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Incidental Findings in 18F-FDG PET/CT and PET/MR

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Incidental Radiological Findings

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

By combining functional and morphological imaging in one single modality, hybrid imaging scanners such as PET/CT and PET/MR have become essential modalities in in whole-body imaging of inflammatory and oncological diseases. As the number of incidental findings is increased due to the simultaneous acquisition of morphological and functional information, it is of utmost important to correctly identify and interpret these findings. Therefore, this chapter provides an overview of the most common incidental findings in 18F-FDG PET/CT and PET/MR. Incidental 18F-FDG uptake is covered in the first part of the chapter, followed by a brief outline of frequent findings in morphological CT that demand special attention in hybrid imaging. At the end of the chapter, potential advantages and pitfalls of 18F-FDG PET/MR imaging in the detection and characterization of incidental findings are discussed.

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References

  • Abhyankar A, Joshi J, Basu S (2012) FDG uptake in unilateral breast related to breastfeeding practice in a patient of pulmonary hydatid cyst. Clin Nucl Med 37:676–678

    Article  PubMed  Google Scholar 

  • Abrams HL, Spiro R, Goldstein N (1950) Metastases in carcinoma. Analysis of 1000 autopsied cases. Cancer 3:74–85

    Article  CAS  PubMed  Google Scholar 

  • Antoch G, Bockisch A (2009) Combined PET/MRI: a new dimension in whole-body oncology imaging? Eur J Nucl Med Mol Imaging 36:113–120

    Article  Google Scholar 

  • Antoch G, Stattaus J, Nemat AT, Marnitz S, Beyer T, Kuehl H, Bockisch A, Debatin JF, Freudenberg LS (2003a) Non–small cell lung cancer: dual-modality PET/CT in preoperative staging. Radiology 229:526–533

    Article  PubMed  Google Scholar 

  • Antoch G, Vogt FM, Freudenberg LS, Nazaradeh F, Goehde SC, Barkhausen J, Dahmen G, Bockisch A, Debatin JF, Ruehm SG (2003b) Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology. JAMA 290:3199–3206

    Article  CAS  PubMed  Google Scholar 

  • Appenzeller P, Mader C, Huellner MW, Schmidt D, Schmid D, Boss A, von Schulthess G, Veit-Haibach P (2013) PET/CT versus body coil PET/MRI: how low can you go? Insights Imaging 4:481–490

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Avril N (2004) GLUT1 expression in tissue and 18F-FDG uptake. J Nucl Med 45:930–932

    CAS  PubMed  Google Scholar 

  • Badiee S, Franc BL, Webb EM, Chu B, Hawkins RA, Coakley F (2008) Role of IV iodinated contrast material in 18F-FDG PET/CT of liver, metastases. Am J Roentgenol 191:1436–1439

    Article  Google Scholar 

  • Bailey CJ (1995) Metformin and intestinal glucose handling. Diabetes Metab Rev 11:23–32

    Article  Google Scholar 

  • Barzon L, Sonino N, Fallo F, Palu G, Boscaro M (2003) Prevalence and natural history of adrenal incidentalomas. Eur J Endocrinol 149:273–285

    Article  CAS  PubMed  Google Scholar 

  • Basu S, Nair N (2005) 18F-FDG uptake in bilateral adrenal hyperplasia causing Cushing’s syndrome. Eur J Nucl Med Mol Imaging 32:384

    Article  PubMed  Google Scholar 

  • Beiderwellen K, Gomez B, Buchbender C, Hartung V, Poeppel TD, Nensa F, Kuehl H, Bockisch A, Lauenstein TC (2013) Depiction and characterization of liver lesions in whole body [18F]-FDG PET/MRI. Eur J Radiol 82:669–675

    Article  Google Scholar 

  • Bertagna F, Evangelista L, Piccardo A, Bertoli M, Bosio G, Giubbini R, Orlando E, Treglia G (2015) Multicentric study on 18F-FDG-PET/CT breast incidental uptake in patients studied for non-breast malignant purposes. Rev Esp Med Nucl Imagen Mol 34:24–29

    PubMed  Google Scholar 

  • Biederer J, Graessner J, Heller M (2001) Magnetic resonance imaging of the lung with a volumetric interpolated 3D-Gradient echo sequence. Rofo Fortschr Dem Geb Rontgenstr Bildgeb Verfahr 173:883–887

    Article  CAS  Google Scholar 

  • Biederer J, Schoene A, Freitag S, Reuter M, Heller M (2003) Simulated pulmonary nodules implanted in a dedicated porcine chest phantom: sensitivity of MR imaging for detection. Radiology 227:475–483

    Article  PubMed  Google Scholar 

  • Bockisch A, Beyer T, Antoch G, Veit P, Müller S, Pink R, Rosenbaum S, Kühl H (2004) Grundlagen und klinischer Nutzen von PET-CT. Radiologe 44:1045–1054

