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Wnt Signaling in Lymphopoiesis

  • Chapter
Molecular Analysis of B Lymphocyte Development and Activation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 290))

Abstract

Wnt signaling elicits changes in gene expression and cell physiology through β-catenin and LEF1/TCF proteins. The signal transduction pathway regulates many cellular and developmental processes, including cell proliferation, cell fate decisions and differentiation. In cells that have been stimulated by a Wnt protein, cytoplasmic β-catenin is stabilized and transferred to the nucleus, where it interacts with the nuclear mediators of Wnt signaling, the LEF1/TCF proteins, to elicit a transcriptional response. Loss-of-function and gain-of-function experiments in the mouse have provided insight into the role of this signaling pathway in lymphopoiesis. The self-renewal and maintenance of hematopoietic stem cells is regulated by Wnt signals. Differentiation of T cells and natural killer cells is blocked in the absence of LEF1/TCF proteins, and pro-B cell proliferation is regulated by Wnt signaling.

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Authors and Affiliations

  1. Gene Center and Institute of Biochemistry, University of Munich, 81377, Munich, Germany

    A. Timm & R. Grosschedl

  2. Max-Plank-Institute of Immunobiology, 79108, Freiburg, Germany

    R. Grosschedl

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  1. A. Timm
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  2. R. Grosschedl
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Editors and Affiliations

  1. Department of Molecular Genetics and Cell Biology Howard Hughes Medical Institute, The University of Chicago, 5841 S. Maryland Ave. N112, Chicago, IL, 60637, USA

    Harinder Singh

  2. Department of Cellular and Molecular Immunology, Max-Plank-Institute of Immunobiology, Stübeweg 51, 79108, Freiburg, Germany

    Rudolf Grosschedl

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Timm, A., Grosschedl, R. (2005). Wnt Signaling in Lymphopoiesis. In: Singh, H., Grosschedl, R. (eds) Molecular Analysis of B Lymphocyte Development and Activation. Current Topics in Microbiology and Immunology, vol 290. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26363-2_10

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