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References
Aberer E, Neumann R, and Stanek G (1985) Is localised scleroderma a Borrelia infection? Lancet, 2: 278
Aiba S, Tabata N, Ohtani H, Tagami H (1994) CD34+ spindle-shaped cells selectively disappear from the skin lesion of scleroderma. Arch Dermatol, 130: 593–597
Akimoto S, Hayashi H, Ishikawa H (1992). Disaccharide analysis of the skin glycosaminoglycans in systemic sclerosis. Br J Dermatol, 126: 29–34
Arnett FC, Tan FK, Uziel Y, Laxer RM, Krafchik BR, Antohi S, and Bona C (1999) Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin 1, in patients with localized scleroderma. Arthritis Rheum, 42: 2656–2659
Balat A, Akinci A, Turgut M, Mizrak B, Aydin A (1999) Eosinophilic fasciitis — progression to linear scleroderma: a case report. Turk J Pediatr, 41: 381–385
Barrera P, Haagsma CJ, Boerbooms AM, Van Riel PL, Borm GF, Van de Putte LB, Van der Meer JW (1995) Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis. Br J Rheumatol, 34: 747–755
Birdi N, Shore A, Rush P, Laxer RM, Silverman ED, Krafchik B (1992). Childhood linear scleroderma: a possible role of thermography for evaluation. J Rheumatol, 19: 968–973
Blaszczyk M, Jablonska S (1999) Linear scleroderma en coup de sabre. Relationship with progressive facial hemiatrophy (PFH). RheumaDerm, M. a. Uitto, ed., Kluwer Academic/Plenum Publishers, New York, 101–104
Blaszczyk M, Krysicka-Janiger K, Jablonska S (2000) Primary atrophic profound linear scleroderma. Report of three cases. Dermatology, 200: 63–66
Blaszczyk M, Krolicki L, Krasu M, Glinska O, Jablonska S (2003). Progressive facial hemiatrophy: central nervous system involvement and relationship with scleroderma en coup de sabre. J Rheumatol, 30: 1997–2004
Bleasel NR, Stapleton KM, Commens C, Ahern VA (1999) Radiation-induced localized scleroderma in breast cancer patients. Australas J Dermatol, 40: 99–102
Bodemer C, Belon M, Hamel-Teillac D, Amoric JC, Fraitag S, Prieur AM, De Prost Y (1999) Scleroderma in children: a retrospective study of 70 cases. Ann Dermatol Venereol, 126: 691–694
Boelsma E, Pavel S, Ponec M (1995) Effects of calcitriol on fibroblasts derived from skin of scleroderma patients. Dermatology, 191: 226–33
Bottomley WW, Jutley J, Wood EJ, Goodfield MD (1995) The effect of calcipotriol on lesional fibroblasts from patients with active morphoea. Acta Derm Venereol, 75: 364–366
Branchet MC, Boisnic S, Bletry O, Robert L, Charron D, Frances C (1992) Expression of HLA class II antigens on skin fibroblasts in scleroderma. Br J Dermatol, 126: 431–435
Caca-Biljanovska NG, Vlckova-Laskoska MT, Dervendi DV, Pesic NP, Laskoski DS (1999) Treatment of generalized morphea with oral 1,25-dihydroxyvitamin D3. Adv Exp Med Biol, 455: 299–304
Camacho NR, Sanchez JE, Martin RF, Gonzalez JR, Sanchez JL (2001). Medium-dose UVA1 phototherapy in localized scleroderma and its effect in CD34-positive dendritic cells. J Am Acad Dermatol, 45: 697–699
Canizares O, Sachs P, Jaimovich L, Torres V (1958) Idiopathic atrophoderma of Pasini and Pierini. Arch Dermatol, 77: 42–59
Cannick L, 3rd, Douglas G, Crater S, Silver R (2003). Nodular scleroderma: case report and literature review. J Rheumatol, 30: 2500–2502
Castanet J, Lacour JP, Perrin C, Taillan B, Dubois D, Ortonne JP (1994) Association of eosinophilic fasciitis, multiple morphea and antiphospholipid antibody. Dermatology, 189: 304–307
Christianson H, Dorsey C, O’Leary P, Kierland R (1956) Localized scleroderma: a clinical study of twohundred thirty-five cases. Arch Dermatol, 74: 629–639
Chung MH, Sum J, Morrell MJ, Horoupian DS (1995) Intracerebral involvement in scleroderma en coup de sabre: report of a case with neuropathologic findings. Ann Neurol, 37: 679–681
Chung H, Hann S (1997) Lupus panniculitis treated by a combination therapy of hydroxychloroquine and quinacrine. J Dermatol, 24: 569–572
Clemens TL, Adams JS, Horiuchi N, Gilchrest BA, Cho H, Tsuchiya Y, Matsuo N, Suda T, Holick MF (1983) Interaction of 1,25-dihydroxyvitamin-D3 with keratinocytes and fibroblasts from skin of normal subjects and a subject with vitamin-D-dependent rickets, type II: a model for study of the mode of action of 1,25-dihydroxyvitamin D3. J Clin Endocrinol Metab, 56: 824–830
