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Estrogens and Schizophrenia

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Estrogen Effects in Psychiatric Disorders

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References

  • Ahokas AJ, Turtiainen S, Aito M (1998) Sublingual oestrogen treatment of postnatal depression. Lancet 351: 109

    Article  PubMed  CAS  Google Scholar 

  • Ahokas A, Aito M, Turtiainen S (2000) Association between oestradiol and puerperal psychosis. Acta Psychiatr Scand 101: 167–170

    Article  PubMed  CAS  Google Scholar 

  • Barrett-Connor E, Stuenkel CA (2001) Hormone replacement therapy (HRT): risks and benefits. Int J Epidemiol 30: 423–426

    Article  PubMed  CAS  Google Scholar 

  • Bédard P, Boucher R, Daigle M, Di Paolo T (1984) Similar effect of estradiol and haloperidol on experimental tardive dyskinesia in monkeys. Psychoendocrinology 9: 375–379

    Google Scholar 

  • Bergemann N, Mundt Ch, Resch F, Parzer P, Nagl I, Eller A, Runnebaum B (1996) On the hypoestrogen hypothesis in female schizophrenia: Preliminary results. Schizophr Res 18: 158

    Article  Google Scholar 

  • Bergemann N, Parzer P, Nagl I, Salbach B, Runnebaum B, Mundt Ch, Resch F (2002) Acute psychiatric admission and menstrual cycle phase in women with schizophrenia. Arch Women Ment Health 5:119–126

    PubMed  CAS  Google Scholar 

  • Bleuler M (1943) Die spätschizophrenen Krankheitsbilder. Neurol XV 9: 259–290

    Google Scholar 

  • Braendle W, Breckwoldt M, Kuhl H, Riecher-Rössler A, Rohde A, Rüther E (2001) Sexualhormone und Psyche — Ergebnisse des 2. Interdisziplinären Frankfurter Gesprächs zur Kontrazeption. Frauenarzt 42: 154–160

    Google Scholar 

  • Canuso CM, Goldstein JM, Wojcik J, Dawson R, Brandman D, Klibanski A, Schildkraut JJ, Green AI (2002) Antipsychotic medication, prolactin elevation, and ovarian function in women with schizophrenia and schizoaffective disorder. Psychiatry Res 111: 11–20

    Article  PubMed  CAS  Google Scholar 

  • Carter DA, McGarrick GM, Norton KRW, Paykel ES, Prysor-Jones RA, Whitehead SA (1982) The effect of chronic neuroleptic treatment on gonadotrophin release. Psychoneuroendocrinology 7: 201–207

    Article  PubMed  CAS  Google Scholar 

  • Chang SS, Renshaw DC (1986) Psychosis and pregnancy. Compr Ther 12: 36–41

    PubMed  CAS  Google Scholar 

  • Choi SH, Kang SB, Joe SH (2001) Changes in premenstrual symptoms in women with schizophrenia: a prospective study. Psychosom Med 6: 822–829

    Google Scholar 

  • Cohen RZ, Seeman MV, Gotowiec A, Kopala L (1999) Earlier puberty as a predictor of later onset of schizophrenia in women. Am J Psychiatry 156: 1059–1064

    PubMed  CAS  Google Scholar 

  • Cyr M, Calon F, Morissette M, Di Paolo T (2002) Estrogenic modulation of brain activity: implications for schizophrenia and Parkinson’s disease. J Psychiatry Neurosci 27: 12–27

    PubMed  Google Scholar 

  • Davis SR (2002) The effects of tibolone on mood and libido. Menopause 9: 162–170

    PubMed  Google Scholar 

  • De Battista C, Lawrence Smith D, Schatzberg AF (1999) Modulation of monoamine neurotransmitters by estrogen: clinical implications. Rev Psychiatry 18: 137–166

    Google Scholar 

  • de Noaves Soares C, Almeida OP, Joffe H, Cohen LS (2001) Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women. Arch Gen Psychiatry 58: 529–534

    Google Scholar 

  • Diczfalusy E, Lauritzen C (1961) Psychiatrische und neurologische Erkrankungen. In: Diczfalusy E, Lauritzen C (eds) Östrogene beim Menschen. Springer, Berlin Heidelberg, pp 461–462

