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Neuroendocrine Complications of Cancer Therapy

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Survivors of Childhood and Adolescent Cancer

Part of the book series: Pediatric Oncology ((PEDIATRICO))

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References

  1. Biller BM, Samuels MH, Zagar A, Cook DM, Arafah BM, Bonert V, Stavrou S, Kleinberg DL, Chipman JJ, Hartman ML (2002) Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab 87:2067–2079

    Article  PubMed  Google Scholar 

  2. Blatt J, Bercu BB, Gillin JC, Mendelson WB, Poplack DG (1984) Reduced pulsatile growth hormone secretion in children after therapy for acute lymphoblastic leukemia. J Pediatr 104:182–186

    PubMed  Google Scholar 

  3. Blethen SL, Allen DB, Graves D, August G, Moshang T, Rosenfeld R (1996) Safety of recombinant deoxyribonucleic acid-derived growth hormone: The National Cooperative Growth Study Experience. J Clin Endocrinol Metab 81:1704–1710

    Article  PubMed  Google Scholar 

  4. Boepple PA, Crowley WF Jr (1996) Precocious puberty. In: Adashi EY, Rock JA, Rosenwaks Z (eds) Reproductive endocrinology, surgery, and technology, vol 1. Lippincott-Raven, Philadelphia, p 989

    Google Scholar 

  5. Bourguignon JP, Pierard GE, Ernould C, Heinrichs C, Craen M, Rochioccioli P, Arrese JE, Franchimont C (1993) Effects of human growth hormone therapy on melanocytic naevi. Lancet 341:1505–1506

    Article  PubMed  Google Scholar 

  6. Brauner R, Malandry F, Rappaport R, Zucker JM, Kalifa C, Pierre-Kahn A, Bataini P, Dufier JL (1990) Growth and endocrine disorders in optic glioma. Eur J Pediatr 149:825–828

    Article  PubMed  Google Scholar 

  7. Burstein S (1994) Growth disorders after cranial radiation in childhood. J Clin Endocrinol Metab 78:1280–1281

    Article  PubMed  Google Scholar 

  8. Cassorla F, Mericq V, Eggers M, Avila A, Garcia C, Fuentes A, Rose SR, Cutler GB Jr (1997) Effects of luteinizing hormone-releasing hormone analog-induced pubertal delay in growth hormone (GH)-deficient children treated with GH: preliminary results. J Clin Endocrinol Metab 82:3989–3992

    Article  PubMed  Google Scholar 

  9. Chrousos GP (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332:1351–1362

    PubMed  Google Scholar 

  10. Clayton RN (1996) Short Synacthen test versus insulin stress test for assessment of the hypothalamo-pituitaryadrenal axis: controversy revisited. Clin Endocrinol (Oxf) 44:147–149

    Article  Google Scholar 

  11. Constine LS, Woolf PD, Cann D, Mick G, McCormick K, Raubertas RF, Rubin P (1993) Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med 328:87–94

    PubMed  Google Scholar 

  12. Cummings DE, Merriam GR (2003) Growth hormone therapy in adults. Annu Rev Med 54:513–33

    Article  PubMed  Google Scholar 

  13. Elias AN, Gwinup G (1980) Effects of some clinically encountered drugs on steroid synthesis and degradation. Metabolism 29:582–592

    Article  PubMed  Google Scholar 

  14. Ferretti E, Persani L, Jaffrain-Rea ML, Giambona S, Tamburrano G, Beck-Peccoz P (1999) Evaluation of the adequacy of levothyroxine replacement in patients with central hypothyroidism. J Clin Endocrinol Metab 84:924–929

    Article  PubMed  Google Scholar 

  15. Fouladi M, Wallace D, Langston JW, Mulhern R, Rose SR, Gajjar A, Sanford RA, Merchant TE, Jenkins JJ, Kun LE, Heideman RL (2003) Survival and functional outcome of children with hypothalamic/chiasmatic tumors. Cancer 97:1084–1092