Cosnes A, Anglade MC, Revuz J, Radier C (2003). Thirteen-megahertz ultrasound probe: its role in diagnosing localized scleroderma. Br J Dermatol, 148: 724–729
Cribier B, Faradji T, Le Coz C, Oberling F, Grosshans E (1995) Extracorporeal photo-chemotherapy in systemic sclerosis and severe morphea. Dermatology, 191: 25–31
Cunningham BB, Landells ID, Langman C, Sailer DE, Paller AS (1998) Topical calcipotriene for morphea/linear scleroderma. J Am Acad Dermatol, 39: 211–215
Curley RK, Macfarlane AW, Evans S, Woodrow JC (1987) The treatment of linear morphoea with D-penicillamine. Clin Exp Dermatol, 12: 56–57
Czarnecki DB, Taft EH (1982) Generalized morphoea successfully treated with salazopyrine. Acta Derm Venereol, 62: 81–82
Daoud MS, Su WP, Leiferman KM, Perniciaro C (1994) Bullous morphea: clinical, pathologic, and immunopathologic evaluation of thirteen cases. J Am Acad Dermatol, 30: 937–943
David J, Wilson J, Woo P (1991) Scleroderma "en coup de sabre". Ann Rheum Dis, 50: 260–262
Dehen L, Roujeau JC, Cosnes A, Revuz J (1994) Internal involvement in localized scleroderma. Medicine (Baltimore), 73: 241–245
Diaz-Perez J, Connolly S, Winkelmann R (1980) Disabling pansclerotic morphea of children. Arch Dermatol, 116: 169–173
Dillon WI, Saed GM, Fivenson DP (1995) Borrelia burgdorferi DNA is undetectable by polymerase chain reaction in skin lesions of morphea, scleroderma, or lichen sclerosus et atrophicus of patients from North America. J Am Acad Dermatol, 33: 617–620
Doyle JA, Ginsburg WW (1989) Eosinophilic fasciitis. Med Clin North Am, 73: 1157–1166
Drago F, Rampini P, Lugani C, Rebora A (1998) Generalized morphoea after antitetanus vaccination. Clin Exp Dermatol, 23: 142
Dubois EL, Chandor S, Friou GJ, Bischel M (1971) Progressive systemic sclerosis (PSS) and localized scleroderma (morphea) with positive LE cell test and unusual systemic manifestations compatible with systemic lupus erythematous (SLE): presentation of 14 cases including one set of identical twins, one with scleroderma and the other with SLE. Review of the literature. Medicine (Baltimore), 50: 199–222
Eisen D, Alster TS (2002). Use of a 585 nm pulsed dye laser for the treatment of morphea. Dermatol Surg, 28: 615–616
El-Mofty M, Zaher H, Bosseila M, Yousef R, Saad B (2000) Low-dose broad-band UVA in morphea using a new method for evaluation. Photodermatol Photoimmunol Photomed, 16: 43–49
El-Mofty M, Mostafa W, El-Darouty M, Bosseila M, Nada H, Yousef R, Esmat S, El-Lawindy M, Assaf M, El-Enani G (2004). Different low doses of broad-band UVA in the treatment of morphea and systemic sclerosis. Photodermatol Photoimmunol Photomed, 20: 148–156
El-Mofty M, Mostafa W, Esmat S, Youssef R, Bousseila M, Nagi N, Shaker O, Abouzeid A (2004). Suggested mechanisms of action of UVA phototherapy in morphea: a molecular study. Photodermatol Photoimmunol Photomed, 20: 93–100
Elst EF, Van Suijlekom-Smit LW, Oranje AP (1999) Treatment of linear scleroderma with oral 1,25-dihydroxyvitamin D3 (calcitriol) in seven children. Pediatr Dermatol, 16: 53–58
Falanga V, Medsger TA, Reichlin M (1985) High titers of antibodies to single-stranded DNA in linear scleroderma. Arch Dermatol, 121: 345–347
Falanga V, Medsger TA, Jr, Reichlin M, Rodnan GP (1986) Linear scleroderma. Clinical spectrum, prognosis, and laboratory abnormalities. Ann Intern Med, 104: 849–857
Falanga V, Medsger TA, Jr, Reichlin M (1987) Antinuclear and anti-single-stranded DNA antibodies in morphea and generalized morphea. Arch Dermatol, 123: 350–353
Falanga V, Medsger TA, Jr (1990) D-penicillamine in the treatment of localized scleroderma. Arch Dermatol, 126: 609–612
Fleischmajer R, Nedwich A (1972) Generalized morphea. I. Histology of the dermis and subcutaneous tissue. Arch Dermatol, 106: 509–514
Fleischmajer R, Perlish JS (1972). Glycosaminoglycans in scleroderma and scleredema. J Invest Dermatol, 58: 129–132
Fleischmajer R, Prunieras M (1972) Generalized morphea. II. Electron microscopy of collagen, cells, and the subcutaneous tissue. Arch Dermatol, 106: 515–524
Fleischmajer R, Perlish JS, Krieg T, Timpl R (1981) Variability in collagen and fibronectin synthesis by scleroderma fibroblasts in primary culture. J Invest Dermatol, 76: 400–403