    Article  CAS  PubMed  Google Scholar 

  • Boeckmann J, Bartel T, Siegel E, Bodenner D, Stack BC (2012) Can the pathology of a thyroid nodule be determined by positron emission tomography uptake? Otolaryngol Head Neck Surg 146:906–912

    Article  PubMed  Google Scholar 

  • Boellaard R, Delgado-Bolton R, Oyen WJ, Giammarile F, Tatsch K, Eschner W, Verzijlbergen FJ, Barrington SF, Pike LC, Weber WA, Stroobants S, Delbeke D, Donohoe KJ, Holbrook S, Graham MM, Testanera G, Hoekstra OS, Zijlstra J, Visser E, Hoekstra CJ, Pruim J, Willemsen A, Arends B, Kotzerke J, Bockisch A, Beyer T, Chiti A, Krause BJ (2015) FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging 42:328–354

    Article  CAS  PubMed  Google Scholar 

  • Börner AR, Voth E, Wienhard K, Wagner R, Schicha H (1998) F-18-FDG-PET der Schilddrüse bei Morbus Basedow. Nukl Nucl Med 37:227–233

    Google Scholar 

  • Bovio S, Cataldi A, Reimondo G, Sperone P, Novello S, Berruti A, Borasio P, Fava C, Dogliotti L, Scagliotti GV, Angeli A, Terzolo M (2006) Prevalence of adrenal incidentaloma in a contemporary computerized tomography series. J Endocrinol Invest 29:298–302

    Article  CAS  PubMed  Google Scholar 

  • Braun JJ, Kessler R, Constantinesco A, Imperiale A (2008) 18F-FDG PET/CT in sarcoidosis management: review and report of 20 cases. Eur J Nucl Med Mol Imaging 35:1537–1543

    Article  PubMed  Google Scholar 

  • Brink I, Reinhardt MJ, Hoegerle S, Altehoefer C, Moser E, Nitzsche EU (2001) Increased metabolic activity in the thymus gland studied with 18F-FDG PET: age dependency and frequency after chemotherapy. J Nucl Med 42:591–595

    CAS  PubMed  Google Scholar 

  • Bruzzi JF, Truong MT, Marom EM, Mawlawi O, Podoloff DA, Macapinlac HA, Munden RF (2006) Incidental findings on integrated PET/CT that do not accumulate 18F-FDG. Am J Roentgenol 187:1116–1123

    Article  Google Scholar 

  • Buchbender C, Heusner TA, Lauenstein TC, Bockisch A, Antoch G (2012a) Oncologic PET/MRI, part 1: tumors of the brain, head and neck, chest, abdomen, and pelvis. J Nucl Med 53:928–938

    Article  PubMed  Google Scholar 

  • Buchbender C, Heusner TA, Lauenstein TC, Bockisch A, Antoch G (2012b) Oncologic PET/MRI, part 2: bone tumors, soft-tissue tumors, melanoma, and lymphoma. J Nucl Med 53:1244–1252

    Article  PubMed  Google Scholar 

  • Burris NS, Johnson KM, Larson PE, Hope MD, Nagle SK, Behr SC, Hope TA (2015) Detection of small pulmonary nodules with ultrashort echo time sequences in oncology patients by using a PET/MR system. Radiology 278:239–246

    Article  PubMed  PubMed Central  Google Scholar 

  • Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA (2014) Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 32:3059–3067

    Article  PubMed  PubMed Central  Google Scholar 

  • Choi JY, Lee KS, Kim HJ, Shim YM, Kwon OJ, Park K, Baek CH, Chung JH, Lee KH, Kim BT (2006) Focal thyroid lesions incidentally identified by integrated 18F-FDG PET/CT: clinical significance and improved characterization. J Nucl Med 47:609–615

    PubMed  Google Scholar 

  • Chondrogiannis S, Marzola MC, Grassetto G, Zorzi A, Milan E, Rampin L, Rubello D, Colletti PM (2015) 18F-FDG PET/CT lung “focalities” without coregistered CT findings: an interpretative clinical dilemma. Nucl Med Commun 36:334–339

    Article  CAS  PubMed  Google Scholar 

  • Cohen M, Hill C, Cangir A, Sullivan M (1980) Thymic rebound after treatment of childhood tumors. Am J Roentgenol 135:151–156

    Article  CAS  Google Scholar 

  • Cook GJ, Fogelman I, Maisey MN (1996) Normal physiological and benign pathological variants of 18-fluoro-2-deoxyglucose positron-emission tomography scanning: potential for error in interpretation. Semin Nucl Med 26:308–314

    Article  CAS  PubMed  Google Scholar 

  • Dong A, Zhao T, Gong J, Zuo C (2014) Diffuse FDG uptake of the bilateral atrial walls in a patient with atrial fibrillation. Clin Nucl Med 39:167–169

