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Leukemia and Lymphoma

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Re-Irradiation: New Frontiers

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Leukemias and lymphomas comprise a diverse collection of malignancies with unique clinical behavior. Radiation therapy plays an integral role in the definitive, adjuvant, and palliative management of these hematologic malignancies. As opposed to most epithelial and mesenchymal malignancies, hematologic malignancies typically require lower doses of radiation therapy. Most can be controlled with 24–40 Gy, well within the tolerance of most normal tissues. In the palliative setting, exceptionally low doses (e.g., 4 Gy) are often sufficient. This characteristic of hematologic malignancies allows for re-treatment, when necessary, in most circumstances. In this chapter, we will review the major histologic subtypes of hematologic malignancies and discuss the settings where re-irradiation is sometimes encountered in clinical practice.

The original version of this chapter was revised. An erratum to this chapter can be found at 10.1007/978-3-319-41825-4_78.

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Abbreviations

ABVD:

Doxorubicin, bleomycin, vinblastine, dacarbazine

GHSG:

German Hodgkin Study Group

ICE:

Ifosfamide, carboplatin, etoposide

R-CHOP:

Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone

MALT:

Mucosa-associated lymphoid tissue

CNS:

Central nervous system

TBI:

Total body irradiation

RT:

Radiation therapy

PET-CT:

Positron emission tomography-computed tomography

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Acknowledgment

The authors would like to thank Leonard R. Prosnitz, M.D., for his thoughtful comments that improved the quality of the chapter.

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Authors and Affiliations

  1. Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA

    Chris R. Kelsey MD & Grace J. Kim MD, PhD

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  1. Chris R. Kelsey MD
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  2. Grace J. Kim MD, PhD
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Correspondence to Chris R. Kelsey MD .

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Editors and Affiliations

  1. Department of Oncology, University of Tromso and Nordland Hospital, Bodo, Norway

    Carsten Nieder

  2. University Medical Center Groningen, Groningen, The Netherlands

    Johannes Langendijk

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Kelsey, C.R., Kim, G.J. (2016). Leukemia and Lymphoma. In: Nieder, C., Langendijk, J. (eds) Re-Irradiation: New Frontiers. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2016_32

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  • DOI: https://doi.org/10.1007/174_2016_32

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