Foeldvari I (1998) Progressive linear scleroderma and morphea in a child. J Pediatr, 133: 308
Fry A, Alvarellos A, Fink C, Blaw M, Roach E (1992) Intracranial findings in progressive facial hemiatrophy. J Rheumatol, 19: 956–958
Fujimoto M, Sato S, Ihn H, Takehara K (1995) Autoantibodies to the heat-shock protein hsp73 in localized scleroderma. Arch Dermatol Res, 287: 581–585
Gambichler T, Kreuter A, Rotterdam S, Altmeyer P, Hoffmann K (2003). Linear scleroderma ‘en coup de sabre’ treated with topical calcipotriol and cream psoralen plus ultraviolet A. J Eur Acad Dermatol Venereol, 17: 601–602
Garcia-Bustinduy M, Noda A, Sanchez R, Gonzalez de Mesa MJ, Guimera F, Garcia-Montelongo R (1998) PUVA therapy in localized scleroderma. J Eur Acad Dermatol Venereol, 10: 283–284
Garzon M, Paller A (1999) Ultrapotent topical corticosteroids treatment of childhood genital lichen sclerosus. Arch Dermatol, 135: 525–528
Gordon GV (1981) Eosinophilic fasciitis. A case report and review of the literature. Cutis, 28:268, 271–273
Grundmann-Kollmann M, Ochsendorf F, Zollner TM, Spieth K, Sachsenberg-Studer E, Kaufmann R, Podda M (2000) PUVA-cream photochemotherapy for the treatment of localized scleroderma. J Am Acad Dermatol, 43: 675–678
Gruss C, Reed JA, Altmeyer P, McNutt NS, Kerscher M (1997a) Induction of interstitial collagenase (MMP-1) by UVA-1 phototherapy in morphea fibroblasts. Lancet, 350:1295–1296
Gruss C, Stucker M, Kobyletzki G, Schreiber D, Altmeyer P, Kerscher M (1997b) Low dose UVA1 phototherapy in disabling pansclerotic morphoea of childhood. Br J Dermatol, 136: 293–294
Hasegawa M, Sato S, Nagaoka T, Fujimoto M, Takehara K (2003). Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma. Dermatology, 207: 141–147
Hatamochi A, Ono M, Arakawa M, Takeda K, Ueki H (1992) Analysis of collagen gene expression by cultured fibroblasts in morphoea. Br J Dermatol, 126: 216–221
Hauser C, Skaria A, Harms M, Saurat JH (1996) Morphoea following Blaschko’s lines. Br J Dermatol, 134: 594–595
Hayakawa I, Hasegawa M, Takehara K, Sato S (2004). Anti-DNA topoisomerase IIalpha autoantibodies in localized scleroderma. Arthritis Rheum, 50: 227–232
Higley H, Persichitte K, Chu S, Waegell W, Vancheeswaran R, Black C(1994). Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud’s phenomenon. Arthritis Rheum, 37: 278–288
Holick MF, Smith E, Pincus S (1987) Skin as the site of vitamin D synthesis and target tissue for 1,25-dihydroxyvitamin D3. Use of calcitriol (1,25-dihydroxyvitamin D3) for treatment of psoriasis. Arch Dermatol, 123: 1677–1683a
Hsu S, Lee MW, Carlton S, Kramer EM (1999) Nodular morphea in a linear pattern. Int J Dermatol, 38: 529–530
Hulshof MM, Pavel S, Breedveld FC, Dijkmans BA, Vermeer BJ (1994) Oral calcitriol as a new therapeutic modality for generalized morphea. Arch Dermatol, 130: 1290–1293
Humbert PG, Dupond JL, Rochefort A, Vasselet R, Lucas A, Laurent R, Agache P (1990) Localized scleroderma — response to 1,25-dihydroxyvitamin D3. Clin Exp Dermatol, 15: 396–398
Humbert P, Aubin F, Dupond JL, Delaporte E (1995) Oral calcitriol as a new therapeutic agent in localized and systemic scleroderma. Arch Dermatol, 131: 850–851
Hunzelmann N, Anders S, Fierlbeck G, Hein R, Herrmann K, Albrecht M, Bell S, Muche R, Wehner-Caroli J, Gaus W, Krieg T (1997) Double-blind, placebo-controlled study of intralesional interferon gamma for the treatment of localized scleroderma. J Am Acad Dermatol, 36: 433–435
Hunzelmann N, Scharffetter Kochanek K, Hager C, Krieg T (1998) Management of localized scleroderma. Semin Cutan Med Surg, 17: 34–40
Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Fujimoto M, Grotendorst GR, Takehara K (1996) Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol, 106: 729–733
Ihn H, Sato S, Fujimoto M, Kikuchi K, Takehara K (1994) Demonstration of interleukin 8 in serum samples of patients with localized scleroderma. Arch Dermatol, 130: 1327–1328
Ihn H, Sato S, Fujimoto M, Kikuchi K, Takehara K (1995) Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma. Arch Dermatol Res, 287: 193–197
Ihn H, Sato S, Fujimoto M, Kikuchi K, Takehara K (1996) Clinical significance of serum levels of soluble interleukin-2 receptor in patients with localized scleroderma. Br J Dermatol, 134: 843–7