    Article  PubMed  Google Scholar 

  16. Gilchrist FJ, Murray RD, Shalet SM (2002) The effect of long-term untreated growth hormone deficiency (GHD) and 9 years of GH replacement on the quality of life (QoL) of GH-deficient adults. Clin Endocrinol (Oxf) 57:363–370

    Article  Google Scholar 

  17. Growth Hormone Research Society (2000) Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab 85:3990–3993

    Google Scholar 

  18. Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, Hasemeier CM (1997) Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics 99:505–512

    Article  PubMed  Google Scholar 

  19. Hovi L, Saarinen-Pihkala UM, Vettenranta K, Lipsanen M, Tapanainen P (1999). Growth in children with poor-risk neuroblastoma after regimens with or without total body irradiation in preparation for autologous bone marrow transplantation. Bone Marrow Transplant 24:1131–1136

    Article  PubMed  Google Scholar 

  20. Kaste SC, Jones-Wallace D, Rose SR, Boyett JM, Lustig RH, Rivera GK, Pui CH, Hudson MM (2001) Bone mineral decrements in survivors of childhood acute lymphoblastic leukemia: frequency of occurrence and risk factors for their development. Leukemia 15:728–734

    Article  PubMed  Google Scholar 

  21. Lam KS, Tse VK, Wang C, Yeung RT, Ho JH (1991) Effects of cranial irradiation on hypothalamic-pituitary function — a 5-year longitudinal study in patients with nasopharyngeal carcinoma. Q J Med 78:165–176

    PubMed  Google Scholar 

  22. Lee HM, Zhu J, Wheeler GC, Helton KJ, Merchant TE (2002) The influence of hydrocephalus on pre-irradiation IQ and endocrine function in children with infratentorial ependymoma. 44th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), New Orleans, LA, 6–10 Oct 2002. Int J Radiat Oncology Biol Phys 54:150

    Article  Google Scholar 

  23. Lee KO, Persani L, Tan M, Sundram FX, Beck-Peccoz P (1995) Thyrotropin with decreased biological activity, a delayed consequence of cranial irradiation for nasopharyngeal carcinoma. J Endocrinol Invest 18:800–805

    PubMed  Google Scholar 

  24. Leung W, Hudson MM, Strickland DK, Phipps S, Srivastava DK, Ribeiro RC, Rubnitz JE, Sandlund JT, Kun LE, Bowman LC, Razzouk BI, Mathew P, Shearer P, Evans WE, Pui CH (2000) Late effects of treatment in survivors of childhood acute myeloid leukemia. J Clin Oncol 18:3273–3279

    PubMed  Google Scholar 

  25. Leung W, Hudson M, Zhu Y, Rivera GK, Ribeiro RC, Sandlund JT, Bowman LC, Evans WE, Kun L, Pui CH (2000) Late effects in survivors of infant leukemia. Leukemia 14:1185–1190

    Article  PubMed  Google Scholar 

  26. Leung W, Rose SR, Zhou Y, Hancock ML, Burstein S, Schriock EA, Lustig R, Danish RK, Evans WE, Hudson MM, Pui CH (2002) Outcomes of growth hormone replacement therapy in survivors of childhood acute lymphoblastic leukemia. J Clin Oncol 20:2959–2964

    Article  PubMed  Google Scholar 

  27. Lustig RH (2001) The neuroendocrinology of childhood obesity. Pediatr Clin North Am 48:909–930

    Article  PubMed  Google Scholar 

  28. Lustig RH, Rose SR, Burghen GA, Velasquez-Mieyer P, Broome DC, Smith K, Li H, Hudson MM, Heideman RL, Kun LE (1999) Hypothalamic obesity caused by cranial insult in children: altered glucose and insulin dynamics and reversal by a somatostatin agonist. J Pediatr 135:162–168

    PubMed  Google Scholar 

  29. Lustig RH, Post SR, Srivannaboon K, Rose SR, Danish RK, Burghen GA, Xiong X, Wu S, Merchant TE (2003) Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab 88:611–616

    Article  PubMed  Google Scholar 

  30. Lustig RH, Hinds PS, Ringwald-Smith K, Christensen RK, Kaste SC, Schreiber RE, Rai SN, Lensing SY, Wu S, Xiong X (2003) Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial. J Clin Endocrinol Metab 88:2586–2592

