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CT Imaging of Myocardial Perfusion and Viability pp 155–171Cite as

Why are We Interested in Viability?

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Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

The number of patients with left ventricular (LV) dysfunction due to coronary artery disease is increasing, as more patients now survive with acute myocardial infarction (MI) through primary reperfusion therapy. Severe LV dysfunction after MI, especially in combination with heart failure, is associated with a poor prognosis. Differentiation between reversible and irreversible LV dysfunction is important, as in the first situation, surgical revascularization improves prognosis. In case of reversible LV dysfunction, the myocardium can be stunned or hibernating. These principles are described. Myocardial viability assessment by noninvasive imaging techniques are indicated for this purpose. The different established imaging modalities for myocardial viability assessment are discussed in this chapter.

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References

  • Abraham WT, Bristow MR (1997) Specialized centers for heart failure management. Circulation 96:2755–2757

    PubMed  CAS  Google Scholar 

  • Abraham WT, Hayes DL (2003) Cardiac resynchronization therapy for heart failure. Circulation 108:2596–2603

    PubMed  Google Scholar 

  • Afridi I, Kleiman NS, Raizner AE et al (1995) Dobutamine echocardiography in myocardial hibernation. Optimal dose and accuracy in predicting recovery of ventricular function after coronary angioplasty. Circulation 91:663–670

    PubMed  CAS  Google Scholar 

  • Afridi I, Grayburn PA, Panza JA, Oh JK, Zoghbi WA, Marwick TH (1998) Myocardial viability during dobutamine echocardiography predicts survival in patients with coronary artery disease and severe left ventricular systolic dysfunction. J Am Coll Cardiol 32:921–926

    PubMed  CAS  Google Scholar 

  • Allman KC, Shaw LJ, Hachamovitch R et al (2002) Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Am Coll Cardiol 39:1151–1158

    PubMed  Google Scholar 

  • Al-Mallah MH, Sitek A, Moore SC, Di Carli M, Dorbala S (2010) Assessment of myocardial perfusion and function with PET and PET/CT. J Nucl Cardiol 17:498–513

    PubMed  Google Scholar 

  • Aoki M, Sakai K, Koyanagi S, Takeshita A, Nakamura M (1991) Effect of nitroglycerin on coronary collateral function during exercise evaluated by quantitative analysis of thallium-201 single photon emission computed tomography. Am Heart J 121:1361–1366

    PubMed  CAS  Google Scholar 

  • Bacharach SL, Bax JJ, Case J et al (2003) PET myocardial glucose metabolism and perfusion imaging: Part 1—Guidelines for data acquisition and patient preparation. J Nucl Cardiol 10:543–556

    PubMed  Google Scholar 

  • Baker WB, Klein MS, Reardon MJ et al (1991) Reversible cardiac dysfunction (hibernation) from ischemia due to compression of the coronary arteries by a pseudoaneurysm. N Engl J Med 325:1858–1861

    PubMed  CAS  Google Scholar 

  • Baker DW, Jones R, Hodges J, Massie BM, Konstam MA, Rose EA (1994) Management of heart failure III. The role of revascularization in the treatment of patients with moderate or severe left ventricular systolic dysfunction. JAMA 272:1528–1534

    PubMed  CAS  Google Scholar 

  • Baliga RR, Schaper J, Narula JP (2000) Role of apoptosis in myocardial hibernation and myocardial stunning. In: Iskandrian AE, Van Der Wall EE (eds) Myocardial Viability, 2nd edn. Kluwer Academic Publishers, Dordrecht, pp 21–45

    Google Scholar 

  • Barkhausen J, Ruehm SG, Goyen M, Buck T, Laub G, Debatin JF (2001) MR evaluation of ventricular function: true fast imaging with steady-state precession versus fast low-angle shot cine MR imaging: feasibility study. Radiology 219:264–269

    PubMed  CAS  Google Scholar 

  • Bax JJ, Wahba FF, Van Der Waal EE (2003) Myocardial viability/hibernation. In: Iskandrian AE, Verani MS (eds) Nuclear cardiac imaging. Oxford University Press, New York, pp 386–398

    Google Scholar 

  • Bax JJ, Schinkel AFL, Boersma E et al (2004) Extensive left ventricular remodeling does not allow viable myocardium to improve in left ventricular ejection fraction after revascularization and is associated with worse long-term prognosis. Circulation 110(suppl 1):II18–II22