Ihn H, Yazawa N, Kubo M, Yamane K, Sato S, Fujimoto M, Kikuchi K, Soma Y, Tamaki K (2000) Circulating levels of soluble CD30 are increased in patients with localized scleroderma and correlated with serological and clinical features of the disease. J Rheumatol, 27: 698–702
Itin PH, Schiller P (1999) Double-lined frontoparietal scleroderma en coup de sabre. Dermatology, 199: 185–186
Jablonska S (1975a) Facial hemiatrophy and it’s relation to localized scleroderma. In: Jablonska S (ed) Scleroderma and pseudoscleroderma. PZWL, Warsaw, pp 537–548
Jablonska S (1975b) Localised Scleroderma.In: Jablonska S (ed) Scleroderma and pseudo-scleroderma. PZWL, Warsaw, pp 277–303
Jablonska S, Rodnan G (1979) Localized forms of scleroderma. Clin Rheumatol Dis, 5: 215–241
Jablonska S, Blaszczyk M (2004). Is superficial morphea synonymous with atrophoderma Pasini-Pierini? J Am Acad Dermatol, 50: 979–980
Janzen L, Jeffery JR, Gough J, Chalmers IM (1995) Response to methotrexate in a patient with idiopathic eosinophilic fasciitis, morphea, IgM hypergammaglobulinemia, and renal involvement. J Rheumatol, 22: 1967–1970
Jaworsky C (1997) Connective tissue diseases. In: Elder D (ed) Lever’s Histopathology of the Skin. Lippincott-Raven, Philadelphia, pp 253–285
Joly P, Bamberger N, Crickx B, Belaich S (1994) Treatment of severe forms of localized scleroderma with oral corticosteroids: follow-up study on 17 patients. Arch Dermatol, 130: 663–664
Jones SM, Mathew CM, Dixey J, Lovell CR, McHugh NJ (1996) VCAM-1 expression on endothelium in lesions from cutaneous lupus erythematosus is increased compared with systemic and localized scleroderma. Br J Dermatol, 135: 678–686
Kahari VM, Heino J, Vuorio T, Vuorio E (1988a) Interferon-alpha and interferon-gamma reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture. Biochim Biophys Acta, 968: 45–50
Kahari VM, Sandberg M, Kalimo H, Vuorio T, Vuorio E (1988b) Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization. J Invest Dermatol, 90: 664–670
Kanekura T, Fukumaru S, Matsushita S, Terasaki K, Mizoguchi S, Kanzaki T (1996) Successful treatment of scleroderma with PUVA therapy. J Dermatol, 23: 455–459
Karrer S, Abels C, Landthaler M, Szeimies RM (2000) Topical photodynamic therapy for localized scleroderma. Acta Derm Venereol, 80: 26–27
Kencka D, Blaszczyk M, Jablonska S (1995) Atrophoderma Pasini-Pierini is a primary atrophic abortive morphea. Dermatology, 190: 203–6
Kerscher M, Volkenandt M, Meurer M, Lehmann P, Plewig G, Rocken M (1994) Treatment of localised scleroderma with PUVA bath photochemotherapy. Lancet, 343: 1233
Kerscher M, Dirschka T, Volkenandt M (1995) Treatment of localised scleroderma by UVA1 phototherapy. Lancet, 346: 1166
Kerscher M, Meurer M, Sander C, Volkenandt M, Lehmann P, Plewig G, Rocken M (1996) PUVA bath photochemotherapy for localized scleroderma. Evaluation of 17 consecutive patients. Arch Dermatol, 132: 1280–1282
Kerscher M, Volkenandt M, Gruss C, Reuther T, von Kobyletzki G, Freitag M, Dirschka T, Altmeyer P (1998) Low-dose UVA phototherapy for treatment of localized scleroderma. J Am Acad Dermatol, 38: 21–26
Kobayashi KA, Lui H, Prendiville JS (1991) Solitary morphea profunda in a 5-year-old girl: case report and review of the literature. Pediatr Dermatol, 8: 292–295
Kobayasi T, Serup J (1985) Vascular changes in morphea. Acta Derm Venereol, 65: 116–120
Kobayasi T, Willeberg A, Serup J, Ullman S (1990) Generalized morphea with blisters. A case report. Acta Derm Venereol, 70: 454–456
Koeger AC, Rozenberg S, Fautrel B (1999) Effectiveness of topical calcitriol for localized scleroderma. J Rheumatol, 26: 239–240
Kowalewski C, Kozlowska A, Zawadzka M, Wozniak K, Blaszczyk M, Jablonska S (2004). Alterations of basement membrane zone in bullous and non-bullous variants of extragenital lichen sclerosus. Am J Dermatopathol, 26: 96–101
Krell JM, Solomon AR, Glavey CM, Lawley TJ (1995) Nodular scleroderma. J Am Acad Dermatol, 32: 343–345
Kreuter A, Gambichler T, Avermaete A, Jansen T, Hoffmann M, Hoffmann K, Altmeyer P, von Kobyletzki G, Bacharach-Buhles M (2001). Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea. Pediatr Dermatol, 18:241–245
Kubo M, Ihn H, Yamane K, Tamaki K (2001). Up-regulated expression of transforming growth factor beta receptors in dermal fibroblasts in skin sections from patients with localized scleroderma. Arthritis Rheum, 44: 731–734