    PubMed  Google Scholar 

  • Fan CM, Fischman AJ, Kwek BH, Abbara S, Aquino SL (2005) Lipomatous hypertrophy of the interatrial septum: increased uptake on FDG PET. Am J Roentgenol 184:339–342

    Article  Google Scholar 

  • Fayad LM, Cohade C, Wahl RL, Fishman EK (2003) Sacral fractures: a potential pitfall of FDG positron emission tomography. Am J Roentgenol 181:1239–1243

    Article  Google Scholar 

  • Fenchel S, Grab D, Nuessle K, Kotzerke J, Rieber A, Kreienberg R, Brambs HJ, Reske SN (2002) Asymptomatic adnexal masses: correlation of FDG PET and histopathologic findings. Radiology 223:780–788

    Article  PubMed  Google Scholar 

  • Furlong MA, Fanburg-Smith JC, Miettinen M (2001) The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol 25:809–814

    Article  CAS  PubMed  Google Scholar 

  • Gatidis S, Schmidt H, Claussen CD, Schwenzer NF (2013) Multiparametrische Bildgebung mittels simultaner MR/PET. Radiologe 53:669–675

    Article  CAS  PubMed  Google Scholar 

  • Goethals I, De Vriendt C, Hoste P, Smeets P, Ham H (2009) Normal uptake of F-18 FDG in the testis as assessed by PET/CT in a pediatric study population. Ann Nucl Med 23:817–820

    Article  PubMed  Google Scholar 

  • Gontier E, Fourme E, Wartski M, Blondet C, Bonardel G, Stanc EL, Mantzarides M, Foehrenbach H, Pecking AP, Alberini JL (2007) High and typical 18F-FDG bowel uptake in patients treated with metformin. Eur J Nucl Med Mol Imaging 35:95–99

    Article  PubMed  CAS  Google Scholar 

  • Gould MK, Maclean CC, Kuschner WG, Rydzak CE, Owens DK (2001) Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions: a meta-analysis. JAMA 285:914–924

    Article  CAS  PubMed  Google Scholar 

  • Grueneisen J, Schaarschmidt BM, Heubner M, Suntharalingam S, Milk I, Kinner S, Heubner A, Forsting M, Lauenstein T, Ruhlmann V, Umutlu L (2015) Implementation of FAST-PET/MRI for whole-body staging of female patients with recurrent pelvic malignancies: a comparison to PET/CT. Eur J Radiol 84:2097–2102

    Article  PubMed  Google Scholar 

  • Haber RS, Weiser KR, Pritsker A, Reder I, Burstein DE (1997) GLUT1 glucose transporter expression in benign and malignant thyroid nodules. Thyroid 7:363–367

    Article  CAS  PubMed  Google Scholar 

  • Haider MA, Ghai S, Jhaveri K, Lockwood G (2004) Chemical shift MR imaging of hyperattenuating (>10 HU) adrenal masses: does it still have a role? Radiology 231:711–716

    Article  PubMed  Google Scholar 

  • Hany TF, Heuberger J, von Schulthess GK (2003) Iatrogenic FDG foci in the lungs: a pitfall of PET image interpretation. Eur Radiol 13:2122–2127

    Article  PubMed  Google Scholar 

  • Hartung-Knemeyer V, Beiderwellen KJ, Buchbender C, Kuehl H, Lauenstein TC, Bockisch A, Poeppel TD (2013) Optimizing positron emission tomography image acquisition protocols in integrated positron emission tomography/magnetic resonance imaging. Invest Radiol 48:290–294

    Article  PubMed  Google Scholar 

  • Heusch P, Buchbender C, Köhler J, Nensa F, Beiderwellen K, Kühl H, Lanzman R, Wittsack H, Gomez B, Gauler T, Schuler M, Forsting M, Bockisch A, Antoch G, Heusner T (2013) Correlation of the apparent diffusion coefficient (ADC) with the standardized uptake value (SUV) in hybrid 18F-FDG PET/MRI in non-small cell lung cancer (NSCLC) lesions: initial results. Rofo Fortschr Dem Geb Rontgenstr Bildgeb Verfahr 185:1056–1062

    Article  CAS  Google Scholar 

  • Heusner TA, Hahn S, Hamami ME, Kim UH, Baumeister R, Forsting M, Stahl A, Bockisch A, Antoch G (2009) Gastrointestinal 18F-FDG accumulation on PET without a corresponding CT abnormality is not an early indicator of cancer development. Eur Radiol 19:2171–2179

    Article  PubMed  Google Scholar 

  • Heyer CM, Kagel T, Lemburg SP, Bauer TT, Nicolas V (2003) Lipomatous hypertrophy of the interatrial septum: a prospective study of incidence, imaging findings, and clinical symptoms. Chest 124:2068–2073

