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Bone Marrow: Chemotherapy

  • Chapter
Imaging of Complications and Toxicity following Tumor Therapy

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Most systemic diseases affecting the bone marrow (BM) will have a major impact on disease progression and life expectancy. Toxic effects on bone marrow caused by exogenic agents such as chemotherapy or other medications that are non-cell specific significantly influence treatment outcome and survival. The bone marrow with its active hematopoietic components, vital microenvironment, and complex cellular interactions among each other and with adjacent support tissue such as bone is vulnerable to a vast number of toxic stresses. We are just beginning to understand the role of normal and yet disease-unaffected bone marrow in patients treated for various illnesses. Morphological and compositional changes, as imaged with MRI, reflect a static picture of dynamic and ongoing biochemical cellular process. Newer techniques, for example, diffusion-weighted MR imaging brings us now closer to the cellular level. This is particularly important for the correct interpretation of bone marrow signal changes in cancer patients receiving chemotherapy. Bone marrow edema, hypo- or aplasia, reconversion, and necrosis are the most frequent changes associated with a broad spectrum of chemotherapeutic agents and their additives. The knowledge of chemotherapeutic regimes and the timeline of administration are essential for the interpretation of bone marrow.

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Abbreviations

Wb:

Whole-body

SI:

Signal intensity

-w:

-Weighted image(s)

fs:

Fat-saturated

Gd:

Gadolinium

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Authors and Affiliations

  1. Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Björn Jobke

  2. Department of Radiology, Leiden University Medical Center, 9600, Leiden, 2300 RC, The Netherlands

    Hans Bloem

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  1. Björn Jobke
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  2. Hans Bloem
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Correspondence to Björn Jobke .

Editor information

Editors and Affiliations

  1. Dept. of Radiology, University Hospital Heidelberg, Heidelberg, Germany

    Hans-Ulrich Kauczor

  2. Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

    Tobias Bäuerle

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Jobke, B., Bloem, H. (2015). Bone Marrow: Chemotherapy. In: Kauczor, HU., Bäuerle, T. (eds) Imaging of Complications and Toxicity following Tumor Therapy. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2015_1051

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  • DOI: https://doi.org/10.1007/174_2015_1051

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12840-5

  • Online ISBN: 978-3-319-12841-2

  • eBook Packages: MedicineMedicine (R0)

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