (1986) The exoerine pancreas. Raven, New York, 35–43

    Google Scholar 

  • Gospodarowicz D (1974) Localization of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature 249:123–127

    Article  PubMed  CAS  Google Scholar 

  • Gospodarowicz D (1975) Purification of a fibroblast growth factor from bovine pituitary. J Biol Chem 250:2515–2520

    PubMed  CAS  Google Scholar 

  • Gossler A, Krabé de Angelis M (1997) Somitogenesis. Curr Top Dev Biol 38:225–287

    Article  Google Scholar 

  • Green PL, Walsh FS, Doherty P (1996) Promiscuity of fibroblast growth factor receptors. Bioessays 18:639–693

    Article  PubMed  CAS  Google Scholar 

  • Gritli-Linde A, Lewis P, McMahon AP, Linde A (2001) The where-abouts of a morphogen: direct evidence for short-and graded long-range activity of hedgehog signaling peptides. Dev Biol 236:364–386

    Article  PubMed  CAS  Google Scholar 

  • Grunz H, Tacke L (1989) Neural differentiation of Xenopus laevis ectoderm takes place after disaggregation and delayed reaggregation without inducer. Cell Differ Dev 28:211–217

    Article  PubMed  CAS  Google Scholar 

  • Gumbiner BM (1996) Signal transduetion by catenin. Curr Opin Cell Biol 7:634–640

    Article  Google Scholar 

  • Gurdon JB (1986) Nuclear transplantation in eggs and ooeytes. J Cell Sci (Suppl) 4:287–318

    CAS  Google Scholar 

  • Gurdon JB, Lemaire P, Kato K (1993) Community effects and related phenomena in development. Cell 75:831–834

    Article  PubMed  CAS  Google Scholar 

  • Harvey P, Clark IM, Jaurand MC, Warn RM, Edwards DR (2000) Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases. Br J Cancer 83:1147–1153

    Article  PubMed  CAS  Google Scholar 

  • Hayamizu TF, Wanek N, Taylor G, Trevino C, Shi C, Anderson R, Gardiner DM et al (1994) Regeneration of HoxD expression domains during pattern regulation in chick wing buds. Dev Biol 161:504–512

    Article  PubMed  CAS  Google Scholar 

  • Hebrok M, Kim SK, St-Jacques B, McMahon AP, Melton DA (2000) Regulation of pancreas development by hedgehog signaling. Development 127:4905–4913

    PubMed  CAS  Google Scholar 

  • Heins N, Malatesta P, Cecconi F, Nakafuku M, Tucker KL, Hack MA, Chapouton P et al (2002) Glial cell generate neurons: the role of the transcription factor Pax6. Nature Neuroscience 5:308–315

    Article  PubMed  CAS  Google Scholar 

  • Hemmati-Brivanlou A, Melton DA (1994) Inhibition of activin receptor signaling promotes neuralization in Xenopus. Cell 77:273–281

    Article  PubMed  CAS  Google Scholar 

  • Hertwig O (1906) Die Entwicklungslehre im 16. bis 18. Jahrhundert. In: Hertwig O (Hrsg) Handbuch der vergleichenden und experimentellen Entwicklungslehre der Wirbeltiere. Fischer, Jena, S 1–12

    Google Scholar 

  • Heymann S, Koudrova M, Arnold HH, Köster M, Braun T (1996) Regulation and function of SF/HGF during migration of limb muscle precursor cells in chicken. Dev Biol 180:655–689

    Article  Google Scholar 

  • Heyner S, Garside WT (1994) Biological actions of IGFs in mammalian development. Bio Essays 16:55–57

    CAS  Google Scholar 

  • His W (1868) Untersuchungen über die erste Anlage des Wirbelthierleibes. Vogel, Leipzig

    Google Scholar 

  • Hooper J, Scott MP (1989) The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 59:751–765

    Article  PubMed  CAS  Google Scholar 

  • Hornbruch A, Wolpert L (1970) Cell division in the early growth and morphogenesis of the chick limb. Nature 226:764–766

    Article  PubMed  CAS  Google Scholar 

  • Howe A, Aplin AE, Suresh K, Alahari K, Juliano RL (1998) Integrin signaling and cell growth control. Curr Opin Cell Biol 10:220–231

    Article  PubMed  CAS  Google Scholar 

  • Hrabé de Angelis M, McIntyre JN, Gossler A (1997) Maintenance of somite borders in mice requires the Delta homologue DII1. Nature 386:717–721