Labandeira J, Leon-Mateos A, Suarez-Penaranda JM, Garea MT, Toribio J (2003). What is nodular-keloidal scleroderma? Dermatology, 207: 130–132
Lee HJ, Kim MY, Ha SJ, Kim JW (2002). Two cases of morphea associated with Hashimoto’s thyroiditis. Acta Derm Venereol, 82: 58–59
Levy JJ, Gassmuller J, Audring H, Brenke A, Albrecht-Nebe H (1993) Imaging subcutaneous atrophy in circumscribed scleroderma with 20 MHz B-scan ultrasound. Hautarzt, 44:446–451
Liu P, Uziel Y, Chuang S, Silverman E, Krafchik B, Laxer R (1994) Localized scleroderma: Imaging features. Pediatr Radiol, 24: 207–209
Luer W, Jockel D, Henze T, Schipper HI (1990) Progressive inflammatory lesions of the brain parenchyma in localized scleroderma of the head. J Neurol, 237: 379–381
Man J, Dytoc MT (2004). Use of Imiquimod Cream 5% in the Treatment of Localized Morphea. J Cutan Med Surg, 8: 166–9
Mancuso G, Berdondini RM (2003). Topical tacrolimus in the treatment of localized scleroderma. Eur J Dermatol, 13: 590–592
Martini G, Murray KJ, Howell KJ, Harper J, Atherton D, Woo P, Zulian F, Black CM (2002). Juvenile-onset localized scleroderma activity detection by infrared thermography. Rheumatology (Oxford), 41: 1178–1182
Marzano AV, Menni S, Parodi A, Borghi A, Fuligni A, Fabbri P, Caputo R (2003). Localized scleroderma in adults and children. Clinical and laboratory investigations on 239 cases. Eur J Dermatol, 13: 171–176
Mattila L, Airola K, Ahonen M, Hietarinta M, Black C, Saarialho-Kere U, Kahari VM (1998) Activation of tissue inhibitor of metalloproteinases-3 (TIMP-3) mRNA expression in scleroderma skin fibroblasts. J Invest Dermatol, 110: 416–421
McColl G, Buchanan RR (1994) Unilateral scleroderma following ischemic hand injury. J Rheumatol, 21: 380–381
McNiff JM, Glusac EJ, Lazova RZ, Carroll CB (1999) Morphea limited to the superficial reticular dermis: an underrecognized histologic phenomenon. Am J Dermatopathol, 21: 315–319
Menni S, Marzano AV, Passoni E (1997) Neurologic abnormalities in two patients with facial hemiatrophy and sclerosis coexisting with morphea. Pediatr Dermatol, 14: 113–116
Micalizzi C, Parodi A, Rebora A (1994) Morphea with nodular lesions. Br J Dermatol, 131: 298–300
Micalizzi C, Parodi A, Rebora A (1996) Generalized bullous morphoea. Efficacy of salazopyrin. Clin Exp Dermatol, 21: 246–247
Miller J (1992) The fasciitis-morphea complex in children. Am J Dis Child, 146: 733–736
Mitchet C, Doyle J, Ginsburg W (1981) Eosinophilic fascitis: report of 15 cases. Mayo Clin Proc, 56: 27–34
Mizutani H, Yoshida T, Nouchi N, Hamanaka H, Shimizu M (1999) Topical tocoretinate improved hypertrophic scar, skin sclerosis in systemic sclerosis and morphea. J Dermatol, 26: 11–7
Mohrenschlager M, Jung C, Ring J, Abeck D (1999) Effect of penicillin G on corium thickness in linear morphea of childhood: An analysis using ultrasound technique. Pediatr Dermatol, 16: 314–316
Moller R, Serup J, Ammitzboll T (1985) Glycosaminoglycans in localized scleroderma (morphoea). Connect Tissue Res, 13: 227–236
Monteiro MR, Murphy EE, Galaria NA, Whitaker-Menezes D, Murphy GF (2000) Cytological alterations in dermal dendrocytes in vitro: evidence for transformation to a non-dendritic phenotype. Br J Dermatol, 143: 84–90
Morison WL (1997) Psoralen UVA therapy for linear and generalized morphea. J Am Acad Dermatol, 37: 657–659
Morita A, Werfel T, Stege H, Ahrens C, Karmann K, Grewe M, Grether-Beck S, Ruzicka T, Kapp A, Klotz LO, Sies H, Krutmann J (1997) Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy. J Exp Med, 186: 1763–1768
Mork NJ (1981) Clinical and histopathologic morphea with immunological evidence of lupus erythematosus: a case report. Acta Derm Venereol, 61: 367–368
Morley SM, Gaylarde PM, Sarkany I (1985) Epidermal thickness in systemic sclerosis and morphoea. Clin Exp Dermatol, 10: 51–57
Moynahan EJ (1973) Morphoea (localized cutaneous scleroderma) treated with low-dosage penicillamine (4 cases, including coup de sabre). Proc R Soc Med, 66: 1083–1085
Nagai M, Hasegawa M, Takehara K, Sato S (2004). Novel autoantibody to Cu/Zn superoxide dismutase in patients with localized scleroderma. J Invest Dermatol, 122: 594–601