    Google Scholar 

  • DiPaolo T, Payet P, Labrie F (1981) Effect of chronic estradiol and haloperidol treatment on striatal dopamine receptors. Eur J Pharmacol 73: 105–106

    CAS  Google Scholar 

  • Endo M, Daiguji M, Asano Y, Yamashita I, Takahashi S (1978) Periodic psychosis recurring in association with menstrual cycle. J Clin Psychiatry 39: 456–466

    PubMed  CAS  Google Scholar 

  • Fink G, Sumner BEH (1996) Oestrogen and mental state. Nature 383: 306

    Article  PubMed  CAS  Google Scholar 

  • Fink G, Sumner BEH, Rosie R, Grace O, Quinn JP (1996) Estrogen control of central neurotransmission: effect on mood, mental state, and memory. Cell Mol Neurobiol 16: 325–344

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Segura LM, Azcoitia I, Don Carlos LL (2001) Neuroprotection by estradiol. Progr Neurobiol 63: 29–60

    Article  PubMed  CAS  Google Scholar 

  • Gattaz WF, Behrens S, De Vry J, Häfner H (1992) Östradiol hemmt Dopaminvermittelte Verhaltensweisen bei Ratten: Ein Tiermodell zur Untersuchung der geschlechtsspezifischen Unterschiede bei der Schizophrenie. Fortschr Neurol Psychiatrie 1: 1–44

    Google Scholar 

  • Gattaz WF, Vogel P, Riecher-Rössler A, Soddu G (1994) Influence of the menstrual cycle phase on the therapeutic response in schizophrenia. Biol Psychiatry 36: 137–139

    Article  PubMed  CAS  Google Scholar 

  • Gerada C, Reveley A (1988) Schizophreniform psychosis associated with the menstrual cycle. Br J Psychiatry 152: 700–702

    PubMed  CAS  Google Scholar 

  • Glick J, Stewart D (1980) A new drug treatment for premenstrual exacerbation of schizophrenia. Compr Psychiatry 21: 281–287

    Article  PubMed  CAS  Google Scholar 

  • Gordon JH, Borison RL, Diamond BL (1980) Modulation of dopamine receptors sensitivity by estrogen. Biol Psychiatry 15: 389–396

    PubMed  CAS  Google Scholar 

  • Gordon JH, Diamond BI (1981) Antagonism of dopamine supersensitivity by estrogen: neurochemical studies in an animal model of tardive dyskinesia. Biol Psychiatry 16: 365–371

    PubMed  CAS  Google Scholar 

  • Gregoire AJP, Kumar R, Everitt B, Henderson AF, Studd JWW (1996) Transdermal oestrogen treatment of severe postnatal depression. Lancet 347: 930–933

    Article  PubMed  CAS  Google Scholar 

  • Grigoriadis S, Seeman MV (2002) The role of estrogen in schizophrenia: implications for schizophrenia practice guidelines for women. Can J Psychiatry 47: 437–442

    PubMed  Google Scholar 

  • Häfner H, Riecher-Rössler A, Hambrecht M, Maurer K, Meissner S, Schmidtke A, Fätkenheuer B, Löffler W, an der Heiden W (1991a) Geschlechtsunterschiede bei schizophrenen Erkrankungen. Fortschr Neurol Psychiatrie 59: 343–360

    Google Scholar 

  • Häfner H, Behrens S, De Vry J, Gattaz WF, Löffler W, Maurer K, Riecher-Rössler A (1991b) Warum erkranken Frauen später an Schizophrenie? Erhöhung der Vulnerabilitätsschwelle durch Östrogen. Nervenheilkunde 10: 154–163

    Google Scholar 

  • Häfner H, Behrens S, De Vry J, Gattaz WF (1991c) An animal model for the effects of estradiol on dopamine-mediated behavior: implications for sex differences in schizophrenia. Psychiatry Res 38: 125–143

    PubMed  Google Scholar 

  • Halbreich U (2002) The spectrum of estrogens, estrogen agonists and SERMS — abstract. Int J Neuropsychopharmacol 5(Suppl 1): S12

    Google Scholar 

  • Hallonquist JD, Seeman MV, Lang M, Rector NA (1993) Variation in symptom severity over the menstrual cycle of schizophrenics. Biol Psychiatry 33: 207–209