    Article  Google Scholar 

  • Huang R, Zhi Q, Christ B (2003) The relationship between limb muscle and endothelial cells migrating from Single somite. Anat Embryol 206:283–289

    PubMed  Google Scholar 

  • Hurle JM, Ros MA, Climent V, Garcia-Martinez V (1996) Morphology and significance of programmed cell death in the developing limb bud of the vertebrate embryo. Microsc Res Tech 34:236–246

    Article  PubMed  CAS  Google Scholar 

  • Hynes RO (1992) Integrins: versatility, modulation, and signalling in cell adhesion. Cell 69:11–25

    Article  PubMed  CAS  Google Scholar 

  • Ingham PW (1994) Hedgehog points the way. Curr Biol 4:347–350

    Article  PubMed  CAS  Google Scholar 

  • Irvine KD (1999) Fringe, notch, and making developmental boundaries. Curr Opin Genet Dev 9:434–441

    Article  PubMed  CAS  Google Scholar 

  • Jahoda C, Reynolds A (2001a) Skin stem cells-a hairy issue. Nature Med 6:1095–1097

    Google Scholar 

  • Jahoda C, Reynolds A (2001b) Hair follicle dermal sheath cells: unsung partieipants in wound healing. Lancet 358:1445–1148

    Article  PubMed  CAS  Google Scholar 

  • Jessell TM, Bovolenta P, Placzek M, Tessier-Lavigne M, Dodd J (1989) Polarity and patterning in the neural tube: the origin and function of the floor plate. Ciba Found Symp 144:255–276

    PubMed  CAS  Google Scholar 

  • Johnson RL, Laufer E, Riddle RD, Tabin C (1994) Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites. Cell 79:1165–1173

    Article  PubMed  Google Scholar 

  • Joubin K, Stern CD (1999) Molecular interactions continuously define the organizer during the cell movements of gastrulation. Cell 98:559–571

    Article  PubMed  CAS  Google Scholar 

  • Kapfhammer JP, Raper JA (1987) Collapse of growth cone strueture on contact with specific neurites in culture. J Neurosci 7:201–212

    PubMed  CAS  Google Scholar 

  • Kaye PL (1993) Insulin-like growth factors: growth in the family. Cell 73:1059–1065

    Google Scholar 

  • Keller SA, Jones JM, Boyle A, Barrow LL, Killen PD, Green DG, Kapousta NV et al (1994) Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus. Genomics 23:309–320

    Article  PubMed  CAS  Google Scholar 

  • Kempermann G, Kuhn HG, Gage FH (1998) Experience-induced neurogenesis in the senescent dentage gyrus. J Neurosci 18:3206–3212

    PubMed  CAS  Google Scholar 

  • Kennedy TE, Serafini T, de la Torre JR, Tessier-Lavigne M (1994) Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78:425–435

    Article  PubMed  CAS  Google Scholar 

  • Kessel M, Gruss P (1990) Murine developmental control genes. Science 249:374–379

    Article  PubMed  CAS  Google Scholar 

  • Kessel M, Gruss P (1991) Homeotic transformation of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 67:89–104

    Article  PubMed  CAS  Google Scholar 

  • Keynes R, Lumsden A (1990) Segmentation and the origin of regional diversily in the vertebrate central nervous system. Neuron 4:1–9

    Article  PubMed  CAS  Google Scholar 

  • Keynes R, Cook GM (1995) Axon guidance molecules. Cell 83:161–169

    Article  PubMed  CAS  Google Scholar 

  • Keynes R, Tannahill D, Morgenstern DA, Johnson AR, Cook GM, Pini A (1997) Surround repulsion of spinal sensory axons in higher vertebrate embryos. Neuron 18:889–897

    Article  PubMed  CAS  Google Scholar 

  • Kim H, Schagat T (1996) Neuroblasts: a model for the asymmetric division of cells. Trends Genet 13:33–39

    Google Scholar 

  • Kim SK, MacDonald RJ (2002) Signaling and transcriptional control of pancreatic organogenesis. Curr Opin Gen Dev 12:540–547

    Article  CAS  Google Scholar 

  • Kim SK, Seleri L, Lee JS, Zhang AY, Gu X, Jacobs Y, Cleary ML (2002) Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nat Genet 30:430–435