Narvaez D, Kanitakis J, Faure M, Claudy A (1996) Immunohistochemical study of CD34-positive dendritic cells of human dermis. Am J Dermatopathol, 18: 283–288
Neldner KH (1978) Treatment of localized linear scleroderma with phenytoin. Cutis, 22: 569–572
Neuhofer J, Fritsch P (1984) Treatment of localized scleroderma and lichen sclerosus with etretinate. Acta Derm Venereol, 64: 171–174
Oikarinen A, Knuutinen A (2001). Ultraviolet A sunbed used for the treatment of scleroderma. Acta Derm Venereol, 81: 432–433
O’Leary P, Montgomery H, Ragsdale W (1957) Dermatohistopathology of various types of scleroderma. Arch Dermatol, 75: 78–87
Oyama N, Chan I, Neill SM, Hamada T, South AP, Wessagowit V, Wojnarowska F, D’Cruz D, Hughes GJ, Black MM, McGrath JA (2003). Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Lancet, 362: 118–123
Oyama N, Chan I, Neill SM, South AP, Wojnarowska F, Kawakami Y, D’Cruz D, Mepani K, Hughes GJ, Bhogal BS, Kaneko F, Black MM, McGrath JA (2004). Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus. J Clin Invest, 113: 1550–1559
Passos CO, Werneck CC, Onofre GR, Pagani EA, Filgueira AL, Silva LC (2003). Comparative biochemistry of human skin: glycosaminoglycans from different body sites in normal subjects and in patients with localized scleroderma. J Eur Acad Dermatol Venereol, 17: 14–19
Perlish JS, Lemlich G, Fleischmajer R (1988) Identification of collagen fibrils in scleroderma skin. J Invest Dermatol, 90: 48–54
Person JR, Su WP (1979) Subcutaneous morphoea: a clinical study of sixteen cases. Br J Dermatol, 100: 371–380
Peter RU, Ruzicka T, Eckert F (1991) Low-dose cyclosporine A in the treatment of disabling morphea. Arch Dermatol, 127: 1420–1421
Peterson LS, Nelson AM, Su WP (1995) Classification of morphea (localized scleroderma). Mayo Clin Proc, 70: 1068–1076
Peterson LS, Nelson AM, Su WP, Mason T, O’Fallon WM, Gabriel SE (1997) The epidemiology of morphea (localized scleroderma) in Olmsted County 1960–1993. J Rheumatol, 24: 73–80
Rai R, Handa S, Gupta S, Kumar B (2000) Bilateral en coup de sabre-a rare entity. Pediatr Dermatol, 17: 222–224
Rencic A, Brinster N, Nousari CH (2003). Keloid morphea and nodular scleroderma: two distinct clinical variants of scleroderma? J Cutan Med Surg, 7: 20–24
Rigby WF, Denome S, Fanger MW (1987) Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA. J Clin Invest, 79: 1659–1664
Rigby WF, Waugh MG (1992) Decreased accessory cell function and costimulatory activity by 1,25-dihydroxyvitamin D3-treated monocytes. Arthritis Rheum, 35: 110–119
Rodnan GP, Lipinski E, Luksick J (1979) Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma. Arthritis Rheum, 22: 130–140
Rose CD, Fawcett PT, Gibney K, Doughty RA, Singsen BH (1994) Serial measurements of soluble interleukin 2 receptor levels (sIL2-R) in children with juvenile rheumatoid arthritis treated with oral methotrexate. Ann Rheum Dis, 53: 471–474
Rosenberg AM, Uziel Y, Krafchik BR, Hauta SA, Prokopchuk PA, Silverman ED, Laxer RM (1995) Antinuclear antibodies in children with localized scleroderma. J Rheumatol, 22: 2337–2343
Ruffatti A, Peserico A, Rondinone R, Calligaro A, Del Ross T, Ghirardello A, Germino M, Todesco S (1991) Prevalence and characteristics of anti-single-stranded DNA antibodies in localized scleroderma. Comparison with systemic lupus erythematosus. Arch Dermatol, 127: 1180–1183
Sakuraoka K, Tajima S, Nishikawa T (1992) Progressive facial hemiatrophy: report of five cases and biochemical analysis of connective tissue. Dermatology, 185: 196–201
Salmon-Ehr V, Serpier H, Nawrocki B, Gillery P, Clavel C, Kalis B, Birembaut P, Maquart FX (1996) Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis. Arch Dermatol, 132: 802–806
Sato S, Fujimoto M, Ihn H, Kikuchi K, Takehara K (1994) Antigen specificity of antihistone antibodies in localized scleroderma. Arch Dermatol, 130: 1273–1277
Sato S, Fujimoto M, Kikuchi K, Ihn H, Tamaki K, Takehara K (1996a) Elevated soluble CD23 levels in the sera from patients with localized scleroderma. Arch Dermatol Res, 288: 74–88
Sato S, Fujimoto M, Kikuchi K, Ihn H, Tamaki K, Takehara K (1996b) Soluble CD4 and CD8 in serum from patients with localized scleroderma. Arch Dermatol Res, 288: 358–362
