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Aktuelle Aspekte genetischer Forschung bei Schizophrenie

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Aktuelle Aspekte der Pathogenese und Therapie der Schizophrenie

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Schlussfolgerung

Die molekulargenetische Erforschung der Schizophrenie hat mit der Entdeckung der ersten Dispositionsgene für Schizophrenie erste Durchbrüche erreicht. Die Bedeutung dieser Erfolge kann nicht unterschätzt werden.

Die zweistufige Strategie zur Genortsuche bei komplexen Erkrankungen (zuerst genomweite Kopplungsanalysen, anschließend Analyse des Kopplungsungleichgewichts) hat sich — anfänglicher skeptischer Einschätzung zum Trotz — als erfolgreich erwiesen. Für diese Aussage gibt es auch weitere Beispiele aus der inneren Medizin (z.B. Colitis ulcerosa, Diabetes mellitus). Aufgrund dieser Einschätzung sind weitere Genortidentifikationen auch bei der Schizophrenie zu erwarten.

Die gefundenen Dispositionsgene und ihre Produkte sind bisher nie im Kontext der Schizophrenie diskutiert worden und weisen auf pathogenetische Mechanismen hin, die bisher unbekannt waren. Somit erweist sich die systematische Genortsuche als eine unerwartet effiziente Suchstrategie nach molekularbiologischen Entstehungsmechanismen von Krankheiten. Diese wiederum können langfristig helfen, gezielt Substanzen zu entwickeln, die in die Pathogenese eingreifen und damit als kausale Therapeutika mit neuen, bisher unbekannten Wirkmechanismen fungieren können. Diese Chancen sind vor allem bei bislang nur unzureichend behandelbaren Erkrankungen — wie der Schizophrenie mit meist überdauernden Defiziten — besonders vielversprechend.

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Authors and Affiliations

  1. Klinik für Psychiatrie und Psychotherapie, Universität Bonn, Sigmund-Freud-Straße 25, 53105, Bonn, Bundesrepublik Deutschland

    Prof. Dr. W. Maier

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  1. Prof. Dr. W. Maier
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Correspondence to W. Maier .

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  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie-Innenstadt, Klinikum der Universität München, Nußbaumstraße 7, 80336, München, Deutschland

    Hans-Jürgen Möller  & Norbert Müller  & 

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Maier, W. (2006). Aktuelle Aspekte genetischer Forschung bei Schizophrenie. In: Möller, HJ., Müller, N. (eds) Aktuelle Aspekte der Pathogenese und Therapie der Schizophrenie. Springer, Vienna. https://doi.org/10.1007/3-211-29109-1_6

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  • DOI: https://doi.org/10.1007/3-211-29109-1_6

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-29043-9

  • Online ISBN: 978-3-211-29109-2

  • eBook Packages: Medicine (German Language)

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