Skip to main content
SpringerLink
Log in

Metabolism of alkanes by yeasts

  • Conference paper
  • First Online:
Reactors and Reactions

Part of the book series: Advances in Biochemical Engineering ((ABE,volume 19))

Abstract

One of the specific features of alkane-utilizing yeasts is the conspicuous appearance of peroxisomes. This review describes the metabolism of alkanes in yeasts with special emphasis on the physiological function of peroxisomes. The subtle diversity in alkane utilization pathway in yeasts is mediated by subcellular localization of enzymes.

In microsomes, alkanes are hydroxylated to the corresponding fatty alcohols which are further oxidized to fatty acids via aldehydes in microsomes, mitochondria and peroxisomes, respectively. Degradation of fatty acids to acetyl-CoA via the β-oxidation pathways is carried out exclusively in peroxisomes while fatty acids formed in microsomes and mitochondria are incorporated into cellular lipids, each after being activated to acyl-CoAs. Acetyl-CoA produced in peroxisomes is converted to C4-compounds by the cooperative action of peroxisomes and mitochondria. Some regulation of enzymes in alkane-assimilating yeasts is also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

12 References

  1. Abbott, B. J., Gledhill, W. E.: Adv. Appl. Microbiol. 14, 249 (1971)

    Article  CAS  Google Scholar 

  2. Fukui, S., Tanaka, A.: Advan. Biochem. Eng. 17, 1 (1980)

    CAS  Google Scholar 

  3. Iguchi, T., Takeda, I., Ohsawa, H.: Agric. Biol. Chem. 33, 1657 (1969)

    CAS  Google Scholar 

  4. Meissel, M. N. et al.: Proc. Third Internatl. Spec. Symp. Yeasts (Otaniemi/Helsinki), p. 149 (1973)

    Google Scholar 

  5. Meissel, M. N., Medvedeva, G. A., Kozlova, T. M.: Mikrobiologiya 45, 844 (1976)

    Google Scholar 

  6. Osumi, M. et al.: J. Ferment. Technol. 53, 244 (1975)

    Google Scholar 

  7. Einsele, A., Schneider, H., Fiechter, A.: J. Ferment. Technol. 53, 241 (1975)

    Google Scholar 

  8. Kaeppeli, O., Fiechter, A.: Biotechnol. Bioeng. 18, 967 (1976)

    Article  CAS  Google Scholar 

  9. Käppeli, O., Fiechter, A.: J. Bacteriol. 131, 917 (1977)

    Google Scholar 

  10. Käppeli, O., Müller, M., Fiechter, A.: J. Bacteriol. 133, 952 (1978)

    Google Scholar 

  11. Peterson, J. A. et al.: J. Biol. Chem. 242, 4334 (1967)

    CAS  Google Scholar 

  12. Cardini, G., Jurtshuk, P.: J. Biol. Chem. 245, 2789 (1970)

    CAS  Google Scholar 

  13. Liu, C.-M, Johnson, M. J.: J. Bacteriol. 106, 830 (1971)

    CAS  Google Scholar 

  14. Lebeault, J. M., Lode, E. T., Coon, M. J.: Biochem. Biophys. Res. Commun. 42, 413 (1971)

    Article  CAS  Google Scholar 

  15. Gallo, M., Bertrand, J. C, Azoulay, E.: FEBS Lett. 19, 45 (1971)

    Article  CAS  Google Scholar 

  16. Müller, H. G. et al.: Acta Biol. Med. Germ. 38, 345 (1979)

    Google Scholar 

  17. Gallo, M. et al.: Biochim. Biophys. Acta 296, 624 (1973)

    CAS  Google Scholar 

  18. Gallo, M. et al.: Biochimie 55, 195 (1973)

    CAS  Google Scholar 

  19. Gallo, M., Roche, B., Azoulay, E.: Biochim. Biophys. Acta 419, 425 (1976)

    Article  CAS  Google Scholar 

  20. Gilewicz, M. et al.: Can. J. Microbiol. 25, 201 (1979)

    Article  CAS  Google Scholar 

  21. Bertrand, J. C. et al.: FEBS Lett. 105, 143 (1979)

    Article  CAS  Google Scholar 

  22. Bertrand, J. C. et al.: Eur. J. Biochem. 93, 237 (1979)

    Article  CAS  Google Scholar 