    Article  PubMed  CAS  Google Scholar 

  • Korn J, Christ B, Kurz H (2002) Neuroectodermal origin of brain pericytes and vascular smooth muscle cells. J Comp Neurol 442:78–88

    Article  PubMed  Google Scholar 

  • Kostakopoulou K, Vogel A, Brickell P, Tickle C (1996) Regeneration of wing bud stumps of chick embryos and reactivation of Msx-1 and shh expression in response to FGF-4 and ridge Signals. Mech Dev 55:119–131

    Article  PubMed  CAS  Google Scholar 

  • Kreis T, Vale R (1999) Guidebook to the extracellular matrix and adhesion proteins, 2nd edn. Oxford University Press

    Google Scholar 

  • Kuhn HG, Dickinson-Anson H, Gage FH (1996) Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci 16:2027–2033

    PubMed  CAS  Google Scholar 

  • Kuhn K (1987) The classical collagens: types I, II and III. In: Mayne R, Burgeson RE (eds) Structure and function of collagen types. Academic press, London, 1–42

    Google Scholar 

  • Kumagai A, Dunphy WG (1991) The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free System. Cell 64:903–914

    Article  PubMed  CAS  Google Scholar 

  • Kurz H, Christ B (2002) Vascular development of the brain and spinal cord. In: Tomanek RJ (ed) Assembly of the vascular and its regulation. Birkhäuser, Boston, 157–191

    Google Scholar 

  • Leshem Y, Spicer DB, Gal-Levi R, Halevy O (2000) Hepatocyte growth factor (HGF) inhibits skeletal muscle cell differentiation: a role for the bHLH protein twist and the cdk inhibitor p27. J Cell Physiol 184:101–109

    Article  PubMed  CAS  Google Scholar 

  • Levi-Montalcini R (1958) Chemical Stimulation of nerve growth. In: McElroy and Glass (eds) The chemical basis of development. Hopkins, Baltimore, 646–664

    Google Scholar 

  • Levi-Montalcini R (1976) The nerve growth factor: its role in growth, differentiation and function of the sympathetic adrenergic neuron. Prog Brain Res 45:235–258

    Article  PubMed  CAS  Google Scholar 

  • Levin M, Johnson RL, Stern CD, Kuehn MR, Tabin CJ (1995) A molecular pathway determining left-right asymmetric in chick embryogenesis. Cell 82:803–814

    Article  PubMed  CAS  Google Scholar 

  • Levin M, Pagän S, Roberts DJ, Cooke J, Kuehn MR, Tabin CJ (1997) Left-right patterning signals and the independent regulation of different aspects of situs in the chick embryo. Dev Biol 189:57–67

    Article  PubMed  CAS  Google Scholar 

  • Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B, McMahon AP (2001) Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc 1. Cell 105:599–610

    Article  PubMed  CAS  Google Scholar 

  • Loomis CA, Harris E, Michaud J, Wurst W, Hanks M, Joyner AL (1996) The mouse Engrailed-1 gene and ventral limb patterning. Nature 382:360–363

    Article  PubMed  CAS  Google Scholar 

  • Lowes KN, Croager EJ, Olynyk JK, Abraham LJ, Yeoh GC (2003) Oval cell-mediated liver regeneration: role of cytokines and growth factor. J Gastroenterol Hepatol 18:4–12

    Article  PubMed  CAS  Google Scholar 

  • Lumsden A (1991) Cell lineage restrictions in the chick embryo hindbrain. Phil Trans Roy Soc Lond 331:281–286

    Article  CAS  Google Scholar 

  • Maier H, Hagman J (2002) Roles of EBF and Pax-5 in B lineage commitment and development. Science 14:415–422

    CAS  Google Scholar 

  • Mansouri A, Gruss P (1998) Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord. Mech Dev 78:171–178

    Article  PubMed  CAS  Google Scholar 

  • Mark von der K, Goodman S (1993) Adhesive glycoproteins. In: Royce PM, Steinman B (eds) Connective tissue and its heritable disorders. Wiley-Liss, New York, 211–236

    Google Scholar 

  • Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ (1996a) Biochemical evidence that patched is the hedgehog receptor. Nature 384:176–179

    Article  PubMed  CAS  Google Scholar 

  • Marigo V, Johnson RL, Vortkamp A, Tabin CJ (1996b) Sonic hedgehog differentially regulates expression of GLI and GLI13 during limb development. Dev Biol 180:273–283