    Article  PubMed  Google Scholar 

  • Hoang JK, Langer JE, Middleton WD, Wu CC, Hammers LW, Cronan JJ, Tessler FN, Grant EG, Berland LL (2015) Managing incidental thyroid nodules detected on imaging: white paper of the ACR Incidental Thyroid Findings Committee. J Am Coll Radiol 12:143–150

    Article  PubMed  Google Scholar 

  • Hollinger EF, Alibazoglu H, Ali A, Green A, Lamonica G (1998) Hematopoietic cytokine-mediated FDG uptake simulates the appearance of diffuse metastatic disease on whole-body PET imaging. Clin Nucl Med 23:93–98

    Article  CAS  PubMed  Google Scholar 

  • Horiuchi M, Yasuda S, Shohtsu A, Ide M (1998) Four cases of Warthin’s tumor of the parotid gland detected with FDG PET. Ann Nucl Med 12:47–50

    Article  CAS  PubMed  Google Scholar 

  • Horiuchi C, Tsukuda M, Taguchi T, Ishiguro Y, Okudera K, Inoue T (2008) Correlation between FDG-PET findings and GLUT1 expression in salivary gland pleomorphic adenomas. Ann Nucl Med 22:693–698

    Article  CAS  PubMed  Google Scholar 

  • Huang YE, Pu YL, Huang YJ, Chen CF, Pu QH, Konda SD, Appelbaum DE (2010) The utility of the nonattenuation corrected 18F-FDG PET images in the characterization of solitary pulmonary lesions. Nucl Med Commun 31:945–951

    Article  PubMed  Google Scholar 

  • Israel O, Yefremov N, Bar-Shalom R, Kagana O, Frenkel A, Keidar Z, Fischer D (2005) PET/CT detection of unexpected gastrointestinal foci of 18F-FDG uptake: incidence, localization patterns, and clinical significance. J Nucl Med 46:758–762

    PubMed  Google Scholar 

  • Jamar F, Buscombe J, Chiti A, Christian PE, Delbeke D, Donohoe KJ, Israel O, Martin-Comin J, Signore A (2013) EANM/SNMMI guideline for 18F-FDG use in inflammation and infection. J Nucl Med 54:647–658

    Article  PubMed  Google Scholar 

  • James OG, Christensen JD, Wong TZ, Borges-Neto S, Koweek LM (2011) Utility of FDG PET/CT in inflammatory cardiovascular disease. Radiographics 31:1271–1286

    Article  PubMed  Google Scholar 

  • Jeon TJ, Lee YS, Lee JH, Chang HS, Ryu YH (2014) Rebound thymic hyperplasia detected by 18F-FDG PET/CT after radioactive iodine ablation therapy for thyroid cancer. Thyroid 24:1636–1641

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kamel EM, Thumshirn M, Truninger K, Schiesser M, Fried M, Padberg B, Schneiter D, Stoeckli SJ, von Schulthess GK, Stumpe KD (2004) Significance of incidental 18F-FDG accumulations in the gastrointestinal tract in PET/CT: correlation with endoscopic and histopathologic results. J Nucl Med 45:1804–1810

    PubMed  Google Scholar 

  • Keyzer C, Dhaene B, Blocklet D, De Maertelaer V, Goldman S, Gevenois PA (2015) Colonoscopic findings in patients with incidental colonic focal FDG uptake. Am J Roentgenol 204:586–591

    Article  Google Scholar 

  • Kitajima K, Nakamoto Y, Senda M, Onishi Y, Okizuka H, Sugimura K (2007) Normal uptake of 18F-FDG in the testis: an assessment by PET/CT. Ann Nucl Med 21:405–410

    Article  PubMed  Google Scholar 

  • Kong G, Jackson C, Koh DM, Lewington V, Sharma B, Brown G, Cunningham D, Cook GJ (2008) The use of 18F-FDG PET/CT in colorectal liver metastases–comparison with CT and liver MRI. Eur J Nucl Med Mol Imaging 35:1323–1329

    Article  CAS  PubMed  Google Scholar 

  • Kostakoglu L, Wong JC, Barrington SF, Cronin BF, Dynes AM, Maisey MN (1996) Speech-related visualization of laryngeal muscles with Fluorine-18-FDG. J Nucl Med 37:1771–1773

    CAS  PubMed  Google Scholar 

  • Kuester LB, Fischman AJ, Fan CM, Halpern EF, Aquino SL (2005) Lipomatous hypertrophy of the interatrial septum: prevalence and features on fusion 18F fluorodeoxyglucose positron emission tomography/CT. Chest 128:3888–3893

    Article  PubMed  Google Scholar 

  • Lerman H, Metser U, Grisaru D, Fishman A, Lievshitz G, Even-Sapir E (2004) Normal and abnormal 18F-FDG endometrial and ovarian uptake in pre- and postmenopausal patients: assessment by PET/CT. J Nucl Med 45:266–271

    PubMed  Google Scholar 

  • Lewis PJ, Salama A (1994) Uptake of fluorine-18-fluorodeoxyglucose in sarcoidosis. J Nucl Med 35:1647–1649