  23. Duppel, W., Lebeault, J. M., Coon, M. J.: Eur. J. Biochem. 36, 583 (1973)

    Article  CAS  Google Scholar 

  24. Strobel, H. W., Coon, M. J.: J. Biol. Chem. 246, 7826 (1971)

    CAS  Google Scholar 

  25. Iida, M., Iizuka, H.: J. Ferment. Technol. 47, 442 (1969)

    CAS  Google Scholar 

  26. Finnerty, W. R.: Trends in Biochem. Sci. 2, 73 (1977)

    Article  CAS  Google Scholar 

  27. Lebeault, J. M. et al.: Biochim. Biophys. Acta 220, 373 (1970)

    CAS  Google Scholar 

  28. Lebeault, J. M. et al.: Biochim. Biophys. Acta 220, 386 (1970)

    CAS  Google Scholar 

  29. Lebeault, J. M., Azoulay, E.: Lipids 6, 444 (1971)

    CAS  Google Scholar 

  30. Gallo, M., Roche-Penverne, B., Azoulay, E.: FEBS Lett. 46, 78 (1974)

    Article  CAS  Google Scholar 

  31. Yamada, T. et al.: Arch. Microbiol. 128, 145 (1980)

    Article  CAS  Google Scholar 

  32. Osumi, M. et al.: Arch. Microbiol. 99, 181 (1974)

    Article  CAS  Google Scholar 

  33. Teranishi, Y. et al.: Agric. Biol. Chem. 38, 1213 (1974)

    CAS  Google Scholar 

  34. Teranishi, Y. et al.: Agric. Biol. Chem. 38, 1221 (1974)

    CAS  Google Scholar 

  35. Osumi, M. et al.: Arch. Microbiol. 103, 1 (1975)

    Article  CAS  Google Scholar 

  36. Kawamoto, S. et al.: Arch. Microbiol. 112, 1 (1977)

    Article  CAS  Google Scholar 

  37. Osumi, M. et al.: J. Gen. Appl. Microbiol. 21, 375 (1975)

    CAS  Google Scholar 

  38. Mishina, M. et al.: Eur. J. Biochem. 89, 321 (1978)

    Article  CAS  Google Scholar 

  39. Osumi, M.: J. Electron Microsc. 25, 43 (1976)

    CAS  Google Scholar 

  40. Osumi, M., Kazama, H., Sato, S.: FEBS Lett. 90, 309 (1978)

    Article  CAS  Google Scholar 

  41. Fukui, S., Tanaka, A.: J. Appl. Biochem. 1, 171 (1979)

    CAS  Google Scholar 

  42. Fukui, S., Tanaka, A.: Trends in Biochem. Sci. 4, 246 (1979)

    Article  CAS  Google Scholar 

  43. Trust, T. J., Millis, N. F.: J. Bacteriol. 104, 1397 (1970)

    CAS  Google Scholar 

  44. Duvnjak, Z. et al.: Biochim. Biophys. Acta 202, 447 (1970)

    CAS  Google Scholar 

  45. Kawamoto, S., Nozaki, C, Tanaka, A., Fukui, S.: Eur. J. Biochem. 83, 609 (1978)

    Article  CAS  Google Scholar 

  46. Kamiryo, T. et al.: Proc. Nat. Acad. Sci. USA 74, 4947 (1977)

    Article  CAS  Google Scholar 

  47. Mishina, M. et al.: Eur. J. Biochem. 82, 347 (1978)

    Article  CAS  Google Scholar 

  48. Hosaka, K. et al.: Eur. J. Biochem. 93, 197 (1979)

    Article  CAS  Google Scholar 

  49. Cooper, T. G., Beevers, H.: J. Biol. Chem. 244, 3514 (1969)

    CAS  Google Scholar 

  50. Lazarow, P. B., de Duve, C: Proc. Nat. Acad. Sci. USA 73, 2043 (1976)

    Article  CAS  Google Scholar 

  51. Kikuchi, T. et al.: Abstr. Res. Meeting Lipid Biochem., p. 144, Toyama, Japan 1979

    Google Scholar 

  52. Shimizu, S. et al.: Biochem. Biophys. Res. Commun. 91, 108 (1979)

    Article  CAS  Google Scholar 

  53. Kawamoto, S. et al.: FEBS Lett. 97, 253 (1979)

    Article  CAS  Google Scholar 

  54. Mishina, M. et al.: Agric. Biol. Chem. 37, 863 (1973)

    CAS  Google Scholar 

  55. Rattray, J. M. B., Schibeci, A., Kidby, D. K.: Bacteriol. Rev. 39, 197 (1975)

    CAS  Google Scholar 

  56. Nomura, S. et al.: J. Antibiotics 25, 365 (1972)

    CAS  Google Scholar 

  57. Vance, D. et al.: Biochem. Biophys. Res. Commun. 48, 649 (1972)

    Article  CAS  Google Scholar 

  58. Tanaka, A. et al.: Eurp. J. Appl. Microbiol. 3, 115 (1976)

    Article  CAS  Google Scholar 