Sato S, Fujimoto M, Hasegawa M, Takehara K (2003). Antiphospholipid antibody in localised scleroderma. Ann Rheum Dis, 62: 771–774
Schaffer JV, Carroll C, Dvoretsky I, Huether MJ, Girardi M (2000) Postirradiation morphea of the breast presentation of two cases and review of the literature. Dermatology, 200: 67–71
Scharffetter-Kochanek K, Goldermann R, Lehmann P, Holzle E, Goerz G (1995) PUVA therapy in disabling pansclerotic morphoea of children. Br J Dermatol, 132: 830–831
Scharffetter K, Lankat-Buttgereit B, Krieg T (1988) Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization. Eur J Clin Invest, 18: 9–17
Schiener R, Behrens-Williams SC, Gottlober P, Pillekamp H, Peter RU, Kerscher M (2000) Eosinophilic fasciitis treated with psoralen-ultraviolet A bath photochemotherapy. Br J Dermatol, 142: 804–807
Seitz M, Loetscher P, Dewald B, Towbin H, Rordorf C, Gallati H, Baggiolini M, Gerber NJ (1995) Methotrexate action in rheumatoid arthritis: stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells. Br J Rheumatol, 34: 602–9
Seitz M, Zwicker M, Loetscher P (1998) Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes. Arthritis Rheum, 41: 2032–2038
Seyger MM, van den Hoogen FH, de Boo T, de Jong EM (1997) Reliability of two methods to assess morphea: skin scoring and the use of a durometer. J Am Acad Dermatol, 37: 793–796
Seyger MM, van den Hoogen FH, de Boo T, de Jong EM (1998) Low-dose methotrexate in the treatment of widespread morphea. J Am Acad Dermatol, 39: 220–225
Seyger MM, van den Hoogen FH, van Vlijmen-Willems IM, van de Kerkhof PC, de Jong EM (2001). Localized and systemic scleroderma show different histological responses to methotrexate therapy. J Pathol, 193: 511–516
Sgonc R, Gruschwitz MS, Dietrich H, Recheis H, Gershwin ME, Wick G (1996) Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. J Clin Invest, 98: 785–792
Shulman L (1974) Diffuse fasciitis with hypergammaglobulinemia and eosinophilia: a new syndrome? Clinical Reaserch, 23: 443A
Silman A, Jannini S, Symmons D, Bacon P (1988) An epidemiological study of scleroderma in the West Midlands. Br J Rheumatol, 27: 286–290
Skobieranda K, Helm KF (1995) Decreased expression of the human progenitor cell antigen (CD34) in morphea. Am J Dermatopathol, 17: 471–475
Soma Y, Fujimoto M (1998). Frontoparietal scleroderma (en coup de sabre) following Blaschko’s lines. J Am Acad Dermatol, 38: 366–368
Soma Y, Tamaki T, Kikuchi K, Abe M, Igarashi A, Takehara K, Ishibashi Y (1993) Coexistence of morphea and systemic sclerosis. Dermatology, 186: 103–105
Stava Z, Kobikova M (1977) Salazopyrin in the treatment of scleroderma. Br J Dermatol, 96: 541–544
Stefanec T (2000) Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease? Chest, 117: 841–854
Stege H, Berneburg M, Humke S, Klammer M, Grewe M, Grether-Beck S, Boedeker R, Diepgen T, Dierks K, Goerz G, Ruzicka T, Krutmann J (1997) High-dose UVA1 radiation therapy for localized scleroderma. J Am Acad Dermatol, 36: 938–944
Steger JW, Matthews JH (1999) UVA therapy for scleroderma. J Am Acad Dermatol, 40: 787–788
Stone J, Franks AJ, Guthrie JA, Johnson MH (2001). Scleroderma "en coup de sabre": pathological evidence of intracerebral inflammation. J Neurol Neurosurg Psychiatry, 70: 382–385
Su WP, Person JR (1981) Morphea profunda. A new concept and a histopathologic study of 23 cases. Am J Dermatopathol, 3: 251–260
Su WP, Greene SL (1986) Bullous morphea profunda. Am J Dermatopathol, 8: 144–147
Takehara K, Moroi Y, Nakabayashi Y, Ishibashi Y (1983) Antinuclear antibodies in localized scleroderma. Arthritis Rheum, 26: 612–616
Taveira M, Selores M, Costa V, Massa A (1999) Generalized morphea and lichen sclerosus et atrophicus successfully treated with sulphasalazine. J Eur Acad Dermatol Venereol, 12: 283–284
Todd DJ, Askari A, Ektaish E (1998) PUVA therapy for disabling pansclerotic morphoea of children. Br J Dermatol, 138: 201–202
Torres JE, Sanchez JL (1998) Histopathologic differentiation between localized and systemic scleroderma. Am J Dermatopathol, 20: 242–245
Tuffanelli DL (1998) Localized scleroderma. Semin Cutan Med Surg, 17: 27–33
Uitto J, Santa Cruz DJ, Bauer EA, Eisen AZ (1980) Morphea and lichen sclerosus et atrophicus. Clinical and histopathologic studies in patients with combined features. J Am Acad Dermatol, 3: 271–279
