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Salvage Prostatectomy After Radiotherapy

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Radiotherapy in Prostate Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Radiotherapy is widely utilized as primary therapy for clinically localized prostate cancer. Biochemical recurrence after external radiotherapy or brachytherapy occurs in up to 60 % of patients treated for prostate cancer within 10 years. Salvage radical prostatectomy represents a secondary local treatment with curative intent in patients with organ confined prostate cancer recurrences following radiation therapy. Patients most likely to benefit from salvage prostatectomy have low-risk disease, a pretreatment PSA velocity <2.0 ng/ml per year at the time of initial presentation, an interval to PSA failure >3 years, and a PSA doubling time >12 months. In experienced hands, morbidity is low with a continence rate of approximately 80 % depending on the type of previous radiation therapy. Long-term oncological control can be achieved in more than 75 % of the patients. Despite these well-established oncological outcomes, salvage radical prostatectomy is infrequently performed or reported.

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Authors and Affiliations

  1. Department of Urology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany

    Hubert Kübler, Tobias Maurer, Thomas Horn & Jürgen E. Gschwend

Authors
  1. Hubert Kübler
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  2. Tobias Maurer
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  3. Thomas Horn
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  4. Jürgen E. Gschwend
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Corresponding author

Correspondence to Hubert Kübler .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Krankenhaus der Barmherzigen, Schwestern Linz, Johannes Kepler University, Linz, Austria

    Hans Geinitz

  2. University of California, San Francisco Department of Radiation Oncology, San Francisco, California, USA

    Mack Roach III

  3. The Institute of Cancer Research Sutton, Sutton Surrey, United Kingdom

    Nicholas van As

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© 2014 Springer-Verlag Berlin Heidelberg

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Kübler, H., Maurer, T., Horn, T., Gschwend, J.E. (2014). Salvage Prostatectomy After Radiotherapy. In: Geinitz, H., Roach III, M., van As, N. (eds) Radiotherapy in Prostate Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2013_950

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  • DOI: https://doi.org/10.1007/174_2013_950

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37098-4

  • Online ISBN: 978-3-642-37099-1

  • eBook Packages: MedicineMedicine (R0)

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