    CAS  PubMed  Google Scholar 

  • Leyn PD, Lardinois D, Schil PEV, Rami-Porta R, Passlick B, Zielinski M, Waller DA, Lerut T, Weder W (2007) ESTS guidelines for preoperative lymph node staging for non-small cell lung cancer. Eur J Cardiothorac Surg 32:1–8

    Article  PubMed  Google Scholar 

  • MacMahon H, Austin JH, Gamsu G, Herold CJ, Jett JR, Naidich DP, Patz EF Jr, Swensen SJ; Fleischner Society (2005) Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society. Radiology 237:395–400

    Google Scholar 

  • Mäki M, Luotolahti M, Nuutila P, Iida H, Voipio-Pulkki LM, Ruotsalainen U, Haaparanta M, Solin O, Hartiala J, Härkönen R, Knuuti J (1996) Glucose uptake in the chronically dysfunctional but viable myocardium. Circulation 93:1658–1666

    Article  PubMed  Google Scholar 

  • Martinez-Möller A, Nekolla SG (2012) Attenuation correction for PET/MR: problems, novel approaches and practical solutions. Z Med Phys 22:299–310

    Article  PubMed  Google Scholar 

  • Martinez-Möller A, Souvatzoglou M, Delso G, Bundschuh RA, Chefd’hotel C, Ziegler SI, Navab N, Schwaiger M, Nekolla SG (2009) Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data. J Nucl Med 50:520–526

    Article  PubMed  Google Scholar 

  • Martinez-Möller A, Eiber M, Nekolla SG, Souvatzoglou M, Drzezga A, Ziegler S, Rummeny EJ, Schwaiger M, Beer AJ (2012) Workflow and scan protocol considerations for integrated whole-body PET/MRI in oncology. J Nucl Med 53:1415–1426

    Article  PubMed  Google Scholar 

  • Maurer AH, Burshteyn M, Adler LP, Steiner RM (2011) How to differentiate benign versus malignant cardiac and paracardiac 18F FDG uptake at oncologic PET/CT. Radiographics 31:1287–1305

    Article  PubMed  Google Scholar 

  • Naidich DP, Bankier AA, MacMahon H, Schaefer-Prokop CM, Pistolesi M, Goo JM, Macchiarini P, Crapo JD, Herold CJ, Austin JH, Travis WD (2013) Recommendations for the management of subsolid pulmonary nodules detected at CT: a statement from the Fleischner society. Radiology 266:304–317

    Article  PubMed  Google Scholar 

  • Nakahara T, Fujii H, Ide M, Nishiumi N, Takahashi W, Yasuda S, Shohtsu A, Kubo A (2001) FDG uptake in the morphologically normal thymus: comparison of FDG positron emission tomography andCT. Br J Radiol 74:821–824

    Article  CAS  PubMed  Google Scholar 

  • Nakamoto Y, Tatsumi M, Hammoud D, Cohade C, Osman MM, Wahl RL (2005) Normal FDG distribution patterns in the head and neck: PET/CT evaluation. Radiology 234:879–885

    Article  PubMed  Google Scholar 

  • Nensa F, Schlosser T (2014) Cardiovascular hybrid imaging using PET/MRI. Rofo Fortschr Dem Geb Rontgenstr Bildgeb Verfahr 186(12):1094–1101

    Article  Google Scholar 

  • Nensa F, Tezgah E, Poeppel TD, Jensen CJ, Schelhorn J, Köhler J, Heusch P, Bruder O, Schlosser T, Nassenstein K (2015) Integrated 18F-FDG PET/MR imaging in the assessment of cardiac masses: a pilot study. J Nucl Med 56:255–260

    Article  PubMed  CAS  Google Scholar 

  • Niekel MC, Bipat S, Stoker J (2010) Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT: a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology 257:674–684

    Article  PubMed  Google Scholar 

  • Nishizawa S, Inubushi M, Okada H (2004) Physiological 18F-FDG uptake in the ovaries and uterus of healthy female volunteers. Eur J Nucl Med Mol Imaging 32:549–556

    Article  PubMed  Google Scholar 

  • Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Uno K (2004) Evaluation of F-18 fluorodeoxyglucose (FDG) PET scanning for pulmonary nodules less than 3 cm in diameter, with special reference to the CT images. Lung Cancer 45:19–27

    Article  PubMed  Google Scholar 

  • Oh JR, Song HC, Chong A, Ha JM, Jeong SY, Min JJ, Bom HS (2010) Impact of medication discontinuation on increased intestinal FDG accumulation in diabetic patients treated with metformin. Am J Roentgenol 195:1404–1410

    Article  Google Scholar 

  • Okamura T, Kawabe J, Koyama K, Ochi H, Yamada R, Sakamoto H, Matsuda M, Ohashi Y, Nakai Y (1998) Fluorine-18 fluorodeoxyglucose positron emission tomography imaging of parotid mass lesions. Acta Otolaryngol Suppl 538:209–213