    Article  PubMed  CAS  Google Scholar 

  • McConnell SK, Kaznowski CE, O’Rourke NA, Dailey ME, Roberts JS (1996) Neurogenesis, determination and migration during cerebral cortical development. In: Bernfield (ed) Molecular basis of morphogenesis. Wiley-Liss, New York, 135–154

    Google Scholar 

  • McMahon AP, Moon RT (1989) int-1-a proto-oncogene involved in cell signalling. Development 107:161–167

    PubMed  CAS  Google Scholar 

  • McPherron AC, Lawler AM, Lee S-J (1997) Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature 387:83–90

    Article  PubMed  CAS  Google Scholar 

  • Metzstein MK, Stansfield GM, Horvitz HR (1998) Genetics of programmed cell death in C. elegans: past present and future. Trends Gene 14:410–417

    Article  CAS  Google Scholar 

  • Mo R, Freer AM, Zinyk DL, Crackower MA, Michaud J, Heng HH, Chik KW et al (1997) Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124:113–123

    PubMed  CAS  Google Scholar 

  • Molkentin JD, Olson EN (1996) Defining the regulatory networks for muscle development. Curr Opin Gen Dev 6:445–453

    Article  CAS  Google Scholar 

  • Monsoro-Burq A-H, Le Douarin N (2000) Duality of molecular signaling involved in vertebral chondrogenesis. Dev Biol 48:43

    CAS  Google Scholar 

  • Moore MW, Klein RD, Farinas I, Sauer H, Armanini M, Phillips H, Reichardt LF et al (1996) Renal and neuronal abnormalities in mice lacking GDNF. Nature 382:76–79

    Article  PubMed  CAS  Google Scholar 

  • Münsterberg AE, Lassar AB (1995) Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the somite. Development 121:651–660

    PubMed  Google Scholar 

  • Muneoka K, Fox W, Bryant SV (1986) Cellular contribution from dermis and cartilage to the regenerating limb blastema in axolotls. Dev Biol 116:256–260

    Article  PubMed  CAS  Google Scholar 

  • Murray A, Hunt T (1993) The cell cycle: An introduction. Oxford University Press

    Google Scholar 

  • Newton K, Strasser A (1998) The Bcl-2 family and cell death regulation. Curr Opin Gen Dev 8:68–75

    Article  CAS  Google Scholar 

  • Niswander L, Tickle C, Vogel A, Booth I, Martin GR (1993) FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75:579–587

    Article  PubMed  CAS  Google Scholar 

  • Niswander L, Jeffrey S, Martin GR, Tickle C (1994) A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371:609–612

    Article  PubMed  CAS  Google Scholar 

  • Nonaka S, Tanaka Y, Okada Y, Takeda S, Havada A, Kanai Y, Kido M et al (1998) Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95:829–837

    Article  PubMed  CAS  Google Scholar 

  • Nusse R (1990) The int genes in mouse mammary tumorgenesis and in normal development. Ciba Found Symp 150:212–222

    PubMed  CAS  Google Scholar 

  • Ohuchi H, Nakagawa T, Yamamoto A, Araga A, Ohata T, Ishimaru Y, Yoshioka H et al (1997) The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 124:2235–2244

    PubMed  CAS  Google Scholar 

  • Oh S-J, Jeltsch MM, Birkenhäger R, McCarthy JE, Weich HA, Christ B, Alitalo K et al (1997) VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane. Dev Biol 188:96–109

    Article  PubMed  CAS  Google Scholar 

  • Orike N, Pini A (1996) Axon guidance: following the Eph plan. Curr Biol 6:108–110

    Article  PubMed  CAS  Google Scholar 

  • Othman-Hassan K, Patel K, Papoutsi M, Rodriguez-Niedenführ M, Christ B, Wilting J (2001) Arterial identity of endothelial cells is controlled by local cues. Dev Biol 237:398–209

    Article  PubMed  CAS  Google Scholar 

  • Pachnis V, Mankoo B, Costantini F (1993) Expression of the c-ret proto-oncogene during mouse embryogenesis. Development 119:1005–1017

    PubMed  CAS  Google Scholar 

  • Palmeirim I, Henrique D, Ish-Horowicz D, Pourquie O (1997) Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis. Cell 91:639–648