    Google Scholar 

  • Beanlands RS, Chow BJ, Dick A et al (2007a) CCS/CAR/CANM/CNCS/CanSCMR joint position statement on advanced noninvasive cardiac imaging using positron emission tomography, magnetic resonance imaging and multidetector computed tomographic angiography in the diagnosis and evaluation of ischemic heart disease—executive summary. Can J Cardiol 23:107–119

    PubMed  CAS  Google Scholar 

  • Beanlands RSB, Nichol G, Huszti E et al (2007b) F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction and suspected coronary disease: a randomized, controlled trial (PARR-2) (see comment). J Am Coll Cardiol 50:2002–2012

    PubMed  Google Scholar 

  • Blitz A, Laks H (1996) The role of coronary revascularization in the management of heart failure: identification of candidates and review of results. Curr Opin Cardiol 11:276–290

    PubMed  CAS  Google Scholar 

  • Bogaert J, Kalantzi M, Rademakers FE, Dymarkowski S, Janssens S (2007) Determinants and impact of microvascular obstruction in successfully reperfused ST-segment elevation myocardial infarction. Assessment by magnetic resonance imaging. Eur Radiol 17:2572–2580

    PubMed  Google Scholar 

  • Bolognese L, Neskovic AN, Parodi G et al (2002) Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications. Circulation 106:2351–2357

    PubMed  Google Scholar 

  • Bonow RO, Dilsizian V, Cuocolo A, Bacharach SL (1991) Identification of viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction. Comparison of thallium scintigraphy with reinjection and PET imaging with 18F-fluorodeoxyglucose (see comment). Circulation 83:26–37

    PubMed  CAS  Google Scholar 

  • Bonow RO, Maurer G, Lee KL et al (2011) Myocardial viability and survival in ischemic left ventricular dysfunction. N Engl J Med 364:1617–1625

    PubMed  CAS  Google Scholar 

  • Bounous EP, Mark DB, Pollock BG et al (1988) Surgical survival benefits for coronary disease patients with left ventricular dysfunction. Circulation 78:I151–I157

    PubMed  CAS  Google Scholar 

  • Braunwald E, Kloner RA (1982) The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation 66:1146–1149

    PubMed  CAS  Google Scholar 

  • Braunwald E, Rutherford JD (1986) Reversible ischemic left ventricular dysfunction: evidence for the ‘‘hibernating myocardium’’. J Am Coll Cardiol 8:1467–1470

    PubMed  CAS  Google Scholar 

  • Brunken RC, Mody FV, Hawkins RA, Nienaber C, Phelps ME, Schelbert HR (1992) Positron emission tomography detects metabolic viability in myocardium with persistent 24-hour single-photon emission computed tomography 201Tl defects. Circulation 86:1357–1369

    PubMed  CAS  Google Scholar 

  • Buckley O, Di Carli M (2011) Predicting benefit from revascularization in patients with ischemic heart failure: imaging f myocardial ischemia and viability. Circulation 123:444–450

    PubMed  Google Scholar 

  • Burns RJ, Gibbons RJ, Yi Q et al (2002) The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis. J Am Coll Cardiol 39:30–36

    PubMed  Google Scholar 

  • Chatterjee K, Swan HJ, Parmley WW et al (1973) Influence of direct myocardial revascularization on left ventricular asynergy and function in patients with coronary heart disease: with and without previous myocardial infarction. Circulation 47:276–286

    PubMed  CAS  Google Scholar 

  • Chaudhry FA, Tauke JT, Alessandrini RS, Vardi G, Parker MA, Bonow RO (1999) Prognostic implications of myocardial contractile reserve in patients with coronary artery disease and left ventricular dysfunction. J Am Coll Cardiol 34:730–738

    PubMed  CAS  Google Scholar 

  • Cigarroa CG, deFilippi CR, Brickner ME, Alvarez LG, Wait MA, Grayburn PA (1993) Dobutamine stress echocardiography identifies hibernating myocardium and predicts recovery of left ventricular function after coronary revascularization. Circulation 88:433–436

    Google Scholar 

  • Cohn JN, Archibald DG, Ziesche S et al (1986) Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study. N Engl J Med 314:1547–1552

    PubMed  CAS  Google Scholar 

  • Colucci WS, Elkayam U, Horton DP et al for the Nesiritide Study Group (2000) Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated congestive heart failure. N Engl J Med 343:246–253

    Google Scholar 

  • Conversano A, Walsh JF, Geltman EM et al (1996) Delineation of myocardial stunning an hibernation by positron emission tomography in advanced coronary artery disease. Am Heart J 131:440–450