    Article  PubMed  Google Scholar 

  31. Merchant TE, Pritchard DL, Vargo JA, Sontag MR (2001) Radiation therapy for the treatment of childhood medulloblastoma: the rationale for current techniques, strategies, and dose-volume considerations. Electro Med 69:69–71

    Google Scholar 

  32. Merchant TE, Williams T, Smith JM, Rose SR, Danish RK, Burghen GA, Kun LE, Lustig RH (2002) Pre-irradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function. Int J Radiat Oncol Biol Phys 54:45–50

    Article  PubMed  Google Scholar 

  33. Merchant TE, Kiehna EN, Sanford RA, Mulhern RK, Thompson SJ, Wilson MW, Lustig RH, Kun LE (2002) Craniopharyngioma: the St Jude Children's Research Hospital experience 1984–2001. Int J Radiat Oncol Biol Phys 53:533–542

    Article  PubMed  Google Scholar 

  34. Merchant TE, Goloubeva O, Pritchard DL, Gaber MW, Xiong X, Danish RK, Lustig RH (2002) Radiation dosevolume effects on growth hormone secretion. Int J Radiat Oncol Biol Phys 52:1264–1270

    Article  PubMed  Google Scholar 

  35. Merchant TE, Zhu Y, Thompson SJ, Sontag MR, Heideman RL, Kun LE (2002) Preliminary results from a phase II trial of conformal radiation therapy for pediatric patients with localized low-grade astrocytoma and ependymoma. Int J Radiat Oncol Biol Phys 52:325–332

    Article  PubMed  Google Scholar 

  36. Merchant TE, Krasin MJ, Kun LE, Xiong X, Mulhern RK, Khan RB, Danish RK, Boop FA, Sanford RA (2003) Results from a phase II trial of conformal radiation therapy for pediatric patients with localized ependymoma and quantification of radiation-related CNS effects. Proc ASCO 22:789, abstract #3206

    Google Scholar 

  37. Midyett LK, Moore WV, Jacobson JD (2003) Are pubertal changes in girls before age 8 benign? Pediatrics 111:47–51

    Article  PubMed  Google Scholar 

  38. National Center for Chronic Disease Prevention and Health Promotion (2000), www.cdc.gov/growtheharts

    Google Scholar 

  39. Oberfield SE, Soranno D, Nirenberg A, Heller G, Allen JC, David R, Levine LS, Sklar CA (1996) Age at onset of puberty following high-dose central nervous system radiation therapy. Arch Pediatr Adolesc Med 150:589–592

    PubMed  Google Scholar 

  40. Ogilvy-Stuart AL, Clayton PE, Shalet SM (1994) Cranial irradiation and early puberty. J Clin Endocrinol Metab 78:1282–1286

    Article  PubMed  Google Scholar 

  41. Ogilvy-Stuart AL, Stirling HF, Kelnar CJ, Savage MO, Dunger DB, Buckler JM, Shalet SM (1997) Treatment of radiation-induced growth hormone deficiency with growth hormone-releasing hormone. Clin Endocrinol (Oxf) 46:571–578

    Article  Google Scholar 

  42. Olshan JS, Willi SM, Gruccio D, Moshang T Jr (1993) Growth hormone function and treatment following bone marrow transplant for neuroblastoma. Bone Marrow Transplant 12:381–385

    PubMed  Google Scholar 

  43. Packer RJ, Boyett JM, Janss AJ, Stavrou T, Kun L, Wisoff J, Russo C, Geyer R, Phillips P, Kieran M, Greenberg M, Goldman S, Hyder D, Heideman R, Jones-Wallace D, August GP, Smith SH, Moshang T (2001) Growth hormone replacement therapy in children with medulloblastoma: use and effect on tumor control. J Clin Oncol 19:480–487

    PubMed  Google Scholar 

  44. Pitukcheewanont P, Rose SR (1997) Nocturnal TSH surge: a sensitive diagnostic test for central hypothyroidism in children. Endocrinologist 7:226–232