    Article  PubMed  CAS  Google Scholar 

  • Hoff AL, Kremen WS, Wieneke MH, Lauriello J, Blankfeld HM, Faustman WO, Csemansky JG, Nordahl TE (2001) Association of estrogen levels with neuropsychological performance in women with schizophrenia. Am J Psychiatry 158: 1134–1139

    Article  PubMed  CAS  Google Scholar 

  • Holsboer F (1983) Hormones. In: Hippius H, Winokur G (eds) Psychopharmacology 1. Excerpta Medica, Amsterdam Oxford Princeton, 144–161

    Google Scholar 

  • Honigfeld G, Gillis RD, Klett CJ (1976) NOSIE: Nurses' observation scale for inpatient evaluation. In: Guy W (ed) ECDEU Assessment Manual for Psychopharmocology. Rockville MD, NIMH

    Google Scholar 

  • Hruska RE, Silbergeld EK (1980) Estrogen treatment enhances dopamine receptor sensitivity in the rat striatum. Eur J Pharmacol 61: 397–400

    Article  PubMed  CAS  Google Scholar 

  • Huber TJ (2001) Hormonspiegel bei Frauen mit psychotischen Erkrankungen. In: Riecher-Rössler A, Rohde A (eds) Psychische Erkrankungen bei Frauen — für eine geschlechtersensible Psychiatrie und Psychotherapie. Karger, Basel Freiburg Paris London New York New Delhi Bangkok Singapore Tokyo Sidney, 165–169

    Google Scholar 

  • Huber TJ, Rollnik J, Wilhelms J, von zur Mühlen A, Emrich HM, Schneider U (2001) Estradiol levels in psychotic disorders. Psychoneuroendocrinology 26: 27–35

    Article  PubMed  CAS  Google Scholar 

  • Hutchinson G, Bhugra D, Mallett R, Burnett R, Corridan B, Leff J (1999) Fertility and marital rates in first-onset schizophrenia. Soc Psychiatry Psychiatr Epidemiol 34: 617–621

    Article  PubMed  CAS  Google Scholar 

  • Jeste DV, Lindamer LA, Lacro JP (2001) Gender differences in late-life schizophrenia and its treatment — abstract. Syllabus and Proc Summary of the American Psychiatric Association’s 2001 Annual Meeting, 310

    Google Scholar 

  • Kendell RE, Chalmers JC, Platz C (1987) Epidemiology of puerperal psychoses. Br J Psychiatry 150: 662–673

    PubMed  CAS  Google Scholar 

  • Klaiber EL, Broverman DM, Vogel U, Kobayashi Y (1979) Estrogen therapy for severe persistent depressions in women. Arch Gen Psychiatry 36: 550–554

    PubMed  CAS  Google Scholar 

  • Koller WC, Weiner WJ, Klawans HL, Nausieda PA (1980) Influence of female sex hormones on neuroleptic-induced behavioral supersensitivity. Neuropharmacol 19: 387–391

    CAS  Google Scholar 

  • Kraepelin E (1909) Psychiatrie, vol. 1–4, 8th ed. Barth, Leipzig

    Google Scholar 

  • Krafft-Ebing G (1896) Untersuchungen über Irresein zur Zeit der Menstruation: Ein klinischer Beitrag zur Lehre vom periodischen Irresein. Arch Psychiatry 8: 65–107

    Google Scholar 

  • Kretschmer E (1921) Körperbau und Charakter. Untersuchungen zum Konstitutionsproblem und zur Lehre von den Temperamenten, 25th ed. Springer, Berlin

    Google Scholar 

  • Kuhl H (2002) Einfluss von Östrogenen und Gestagenen auf das Zentralnervensystem. In: Kuhl H (ed) Sexualhormone und Psyche. Thieme, Stuttgart, 9–17

    Google Scholar 

  • Kulkarni J, de Castella A, Smith D, Taffe J, Keks N, Copolov D (1996) A clinical trial of the effects of estrogen in acutely psychotic women. Schizophr Res 20: 247–252

    Article  PubMed  CAS  Google Scholar 

  • Kulkarni J, Riedel A, de Castella AR et al. (2001) Estrogen — a potential treatment for schizophrenia. Schizophr Res 48: 137–144

