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Nature's Choice of Genes Controlling Chronic Inflammation

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Immunotherapy in 2020

Part of the book series: Ernst Schering Foundation Symposium Proceedings ((SCHERING FOUND,volume 2006/4))

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Abstract

Inflammation is a physiological response that may go uncontrolled and thereby develop in a chronic way. This seems to happen in many common diseases of autoimmune, degenerative, or allergic character. Rheumatoid arthritis (RA) is by definition a chronic disease with an autoimmune inflammatory attack on diarthrodial cartilaginous joints. The development of new treatment neutralizing cytokines involved in the inflammatory attack has given relief and gives the promise of more effective treatment of already established disease. It is now time to set our eyes on a new vision to develop preventive and curative treatment based on knowledge of the unique and causative pathogenic mechanisms. To do this we believe it is important to identify the natural-selected polymorphisms that are associated with disease. These have proven to be extremely difficult to identify in complex diseases such as RA, but using animal models, this work is closer to reality. Animal models have recently been developed mimicking various aspects of the human disease. We will present an example in which a genetic polymorphism associated with the development of arthritis has been identified. On the basis of this finding, a new pathway involving control of immune tolerance by reactive oxidative species has been identified and a new class of antiinflammatory agents activating the induced oxidative burst protein complex is suggested.

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Acknowledgements

I am grateful for support from several foundations that have made this work possible: the Anna Greta Crafoord, King Gustaf V:s 80-year, the Swedish Science Research Council, the Strategic Research Foundation, and the EU project NeuroproMiSe—LSHM-CT-2005-018637 and LSHM-CT-2005-005223 (Euraps).

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Authors and Affiliations

  1. Medical Inflammation Research, I11 BMC, Lund University, 22184, Lund, Sweden

    R. Holmdahl

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  1. R. Holmdahl
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Correspondence to R. Holmdahl .

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A. Radbruch H.-D. Volk K. Asadullah W.-D. Doecke

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© 2007 Springer-Verlag

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Holmdahl, R. (2007). Nature's Choice of Genes Controlling Chronic Inflammation. In: Radbruch, A., Volk, HD., Asadullah, K., Doecke, WD. (eds) Immunotherapy in 2020. Ernst Schering Foundation Symposium Proceedings, vol 2006/4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/2789_2007_036

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  • DOI: https://doi.org/10.1007/2789_2007_036

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-70850-6

  • Online ISBN: 978-3-540-70851-3

  • eBook Packages: MedicineMedicine (R0)

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