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Head and Neck Squamous Cell Cancer

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Decision Tools for Radiation Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Patients with head and neck squamous cell cancer are a very heterogeneous group with regard to aetiology, age and other host factors, disease stage and biology, and treatment approaches and outcome. Given the major implications of both tumour and treatment on quality of life and functional status, comprehensive pre-treatment assessments and multidisciplinary approaches are recommended. Models and tools facilitating decision making such as staging systems and nomograms are discussed in this chapter, which is dedicated to Kie Kian Ang, an outstanding leader in the field of head and neck cancer, who passed away much too early. During a post doctoral fellowship at the University of Texas M.D. Anderson Cancer Center Dr. Ang taught me the art and science of writing reviews and book chapters.

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References

  • Agarwala SS, Cano E, Heron DE, Johnson J, Myers E, Sandulache V et al (2007) Long-term outcomes with concurrent carboplatin, paclitaxel and radiation therapy for locally advanced, inoperable head and neck cancer. Ann Oncol 18:1224–1229

    Article  CAS  PubMed  Google Scholar 

  • Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH et al (2002) Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 62:7350–7356

    CAS  PubMed  Google Scholar 

  • Balermpas P, Michel Y, Wagenblast J, Seitz O, Sipek F, Rödel F et al (2013) Nuclear NF-κB expression correlates with outcome among patients with head and neck squamous cell carcinoma treated with primary chemoradiation therapy. Int J Radiat Oncol Biol Phys 86:785–790

    Article  PubMed  Google Scholar 

  • Bauman JE, Austin MC, Schmidt R, Kurland BF, Vaezi A, Hayes DN et al (2013) ERCC1 is a prognostic biomarker in locally advanced head and neck cancer: results from a randomised, phase II trial. Br J Cancer. doi:10.1038/bjc.2013.576

    PubMed  Google Scholar 

  • Beetz I, Schilstra C, Burlage FR, Koken PW, Doornaert P, Bijl HP et al (2012) Development of NTCP models for head and neck cancer patients treated with three-dimensional conformal radiotherapy for xerostomia and sticky saliva: the role of dosimetric and clinical factors. Radiother Oncol 105:86–93

    Article  PubMed  Google Scholar 

  • Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefebvre JL, Greiner RH et al (2004) Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350:1945–1952

    Article  CAS  PubMed  Google Scholar 

  • Bøje CR, Dalton SO, Grønborg TK, Primdahl H, Kristensen CA, Andersen E et al (2013) The impact of comorbidity on outcome in 12 623 Danish head and neck cancer patients: a population based study from the DAHANCA database. Acta Oncol 52:285–293

    Article  PubMed  Google Scholar 

  • Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB et al (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354:567–578

    Article  CAS  PubMed  Google Scholar 

  • Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J et al (2006) Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet 368:843–854

    Article  PubMed  Google Scholar 

  • Brockstein B, Haraf DJ, Rademaker AW, Kies MS, Stenson KM, Rosen F et al (2004) Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: a 9-year, 337-patient, multi-institutional experience. Ann Oncol 15:1179–1186

    Article  CAS  PubMed  Google Scholar 

  • Chen KW, Lin JF, Jan JS, Chao JY, Lin JC (2009) The effect of primary tumor volume measured by MR imaging on T-stage, local control, and survival in patients with advanced nasopharyngeal carcinoma. Therapeut Radiol Oncol 16:1–13

    CAS  Google Scholar 

  • Christianen ME, Schilstra C, Beetz I, Muijs CT, Chouvalova O, Burlage FR et al (2012) Predictive modelling for swallowing dysfunction after primary (chemo)radiation: results of a prospective observational study. Radiother Oncol 105:107–114

    Article  PubMed  Google Scholar 

  • Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB et al (2004) Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350:1937–1944

    Article  PubMed  Google Scholar 

  • Coyne JC, Pajak TF, Harris J, Konski A, Movsas B, Ang KK et al (2007) Emotional well-being does not predict survival in head and neck cancer patients: a Radiation Therapy Oncology Group study. Cancer 110:2568–2575

    Article  PubMed  Google Scholar 

  • De Crevoisier R, Bourhis J, Domenge C, Wibault P, Koscielny S, Lusinchi A et al (1998) Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients. J Clin Oncol 16:3556–3562