    PubMed  CAS  Google Scholar 

  • Cornel JH, Bax JJ, Elhendy A, Maat AP, Kimman GJ, Geleijnse ML, Rambaldi R, Boersma E, Fioretti PM (1998) Biphasic response to dobutamine predicts improvement of global left ventricular function after surgical revascularization in patients with stable coronary artery disease: implications of time course of recovery on diagnostic accuracy. J Am Coll Cardiol 31:1002–1010

    PubMed  CAS  Google Scholar 

  • Cornel JH, Bax JJ, Elhendy A et al (1999) Agreement and disagreement between “metabolic viability” and “contractile reserve” in akinetic myocardium. J Nucl Cardiol 6:383–388

    PubMed  CAS  Google Scholar 

  • Cwajg JM, Cwajg E, Nagueh SF, He ZX, Qureshi U, Olmos LI et al (2000) End-diastolic wall thickness as a predictor of recovery of function in myocardial hibernation: relation to restredistribution T1–201 tomography and dobutamine stress echocardiography. J Am Coll Cardiol 35:1152–1161

    PubMed  CAS  Google Scholar 

  • D’Egidio G, Nichol G, Williams KA et al (2009) Increasing benefit from revascularization is associated with increasing amounts of myocardial hibernation: a substudy of the PARR-2 trial. JACC: Cardiovasc Imaging 2:1060–1068

    Google Scholar 

  • Deedwania PC (2003) The key to unraveling the mystery of mortality in heart failure. An integrated approach. Circulation 107:1719–1721

    Google Scholar 

  • Di Carli MF, Asgarzadie F, Schelbert HR, Brunken RC, Laks H, Phelps ME, Maddahi J (1995) Quantitative relation between myocardial viability and improvement in heart failure symptoms after revascularization in patients with ischemic cardiomyopathy. Circulation 92:3436–3444

    PubMed  Google Scholar 

  • Dilsizian V (2003) Myocardial viability: reversible left ventricular dysfunction. In: Dilsizian V, Narula J, Braunwald E (eds) Atlas of nuclear cardiology. Current Medicine, Philadelphia, pp 19–46

    Google Scholar 

  • Dilsizian V (2007) Cardiac magnetic resonance versus SPECT: are all non-infarct myocardial regions created equal? J Nucl Card 14:9–14

    Google Scholar 

  • Dilsizian V, Rocco TP, Freedman NM, Leon MB, Bonow RO (1990) Enhanced detection of ischemic but viable myocardium by the reinjection of thallium after stress-redistribution imaging. N Engl J Med 323:141–146

    PubMed  CAS  Google Scholar 

  • Dilsizian V, Bacharach SL, Beanlands RS, Bergmann SR, Delbeke D, Gropler RJ, Knuuti J, Schelbert HR, Travin M (2008) PET myocardial perfusion and metabolism clinical imaging. http://www.asnc.org/imageuploads/ImagingGuidelinesPETJuly2009.pdf

  • Dispersyn GD, Ausma J, Thone F et al (1999) Cardiomyocyte remodelling during myocardial hibernation and atrial fibrillation: prelude to apoptosis. Cardiovasc Res 43:947–957

    PubMed  CAS  Google Scholar 

  • Douglas PS, Garcia MJ, Haines DE et al (2011) ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 Appropriate Use Criteria for Echocardiography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Society of Echocardiography, American Heart Association, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Critical Care Medicine, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance American College of Chest Physicians. J Am Soc Echocardiogr 24:229–267

    PubMed  Google Scholar 

  • Eitzman D, al-Aouar Z, Kanter HL et al (1992) Clinical outcome of patients with advanced coronary artery disease after viability studies with positron emission tomography (see comment). J Am Coll Cardiol 20:559–565

    PubMed  CAS  Google Scholar 

  • Emond M, Mock M, Davis K et al (1994) Long-term survival of medically treated patients in the Coronary Artery Surgery Study (CASS) registry. Circulation 90:2645–2657

    PubMed  CAS  Google Scholar 

  • Fallavollita JA, Riegel BJ, Suzuki G, Valeti U, Canty JM Jr (2005) Mechanism of sudden cardiac death in pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy. Am J Physiol Heart Circ Physiol 289:H2688–H2696

    PubMed  CAS  Google Scholar 

  • Fieno DS, Hillenbrand HB, Rehwald WG et al (2004) Infarct resorption, compensatory hypertrophy, and differing patterns of ventricular remodeling following myocardial infarctions of varying size. J Am Coll Cardiol 43:2124–2131