    Article  PubMed  CAS  Google Scholar 

  • Patel K, Christ B, Stockdale FE (2002) Control of muscle size during embryonic, fetal, and adult life. In: Brand-Saberi B (ed) Results and problems in cell differentiation. Vertebrate myogenesis, vol 38. Springer, Berlin Heidelberg New York Tokyo, pp 163–186

    Google Scholar 

  • Pearse RV, Tabin CJ (1998) The molecular ZPA. J Exp Zool 282:677–690

    Article  PubMed  CAS  Google Scholar 

  • Peters G, Lee AE, Dickson C (1986) Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus. Nature 320:628–631

    Article  PubMed  CAS  Google Scholar 

  • Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ et al (1996) Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382:73–76

    Article  PubMed  CAS  Google Scholar 

  • Placzek M, Furley A (1996) Patterning cascades in the neural tube. Neural development. Curr Biol 6:526–529

    Article  PubMed  CAS  Google Scholar 

  • Pourquié O (1999) Notch around the clock. Curr Opin Genet Dev 9:559–565

    Article  PubMed  Google Scholar 

  • Psychoyos D, Stern CD (1996) Fates and migratory routes of primitive streak cells in the chick embryo. Development 122:1523–1534

    PubMed  CAS  Google Scholar 

  • Raff MC (1996) Size control: the regulation of cell numbers in animal development. Cell 86:173–175

    Article  PubMed  CAS  Google Scholar 

  • Rice DS, Curran T (2001) Role of the reelin signaling pathway in central nervous system development. Ann Rev Neurosci 24:1005–1039

    Article  PubMed  CAS  Google Scholar 

  • Riddle RD, Johnson RL, Laufer E, Tabin C (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75:1401–1416

    Article  PubMed  CAS  Google Scholar 

  • Riddle RD, Ensini M, Nelson C, Tsuchida T, Jessell TM, Tabin C (1995) Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell 83:631–640

    Article  PubMed  CAS  Google Scholar 

  • Risau W (1995) Differentiation of endothelium. FASEB J 9:926–933

    PubMed  CAS  Google Scholar 

  • Risau W (1997) Mechanisms of angiogenesis. Nature 386:671–674

    Article  PubMed  CAS  Google Scholar 

  • Roberts AB, Sporn MB (1990) The transforming growth factor-betas: past, present, and future. Ann NY Acad Sci 593:1–6

    Article  PubMed  Google Scholar 

  • Rodriguez-Esteban C, Capdevila J, Economides AN, Pascual J, Ortiz A, Izipsua Belmonte JC (1999) The novel Cer-like protein caronte mediates the establishment of embryonic left-right asymmetry. Nature 401:243–251

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez-Esteban C, Capdevila J, Kawakami Y, Izipsua Belmonte JC (2001) Wnt signalling and PKA control Nodal expression and left-right determination in the chick embryo. Development 128:3189–3195

    PubMed  CAS  Google Scholar 

  • Roth RA, Stover C, Hari J, Morgan DO, Smith MC, Sara V, Fried VA (1987) Interactions of the receptor for insulin-like growth factor II with mannose-6-phosphatase and antibodies to the mannose-6-phophate receptor. Biochem Biophys Res Commun 149:600–606

    Article  PubMed  CAS  Google Scholar 

  • Rubin L, Saunders JW Jr (1972) Ectodermal-mesodermal interaction in the growth of limb buds in the chick embryo: constancy and temporal limits of the ectodermal induction. Dev Biol 28:94–112

    Article  PubMed  CAS  Google Scholar 

  • Rudnicki MA, Schnegelsberg PN, Stead RH, Braun T, Arnold HH, Jaenisch R (1993) MyoD or Myf-5 is required for the formation of skeletal muscle. Cell 75:1351–1359

    Article  PubMed  CAS  Google Scholar 

  • Sanchez MP, Silos-Santiago I, Frisen J, He B, Lira SA, Barbacid M (1996) Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382:70–73

    Article  PubMed  CAS  Google Scholar 

  • Sasai Y, Lu B, Steinbesser H, De Robertis EM (1995) Regulation of neural induction by the Chd and BMP-4 antagonistic patterning signals in Xenopus. Nature 376:333–336

    Article  PubMed  CAS  Google Scholar 

  • Saunders JW (1948) The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. J Exp Zool 108:363–403