    PubMed  Google Scholar 

  • De Crevoisier R, Domenge C, Wibault P, Koscielny S, Lusinchi A, Janot F et al (2001) Full dose reirradiation combined with chemotherapy after salvage surgery in head and neck carcinoma. Cancer 91:2071–2076

    Article  PubMed  Google Scholar 

  • Dorth JA, Patel PR, Broadwater G, Brizel DM (2013) Incidence and risk factors of significant carotid artery stenosis in asymptomatic survivors of head and neck cancer after radiotherapy. Head Neck. doi:10.1002/hed.23280

    PubMed  Google Scholar 

  • Dos Santos M, Mercante AM, Louro ID, Gonçalves AJ, de Carvalho MB, da Silva EH et al (2012) HIF1-alpha expression predicts survival of patients with squamous cell carcinoma of the oral cavity. PLoS One 7:e45228

    Article  PubMed Central  PubMed  Google Scholar 

  • EdgeSB, Byrd DR, Compton CC et al (2009) American Joint Committee on Cancer, American Cancer Society. AJCC cancer staging manual, 7th edn. Springer, Berlin

    Google Scholar 

  • Egelmeer AG, Velazquez ER, de Jong JM, Oberije C, Geussens Y, Nuyts S et al (2011) Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: a cohort study based on 994 patients. Radiother Oncol 100:108–115

    Article  PubMed  Google Scholar 

  • Eriksen JG, Steiniche T, Overgaard J (2005) Danish Head and Neck Cancer study group (DAHANCA). The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7 study. Radiother Oncol 74:93–100

    Google Scholar 

  • Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H et al (2008) Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 100:261–269

    Article  CAS  PubMed  Google Scholar 

  • Garg MK, Glanzman J, Kalnicki S (2012) The evolving role of positron emission tomography-computed tomography in organ-preserving treatment of head and neck cancer. Semin Nucl Med 42:320–327

    Article  PubMed  Google Scholar 

  • Ghadjar P, Simcock M, Zimmermann F, Betz M, Bodis S, Bernier J et al (2012) Predictors of severe late radiotherapy-related toxicity after hyperfractionated radiotherapy with or without concomitant cisplatin in locally advanced head and neck cancer. Secondary retrospective analysis of a randomized phase III trial (SAKK 10/94). Radiother Oncol 104:213–218

    Article  CAS  PubMed  Google Scholar 

  • Gillison ML, Zhang Q, Jordan R, Xiao W, Westra WH, Trotti A et al (2012) Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer. J Clin Oncol 30:2102–2111

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gregoire V, Coche E, Cosnard G, Hamoir M, Reychler H (2000) Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience. Radiother Oncol 56:135–150

    Google Scholar 

  • Guo R, Sun Y, Yu XL, Yin WJ, Li WF, Chen YY et al (2012) Is primary tumor volume still a prognostic factor in intensity modulated radiation therapy for nasopharyngeal carcinoma? Radiother Oncol 104:294–299

    Article  PubMed  Google Scholar 

  • Haughey BH, Gates GA, Arfken CL, Harvey J (1992) Meta-analysis of second malignant tumors in head and neck cancer: the case for an endoscopic screening protocol. Ann Otol Rhinol Laryngol 101:105–112

    CAS  PubMed  Google Scholar 

  • Heukelom J, Hamming O, Bartelink H, Hoebers F, Giralt J, Herlestam T et al (2013) Adaptive and innovative Radiation Treatment FOR improving Cancer treatment outcomE (ARTFORCE); a randomized controlled phase II trial for individualized treatment of head and neck cancer. BMC Cancer 13:84

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hitt R, Lopez-Pousa A, Martinez-Trufero J, Escrig V, Carles J, Rizo A et al (2005) Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin, and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer. J Clin Oncol 23:8636–8645

    Article  PubMed  Google Scholar 

  • Hoebers F, Rios E, Troost E, van den Ende P, Kross K, Lacko M et al (2013) Definitive radiation therapy for treatment of laryngeal carcinoma : impact of local relapse on outcome and implications for treatment strategies. Strahlenther Onkol 189:834–841