    Article  PubMed  CAS  Google Scholar 

  • Labhart A (1978) Klinik der inneren Sekretion. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Lindamer LA, Lohr JB, Harris MJ et al. (1997) Gender, estrogen, and schizophrenia. Psychopharmacol Bull 33: 221–228

    PubMed  CAS  Google Scholar 

  • Lindamer LA, Buse DC, Lohr JB, Jeste DV (2001) Hormone replacement therapy in postmenopausal women with schizophrenia: positive effect on negative symptoms? Biol Psychiatry 49: 47–51

    Article  PubMed  CAS  Google Scholar 

  • Maguire GA (2002) Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry 63(Suppl 4): 56–62

    PubMed  CAS  Google Scholar 

  • Mahé V, Dumaine A (2001) Oestrogen withdrawal associated psychoses. Acta Psychiatr Scand 104: 323–331

    PubMed  Google Scholar 

  • Mall G (1959) Neuere Ergebnisse der Psycho-Endokrinologie. Ärztliche Praxis XI: 1357–1360

    Google Scholar 

  • Mall G (1960) Diagnostik und Therapie ovarieller Psychosen. Zentralblatt Gesamte Neurol Psychiatrie 155: 250

    Google Scholar 

  • McEwen BS, Alves SE, Bulloch K, Weiland NG (1998) Clinically relevant basic science studies of gender differences and sex hormone effects. Psychopharmacol Bull 34: 251–259

    PubMed  CAS  Google Scholar 

  • NAMS (2000) A decision tree for the use of estrogen replacement therapy or hormone replacement therapy in postmenopausal women: consensus opinion of the North American Menopause Society. Menopause 7: 76–86

    Google Scholar 

  • Neumann NU, Frasch K (2001) Olanzapin und Schwangerschaft — zwei Kasuistiken. Nervenarzt 72: 876–878

    Article  PubMed  CAS  Google Scholar 

  • Nicoletti F, Ferrara N, Patti F, Viglianesi M, Rampello L, Bianchi A, Reggio A, Scapagnini U (1983) Influence of sex steroids and prolactin on haloperidol-induced catalepsy. Brain Res 279: 352–358

    Article  PubMed  CAS  Google Scholar 

  • Oesterlund MK (2002) The role of estrogens in neuropsychiatric disorders. Curr Opin Psychiatry 15: 307–312

    Google Scholar 

  • Overall JE, Gorham DR (1962) The brief psychiatric rating scale. Psychol Report 10: 799–812

    Google Scholar 

  • Rasgon NL, Small GW, Siddarth P, Miller K, Ercoli LM, Bookheimer SY, Lavretsky H, Huang SC, Barrio JR, Phelps ME (2001) Estrogen use and brain metabolic change in older adults. A preliminary report. Psychiatry Research: Neuroimaging Section 107: 11–18

    CAS  Google Scholar 

  • Riecher A, Maurer K, Löffler W, Fätkenheuer B, an der Heiden W, Munk-Jørgensen P, Strömgren E, Häfner H (1990) Gender differences in age at onset and course of schizophrenic disorders. In: Häfner H, Gattaz WF (eds) Search for the causes of schizophrenia, vol. 2, 15–33

    Google Scholar 

  • Riecher-Rössler A, Häfner H (1993) Schizophrenia and oestrogens — is there an association? Euro Arch Psychiatry Clin Neurosci 242: 323–328

    Google Scholar 

  • Riecher-Rössler A (1994) Die Spätschizophrenie — eine valide Entität? Eine empirische Studie zu Risikofaktoren, Krankheitsbild und Verlauf. Habilitationsschrift, Universität Heidelberg-Mannheim

    Google Scholar 

  • Riecher-Rössler A, Häfner H, Stumbaum M, Maurer K, Schmidt R (1994a) Can estradiol modulate schizophrenic symptomatology? Schizophr Bull 20: 203–214

    PubMed  Google Scholar 

  • Riecher-Rössler A, Häfner H, Dütsch-Strobel A, Oster M, Stumbaum M, van Gülick-Bailer M, Löffler W (1994b) Further evidence for a specific role of estradiol in schizophrenia? Biol Psychiatry 36: 492–494

    PubMed  Google Scholar 

  • Riecher-Rössler A, Löffler W, Munk-Jørgensen P (1997) What do we really know about late-onset schizophrenia? Eur Arch Psychiatry Clin Neurosci 247: 195–208

