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Whole-Breast Hypofractionated Radiotherapy

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Alternate Fractionation in Radiotherapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Breast cancer is the most common malignancy diagnosed in women (http://seer.cancer.gov/statfacts/html/breast.html). Today, with the widespread generalization of mammography, it is most frequently diagnosed at an early stage (Nystrom et al. 2002). The outcomes of those early-stage cancers are excellent, with local control above 98% and a risk of dying of cancer at 5 years below 2% (http://seer.cancer.gov/statfacts/html/breast.html; Strnad et al. 2016). Clinical researches since the 1980s have aimed at optimizing the cosmetic outcome, minimizing the long-term side effects, and reducing the treatment burden. Several randomized clinical trials and meta-analyses have shown that breast-conserving surgery followed by adjuvant radiotherapy (XRT) to the whole breast achieves local control rate and survival equivalent to mastectomy, with the advantage of allowing breast conservation and hence improved quality of life (Fisher et al. 2002; Veronesi et al. 2002; Clark et al. 1996; EBCTCG et al. 2011).

The original version of this chapter was revised. The affiliations of the authors have been updated.

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Authors and Affiliations

  1. Division of Radiation Oncology, Institut de Cancérologie de Libreville (ICL), Libreville, Gabon, USA

    Fernand Missohou

  2. Allegheny General Hospital, Allegheny Health Network Cancer Institute, Drexel University College of Medicine, Pittsburgh, PA, USA

    Mark Trombetta

  3. Erasmus Medical Center, Rotterdam, The Netherlands

    Jean-Philippe Pignol

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  1. Fernand Missohou
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  2. Mark Trombetta
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  3. Jean-Philippe Pignol
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Correspondence to Mark Trombetta .

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Editors and Affiliations

  1. Allegheny General Hospital Allegheny Health Network Cancer Institute, Drexel University College of Medicine, Pittsburgh, PA, USA

    Mark Trombetta

  2. Radiation Oncology Department, Erasmus University Medical Center, Rotterdam, The Netherlands

    Jean-Philippe Pignol

  3. Allegheny Health Network, Temple University School of Medicine, Pittsburgh Campus, Pittsburgh, PA, USA

    Paolo Montemaggi

  4. Hylda Cohn/American Cancer Society, Drexel University College of Medicine, Philadelphia, PA, USA

    Luther W. Brady

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Missohou, F., Trombetta, M., Pignol, JP. (2017). Whole-Breast Hypofractionated Radiotherapy. In: Trombetta, M., Pignol, JP., Montemaggi, P., Brady, L.W. (eds) Alternate Fractionation in Radiotherapy. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2017_33

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  • DOI: https://doi.org/10.1007/174_2017_33

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