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Strategies to Induce Nuclear Reprogramming

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Cancer Stem Cells

Part of the book series: Springer Series on Biofilms ((SCHERING FOUND,volume 2006/5))

Abstract

The cloning of mammals from adult donor cells has demonstrated that the oocyte can reprogram a differentiated nucleus into a pluripotent embryonic state. Reprogramming of committed cells into pluripotent cells can also be achieved by the explantation of germ line cells and by the fusion of differentiated cells with embryonic cells. The future challenge will be to stably convert a differentiated cell into embryonic stem (ES) cells by the transient expression of defined genes. Recent findings suggest that the exposure of adult cells to a few defined factors can indeed induce a pluripotent-like state resembling that of ES cells. This approach may allow for the generation of patient-specific stem cells in order to study and treat degenerative diseases without recourse to nuclear transfer.

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Authors and Affiliations

  1. Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Harvard Medical School and Harvard Stem Cell Institute, 185 Cambridge Street, Boston, MA, 02114, USA

    S. Eminli & K. Hochedlinger

  2. Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute, 9 Cambridge Center, Cambridge, MA, 02142, USA

    R. Jaenisch

Authors
  1. S. Eminli
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  2. R. Jaenisch
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  3. K. Hochedlinger
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Correspondence to K. Hochedlinger .

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O.D. Wiestler B. Haendler D. Mumberg

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© 2007 Springer-Verlag

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Eminli, S., Jaenisch, R., Hochedlinger, K. (2007). Strategies to Induce Nuclear Reprogramming. In: Wiestler, O., Haendler, B., Mumberg, D. (eds) Cancer Stem Cells. Springer Series on Biofilms, vol 2006/5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/2789_2007_045

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  • DOI: https://doi.org/10.1007/2789_2007_045

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