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Brain Metastases

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Re-Irradiation: New Frontiers

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

In many patients with brain metastases, the primary therapeutic aim is symptom palliation and maintenance of neurologic function, but in a small selected cohort, long-term survival and even cure are possible. Central nervous system failures might develop after initial treatment, either locally (regrowth of a previously treated lesion), regionally (elsewhere in the brain parenchyma), or even in the form of leptomeningeal dissemination, the latter carrying the worst prognosis. Some of these failures will not require local therapy because they develop in the terminal phase of general cancer progression where active brain metastasis treatment is neither expected to prolong survival nor improve the patient’s quality of life. At the other end of the spectrum, patients with limited, brain-only, relapse require effective intracranial disease control as a prerequisite for extended survival. The present chapter reviews reirradiation with brachytherapy, stereotactic radiosurgery, fractionated stereotactic radiotherapy and whole-brain radiotherapy.

The original version of this chapter was revised. An erratum to this chapter can be found at 10.1007/978-3-319-41825-4_78.

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Authors and Affiliations

  1. Department of Oncology and Palliative Medicine, Nordland Hospital, Prinsensgate 164, Bodø, 8092, Norway

    Carsten Nieder MD

  2. Department of Radiation Oncology, University Hospital Freiburg, Robert Koch Str. 3, Freiburg, 79106, Germany

    Anca L. Grosu MD

  3. Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA

    Minesh P. Mehta MD

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  1. Carsten Nieder MD
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  2. Anca L. Grosu MD
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  3. Minesh P. Mehta MD
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Correspondence to Carsten Nieder MD .

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Editors and Affiliations

  1. Department of Oncology, University of Tromso and Nordland Hospital, Bodo, Norway

    Carsten Nieder

  2. University Medical Center Groningen, Groningen, The Netherlands

    Johannes Langendijk

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Nieder, C., Grosu, A.L., Mehta, M.P. (2016). Brain Metastases. In: Nieder, C., Langendijk, J. (eds) Re-Irradiation: New Frontiers. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2016_58

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