    Article  PubMed  Google Scholar 

  • Saunders JW Jr (1966) Death in embryonic Systems. Science 154:604–612

    Article  PubMed  Google Scholar 

  • Scaal M, Pröls F, Füchtbauer EM, Patel K, Hornik C, Köhler T, Christ B et al (1999) BMPs induce dermal markers and ectopic feather tracts. Mech Dev 110:51–60

    Article  Google Scholar 

  • Schlange T, Schnipkoweit I, André B, Ebert A, Zile MH, Arnold HH, Brand T (2001) Chick CFC controls Lefty 1 expression in the embryonic midline and nodal expression in the lateral plate. Dev Biol 234:376–389

    Article  PubMed  CAS  Google Scholar 

  • Schlange T, Arnold HH, Brand T (2002) BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo. Development 129:3421–3429

    PubMed  CAS  Google Scholar 

  • Schmidt C, Christ B, Patel K, Brand-Saberi B (1998) Experimental induction of BMP-4 expression leads to apoptosis in the paraxial and lateral plate mesoderm. Dev Biol 202:253–263

    Article  PubMed  CAS  Google Scholar 

  • Schmidt C, Christ B, Maden M, Brand-Saberi B, Patel K (2001) Regulation of EphA4 expression in paraxial and lateral plate mesoderm by ectoderm-derived Signals. Dev Dyn 220:377–386

    Article  PubMed  CAS  Google Scholar 

  • Schnabel C, Godin R, Cleary M (2003) Pbxl regulates nephrogenesis and ureteric branching in the developing kidney. Dev Biol 254:262–276

    Article  PubMed  CAS  Google Scholar 

  • Schwann T (1839) Mikroskopische Untersuchungen über die Übereinstimmung in der Struktur und im Wachstum der Tiere und Pflanzen. Berlin

    Google Scholar 

  • Schwitzgebel VM (2001) Programming of the pancreas. Mol Cell Endocrinol 185:99–108

    Article  PubMed  CAS  Google Scholar 

  • Seale P, Sabourin LA, Girgis-Gabardo A, Mansouri A, Gruss P, Rudnicki MA (2000) Pax7 is required for the specification of myogenic satelite cells. Cell 102:777–786

    Article  PubMed  CAS  Google Scholar 

  • Seil S (2001) Heterogeneity and plasticity of hepatocyte lineage cells. Hepatology 33:738–750

    Article  Google Scholar 

  • Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, Tesiier-Lavigne M (1996) Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous System. Cell 87:1001–1004

    Article  PubMed  CAS  Google Scholar 

  • Slack JM (2001) Essential developmental biology. Blackwell, Oxford

    Google Scholar 

  • Smith JL, Schoenwolf GC (1998) Getting organized: new insights into the organizer of higher vertebrates. Curr Top Dev Biol 40:79–110

    Article  PubMed  CAS  Google Scholar 

  • Snider WD (1994) Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77:627–638

    Article  PubMed  Google Scholar 

  • Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P (1997) The Pax4 gene is essential for differentiation of insulin-producing β-cells in mammalian pancreas. Nature 386:399–402

    Article  PubMed  CAS  Google Scholar 

  • Sosic D, Brand-Saberi B, Schmidt C, Christ B, Olson EN (1997) Regulation of paraxis expression and somite formation by ectoderm-and neural tube-derived Signals. Dev Biol 185:229–243

    Article  PubMed  CAS  Google Scholar 

  • Spemann H, Mangold H (1924) Über Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren. Roux Arch Entw Mech Org 100:599–638

    Google Scholar 

  • Spemann H, Schotté O (1932) Über xenoplastische Translation als Mittel zur Analyse der embryonalen Induktion. Naturwissenschaften 20:463–467

    Article  Google Scholar 

  • Srinivas S, Wu Z, Chen C-M, D’Agati V, Constantini F (1999) Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development. Development 126:1375–1386

    PubMed  CAS  Google Scholar 

  • St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P (1997) Pax6 is required for differentiation of glucagon-producing alphacells in mouse pancreas. Nature 387:406–409

    Article  PubMed  CAS  Google Scholar 

  • Summerbell D (1974) Interaction between the proximo-distal and antero-posterior co-ordinates of positional value during the specification of positional information in the early development of the chick limb bud. J Embryol Exp Morphol 32:227–237

    PubMed  CAS  Google Scholar 

  • Summerbell D, Lewis JH, Wolpert L (1973) Positional information in chick limb morphogenesis. Nature 244:492–496

