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The pathology of marginal renal function

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Reviews of Physiology, Biochemistry and Pharmacology, Volume 91

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 91))

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Abstract

The residual nephrons respond to the progressive nephron loss by an organized functional adaptation which permits them to maintain homeostasis. They do this by magnifying their response to the information provided by the control systems for the major key solutes (i.e., sodium, phosphorus, and possibly potassium), by increasing secondary to hyperplasia the number of specific cells (i.e., ammonium), or by unknown mechanisms (i.e., bicarbonate). As discussed, all the physiologic mechanisms of intrarenal transports apply to the residual nephrons which behave like normal nephrons facing an overload of solute and water.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, University of Geneva, Hôpital Cantonal Universitaire, CH-1211, Genève 4, Switzerland

    Hervé Favre

  2. Department of Medicine, School of Medicine, The Center for the Health Sciences, Los Angeles, California, USA

    Neal S. Bricker

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  1. Hervé Favre
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© 1981 Springer-Verlag

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Favre, H., Bricker, N.S. (1981). The pathology of marginal renal function. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 91. Reviews of Physiology, Biochemistry and Pharmacology, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-10961-7_1

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  • DOI: https://doi.org/10.1007/3-540-10961-7_1

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