    CAS  PubMed  Google Scholar 

  • Osman MM, Cohade C, Fishman EK, Wahl RL (2005) Clinically significant incidental findings on the unenhanced CT portion of PET/CT studies: frequency in 250 patients. J Nucl Med 46:1352–1355

    PubMed  Google Scholar 

  • Özülker T, Özülker F, Mert M, Özpaçacı T (2010) Clearance of the high intestinal 18F-FDG uptake associated with metformin after stopping the drug. Eur J Nucl Med Mol Imaging 37:1011–1017

    Article  PubMed  CAS  Google Scholar 

  • Park BK, Kim CK, Kim B, Lee JH (2007) Comparison of delayed enhanced CT and chemical shift MR for evaluating hyperattenuating incidental adrenal masses. Radiology 243:760–765

    Article  PubMed  Google Scholar 

  • Pichler BJ, Kolb A, Nägele T, Schlemmer HP (2010) PET/MRI: paving the way for the next generation of clinical multimodality imaging applications. J Nucl Med 51:333–336

    Article  PubMed  Google Scholar 

  • Poh F, Wong SK (2014) Imaging of Hidradenitis Suppurativa and its complications. Case Rep Radiol 2014:294753

    PubMed  PubMed Central  Google Scholar 

  • Purohit BS, Ailianou A, Dulguerov N, Becker CD, Ratib O, Becker M (2014) FDG-PET/CT pitfalls in oncological head and neck imaging. Insights Imaging 5:585–602

    Article  PubMed  PubMed Central  Google Scholar 

  • Quick HH (2014) Integrated PET/MR. J Magn Reson Imaging 39:243–258

    Article  PubMed  Google Scholar 

  • Rakheja R, Ciarallo A, Alabed YZ, Hickeson M (2011) Intravenous administration of diazepam significantly reduces brown fat activity on 18F-FDG PET/CT. Am J Nucl Med Mol Imaging 1:29–35

    CAS  PubMed  PubMed Central  Google Scholar 

  • Reesink DJ, Fransen van de Putte EE, Vegt E, De Jong J, van Werkhoven E, Mertens LS, Bex A, van der Poel HG, van Rhijn BW, Horenblas S, Meijer RP (2015) Clinical relevance of incidental prostatic lesions on FDG-PET/CT Scan. J Urol. Advance online publication

    Google Scholar 

  • Reinhardt MJ, Wiethoelter N, Matthies A, Joe AY, Strunk H, Jaeger U, Biersack HJ (2005) PET recognition of pulmonary metastases on PET/CT imaging: impact of attenuation-corrected and non-attenuation-corrected PET images. Eur J Nucl Med Mol Imaging 33:134–139

    Article  PubMed  Google Scholar 

  • Rosenbaum SJ, Lind T, Antoch G, Bockisch A (2006) False-positive FDG PET uptake – the role of PET/CT. Eur Radiol 16:1054–1065

    Article  PubMed  Google Scholar 

  • Sacks A, Peller PJ, Surasi DS, Chatburn L, Mercier G, Subramaniam RM (2011) Value of PET/CT in the management of liver metastases, part 1. Am J Roentgenol 197:256–259

    Article  Google Scholar 

  • Sawicki LM, Grueneisen J, Buchbender C, Schaarschmidt BM, Gomez B, Ruhlmann V, Umutlu L, Antoch G, Heusch P (2016a) Evaluation of the outcome of lung nodules missed on 18F-FDG PET/MRI compared with 18F-FDG PET/CT in patients with known malignancies. J Nucl Med 57:15–20

    Article  CAS  PubMed  Google Scholar 

  • Sawicki LM, Grueneisen J, Buchbender C, Schaarschmidt BM, Gomez B, Ruhlmann V, Wetter A, Umutlu L, Antoch G, Heusch P (2016b) Comparative performance of 18F-FDG PET/MRI and 18F-FDG PET/CT regarding detection and characterization of pulmonary lesions in 121 oncologic patients. J Nucl Med. Advance online publication

    Google Scholar 

  • Schaaf WE, Patel Z, Retrouvey M, Cunningham TD, Johnson LS (2014) Frequency and clinical relevance of PET/CT incidentalomas. Abdom Imaging 39:657–662

    Article  PubMed  Google Scholar 

  • Schaarschmidt B, Buchbender C, Gomez B, Rubbert C, Hild F, Köhler J, Grueneisen J, Reis H, Ruhlmann V, Wetter A, Quick HH, Antoch G, Heusch P (2015a) Thoracic staging of non-small-cell lung cancer using integrated 18F-FDG PET/MR imaging: diagnostic value of different MR sequences. Eur J Nucl Med Mol Imaging 42:1257–1267