    Article  PubMed  CAS  Google Scholar 

  • Sun X, Mariani FV, Martin GR (2002) Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature 418:501–509

    Article  PubMed  CAS  Google Scholar 

  • Tajbakhsh S, Borello U, Vivarelli E, Kelly R, Papkoff J, Duprez D, Buckingham M et al (1998) Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5. Development 125:4155–4162

    PubMed  CAS  Google Scholar 

  • Takeichi M (1990) Cadherins: a molecular family important in selective cell-cell adhesion. Ann Rev Biochem 59:237–252

    Article  PubMed  CAS  Google Scholar 

  • Takeichi M (1995) Morphogenetic roles of classis cadherins. Curr Opin Cell Biol 7:619–627

    Article  PubMed  CAS  Google Scholar 

  • Tatsumi R, Anderson JE, Nevoret CJ, Halevy O, Allen RE (1998) HGF/SF is present in normal adult skeletal muscle and is capable of activating satellite cells. Dev Biol 194:114–128

    Article  PubMed  CAS  Google Scholar 

  • Teillet M-A, Watanabe Y, Jeffs P, Duprez D, Lapointe F, Le Douarin NM (1998) Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages. Development 125:2019–2030

    PubMed  CAS  Google Scholar 

  • Tessier-Lavigne M, Goodman CS (1996) The molecular biology of axon guidance. Science 274:1123–1133

    Article  PubMed  CAS  Google Scholar 

  • Thomson GH (1997) Antagonism within and around the organizer: BMP inhibitors in vertebrate body patterning. Trends Genet 13:209–211

    Article  Google Scholar 

  • Tickle C, Summerbell D, Wolpert L (1975) Positional signalling and specification of digits in chick limb morphogenesis. Nature 254:199–202

    Article  PubMed  CAS  Google Scholar 

  • Toma JG, Akhavan M, Fernandes K, Barnabé-Heider F, Sadikots A, Kaplan D, Moller F (2001) Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nature Cell Biol 3:778–784

    Article  PubMed  CAS  Google Scholar 

  • Torres M, Gomez-Pardo E, Dressler GR, Gruss P (1995) Pax-2 controls multiple Steps of urogenital development. Development 121:4057–4065

    PubMed  CAS  Google Scholar 

  • Trusolino L, Cavassa S, Angelini P, Ando M, Bertotti A, Comoglio PM, Boccaccio C (2000) HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity. FASEB J 14:1629–1640

    Article  PubMed  CAS  Google Scholar 

  • Tsuchida T, Endini M, Morton SB, Baldassare M, Edlund T, Jessell TM, Pfaff SL (1994) Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79:957–970

    Article  PubMed  CAS  Google Scholar 

  • Vikkula M, Boon LM, Carraway KL 3rd, Calvert JT, Diamonti AJ, Goumnerov B, Pasyk KA et al (1996) Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell 87:1181–1190

    Article  PubMed  CAS  Google Scholar 

  • Vikkula M, Boon LM, Mulliken JB, Olsen BR (1998) Molecular basis of vascular anomalies. Trends Cardiovasc Med 8:281–291

    Article  PubMed  CAS  Google Scholar 

  • Vogel A, Rodriguez C, Warnken W, Izipsua Belmonte JC (1995) Dorsal cell fate specified by chick Lmx1 during vertebrate limb development. Nature 378:716–720

    Article  PubMed  CAS  Google Scholar 

  • Wagner J, Schmidt C, Nikowits W, Christ B (2001) Compart-mentalization of the somite and myogenesis in chick embryos are influenced by Wnt expression. Dev Biol 228:86–94

    Article  CAS  Google Scholar 

  • Wagner M, Adler G (2002) Somatische Stammzellen des Pankreas. Perspektiven für die Transplantationsmedizin. Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz 45:102–107

    Article  Google Scholar 

  • Wallace H (1981) „Vertebrate limb regeneration“. Wiley, Chichester

    Google Scholar 

  • Wanek N, Muneoka K, Bryant D (1989) Evidence for regulation following amputation and tissue grafting in the developing mouse limb. J Exp Zool 249:55–61

    Article  PubMed  CAS  Google Scholar 

  • Wang HU, Chen ZF, Anderson DJ (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin B2 and its receptor EphB4. Cell 93:741–753

