Abstract
While recurrent esophageal cancer is a common clinical scenario, limited data exist regarding management approaches that include re-irradiation. Tremendous technological advances in the treatment planning and delivery of radiotherapy pave the way to evaluate the appropriateness of re-irradiation in the management of radio-recurrent esophageal cancer. Patients with radio-recurrent esophageal cancer may still be selected for a potentially curative treatment, especially those in good clinical condition, who may experience prolonged survival and good symptom control rates. None of the different therapeutic options is carried out without potentially life-threatening treatment-related toxicities in a relevant proportion of the patients. In this scenario, patient selection performed on individual basis could help to identify the most appropriate treatment modality, including re-irradiation with cutting-edge techniques. Enrollment of these patients in clinical trials is highly warranted.
The original version of this chapter was revised. An erratum to this chapter can be found at 10.1007/978-3-319-41825-4_78.
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References
Fernandes A, Berman AT, Mick R et al (2016) A prospective study of proton beam reirradiation for esophageal cancer. Int J Radiat Oncol Biol Phys 95:483–487
Fujita H, Kakegawa T, Yamana H et al (1994) Lymph node metastasis and recurrence in patients with a carcinoma of the thoracic esophagus who underwent three-field dissection. World J Surg 18:266–272
Haefner MF, Lang K, Krug D et al (2015) Prognostic factors, patterns of recurrence and toxicity for patients with esophageal cancer undergoing definitive radiotherapy or chemo-radiotherapy. J Radiat Res 56:742–749
Harms W, Krempien R, Grehn C et al (2005) Daytime pulsed dose rate brachytherapy as a new treatment option for previously irradiated patients with recurrent oesophageal cancer. Br J Radiol 78:236–241
Homs MY, Steyerberg EW, Eijkenboom WM et al (2004) Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trial. Lancet 364:1497–1504
Kim YS, Lee CG, Kim KH et al (2012) Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy. Radiat Oncol J 30:182–188
Mantel F, Flentje M, Guckenberger M (2013) Stereotactic body radiation therapy in the re-irradiation situation – a review. Radiat Oncol 8:7
Markar SR, Karthikesalingam A, Penna M et al (2014) Assessment of short-term clinical outcomes following salvage esophagectomy for the treatment of esophageal malignancy: systematic review and pooled analysis. Ann Surg Oncol 21:922–931
Marks JL, Hofstetter W, Correa AM et al (2012) Salvage esophagectomy after failed definitive chemoradiation for esophageal adenocarcinoma. Ann Thorac Surg 94:1126–1133
NCCN Guidelines Version 2.2016 Updates Esophageal and Esophagogastric Junction Cancers Available online
Ordu AD, Nieder C, Geinitz H et al (2015) Radio(chemo)therapy for locally advanced squamous cell carcinoma of the esophagus: long-term outcome. Strahlenther Onkol 191:153–160
Shioyama Y, Nakamura K, Ohga S et al (2007) Radiation therapy for recurrent esophageal cancer after surgery: clinical results and prognostic factors. Jpn J Clin Oncol 37:918–923
Stahl M, Stuschke M, Lehmann N et al (2005) Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol 23:2310–2317
Sudo K, Taketa T, Correa AM et al (2013) Locoregional failure rate after preoperative chemoradiation of esophageal adenocarcinoma and the outcomes of salvage strategies. J Clin Oncol 31:4306–4310
Sudo K, Xiao L, Wadhwa R et al (2014) Importance of surveillance and success of salvage strategies after definitive chemoradiation in patients with esophageal cancer. J Clin Oncol 32:3400–3405
Swisher SG, Wynn P, Putnam JB et al (2002) Salvage esophagectomy for recurrent tumors after definitive chemotherapy and radiotherapy. J Thorac Cardiovasc Surg 123:175–183
Yamaguchi S, Ohguri T, Imada H et al (2011) Multimodal approaches including three-dimensional conformal re-irradiation for recurrent or persistent esophageal cancer: preliminary results. J Radiat Res 52:812–820
Yano M, Takachi K, Doki Y et al (2006) Prognosis of patients who develop cervical lymph node recurrence following curative resection for thoracic esophageal cancer. Dis Esophagus 19:73–77
Zerini D, Jereczek-Fossa BA, Fodor C et al (2015) Salvage image-guided intensity modulated or stereotactic body reirradiation of local recurrence of prostate cancer. Br J Radiol 88:20150197
Zhou Z, Zhen C, Bai W et al (2015) Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy. Radiat Oncol 10:54
Zwicker F, Roeder F, Thieke C et al (2011) IMRT reirradiation with concurrent cetuximab immunotherapy in recurrent head and neck cancer. Strahlenther Onkol 187:32–38
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Arcangeli, S., Donato, V. (2016). Re-irradiation for Esophageal Cancer. In: Nieder, C., Langendijk, J. (eds) Re-Irradiation: New Frontiers. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2016_77
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DOI: https://doi.org/10.1007/174_2016_77
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