    Article  CAS  PubMed  Google Scholar 

  • Schaarschmidt BM, Grueneisen J, Heusch P, Gomez B, Beiderwellen K, Ruhlmann V, Umutlu L, Quick HH, Antoch G, Buchbender C (2015b) Oncological whole-body staging in integrated 18F-FDG PET/MR: value of different MR sequences for simultaneous PET and MR reading. Eur J Radiol 84:1285–1292

    Article  PubMed  Google Scholar 

  • Schaarschmidt BM, Grueneisen J, Heusch P, Gomez B, Umutlu L, Ruhlmann V, Rosenbaum-Krumme S, Antoch G, Buchbender C (2015c) Does 18F-FDG PET/MRI reduce the number of indeterminate abdominal incidentalomas compared with 18F-FDG PET/CT? Nucl Med Commun 36:588–595

    Article  CAS  PubMed  Google Scholar 

  • Scharitzer M, Ba-Ssalamah A, Ringl H, Kölblinger C, Grünberger T, Weber M, Schima W (2013) Preoperative evaluation of colorectal liver metastases: comparison between gadoxetic acid-enhanced 3.0-T MRI and contrast-enhanced MDCT with histopathological correlation. Eur Radiol 23:2187–2196

    Article  CAS  PubMed  Google Scholar 

  • Schroeder T, Ruehm SG, Debatin JF, Ladd ME, Barkhausen J, Goehde SC (2005) Detection of pulmonary nodules using a 2D HASTE MR sequence: comparison with MDCT. Am J Roentgenol 185:979–984

    Article  Google Scholar 

  • Schwartz LH, Gandras EJ, Colangelo SM, Ercolani MC, Panicek DM (1999) Prevalence and importance of small hepatic lesions found at CT in patients with cancer. Radiology 210:71–74

    Article  CAS  PubMed  Google Scholar 

  • Seo YL, Yoon DY, Baek S, Lim KJ, Yun EJ, Cho YK, Bae WJ, Chung EJ, Kwon KH (2015) Incidental focal FDG uptake in the parotid glands on PET/CT in patients with head and neck malignancy. Eur Radiol 25:171–177

    Article  PubMed  Google Scholar 

  • Sharma P, Mukherjee A, Karunanithi S, Bal C, Kumar R (2014) Potential role of 18F-FDG PET/CT in patients with fungal infections. Am J Roentgenol 203:180–189

    Article  Google Scholar 

  • Shim JH, JH O, Oh SI, Yoo HM, Jeon HM, Park CH, Kim SH, Song KY (2012) Clinical significance of incidental colonic 18F-FDG uptake on PET/CT images in patients with gastric adenocarcinoma. J Gastrointest Surg 16:1847–1853

    Article  PubMed  Google Scholar 

  • Shimaoka K, Sokal JE, Pickren JW (1962) Metastatic neoplasms in the thyroid gland. Pathological and clinical findings. Cancer 15:557–565

    Article  CAS  PubMed  Google Scholar 

  • Shimizu A, Oriuchi N, Tsushima Y, Higuchi T, Aoki J, Endo K (2003) High [18F] 2-fluoro-2-deoxy-D-glucose (FDG) uptake of adrenocortical adenoma showing subclinical Cushing’s syndrome. Ann Nucl Med 17:403–406

    Article  PubMed  Google Scholar 

  • Shirone N, Shinkai T, Yamane T, Uto F, Yoshimura H, Tamai H, Imai T, Inoue M, Kitano S, Kichikawa K, Hasegawa M (2012) Axillary lymph node accumulation on FDG-PET/CT after influenza vaccination. Ann Nucl Med 26:248–252

    Article  PubMed  Google Scholar 

  • Sidhu P, Lin P, Son H, Rosenfeld D, Lin M (2014) Testicular fluorine-18 fludeoxyglucose uptake on positron emission tomography CT in patients with lymphoma: clinical significance and management impact. Br J Radiol 87:20140472

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Simpson RC, Dyer MJ, Entwisle J, Harman KE (2011) Positron emission tomography features of hidradenitis suppurativa. Br J Radiol 84:164–165

    Article  Google Scholar 

  • Skolnik EM, Friedman M, Becker S, Sisson GA, Keyes GR (1977) Tumors of the major salivary glands. Laryngoscope 87:843–861

    Article  CAS  PubMed  Google Scholar 

  • Smith CS, Teruya-Feldstein J, Caravelli JF, Yeung HW (2008) False-positive findings on 18F-FDG PET/CT: differentiation of hibernoma and malignant fatty tumor on the basis of fluctuating standardized uptake values. Am J Roentgenol 190:1091–1096

    Article  Google Scholar 

  • Söderlund V, Larsson SA, Jacobsson H (2007) Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol. Eur J Nucl Med Mol Imaging 34:1018–1022

