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Bone Metastases

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Book cover Decision Tools for Radiation Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Bone is one of the most common sites of metastasis. This chapter addresses three notable issues for bone metastases patients receiving radiotherapy: prognosis, complications affecting this patient population and predictive factors for various toxicities. Overall survival estimates for bone metastases patients have improved considerably over the past 50 years and vary with respect to primary tumour location. Numerous general and tumour-specific predictors influence survival in this patient population; when combined, these covariates have been used to develop relevant predictive models for survival. Toxicities in bone metastases patients are generally mild, and risk is determined by radiation site and dose. One noteworthy toxicity that has garnered significant research in recent years is radiotherapy-induced nausea and vomiting, for which risk factors include the anatomic site being irradiated, a greater radiotherapy field size, a female gender and anxiety. Complications that may affect bone metastases patients are spinal cord compression, impending or pathologic fractures, neuropathic pain and recurrence of bone metastasis. In closing, this chapter contains essential information that should be considered in the delivery of treatment; ultimately, however, treatment choice should be tailored to the individual patient and should be based on a variety of clinical and sociodemographic factors.

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Authors and Affiliations

  1. Rapid Response Radiotherapy Program, Department of Radiation Oncology, University of Toronto, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, M4N 3M5, Canada

    Marko Popovic, Michael Poon, Erin Wong, Danielle Rodin & Edward Chow

  2. Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China

    Kenneth Li

  3. Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, China

    Florence Mok

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  1. Marko Popovic
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  2. Michael Poon
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  7. Edward Chow
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Correspondence to Edward Chow .

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  1. Department of Oncology, Nordland Hospital Trust Bodø University of Tromsø, Bodø, Norway

    Carsten Nieder

  2. Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado, USA

    Laurie E. Gaspar

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Popovic, M. et al. (2013). Bone Metastases. In: Nieder, C., Gaspar, L. (eds) Decision Tools for Radiation Oncology. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2013_836

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