    Google Scholar 

  45. Rose SR (1994) Neuroendocrine basis for insufficient growth hormone and its assessment. In: Savage MO, Bourguignon JP, Grossman AB (eds) Frontiers paediatric neuroendocrinology. Blackwell Scientific, Oxford, p. 149

    Google Scholar 

  46. Rose SR (1995) Isolated central hypothyroidism in short stature. Pediatr Res 38:967–973

    PubMed  Google Scholar 

  47. Rose SR (1996) Induction of puberty in female hypogonadism. Endocrinologist 6:439

    Google Scholar 

  48. Rose SR (2000) Disorders of thyrotropin synthesis, secretion, and function. Curr Opin Pediatr 12:375–381

    Article  PubMed  Google Scholar 

  49. Rose SR (2001) Cranial irradiation and central hypothyroidism. Trends Endocrinol Metab 12:97–104

    Article  PubMed  Google Scholar 

  50. Rose SR, Municchi G (1999) Six-hour and four-hour nocturnal sampling for growth hormone. J Pediatr Endocrinol Metab 12:167–173

    PubMed  Google Scholar 

  51. Rose SR, Nisula BC (1989) Circadian variation of thyrotropin in childhood. J Clin Endocrinol Metab 68:1086–1090

    PubMed  Google Scholar 

  52. Rose SR, Ross JL, Uriarte M, Barnes KM, Cassorla FG, Cutler GB Jr (1988) The advantage of measuring stimulated as compared with spontaneous growth hormone levels in the diagnosis of growth hormone deficiency. N Engl J Med 319:201–207

    PubMed  Google Scholar 

  53. Rose SR, Manasco PK, Pearce S, Nisula BC (1990) Hypothyroidism and deficiency of the nocturnal thyrotropin surge in children with hypothalamic-pituitary disorders. J Clin Endocrinol Metab 70:1750–1755

    PubMed  Google Scholar 

  54. Rose SR, Lustig RH, Pitukcheewanont P, Broome DC, Burghen CA, Li H, Hudson MM, Kun L, Heideman RL. A (1999) Diagnosis of hidden central hypothyroidism in survivors of childhood cancer. J Clin Endocrinol Metab 84:4472

    Article  PubMed  Google Scholar 

  55. Rose SR, Lustig RH, Burstein S, Pitukcheewanont P, Broome DC, Burghen GA(1999) Diagnosis of ACTH deficiency. Comparison of overnight metyrapone test to either low-dose or high-dose ACTH test. Horm Res 52:73–79

    Article  PubMed  Google Scholar 

  56. Rose SR, Danish RK, Schreiber RE, Kearney NS, Hudson MM (2002) ACTH deficiency in childhood cancer survivors. Pediatr Res 51:116A #671

    Google Scholar 

  57. Rose SR, Schreiber RE, Kearney NS, Lustig RH, Danish RK, Burhhan GA, Hudson MM (2004) Hypothalamic dysfunction after chemotherapy. J Pediatr Endocrinol Metab 17:55–66

    PubMed  Google Scholar 

  58. Roth C, Lakomek M, Schmidberger H, Jarry H (2001) Cranial irradiation induces premature activation of the gonadotropin-releasing-hormone. Klin Paediatr 213:239–243

    Article  Google Scholar 

  59. Shalet SM, Beardwell CG, Pearson D, Jones PH (1976) The effect of varying doses of cerebral irradiation on growth hormone production in childhood. Clin Endocrinol (Oxf) 5:287

    Google Scholar 

  60. Shalet SM (1993) Radiation and pituitary dysfunction. N Engl J Med 328:131–133

    Article  PubMed  Google Scholar 

  61. Shankar RR, Jakacki RI, Haider A, Lee MW, Pescovitz OH (1997) Testing the hypothalamic-pituitary-adrenal axis in survivors of childhood brain and skull-based tumors. J Clin Endocrinol Metab 82:1995–1998

    Article  PubMed  Google Scholar 

  62. Sklar CA (1997) Growth and neuroendocrine dysfunction following therapy for childhood cancer. Pediatr Clin North Am 44:489–503