    PubMed  Google Scholar 

  • Ganame J, Messalli G, Masci PG, Dymarkowski S, Abbasi K, Van de Werf F, Janssens S, Bogaert J (2011) Time course of infarct healing and left ventricular remodelling in patients with reperfused ST segment elevation myocardial infarction using comprehensive magnetic resonance imaging. Eur Radiol 21:693–701

    PubMed  Google Scholar 

  • Gerber BL, Rousseau MF, Ahn SA et al (2012) Prognostic value of myocardial viability by delayed-enhanced magnetic resonance in patients with coronary artery disease and low ejection fraction: impact of revascularization therapy. J Am Coll Cardiol 59:825–835

    PubMed  Google Scholar 

  • Gewirtz H, Fischman AJ, Abraham S et al (1994) Positron emission tomographic measurements of absolute regional myocardial blood flow permits identification of nonviable myocardium in patients with chronic myocardial infarction. J Am Coll Cardiol 23:851–859

    PubMed  CAS  Google Scholar 

  • Gheorgiade M, Bonow RO (1998) Chronic heart failure in the United States. A manifestation of coronary artery disease. Circulation 97:282–289

    Google Scholar 

  • Gibbons RJ, Miller TD (2005) Tc-99m sestamibi infarct size as a surrogate endpoint. J Nucl Cardiol 12:12–19

    PubMed  Google Scholar 

  • Gursurer M, Emre A, Gercekoglu H, Uslubas S, Aksoy M, Ersek B (2002) Long-term prognostic value of stress-redistribution-reinjection Tl-201 imaging in patients with severe left ventricular dysfunction and coronary artery bypass surgery. Int J Cardiovasc Imaging 18:125–133

    PubMed  Google Scholar 

  • Hendel RC, Patel MR, Kramer CM et al (2006) ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 appropriateness criteria for cardiac computed tomography and cardiac magnetic resonance imaging. A report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group. J Am Coll Cardiol 48:1475–1497

    PubMed  Google Scholar 

  • Hendel RC, Berman DS, Di Carli MF et al (2009) ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 Appropriate Use Criteria for Cardiac Radionuclide Imaging: A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, The Society of Cardiovascular Computed Tomography, The Society for Cardiovascular Magnetic Resonance, and The Society of Nuclear Medicine. J Am Coll Cardiol 53:2201–2229

    PubMed  Google Scholar 

  • Heyndrickx GR, Baig H, Nellens P et al (1978) Depression of regional blood flow and wall thickening after brief coronary occlusions. Am J Physiol 234:H653–H659

    PubMed  CAS  Google Scholar 

  • Ibrahim T, Hackl T, Nekolla SG et al (2010) Acute myocardial infarction: serial cardiac MR imaging shows a decrease in delayed enhancement of the myocardium during the 1st week after reperfusion. Radiology 254:88–97

    PubMed  Google Scholar 

  • Iskandrian AE, Acio E (1998) Methodology of a novel myocardial viability protocol. J Nucl Cardiol 5:206–209

    PubMed  CAS  Google Scholar 

  • Ito H, Maruyama A, Iwakura K et al (1996) Clinical implications of the “no reflow” phenomenon: a predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation 93:223–228

    PubMed  CAS  Google Scholar 

  • Kelle S, Roes SD, Klein C et al (2009) Prognostic value of myocardial infarct size and contractile reserve using magnetic resonance imaging. J Am Coll Cardiol 54:1770–1777

    PubMed  Google Scholar 

  • Kim RJ, Wu E, Rafael A et al (2000) The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. New Engl J Med 343:1445–1453

    PubMed  CAS  Google Scholar 

  • Klein C, Nekolla SG, Bengel FM et al (2002) Assessment of myocardial viability with contrast enhanced magnetic resonance imaging: comparison with positron emission tomography. Circulation 105:162–167

    PubMed  Google Scholar 

  • Klocke FJ, Baird MG, Lorell BH et al (2003) ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging—executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Guidelines for the clinical use of Cardiac Radionuclide Imaging). Circulation 108:1404–1418

    PubMed  Google Scholar 

  • Kloner RA, Ganote CE, Jennings RB (1974) The “no-reflow” phenomenon after temporary coronary occlusion in the dog. Clin Investig 54:1496–1508

    CAS  Google Scholar 

  • Kloner RA, Bolli R, Marban E et al (1998) Medical and cellular implications of stunning, hibernation, and preconditioning. An NHLBI workshop. Circulation 97:1848–1867

    CAS  Google Scholar 

  • Krug A, de Rochemont WM, Korb G (1996) Blood supply of the myocardium after temporary coronary occlusion. Circ Res 19:57–62