    Article  CAS  PubMed  Google Scholar 

  • Hoff CM (2012) Importance of hemoglobin concentration and its modification for the outcome of head and neck cancer patients treated with radiotherapy. Acta Oncol 51:419–432

    Article  CAS  PubMed  Google Scholar 

  • Hong AM, Martin A, Armstrong BK, Lee CS, Jones D, Chatfield MD et al (2013) Human papillomavirus modifies the prognostic significance of T stage and possibly N stage in tonsillar cancer. Ann Oncol 24:215–219

    Article  CAS  PubMed  Google Scholar 

  • Honoré HB, Bentzen SM, Møller K, Grau C (2002) Sensori-neural hearing loss after radiotherapy for nasopharyngeal carcinoma: individualized risk estimation. Radiother Oncol 65:9–16

    Article  PubMed  Google Scholar 

  • Huang PY, Wang CT, Cao KJ, Guo X, Guo L, Mo HY et al (2013) Pretreatment body mass index as an independent prognostic factor in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy: findings from a randomised trial. Eur J Cancer 49:1923–1931

    Article  PubMed  Google Scholar 

  • Janot F, De Raucourt D, Benhamou E, Ferron C, Dolivet G, Bensadoun RJ et al (2008) Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck carcinoma. J Clin Oncol 26:5518–5523

    Article  CAS  PubMed  Google Scholar 

  • Kasperts N, Slotman B, Leemans CR, Langendijk JA (2005) A review on re-irradiation for recurrent and second primary head and neck cancer. Oral Oncol 41:225–243

    Article  CAS  PubMed  Google Scholar 

  • Kim KY, Li S, Cha JD, Zhang X, Cha IH (2012) Significance of molecular markers in survival prediction of oral squamous cell carcinoma. Head Neck 34:929–936

    Article  PubMed  Google Scholar 

  • Koiwai K, Shikama N, Sasaki S, Shinoda A, Kadoya M (2010) Validation of the Total Dysphagia Risk Score (TDRS) as a predictive measure for acute swallowing dysfunction induced by chemoradiotherapy for head and neck cancers. Radiother Oncol 97:132–135

    Article  PubMed  Google Scholar 

  • Langendijk JA, Leemans CR, Buter J, Berkhof J, Slotman BJ (2004) The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature. J Clin Oncol 22:4604–4612

    Article  CAS  PubMed  Google Scholar 

  • Langendijk JA, Doornaert P, Rietveld DH, Verdonck-de Leeuw IM, Leemans CR, Slotman BJ (2009) A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiother Oncol 90:189–195

    Google Scholar 

  • Langer CJ, Harris J, Horwitz EM, Nicolaou N, Kies M, Curran W et al (2007) Phase II study of low-dose paclitaxel and cisplatin in combination with split-course concomitant twice-daily reirradiation in recurrent squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Protocol 9911. J Clin Oncol 25:4800–4805

    Article  CAS  PubMed  Google Scholar 

  • Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J (2009) Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 27:1992–1998

    Article  CAS  PubMed  Google Scholar 

  • Le QT, Harris J, Magliocco AM, Kong CS, Diaz R, Shin B et al (2009) Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90–03. J Clin Oncol 27:4281–4286

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Le QT, Fisher R, Oliner KS, Young RJ, Cao H, Kong C et al (2012) Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer. Clin Cancer Res 18:1798–1807

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lee NY, de Arruda FF, Puri DR, Wolden SL, Narayana A, Mechalakos J et al (2006) A comparison of intensity-modulated radiation therapy and concomitant boost radiotherapy in the setting of concurrent chemotherapy for locally advanced oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 66:966–974

    Article  PubMed  Google Scholar 

  • Lee IJ, Koom WS, Lee CG, Kim YB, Yoo SW, Keum KC et al (2009) Risk factors and dose-effect relationship for mandibular osteoradionecrosis in oral and oropharyngeal cancer patients. Int J Radiat Oncol Biol Phys 75:1084–1091

    Article  PubMed  Google Scholar 

  • Lim AM, Rischin D, Fisher R, Cao H, Kwok K, Truong D et al (2012) Prognostic significance of plasma osteopontin in patients with locoregionally advanced head and neck squamous cell carcinoma treated on TROG 02.02 phase III trial. Clin Cancer Res 18:301–307

