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Synthesis and investigation of collagen model peptides

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Polymerizations and Polymer Properties

Part of the book series: Advances in Polymer Science ((POLYMER,volume 43))

Abstract

So far, model peptides have been synthesized mainly by the liquid- or solid-phase technique in which tripeptides with negligible degree of racemization are coupled in a stepwise manner with polypeptides with defined chain lengths. Through cross bridging of such chains, triple helical models can be obtained containing 15–30 tripeptides which fold and unfold quickly and reversibly. This paper reviews the present state of knowledge in this area and discusses some consequences for the collagen structure based on experimental findings.

We thank Mrs. L. Jourdan and Mr. Dr. H. G. Neiss for the assistance during the preparation of this paper

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  1. Fachgebiet Makromolekulare Chemie, Abteilung Eiweiß und Leder, Technische Hochschule Darmstadt, Darmstadt, Federal Republic of Germany

    Eckhart Heidemann & Werner Roth

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  1. Eckhart Heidemann
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Heidemann, E., Roth, W. (1982). Synthesis and investigation of collagen model peptides. In: Polymerizations and Polymer Properties. Advances in Polymer Science, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-11048-8_3

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