    Google Scholar 

  • Kuhl HP, Lipke CS, Krombach GA et al (2006) Assessment of reversible myocardial dysfunction in chronic ischaemic heart disease: comparison of contrast-enhanced cardiovascular magnetic resonance and a combined positron emission tomography-single photon emission computed tomography imaging protocol. Eur Heart J 27:846–853

    PubMed  Google Scholar 

  • Kuijpers D, Ho KY, van Dijkman PR, Vliegenthart R, Oudkerk M (2003) Dobutamine cardiovascular magnetic resonance for the detection of myocardial ischemia with the use of myocardial tagging. Circulation 107:1592–1597

    PubMed  Google Scholar 

  • Kuijpers D, van Dijkman PR, Janssen CH, Vliegenthart R, Zijlstra F, Oudkerk M (2004) Dobutamine stress MRI. Part II. Risk stratification with dobutamine cardiovascular magnetic resonance in patients suspected of myocardial ischemia. Eur Radiol 14:2046–2052

    PubMed  Google Scholar 

  • Kumar A, Green JD, Sykes JM, Ephrat P, Carson JJ, Mitchell AJ, Wisenberg G, Friedrich MG (2011) Detection and quantification of myocardial reperfusion hemorrhage using T2*-weighted CMR. JACC Cardiovasc Imaging 4:1274–1283

    PubMed  Google Scholar 

  • Kwon DH, Halley CM, Carrigan TP et al (2009) Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study. J Am Coll Cardiol Imaging 2:34–44

    Google Scholar 

  • Kwong RY, Chan AK, Brown KA, Chan CW, Reynolds HG, Tsang S, Davis RB (2006) Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease. Circulation 113:2733–2743

    PubMed  Google Scholar 

  • La Canna G, Rahimtoola SH, Visioli O et al (2000) Sensitivity, specificity, and predictive accuracies of non-invasive tests, singly and in combination, for diagnosis of hibernating myocardium. Eur Heart J 21:1358–1367

    PubMed  Google Scholar 

  • Lang RM, Mor-Avi V, Sugeng L et al (2006) Three-dimensional echocardiography: the benefits of the added dimension. J Am Coll Cardiol 48:2053–2069

    PubMed  Google Scholar 

  • Lepper W, Hoffmann R, Kamp O et al (2000) Assessment of myocardial reperfusion by intravenous myocardial contrast echocardiography and coronary flow reserve after primary percutaneous transluminal coronary angioplasty in patients with acute myocardial infarction. Circulation 101:2368–2374

    PubMed  CAS  Google Scholar 

  • Levy D, Kenchaiah S, Larson MG et al (2002) Long-term trends in the incidence of and survival with heart failure. N Engl J Med 93:1397–1402

    Google Scholar 

  • Lund GK, Stork A, Muellerleile K et al (2007) Prediction of left ventricular remodeling and analysis of infarct resorption in patients with reperfused myocardial infarcts by using contrast-enhanced MR imaging. Radiology 245:95–102

    PubMed  Google Scholar 

  • Marinho NV, Keogh BE, Costa DC et al (1996) Pathophysiology of chronic left ventricular dysfunction: new insights from the measurement of absolute myocardial blood flow and glucose utilization. Circulation 93:737–744

    PubMed  CAS  Google Scholar 

  • Marin-Neto JA, Dilsizian V, Arrighi JA, Perrone-Filardi P, Bacharach SL, Bonow RO (1998) Thallium scintigraphy compared with 18F-fluorodeoxyglucose positron emission tomography for assessing myocardial viability in patients with moderate versus severe left ventricular dysfunction. Am J Cardiol 82:1001–1007

    PubMed  CAS  Google Scholar 

  • Marwick TH, Nemec JJ, Lafont A, Salcedo EE, MacIntyre WJ (1992) Prediction by postexercise fluoro-18 deoxyglucose positron emission tomography of improvement in exercise capacity after revascularization. Am J Cardiol 69:854–859

    PubMed  CAS  Google Scholar 

  • Matsunari I, Fujino S, Taki J et al (1997) Quantitative rest technetium-99m tetrofosmin imaging in predicting functional recovery after revascularization: comparison with rest-redistribution thallium-201. J Am Coll Cardiol 29:1226–1233

    PubMed  CAS  Google Scholar 

  • Nagel E, Lehmkuhl HB, Bocksch W et al (1999) Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI: comparison with dobutamine stress echocardiography. Circulation 99:763–770