  59. Mishina, M. et al.: Eur. J. Biochem. 71, 301 (1976)

    Article  CAS  Google Scholar 

  60. Gill, C. O. Ratledge, C.: J. Gen. Microbiol. 78, 337 (1973)

    CAS  Google Scholar 

  61. Mishina, M. et al.: Eur. J. Biochem. 71, 295 (1976)

    Article  CAS  Google Scholar 

  62. Tanaka, A. et al.: Europ. J. Appl. Microbiol. Biotechnol. 5, 79 (1978)

    Article  CAS  Google Scholar 

  63. Hildebrandt, W., Weide, H.: Z. Allg. Mikrobiol. 14, 47 (1974)

    CAS  Google Scholar 

  64. Nabeshima, S., Tanaka, A., Fukui, S.: Agric. Biol. Chem. 41, 275 (1977)

    CAS  Google Scholar 

  65. Hirai, M. et al.: Agric. Biol. Chem. 40, 1819 (1976)

    CAS  Google Scholar 

  66. Tanaka, A. et al.: Agric. Biol. Chem. 41, 795 (1977)

    CAS  Google Scholar 

  67. Hirai, M. et al: Agric. Biol. Chem. 40, 1979 (1976)

    CAS  Google Scholar 

  68. Kawamoto, S. et al.: FEBS Lett. 96, 37 (1978)

    Article  CAS  Google Scholar 

  69. Tabuchi, T., Serizawa, N.: Agric. Biol. Chem. 39, 1055 (1975)

    CAS  Google Scholar 

  70. Tabuchi, T., Uchiyama, H.: Agric. Biol. Chem. 39, 2035 (1975)

    CAS  Google Scholar 

  71. Uchiyama, H., Tabuchi, T.: Agric. Biol. Chem. 40, 1411 (1976)

    CAS  Google Scholar 

  72. Tabuchi, T., Satoh, T.: Agric. Biol. Chem. 40, 1863 (1976)

    CAS  Google Scholar 

  73. Tabuchi, T., Satoh, T.: Agric. Biol. Chem. 41, 169 (1977)

    CAS  Google Scholar 

  74. Tabuchi, T., Igoshi, K.: Agric. Biol. Chem. 42, 2381 (1978)

    CAS  Google Scholar 

  75. Hatton, K., Suzuki, T.: Agric. Biol. Chem. 38, 2419 (1974)

    Google Scholar 

  76. Hattori, K., Suzuki, T.: Agric. Biol. Chem. 39, 57 (1975)

    CAS  Google Scholar 

  77. Akiyama, S. et al.: Agric. Biol. Chem. 37, 885 (1973)

    CAS  Google Scholar 

  78. Sato, S., Nakahara, T., Minoda, Y.: Agric. Biol. Chem. 41, 1903 (1977)

    CAS  Google Scholar 

  79. Teranishi, Y. et al.: Agric. Biol. Chem. 38, 1581 (1974)

    CAS  Google Scholar 

  80. Teranishi, Y., Tanaka, A., Fukui, S.: Agric. Biol. Chem. 38, 1779 (1974)

    CAS  Google Scholar 

  81. Yamamura, M. et al.: Agric. Biol. Chem. 39, 13 (1975)

    CAS  Google Scholar 

  82. Akimenko, V. K., Medentsev, A. G., Golovchenko, N. P.: FEBS Lett. 45, 22 (1974)

    Article  CAS  Google Scholar 

  83. Gallo, M., Azoulay, E.: Biochimie 56, 1129 (1974)

    CAS  Google Scholar 

  84. Mitsushima, K., Shinmyo, A., Enatsu, T.: J. Ferment. Technol. 54, 863 (1976)

    CAS  Google Scholar 

  85. Mitsushima, K., Shinmyo, A., Enatsu, T.: J. Ferment. Technol. 55, 84 (1977)

    CAS  Google Scholar 

  86. Mitsushima, K., Shinmyo, A., Enatsu, T.: Biochim. Biophys. Acta 538, 481 (1978)

    CAS  Google Scholar 

  87. Hirai, M. et al.: Biochim. Biophys. Acta 480, 357 (1977)

    CAS  Google Scholar 

  88. Hirai, M., Tanaka, A., Fukui, S.: Biochim. Biophys. Acta 391, 282 (1975)

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo-ku, 606, Kyoto, Japan

    S. Fukui & A. Tanaka

Authors
  1. S. Fukui
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag

About this paper

Cite this paper

Fukui, S., Tanaka, A. (1981). Metabolism of alkanes by yeasts. In: Reactors and Reactions. Advances in Biochemical Engineering, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-10464-X_19

Download citation

  • DOI: https://doi.org/10.1007/3-540-10464-X_19

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10464-3

  • Online ISBN: 978-3-540-70660-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation