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The pre-B cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms

  • Chapter
Molecular Analysis of B Lymphocyte Development and Activation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 290))

Abstract

B cell development is a process tightly regulated by the orchestrated signaling of cytokine receptors, the pre-B cell receptor (BCR) and the B cell receptor (BCR). It commences with common lymphoid progenitors (CLP) up-regulating the expression of B cell-related genes and committing to the B cell lineage. Cytokine signaling (IL-7, stem cell factor, FLT3-L) is essential at this stage of development as it suppresses cell death, sustains proliferation and facilitates heavy chain rearrangements. As a result of heavy chain recombination, the pre-BCR is expressed, which then becomes the primary determiner of survival, cell cycle entry and allelic exclusion. In this review, we discuss the mechanisms of B cell lineage commitment and describe the signaling pathways that are initiated by the pre-BCR. Finally, we compare pre-BCR and pre-TCR structure, signal transduction and function, drawing parallels between early pre-B and pre-T cell development.

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Authors and Affiliations

  1. Section of Rheumatology, University of Chicago, MC0930, 5841 S. Maryland Ave., Chicago, IL, 60637, USA

    M. R. Clark, A. B. Cooper, L. D. Wang & I. Aifantis

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  1. M. R. Clark
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  2. A. B. Cooper
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  3. L. D. Wang
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  4. I. Aifantis
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Editors and Affiliations

  1. Department of Molecular Genetics and Cell Biology Howard Hughes Medical Institute, The University of Chicago, 5841 S. Maryland Ave. N112, Chicago, IL, 60637, USA

    Harinder Singh

  2. Department of Cellular and Molecular Immunology, Max-Plank-Institute of Immunobiology, Stübeweg 51, 79108, Freiburg, Germany

    Rudolf Grosschedl

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Clark, M.R., Cooper, A.B., Wang, L.D., Aifantis, I. (2005). The pre-B cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms. In: Singh, H., Grosschedl, R. (eds) Molecular Analysis of B Lymphocyte Development and Activation. Current Topics in Microbiology and Immunology, vol 290. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26363-2_5

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