    PubMed  CAS  Google Scholar 

  • Nagueh SF, Vaduganathan P, Ali N et al (1997) Identification of hibernating myocardium: comparative accuracy of myocardial contrast echocardiography, rest-redistribution thallium-201 tomography and dobutamine echocardiography. J Am Coll Cardiol 29:985–993

    PubMed  CAS  Google Scholar 

  • Nijveldt R, Hofman MB, Hirsch A, Beek AM, Umans VA, Algra PR, Piek JJ, van Rossum AC (2009) Assessment of microvascular obstruction and prediction of short-term remodeling after acute myocardial infarction: cardiac MR imaging study. Radiology 250:363–370

    PubMed  Google Scholar 

  • Orn S, Manhenke C, Anand IS, Squire I, Nagel E, Edvardsen T, Dickstein K (2007) Effect of left ventricular scar size, location, and transmurality on left ventricular remodeling with healed myocardial infarction. Am J Cardiol 99:1109–1114

    PubMed  Google Scholar 

  • Pagano D, Bonser RS, Townend JN, Ordoubadi F, Lorenzoni R, Camici PG (1998) Predictive value of dobutamine echocardiography and positron emission tomography in identifying hibernating myocardium in patients with postischaemic heart failure. Heart 79:281–288

    PubMed  CAS  Google Scholar 

  • Panza JA, Dilsizian V, Laurienzo JM et al (1995) Relation between thallium uptake and contractile response to dobutamine: implications regarding myocardial viability in patients with chronic coronary artery disease and left ventricular dysfunction. Circulation 91:990–998

    PubMed  CAS  Google Scholar 

  • Perrone Filardi P, Pace L, Prastaro M, Piscione F, Betocchi S, Squame F et al (1995) Dobutamine echocardiography predicts improvement of hypoperfused dysfunctional myocardium after revascularization in patients with coronary artery disease. Circulation 91:2556–2565

    PubMed  CAS  Google Scholar 

  • Perrone-Filardi P, Pace L, Prastaro M et al (1996) Assessment of myocardial viability in patients with chronic coronary artery disease. Rest-4-hour-24-hour 201T1 tomography versus dobutamine echocardiography. Circulation 94:2712–2719

    PubMed  CAS  Google Scholar 

  • Pierard LA, De Landsheere CM, Berthe C, Rigo P, Kulbertus HE (1990) Identification of viable myocardium by echocardiography during dobutamine infusion in patients with myocardial infarction after thrombolytic therapy: comparison with positron emission tomography. J Am Coll Cardiol 15:1021–1031

    PubMed  CAS  Google Scholar 

  • Pitt B, Zannad F, Remme WJ et al (1999) Randomized aldactone evaluation study investigators: the effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 341:709–717

    PubMed  CAS  Google Scholar 

  • Pitt B, Poole-Wilson PA, Segal R et al (2000) Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomized trial—the losartan heart failure study ELITE II. Lancet 355:1582–1587

    PubMed  CAS  Google Scholar 

  • Piwnicka-Worms DP, Kronauge JF, LeFurgey A et al (1994) Mitochondrial localization and characterization of 99Tcsestamibi in heart cells by electron probe x-ray microanalysis and 99Tc-NMR spectroscopy. Magn Reson Imaging 12:641–652

    Google Scholar 

  • Plein S, Bloomer TN, Ridgway JP, Jones TR, Bainbridge GJ, Sivananthan MU (2001) Steady-state free precession magnetic resonance imaging of the heart: comparison with segmented k-space gradient-echo imaging. J Magn Reson Imaging 14:230–236

    PubMed  CAS  Google Scholar 

  • Qureshi U, Nagueh SF, Afridi I et al (1997) Dobutamine echocardiography and quantitative rest-redistribution 201Tl tomography in myocardial hibernation. Relation of contractile reserve to 201Tl uptake and comparative prediction of recovery of function. Circulation 95:626–635

    PubMed  CAS  Google Scholar 

  • Ragosta M, Beller GA, Watson DD et al (1993) Quantitative planar rest redistribution 201-Tl imaging in detection of myocardial viability and prediction of improvement in left ventricular function after coronary artery bypass surgery in patients with severely depressed left ventricular function. Circulation 87:1630–1641

    PubMed  CAS  Google Scholar 

  • Rahimtoola SH (1982) Coronary bypass surgery for chronic angina—1981: a perspective. Circulation 65:225–241

    PubMed  CAS  Google Scholar 

  • Rahimtoola SH (1985) A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 72(suppl V):V123–V135