    Article  PubMed  CAS  Google Scholar 

  • Warady BA, Cibis G, Alon V, Blowey D, Hellerstein S (1994) Senior-Loken syndrome: revisited. Pediatrics 94:111–112

    PubMed  CAS  Google Scholar 

  • Watson JD, Crick FHC (1953) Molecular structure of nucleic acids. A structure for desoxyribose nucleic acids. Nature 171:737–738

    CAS  Google Scholar 

  • Weinmaster G (1998) Notch signaling: direct or what? Curr Opin Gen Dev 8:436–442

    Article  CAS  Google Scholar 

  • Weintraub H (1993) The myoD family and myogenesis: redundancy, networks and thresholds. Cell 75:1241–1244

    Article  PubMed  CAS  Google Scholar 

  • Weismann A (1885) Die Continuität des Keimplasmas als Grundlage einer Theorie der Vererbung. Fischer, Jena, 101–207

    Google Scholar 

  • Wetering van de M, de Lau W, Clevers H (2002) WNT signaling and lymphocyte development. Cell 109:13–29

    Article  Google Scholar 

  • Willert K, Nusse R (1998) β-Catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev 8:95–102

    Article  PubMed  CAS  Google Scholar 

  • Willmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385:810–813

    Article  Google Scholar 

  • Wilting J, Ebensperger C, Müller TS, Koseki H, Wallin J, Christ B (1995) Pax-1 in the development of the cervico-occipital transitional zone. Anat Embryol 192:221–227

    Article  PubMed  CAS  Google Scholar 

  • Wilting J, Papoutsi M, Othman-Hassan K, Rodriguez-Niedenführ M, Pröls F, Tomarev SI, Eichmann A (2001) Development of the avian lymphatic System. Microsc Res Tech 55:81–91

    Article  PubMed  CAS  Google Scholar 

  • Wilting J, Papoutsi M, Christ B, Nicolaides K, von Kaisenberg C, Borges J, Stark G et al (2002) The transcription factor Prox 1 is a marker for lymphatic endothelial cells in normal and diseased human tissues. FASEB J 16:1271–1273

    PubMed  CAS  Google Scholar 

  • Wilting J, Tomarev S, Christ B (2003) Lymphangioblasts in embryonic lymphangiogenesis. Lymph Res Biol 1:33–36

    Article  Google Scholar 

  • Wodarz A, Nüsse R (1998) Mechanisms of Wnt signaling in development. Ann Rev Cell Dev Biol 14:59–88

    Article  CAS  Google Scholar 

  • Wolf E, Zakhartchenko V, Brem G (1998) Nuclear transfer in mammals: recent developments and future perspectives. J Biotechnol 65:99–110

    Article  PubMed  CAS  Google Scholar 

  • Wolff CF (1759) Theoria generationis. Dissertation, Halle

    Google Scholar 

  • Yamada T, Placzek M, Tanaka H, Dodd J, Jessell T (1991) Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord. Cell 64:635–647

    Article  PubMed  CAS  Google Scholar 

  • Yamada T, Pfaff SL, Edlund T, Jessell TM (1993) Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate. Cell 73:673–686

    Article  PubMed  CAS  Google Scholar 

  • Zapf J, Waldvogel M, Froesch ER (1975) Binding of non-suppressible insulin-like activity to human serum. Arch Biochem Biophys 168:638–645

    Article  PubMed  CAS  Google Scholar 

  • Zeng X, Goetz JA, Suber LM, Scott WJ, Schreiner CM, Robbins DJ (2001) A freely diffusible form of Sonic hedgehog mediates long-range signaling. Nature 411:716–720

    Article  PubMed  CAS  Google Scholar 

  • Zhou Y, Yamamoto M, Engel JD (2000) GATA2 is required for the generation of V2 interneurons. Development 127:3829–3838

    PubMed  CAS  Google Scholar 

  • Zimmermann A (2002) Liver regeneration: the emergence of new pathways. Med Sci Monit 8:53–63

    Google Scholar 

  • Zuniga A, Quillet R, Perrin-Schmitt F, Zeller R (2002) Mouse twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis. Mech Dev 114:51–59

    Article  PubMed  CAS  Google Scholar 

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Christ, B., Brand-Saberi, B. (2005). Mechanismen der Steuerung der Embryonalentwicklung. In: Ganten, D., Ruckpaul, K. (eds) Molekularmedizinische Grundlagen von fetalen und neonatalen Erkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26524-4_1

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