Umbert P, Winkelmann RK (1978) Concurrent localized scleroderma and discoid lupus erythematosus. Cutaneous ‘mixed’ or ‘overlap’ syndrome. Arch Dermatol, 114: 1473–1478
Unterberger I, Trinka E, Engelhardt K, Muigg A, Eller P, Wagner M, Sepp N, Bauer G (2003). Linear scleroderma "en coup de sabre" coexisting with plaque-morphea: neuroradiological manifestation and response to corticosteroids. J Neurol Neurosurg Psychiatry, 74: 661–664
Uziel Y, Krafchik BR, Feldman B, Silverman ED, Rubin LA, Laxer RM (1994). Serum levels of soluble interleukin-2 receptor. A marker of disease activity in localized scleroderma. Arthritis Rheum, 37: 898–901
Uziel Y, Krafchik BR, Silverman ED, Thorner PS, Laxer RM (1994b) Localized scleroderma in childhood: a report of 30 cases. Semin Arthritis Rheum, 23: 328–340
Uziel Y, Feldman BM, Krafchik BR, Yeung RS, Laxer RM (2000) Methotrexate and corticosteroid therapy for pediatric localized scleroderma. J Pediatr, 136: 91–95
van Bergen BH, van Dooren-Greebe RJ, Fiselier TJ, Koopman RJ (1997) D-penicillamine in treatment of scleroderma "en coup de sabre". Hautarzt, 48: 42–44
van den Hoogen FH, Boerbooms AM, Swaak AJ, Rasker JJ, van Lier HJ, van de Putte LB (1996) Comparison of methotrexate with placebo in the treatment of systemic sclerosis: a 24 week randomized double-blind trial, followed by a 24 week observational trial. Br J Rheumatol, 35: 364–372
Venneker GT, Das PK, Naafs B, Tigges AJ, Bos JD, Asghar SS (1994) Morphoea lesions are associated with aberrant expression of membrane cofactor protein and decay accelerating factor in vascular endothelium. Br J Dermatol, 131: 237–242
Wach F, Ullrich H, Schmitz G, Landthaler M, Hein R (1995) Treatment of severe localized scleroderma by plasmapheresis — report of three cases. Br J Dermatol, 133: 605–609
Wakelin SH, James MP (1995) Zosteriform atrophoderma of Pasini and Pierini. Clin Exp Dermatol, 20: 244–246
Weedon D (1997) Disorders of collagen. In: Skin Pathology, Churchill Livingstone, HongKong, pp 288–293
Weide B, Walz T, Garbe C (2000) Is morphoea caused by Borrelia burgdorferi? A review. Br J Dermatol, 142: 636–644
Whittaker SJ, Smith NP, Jones RR (1989) Solitary morphoea profunda. Br J Dermatol, 120: 431–440
Winkelmann RK, Connolly SM, Doyle JA (1982) Carpal tunnel syndrome in cutaneous connective tissue disease: generalized morphea, lichen sclerosus, fasciitis, discoid lupus erythematosus, and lupus panniculitis. J Am Acad Dermatol, 7: 94–99
Winkelmann R (1985) Localized cutaneous scleroderma. Seminars in Dermatology, 4: 90–103
Wlaschek M, Briviba K, Stricklin GP, Sies H, Scharffetter-Kochanek K (1995) Singlet oxygen may mediate the ultraviolet A-induced synthesis of interstitial collagenase. J Invest Dermatol, 104: 194–198
Wollenberg A, Baumann L, Plewig G (1995) Linear atrophoderma of Moulin: a disease which follows Blaschko’s lines. Br J Dermatol, 135: 277–279
Wollina U, Looks A, Schneider R, Maak B (1998) Disabling morphoea of childhood-beneficial effect of intravenous immunoglobulin therapy. Clin Exp Dermatol, 23: 292–293
Wuthrich RC, Roenigk HH, Steck WD (1975) Localized scleroderma. Arch Dermatol, 111: 98–100
Yamaguchi K, Takeuchi I, Yoshii N, Gushi A, Kanekura T, Kanzaki T (1998) The discrepancy in hardness between clinical and histopathological findings in localized scleroderma treated with PUVA. J Dermatol, 25: 544–546
Yamanaka CT, Gibbs NF (1999) Trauma-induced linear scleroderma. Cutis, 63: 29–32
Yamane K, Ihn H, Kubo M, Yazawa N, Kikuchi K, Soma Y, Tamaki K (2000) Increased serum levels of soluble vascular cell adhesion molecule 1 and E-selectin in patients with localized scleroderma. J Am Acad Dermatol, 42: 64–69
Young EM, Jr, Barr RJ (1985) Sclerosing dermatoses. J Cutan Pathol, 12: 426–441
Zheng XY, Zhang JZ, Tu P, Ma SQ (1998) Expression of platelet-derived growth factor B-chain and platelet-derived growth factor beta-receptor in fibroblasts of scleroderma. J Dermatol Sci, 18: 90–97
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Orteu, C.H., Dutz, J.P. (2005). Localized Scleroderma. In: Hertl, M. (eds) Autoimmune Diseases of the Skin. Springer, Vienna. https://doi.org/10.1007/3-211-27377-8_7
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