    Google Scholar 

  • Rahimtoola SH (1989) The hibernating myocardium. Am Heart J 117:211–221

    PubMed  CAS  Google Scholar 

  • Rees G, Bristow JD, Kremkau EL et al (1971) Influence of aortocoronary bypass surgery on left ventricular performance. N Engl J Med 284:1116–1120

    PubMed  CAS  Google Scholar 

  • Reimer KA, Jennings RB (1979) The “wavefront phenomenon” of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 40:633–644

    PubMed  CAS  Google Scholar 

  • Rochitte CE, Lima JA, Bluemke DA et al (1998) Magnitude and time course of microvascular obstruction and tissue injury after acute myocardial infarction. Circulation 98:1006–1014

    PubMed  CAS  Google Scholar 

  • Rohatgi R, Epstein S, Henriquez J et al (2001) Utility of positron emission tomography in predicting cardiac events and survival in patients with coronary artery disease and severe left ventricular dysfunction. Am J Cardiol 87:1096–1099

    PubMed  CAS  Google Scholar 

  • Romero J, Xue X, Gonzalez W, Garcia MJ (2012) CMR imaging assessing viability in patients with chronic ventricular dysfunction due to coronary artery disease: a meta-analysis of prospective trials. JACC Cardiovasc Imaging 5:494–508

    PubMed  Google Scholar 

  • Savoye C, Equine O, Tricot O et al (2006) Left ventricular remodeling after anterior wall acute myocardial infarction in modern clinical practice [from the REmodelage VEntriculaire (REVE) study group]. Am J Cardiol 98:1144–1149

    PubMed  Google Scholar 

  • Schinkel AFL, Bax JJ, Boersma E et al (2002) Assessment of residual myocardial viability in regions with chronic electrocardiographic Q-wave infarction. Am Heart J 144:865–869

    PubMed  Google Scholar 

  • Schinkel AF, Bax JJ, Poldermans D, Elhendy A, Ferrari R, Rahimtoola SH (2007) Hibernating myocardium: diagnosis and patient outcomes. Curr Probl Cardiol 32:375–410

    PubMed  Google Scholar 

  • Schwaiger M, Schricke U (2000) Hibernating and stunned myocardium. Pathophysiological considerations. In: Iskandrian AE, Van Der Wall EE (eds) Myocardial viability, 2nd edn. Kluwer Academic Publishers, Dordrecht, pp 1–20

    Google Scholar 

  • Shivalkar B, Maes A, Borgers M et al (1996) Only hibernating myocardium invariably shows early recovery after coronary revascularization. Circulation 94:308–315

    PubMed  CAS  Google Scholar 

  • Sicari R, Picano E, Cortigiani L, Borges AC, Varga A, Palagi C et al (2003) VIDA (Viability Identification with Dobutamine Administration) Study Group. Prognostic value of myocardial viability recognized by low-dose dobutamine echocardiography in chronic ischaemic left ventricular dysfunction. Am J Cardio 92:1263–1266

    Google Scholar 

  • Sicari R, Nihoyannopoulos P, Evangelista A et al (2008) Stress echocardiography expert consensus statement: European Association of Echocardiography (EAE) (a registered branch of the ESC). Eur J Echocardiogr 9:415–437

    PubMed  Google Scholar 

  • Slart RHJA, Bax JJ, van Veldhuisen DJ et al (2006) Imaging techniques in nuclear cardiology for the assessment of myocardial viability. Int J Cardiovasc Imaging 22:63–80

    PubMed  Google Scholar 

  • Smart SC, Sawada S, Ryan T, Segar D, Atherton L, Berkovitz K et al (1993) Low-dose dobutamine echocardiography detects reversible dysfunction after thrombolytic therapy of acute myocardial infarction. Circulation 88:405–415

    PubMed  CAS  Google Scholar 

  • Stork A, Muellerleile K, Bansmann PM et al (2007) Value of T2-weighted, first-pass and delayed enhancement, and cine CMR to differentiate between acute and chronic myocardial infarction. Eur Radiol 17:610–617

    PubMed  Google Scholar 

  • Taegtmeyer H (2010) Tracing cardiac metabolism in vivo: one substrate at a time. J Nucl Med 51(Suppl 1):80S–87S

    PubMed  CAS  Google Scholar 

  • Task Force of the European Society of Cardiology, in collaboration with the Association of European Paediatric Cardiologists (1998) The clinical role of magnetic resonance in cardiovascular disease. Eur Heart J 19:19–39

    Google Scholar 

  • Taylor AJ, Al-Saadi N, Abdel-Aty H et al (2006) Elective percutaneous coronary intervention immediately impairs resting microvascular perfusion assessed by cardiac magnetic resonance imaging. Am Heart J 151:891.e1–891.e7