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lv X, Xiang YQ, Cao SM, Qian CN, Li NW, Guo L et al (2011) Prospective validation of the prognostic value of elevated serum vascular endothelial growth factor in patients with nasopharyngeal carcinoma: more distant metastases and shorter overall survival after treatment. Head Neck 33:780–785

    Article  PubMed  Google Scholar 

  • Machtay M, Moughan J, Farach A, Martin-O’Meara E, Galvin J, Garden AS et al (2012) Hypopharyngeal dose is associated with severe late toxicity in locally advanced head-and-neck cancer: an RTOG analysis. Int J Radiat Oncol Biol Phys 84:983–989

    Article  PubMed Central  PubMed  Google Scholar 

  • McCloskey SA, Jaggernauth W, Rigual NR, Hicks WL Jr, Popat SR, Sullivan M et al (2009) Radiation treatment interruptions greater than one week and low hemoglobin levels (12 g/dL) are predictors of local regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck. Am J Clin Oncol 32:587–591

    Article  CAS  PubMed  Google Scholar 

  • McMillan AS, Pow EH, Kwong DL, Wong MC, Sham JS, Leung LH, Leung WK (2006) Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: results of a prospective longitudinal study. Head Neck 28:712–722

    Article  PubMed  Google Scholar 

  • Monnier Y, Broome M, Betz M, Bouferrache K, Ozsahin M, Jaques B (2011) Mandibular osteoradionecrosis in squamous cell carcinoma of the oral cavity and oropharynx: incidence and risk factors. Otolaryngol Head Neck Surg 144:726–732

    Article  PubMed  Google Scholar 

  • Moon SH, Choi JY, Lee HJ, Son YI, Baek CH, Ahn YC et al (2013) Prognostic value of 18F-FDG PET/CT in patients with squamous cell carcinoma of the tonsil: comparisons of volume-based metabolic parameters. Head Neck 35:15–22

    Article  PubMed  Google Scholar 

  • Mortensen LS, Johansen J, Kallehauge J, Primdahl H, Busk M, Lassen P et al (2012) FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial. Radiother Oncol 105:14–20

    Article  PubMed  Google Scholar 

  • Mortensen HR, Jensen K, Aksglæde K, Behrens M, Grau C (2013) Late dysphagia after IMRT for head and neck cancer and correlation with dose-volume parameters. Radiother Oncol 107:288–294

    Article  PubMed  Google Scholar 

  • Nichols AC, Whelan F, Basmaji J, Dhaliwal S, Dowthwaite S, Chapeskie C et al (2012) Ki-67 expression predicts radiotherapy failure in early glottic cancer. J Otolaryngol Head Neck Surg 41:124–130

    PubMed  Google Scholar 

  • Nieder C, Milas L, Ang KK (2000) Tissue tolerance to reirradiation. Semin Radiat Oncol 10:200–209

    Article  CAS  PubMed  Google Scholar 

  • Nieder C, Gregoire V, Ang KK (2001) Cervical lymph node metastases from occult squamous cell carcinoma: cut down a tree to get an apple? Int J Radiat Oncol Biol Phys 50:727–733

    Article  CAS  PubMed  Google Scholar 

  • Nijkamp MM, Span PN, Terhaard CH, Doornaert PA, Langendijk JA, van den Ende PL et al (2013) Epidermal growth factor receptor expression in laryngeal cancer predicts the effect of hypoxia modification as an additive to accelerated radiotherapy in a randomised controlled trial. Eur J Cancer 49:3202–3209

    Article  CAS  PubMed  Google Scholar 

  • Nourissat A, Bairati I, Samson E, Fortin A, Gélinas M, Nabid A et al (2010) Predictors of weight loss during radiotherapy in patients with stage I or II head and neck cancer. Cancer 116:2275–2283

    PubMed  Google Scholar 

  • Oguejiofor KK, Hall JS, Mani N, Douglas C, Slevin NJ, Homer J et al (2013) The prognostic significance of the biomarker p16 in oropharyngeal squamous cell carcinoma. Clin Oncol (R Coll Radiol) 25:630–638