    Article  PubMed  CAS  Google Scholar 

  • Soelberg KK, Bonnema SJ, Brix TH, Hegedüs L (2012) Risk of malignancy in thyroid incidentalomas detected by 18F-fluorodeoxyglucose positron emission tomography: a systematic review. Thyroid 22:918–925

    Article  CAS  PubMed  Google Scholar 

  • Sommer G, Tremper J, Koenigkam-Santos M, Delorme S, Becker N, Biederer J, Kauczor HU, Heussel CP, Schlemmer HP, Puderbach M (2014) Lung nodule detection in a high-risk population: comparison of magnetic resonance imaging and low-dose computed tomography. Eur J Radiol 83:600–605

    Article  PubMed  Google Scholar 

  • Stagg J, Farukhi I, Lazaga F, Thompson C, Bradshaw L, Kaif M, Gould-Simon A, Schmidt R (2014) Significance of 18F-fluorodeoxyglucose uptake at the gastroesophageal junction: comparison of PET to esophagogastroduodenoscopy. Dig Dis Sci 60:1335–1342

    Article  PubMed  CAS  Google Scholar 

  • Stahl A, Dzewas B, Schwaiger M, Weber WA (2002) Excretion of FDG into saliva and its significance for PET imaging. Nukl Nucl Med 41:214–216

    CAS  Google Scholar 

  • Thie JA (2004) Understanding the standardized uptake value, its methods, and implications for usage. J Nucl Med 45:1431–1434

    PubMed  Google Scholar 

  • Thomassen A, Lerberg Nielsen A, Gerke O, Johansen A, Petersen H (2011) Duration of 18F-FDG avidity in lymph nodes after pandemic H1N1v and seasonal influenza vaccination. Eur J Nucl Med Mol Imaging 38:894–898

    Article  PubMed  Google Scholar 

  • Ulaner GA, Lyall A (2013) Identifying and distinguishing treatment effects and complications from malignancy at FDG PET/CT. Radiographics 33:1817–1834

    Article  PubMed  Google Scholar 

  • von Schulthess GK, Veit-Haibach P (2014) Workflow considerations in PET/MR imaging. J Nucl Med 55:19–24

    Article  Google Scholar 

  • von Schulthess GK, Meier N, Stumpe KD (2001) Joint accumulations of FDG in whole body PET scans. Nukl Nucl Med 40:193–197

    Google Scholar 

  • Wadih A, Rehm PK, Deng C, Douvas M (2015) Active herpes zoster infection with cutaneous manifestation and adenopathy on FDG PET/CT. Radiol Case Rep 10:27–29

    Article  PubMed  PubMed Central  Google Scholar 

  • Warburg O (1956) On the origin of cancer cells. Science 123:309–314

    Article  CAS  PubMed  Google Scholar 

  • Weng L-J, Schöder H (2004) Melanoma metastasis to the testis demonstrated with FDG PET/CT. Clin Nucl Med 29:811–812

    Article  PubMed  Google Scholar 

  • Wong WL, Gibson D, Sanghera B, Goodchild K, Saunders M (2007) Evaluation of normal FDG uptake in palatine tonsil and its potential value for detecting occult head and neck cancers: a PET CT study. Nucl Med Commun 28:675–680

    Article  PubMed  Google Scholar 

  • Wu X, Pertovaara H, Korkola P, Dastidar P, Järvenpää R, Eskola H, Kellokumpu-Lehtinen PL (2014) Correlations between functional imaging markers derived from PET/CT and diffusion-weighted MRI in diffuse large B-cell lymphoma and follicular lymphoma. PLoS One 9:84999

    Article  CAS  Google Scholar 

  • Yasuda S, Shohtsu A, Ide M, Takagi S, Takahashi W, Suzuki Y, Horiuchi M (1998) Chronic thyroiditis: diffuse uptake of FDG at PET. Radiology 207:775–778

    Article  CAS  PubMed  Google Scholar 

  • Yun M, Kim W, Alnafisi N, Lacorte L, Jang S, Alavi A (2001) 18F-FDG PET in characterizing adrenal lesions detected on CT or MRI. J Nucl Med 42:1795–1799

    CAS  PubMed  Google Scholar 

  • Zhuang H, Sam JW, Chacko TK, Duarte PS, Hickeson M, Feng Q, Nakhoda KZ, Guan L, Reich P, Altimari SM, Alavi A (2003) Rapid normalization of osseous FDG uptake following traumatic or surgical fractures. Eur J Nucl Med Mol Imaging 30:1096–1103

    Article  PubMed  Google Scholar 

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  1. Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, Dusseldorf, D-40225, Germany

    Benedikt M. Schaarschmidt & Christian Buchbender

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Correspondence to Benedikt M. Schaarschmidt .

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  1. Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany

    Sabine Weckbach

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Schaarschmidt, B.M., Buchbender, C. (2016). Incidental Findings in 18F-FDG PET/CT and PET/MR. In: Weckbach, S. (eds) Incidental Radiological Findings. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2016_36

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