    Google Scholar 

  • The SOLVD investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 325:293–302

    Google Scholar 

  • Tillisch J, Brunken R, Marshall R et al (1986) Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med 314:884–888

    PubMed  CAS  Google Scholar 

  • Topol EJ, Weiss JL, Brinker JA et al (1985) Regional wall motion improvement after coronary thrombolysis with recombinant tissue plasminogenactivator: importance of coronary angioplasty. J Am Coll Cardiol 6:426–433

    PubMed  CAS  Google Scholar 

  • Travin MI, Bergmann SR (2005) Assessment of myocardial viability. Semin Nucl Med 35:2–16

    PubMed  Google Scholar 

  • Udelson JE, Coleman PS, Metherall J et al (1994) Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc-sestamibi. Circulation 89:2552–2561

    PubMed  CAS  Google Scholar 

  • Vanoverschelde JLJ, Wijns W, Depre C et al (1993) Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium. Circulation 87:1513–1523

    PubMed  CAS  Google Scholar 

  • Vanoverschelde JL, Depre C, Gerber BL et al (2000) Time course of functional recovery after coronary artery bypass graft surgery in patients with chronic left ventricular ischemic dysfunction. Am J Cardiol 85:1432–1439

    PubMed  CAS  Google Scholar 

  • Velazquez EJ, Lee KL, Deja MA et al (2011) Coronary-artery bypass surgery in patients with left ventricular dysfunction. N Engl J Med 364:1607–1616

    PubMed  CAS  Google Scholar 

  • vom Dahl J, Eitzman DT, al-Aouar ZR et al (1994) Relation of regional function, perfusion, and metabolism in patients with advanced coronary artery disease undergoing surgical revascularization. Circulation 90:2356–2366

    PubMed  CAS  Google Scholar 

  • Watada H, Ito H, Oh H, Masuyama T, Aburaya M, Hori M et al (1994) Dobutamine stress echocardiography predicts reversible dysfunction and quantitates the extent of irreversibly damaged myocardium after reperfusion of anterior myocardial infarction. J Am Coll Cardiol 24:624–630

    PubMed  CAS  Google Scholar 

  • Wellnhofer E, Olariu A, Klein C et al (2004) Magnetic resonance low-dose dobutamine test is superior to scar quantification for the prediction of functional recovery. Circulation 109:2172–2174

    PubMed  Google Scholar 

  • Wilson JM (1999) Reversible congestive heart failure caused by myocardial hibernation. Tex Heart Inst J 26:19–27

    PubMed  CAS  Google Scholar 

  • Wu KC, Zerhouni EA, Judd RM, Lugo-Olivieri CH, Barouch LA, Schulman SP et al (1998) Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation 97:765–772

    PubMed  CAS  Google Scholar 

  • Zimmermann R, Mall G, Rauch B et al (1995) Residual 201Tl activity in irreversible defects as a marker of myocardial viability. Clinicopathological study. Circulation 91:1016–1021

    CAS  Google Scholar 

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Authors and Affiliations

  1. Center for Medical Imaging—North East Netherlands, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Rozemarijn Vliegenthart & Daniel Lubbers

  2. Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Rozemarijn Vliegenthart

  3. Department of Radiology, Nij Smellinghe Hospital, Drachten, The Netherlands

    Daniel Lubbers

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  1. Rozemarijn Vliegenthart
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  2. Daniel Lubbers
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Correspondence to Rozemarijn Vliegenthart .

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Editors and Affiliations

  1. Center for Advanced Imaging Research (CAIR), Medical University of South Carolina Dept. Radiology, Charleston, South Carolina, USA

    U. Joseph Schoepf

  2. Ludwig-Maximilians-University Munich, Munich, Bayern, Germany

    Fabian Bamberg

  3. Department of Cardiology, Royal Liverpool and Broadgreen Universit, Liverpool, United Kingdom

    Balazs Ruzsics

  4. University Medical Center Groningen Center for Medical Imaging, Groningen, The Netherlands

    Rozemarijn Vliegenthart

  5. Sunnybrook Health Sciences Centre, Cardiothoracic Imaging Division, Department of Medical Imaging, Toronto, Ontario, Canada

    Gorka Bastarrika

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Vliegenthart, R., Lubbers, D. (2012). Why are We Interested in Viability?. In: Schoepf, U., Bamberg, F., Ruzsics, B., Vliegenthart, R., Bastarrika, G. (eds) CT Imaging of Myocardial Perfusion and Viability. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_774

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