    Article  PubMed  Google Scholar 

  63. Sklar CA, Mertens AC, Mitby P, Occhiogrosso G, Qin J, Heller G, Yasui Y, Robison LL (2002) Risk of disease recurrence and second neoplasms in survivors of childhood cancer treated with growth hormone: a report from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab 87:3136–3141

    Article  PubMed  Google Scholar 

  64. Soule SG, Fahie-Wilson M, Tomlinson S (1996) Failure of the short ACTH test to unequivocally diagnose long-standing symptomatic secondary hypoadrenalism. Clin Endocrinol (Oxf) 44:137–140

    Article  Google Scholar 

  65. Spoudeas HA (1996) Hypothalamic dysregulation after cranio-spinal irradiation for childhood cerebellar tumors. 10th Int Cong Endocrinol, San Francisco, CA,165, #P1–123 (abstract)

    Google Scholar 

  66. Spoudeas HA (2002) Growth and endocrine function after chemotherapy and radiotherapy in childhood. Eur J Cancer 38:1748–1759

    Article  PubMed  Google Scholar 

  67. Spoudeas HA, Charmandari E, Brook CG (2003) Hypothalamo-pituitary-adrenal axis integrity after cranial irradiation for childhood posterior fossa tumors. Med Pediatr Oncol 40:224–229

    Article  PubMed  Google Scholar 

  68. Swerdlow AJ, Reddingius RE, Higgins CD, Spoudeas HA, Phipps K, Qiao Z, Ryder WD, Brada M, Hayward RD, Brook CG, Hindmarsh PC, Shalet SM (2000) Growth hormone treatment of children with brain tumors and risk of tumor recurrence. J Clin Endocrinol Metab 85:4444–4449

    Article  PubMed  Google Scholar 

  69. Tanner JM, Davies PS (1985) Clinical longitudinal standards for height and height velocity in North American children. J Pediatr 107:317–329

    PubMed  Google Scholar 

  70. Toogood AA, Taylor NF, Shalet SM, Monson JP (2000) Modulation of cortisol metabolism by low-dose growth hormone replacement in elderly hypopituitary patients. J Clin Endocrinol Metab 85:1727–1730

    Article  PubMed  Google Scholar 

  71. Vance ML, Mauras N (1999) Growth hormone therapy in adults and children. N Engl J Med 341:1206–1216

    Article  PubMed  Google Scholar 

  72. Wilson T, Rose SR, Rogol A, Cohen P and the Drug and Therapeutic Committee of the Lawson Wilkins Pediatric Endocrine Society (2003) Update of guidelines for the use of growth hormone in children. J Pediatr 143:415–421

    Article  PubMed  Google Scholar 

  73. Yanovski JA, Rose SR, Municchi G, Pescovitz OH, Hill SC, Cassorla FG, Cutler GB Jr (2003) Treatment with a luteinizing hormone-releasing hormone agonist in adolescents with short stature. N Engl J Med 348:908–917

    Article  PubMed  Google Scholar 

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Authors
  1. Wing Leung
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  2. Susan R. Rose
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  3. Thomas E. Merchant
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Editor information

Editors and Affiliations

  1. The Sidney Kimmel Cancer Center at Johns Hopkins, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD, 21287-5001, USA

    Cindy L. Schwartz

  2. Division of Oncology, Childrens Hospital of Philadelphia, 34th St. & Civic Ctr. Blvd., Philadelphia, PA, 19104, USA

    Wendy L. Hobbie

  3. Radiation Oncology and Pediatrics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY, 14642, USA

    Louis S. Constine

  4. Center for Cancer and Blood Diseases, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA, 90027, USA

    Kathleen S. Ruccione

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Leung, W., Rose, S.R., Merchant, T.E. (2005). Neuroendocrine Complications of Cancer Therapy. In: Schwartz, C.L., Hobbie, W.L., Constine, L.S., Ruccione, K.S. (eds) Survivors of Childhood and Adolescent Cancer. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26498-1_5

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  • DOI: https://doi.org/10.1007/3-540-26498-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40840-6

  • Online ISBN: 978-3-540-26498-9

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