    Article  CAS  Google Scholar 

  • Overgaard J, Eriksen JG, Nordsmark M, Alsner J, Horsman MR (2005) Danish Head and Neck Cancer Study Group. Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial. Lancet Oncol 6:757–764

    Google Scholar 

  • Pai PC, Chuang CC, Tseng CK, Tsang NM, Chang KP, Yen TC et al (2012) Impact of pretreatment body mass index on patients with head-and-neck cancer treated with radiation. Int J Radiat Oncol Biol Phys 83:e93–e100

    Article  PubMed  Google Scholar 

  • Park GC, Kim JS, Roh JL, Choi SH, Nam SY, Kim SY (2013) Prognostic value of metabolic tumor volume measured by 18F-FDG PET/CT in advanced-stage squamous cell carcinoma of the larynx and hypopharynx. Ann Oncol 24:208–214

    Article  CAS  PubMed  Google Scholar 

  • Pignon JP, Bourhis J, Domenge C, Designe L (2000) Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-analysis of chemotherapy on head and neck cancer. Lancet 355:949–955

    Article  CAS  PubMed  Google Scholar 

  • Pignon JP, le Maitre A, Maillard E, Bourhis J (2009) Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol 92:4–14

    Article  PubMed  Google Scholar 

  • Platek ME, Reid ME, Wilding GE, Jaggernauth W, Rigual NR, Hicks WL Jr et al (2011) Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy. Head Neck 33:1561–1568

    Article  PubMed  Google Scholar 

  • Posner MR, Hershock DM, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V et al (2007) Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 357:1705–1715

    Article  CAS  PubMed  Google Scholar 

  • Pow EH, Kwong DL, McMillan AS, Wong MC, Sham JS, Leung LH, Leung WK (2006) Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys 66:981–991

    Article  PubMed  Google Scholar 

  • Quon H, Brizel DM (2012) Predictive and prognostic role of functional imaging of head and neck squamous cell carcinomas. Semin Radiat Oncol 22:220–232

    Article  PubMed  Google Scholar 

  • Rades D, Seibold ND, Schild SE, Gebhard MP, Noack F (2013a) Androgen receptor expression: prognostic value in locally advanced squamous cell carcinoma of the head and neck. Strahlenther Onkol 189:849–855

    Article  CAS  PubMed  Google Scholar 

  • Rades D, Seibold ND, Gebhard MP, Noack F, Thorns C, Schild SE (2013b) Impact of the HPV-positivity definition on the prognostic value of HPV status in patients with locally advanced squamous cell carcinoma of the head and neck. Strahlenther Onkol 189:856–860

    Article  CAS  PubMed  Google Scholar 

  • Rischin D, Young RJ, Fisher R, Fox SB, Le QT, Peters LJ et al (2010) Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial. J Clin Oncol 28:4142–4148

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Rutkowski T, Wygoda A, Składowski K, Hejduk B, Rutkowski R, Kołosza Z, Maciejewski B (2013) Prognostic role of tumor volume for radiotherapy outcome in patient with T2 laryngeal cancer. Strahlenther Onkol 189:861–866

    Article  CAS  PubMed  Google Scholar 

  • Schaefer U, Micke O, Schueller P, Willich N (2000) Recurrent head and neck cancer: retreatment of previously irradiated areas with combined chemotherapy and radiation therapy-results of a prospective study. Radiology 216:371–376

    Article  CAS  PubMed  Google Scholar 

  • Schrijvers ML, Pattje WJ, Slagter-Menkema L, Mastik MF, Gibcus JH, Langendijk JA et al (2012) FADD expression as a prognosticator in early-stage glottic squamous cell carcinoma of the larynx treated primarily with radiotherapy. Int J Radiat Oncol Biol Phys 83:1220–1226

    Article  CAS  PubMed  Google Scholar 

  • Seibold ND, Schild SE, Gebhard MP, Noack F, Rades D (2013) Prognosis of patients with locally advanced squamous cell carcinoma of the head and neck. Impact of tumor cell expression of EPO and EPO-R. Strahlenther Onkol 189:559–565

    Article  CAS  PubMed  Google Scholar 

  • Self EM, Bumpous J, Ziegler C, Wilson L, Potts K (2013) Risk factors for hemorrhage after chemoradiation for oropharyngeal squamous cell carcinoma. JAMA Otolaryngol Head Neck Surg 139:356–361

    Article  PubMed  Google Scholar 

  • Semrau R, Duerbaum H, Temming S, Huebbers C, Stenner M, Drebber U et al (2013) Prognostic impact of human papillomavirus status, survivin, and epidermal growth factor receptor expression on survival in patients treated with radiochemotherapy for very advanced nonresectable oropharyngeal cancer. Head Neck 35:1339–1344

    Article  PubMed  Google Scholar 

  • Shikama N, Kumazaki Y, Tsukamoto N, Ebara T, Makino S, Abe T et al (2013) Validation of nomogram-based prediction of survival probability after salvage re-irradiation of head and neck cancer. Jpn J Clin Oncol 43:154–160

    Article  PubMed  Google Scholar 

  • Snietura M, Jaworska M, Mlynarczyk-Liszka J, Goraj-Zajac A, Piglowski W, Lange D et al (2012) PTEN as a prognostic and predictive marker in postoperative radiotherapy for squamous cell cancer of the head and neck. PLoS One 7:e33396

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Spencer SA, Wheeler RH, Peters GE, Beenken SW, Meredith RF, Smith J, Conner W, Salter MM (1999) Concomitant chemotherapy and reirradiation as management for recurrent cancer of the head and neck. Am J Clin Oncol 22:1–5

    Article  CAS  PubMed  Google Scholar 

  • Spencer SA, Harris J, Wheeler RH, Machtay M, Schultz C, Spanos W et al (2001) RTOG 96–10: reirradiation with concurrent hydroxyurea and 5-fluorouracil in patients with squamous cell cancer of the head and neck. Int J Radiat Oncol Biol Phys 51:1299–1304

    Article  CAS  PubMed  Google Scholar 

  • Spencer SA, Harris J, Wheeler RH, Machtay M, Schultz C, Spanos W et al (2008) Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. Head Neck 30:281–288

    Article  PubMed  Google Scholar 

  • Su SF, Huang SM, Han F, Huang Y, Chen CY, Xiao WW et al (2013) Analysis of dosimetric factors associated with temporal lobe necrosis (TLN) in patients with nasopharyngeal carcinoma (NPC) after intensity modulated radiotherapy. Radiat Oncol 8:17

    Article  PubMed Central  PubMed  Google Scholar 

  • Sulman EP, Schwartz DL, Le TT, Ang KK, Morrison WH, Rosenthal DI et al (2009) IMRT reirradiation of head and neck cancer-disease control and morbidity outcomes. Int J Radiat Oncol Biol Phys 73:399–409

    Article  PubMed  Google Scholar 

  • Sun JM, Ahn MJ, Park MJ, Lee HY, Ahn JS, Lee S et al (2011) Expression of excision repair cross-complementation group 1 as predictive marker for nasopharyngeal cancer treated with concurrent chemoradiotherapy. Int J Radiat Oncol Biol Phys 80:655–660

    Article  PubMed  Google Scholar 

  • Sze WM, Lee AW, Yau TK, Yeung RM, Lau KY, Leung SK et al (2004) Primary tumor volume of nasopharyngeal carcinoma: prognostic significance of local control. Int J Radiat Oncol Biol Phys 59:21–27

    Article  PubMed  Google Scholar 

  • Tang C, Murphy JD, Khong B, La TH, Kong C, Fischbein NJ et al (2012) Validation that metabolic tumor volume predicts outcome in head-and-neck cancer. Int J Radiat Oncol Biol Phys 83:1514–1520

    Article  PubMed Central  PubMed  Google Scholar 

  • Tanvetyanon T, Padhya T, McCaffrey J, Zhu W, Boulware D, Deconti R, Trotti A (2009) Prognostic factors for survival after salvage reirradiation of head and neck cancer. J Clin Oncol 27:1983–1991

    Google Scholar 

  • Teguh DN, Levendag PC, Voet P, van der Est H, Noever I, de Kruijf W et al (2008) Trismus in patients with oropharyngeal cancer: relationship with dose in structures of mastication apparatus. Head Neck 30:622–630

    Article  PubMed  Google Scholar 

  • Teguh DN, Levendag PC, Ghidey W, van Montfort K, Kwa SL (2013) Risk model and nomogram for dysphagia and xerostomia prediction in head and neck cancer patients treated by radiotherapy and/or chemotherapy. Dysphagia 28:388–394

    Article  PubMed  Google Scholar 

  • Thomas B, Stedman M, Davies L (2013) Grade as a prognostic factor in oral squamous cell carcinoma: A population based analysis of the data. Laryngoscope. doi:10.1002/lary.24357

    Google Scholar 

  • Toustrup K, Sørensen BS, Alsner J, Overgaard J (2012) Hypoxia gene expression signatures as prognostic and predictive markers in head and neck radiotherapy. Semin Radiat Oncol 22:119–127

    Article  PubMed  Google Scholar 

  • Tribius S, Reemts E, Prosch C, Raguse M, Petersen C, Kruell A et al (2012) Global quality of life during the acute toxicity phase of multimodality treatment for patients with head and neck cancer: can we identify patients most at risk of profound quality of life decline? Oral Oncol 48:898–904

    Article  CAS  PubMed  Google Scholar 

  • Vergeer MR, Doornaert PA, Rietveld DH, Leemans CR, Slotman BJ, Langendijk JA (2009) Intensity-modulated radiotherapy reduces radiation-induced morbidity and improves health-related quality of life: results of a nonrandomized prospective study using a standardized follow-up program. Int J Radiat Oncol Biol Phys 74:1–8

    Article  PubMed  Google Scholar 

  • Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M et al (2007) Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med 357:1695–1704

    Article  CAS  PubMed  Google Scholar 

  • Wan XB, Wei L, Li H, Dong M, Lin Q, Ma XK et al (2013) High pretreatment serum lactate dehydrogenase level correlates with disease relapse and predicts an inferior outcome in locally advanced nasopharyngeal carcinoma. Eur J Cancer 49:2356–2364

    Article  CAS  PubMed  Google Scholar 

  • Wang YL, Feng SH, Zhu J, Zhu GP, Li DS, Wang Y et al (2013a) Impact of lymph node ratio on the survival of patients with hypopharyngeal squamous cell carcinoma: a population-based analysis. PLoS One 8:e56613

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Wang SJ, Patel SG, Shah JP, Goldstein DP, Irish JC, Carvalho AL et al (2013b) An oral cavity carcinoma nomogram to predict benefit of adjuvant radiotherapy. JAMA Otolaryngol Head Neck Surg 139:554–559

    PubMed  Google Scholar 

  • Weiss MH, Harrison LB, Isaacs RS (1994) Use of decision analysis in planning a management strategy for the stage N0 neck. Arch Otolaryngol Head Neck Surg 120:699–702

    Article  CAS  PubMed  Google Scholar 

  • Yoo J, Henderson S, Walker-Dilks C (2013) Evidence-based guideline recommendations on the use of positron emission tomography imaging in head and neck cancer. Clin Oncol (R Coll Radiol) 25:e33–e66

    Article  CAS  Google Scholar 

  • Zhou GQ, Tang LL, Mao YP, Chen L, Li WF, Sun Y et al (2012) Baseline serum lactate dehydrogenase levels for patients treated with intensity-modulated radiotherapy for nasopharyngeal carcinoma: a predictor of poor prognosis and subsequent liver metastasis. Int J Radiat Oncol Biol Phys 82:e359–e365

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway

    Carsten Nieder

  2. Faculty of Health Sciences, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway

    Carsten Nieder

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  1. Carsten Nieder
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Correspondence to Carsten Nieder .

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Editors and Affiliations

  1. Department of Oncology, Nordland Hospital Trust Bodø University of Tromsø, Bodø, Norway

    Carsten Nieder

  2. Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado, USA

    Laurie E. Gaspar

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Nieder, C. (2013). Head and Neck Squamous Cell Cancer. In: Nieder, C., Gaspar, L. (eds) Decision Tools for Radiation Oncology. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2013_934

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  • DOI: https://doi.org/10.1007/174_2013_934

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