    Article  PubMed  Google Scholar 

  • Riecher-Rössler A, Häfner H, Dütsch-Strobel A, Stumbaum M (1998) Gonadal function and its influence on psychopathology. A comparison of schizophrenic and non-schizophrenic female inpatients. Arch Women Ment Health 1: 15–26

    Google Scholar 

  • Riecher-Rössler A (2002) Estrogen effects in schizophrenia and their potential the-rapeutic implications — review. Arch Women Ment Health 5: 111–118

    PubMed  Google Scholar 

  • Riecher-Rössler A (2003) Estrogens and schizophrenia. Curr Opin Psychiatry 16: 187–192

    Google Scholar 

  • Ripley HS, Papanicolaou GN (1942) The menstrual cycle with vaginal smear studies in schizophrenia, depression and elation. Am J Psychiatry 98: 567–573

    Google Scholar 

  • Schepp A (1997) Pilotstudie zur Frage eines überdauernden relative Hypoöstrogenismus bei schizophrenen Frauen. Inauguraldissertation zur Erlangung des medizinischen Doktorgrades, Universität Heidelberg-Mannheim

    Google Scholar 

  • Schmidt PJ, Nieman L, Danaceau MA, Tobin MB, Roca CA, Murphy JH, Rubinow DR (2000) Estrogen replacement in perimenopause-related depression: a preliminary report. Am J Obstet Gynecology 183: 414–420

    CAS  Google Scholar 

  • Scriba PC, von Werder K (1976) Hypothalamus und Hypophyse. In: Siegenthaler W (ed) Klinische Pathophysiologie. Thieme, Stuttgart, pp 278–306

    Google Scholar 

  • Seeman MV (1983) Interaction of sex, age and neuroleptic dose. Compr Psychiatry 24: 125–128

    Article  PubMed  CAS  Google Scholar 

  • Sichel DA, Cohen LS, Robertson LM et al. (1995) Prophylactic estrogen in recurrent postpartum affective disorders. Biol Psychiatry 38: 814–818

    Article  PubMed  CAS  Google Scholar 

  • Smith S, Wheeler MJ, Murray R, O'Keane V (2002) The effects of antipsychotic-induced hyperprolactinaemia on the hypothalamic-pituitary-gonadal axis. J Clin Psychopharmacol 22: 109–114

    Article  PubMed  CAS  Google Scholar 

  • Stahl SM (1998) Basic psychopharmacology of antidepressants, part 2: estrogen as an adjunct to antidepressant treatment. J Clin Psychiatry 59(Suppl 4): 15–24

    PubMed  CAS  Google Scholar 

  • Stahl SM (2001a) Effects of estrogen on the central nervous system. J Clin Psychiatry 62: 317–318

    PubMed  CAS  Google Scholar 

  • Stahl SM (2001b) Why drugs and hormones may interact in psychiatric disorders. J Clin Psychiatry 62: 225–226

    PubMed  CAS  Google Scholar 

  • von Zerssen D, Koeller DM (1976) Klinische Selbstbeurteilungs-Skalen (KSb-Si) aus dem Münchener Psychiatrischen Informations-System (PSYCHIS München). Manual. Beltz, Weinheim

    Google Scholar 

  • Writing Group for the Women’s Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA 288: 321–333

    Google Scholar 

  • Zhang-Wong J, Seeman MV (2002) Antipsychotic drugs, menstrual regularity, and osteoporosis risk. Arch Women Ment Health 5: 93–98

    PubMed  CAS  Google Scholar 

  • Zweifel JE, O'Brien WH (1997) A meta-analysis of the effect of hormone replacement therapy upon depressed mood. Psychoneuroendocrinology 22: 189–212

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Anita Riecher-Rössler
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Editors and Affiliations

  1. Department of Psychiatry, University of Heidelberg, Germany

    Niels Bergemann

  2. Psychiatric Outpatient Department, University of Basel, Switzerland

    Anita Riecher-Rössler

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Riecher-Rössler, A. (2005). Estrogens and Schizophrenia. In: Bergemann, N., Riecher-Rössler, A. (eds) Estrogen Effects in Psychiatric Disorders. Springer, Vienna. https://doi.org/10.1007/3-211-27063-9_2

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  • DOI: https://doi.org/10.1007/3-211-27063-9_2

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