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Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Osteoporosis is characterized by reduced bone mass and microarchitectural deterioration of bone, leading to an increase in bone fragility and susceptibility to low-traumatic or atraumatic fractures, most commonly vertebral fractures. Osteoporotic vertebral fractures have a significant impact on morbidity, mortality, and healthcare costs. Vertebral fracture is an independent and significant predictor of increased risk for further fractures. The occurrence of vertebral fracture is often clinically asymptomatic, and many of these fractures, therefore, remain undiagnosed. Several techniques are available for their reliable identification on radiographs. The two most widely used methods are the semiquantitative (SQ) assessment, which is based on visual evaluation, and the quantitative approach, which is based on morphometric criteria. Genant’s SQ approach is an accurate and reproducible method, tested and applied in many clinical studies. The newest generation of fan-beam dual energy X-ray absorptiometry (DXA) systems delivering lateral spine images of higher resolution offer a practical alternative to radiographs for vertebral fracture analysis. The advantages of DXA over radiography are its minimal radiation exposure and the practicalities of a one-step image acquisition allowing concurrent evaluation of vertebral fracture and bone mineral density, which are important criteria when assessing the risk of osteoporotic fracture. Standard computed tomography (CT) is not primarily used to detect vertebral fracture, though it often leads to the fortuitous detection of asymptomatic fracture. Magnetic resonance imaging (MRI) is an increasingly used modality for assessing the age and other important aspects of vertebral fracture.

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References

  • Adams JE, Lenchik L, Roux C, Genant HK (2010) Radiological assessment of vertebral fracture. International osteoporosis foundation vertebral fracture initiative resource document part II 2010, pp 1–49. http://www.iofbonehealth.org/health-professionals/educational-tools-and-slide-kits/vertebral-fracture-teaching-program.html

  • Banse X, Devogelaer JP, Grynpas M (2002) Patient-specific microarchitecture of vertebral cancellous bone: a peripheral quantitative computed tomographic and histological study. Bone 30(6):829–835

    Article  PubMed  CAS  Google Scholar 

  • Black DM, Arden NK, Palermo L, Pearson J, Cummings SR (1999a) Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures. Study of osteoporotic fractures research group. J Bone Miner Res 14(5):821–828

    Article  PubMed  CAS  Google Scholar 

  • Black DM, Palermo L, Nevitt MC, Genant HK, Christensen L, Cummings SR (1999b) Defining incident vertebral deformity: a prospective comparison of several approaches. the study of osteoporotic fractures research group. J Bone Miner Res 14(1):90–101

    Article  PubMed  CAS  Google Scholar 

  • Buehring B, Krueger D, Checovich M, Gemar D, Vallarta-Ast N, Genant HK et al (2010) Vertebral fracture assessment: impact of instrument and reader. Osteoporos Int 21(3):487–494

    Article  PubMed  CAS  Google Scholar 

  • Chan KK, Sartoris DJ, Haghighi P, Sledge P, Barrett-Connor E, Trudell DT et al (1997) Cupid’s bow contour of the vertebral body: evaluation of pathogenesis with bone densitometry and imaging-histopathologic correlation. Radiology 202(1):253–256

    PubMed  CAS  Google Scholar 

  • Chesnut IC, Skag A, Christiansen C, Recker R, Stakkestad JA, Hoiseth A et al (2004) Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res 19(8):1241–1249

    Article  CAS  Google Scholar 

  • Christiansen BA, Bouxsein ML (2010) Biomechanics of vertebral fractures and the vertebral fracture cascade. Curr Osteoporos Rep 8(4):198–204

    Article  PubMed  Google Scholar 

  • Clark P, Cons-Molina F, Deleze M, Ragi S, Haddock L, Zanchetta JR et al (2009) The prevalence of radiographic vertebral fractures in Latin American countries: the Latin American vertebral osteoporosis study (LAVOS). Osteoporos Int 20(2):275–282

    Article  PubMed  CAS  Google Scholar 

  • Cooper C, Melton LJ 3rd (1992) Vertebral fractures. BMJ 304(6842):1634–1635

    Article  PubMed  CAS  Google Scholar 

  • Cooper C, Atkinson EJ, O’Fallon WM, Melton LJ 3rd (1992) Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985–1989. J Bone Miner Res 7(2):221–227

    Article  PubMed  CAS  Google Scholar 

  • Damilakis J, Adams JE, Guglielmi G, Link TM (2010) Radiation exposure in X-ray-based imaging techniques used in osteoporosis. Eur Radiol 20(11):2707–2714

    Article  PubMed  Google Scholar 

  • Delmas PD, Genant HK, Crans GG, Stock JL, Wong M, Siris E et al (2003) Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial. Bone 33(4):522–532

    Article  PubMed  CAS  Google Scholar 

  • Delmas PD, Van de Langerijt L, Watts NB, Eastell R, Genant H, Grauer A, Cahall DL (2005) Underdiagnosis of vertebral fractures is a worldwide problem: The IMPACT study. J Bone Miner Res 20(4):557–563

    Article  PubMed  Google Scholar 

  • Diacinti D, Guglielmi G (2010) Vertebral morphometry. Radiol Clin North Am 48(3):561–575

    Article  PubMed  Google Scholar 

  • Diacinti D, Acca M, D’Erasmo E, Tomei E, Mazzuoli GF (1995) Aging changes in vertebral morphometry. Calcif Tissue Int 57(6):426–429

    Article  PubMed  CAS  Google Scholar 

  • Diamond TH, Clark WA, Kumar SV (2007) Histomorphometric analysis of fracture healing cascade in acute osteoporotic vertebral body fractures. Bone 40(3):775–780

    Article  PubMed  Google Scholar 

  • Eastell R, Cedel SL, Wahner HW, Riggs BL, Melton LJ 3rd (1991) Classification of vertebral fractures. J Bone Miner Res 6(3):207–215

    Article  PubMed  CAS  Google Scholar 

  • Ensrud KE, Schousboe JT (2011) Clinical practice. Vertebral fractures. N Engl J Med 364(17):1634–1642

    Article  PubMed  CAS  Google Scholar 

  • Ensrud KE, Thompson DE, Cauley JA, Nevitt MC, Kado DM, Hochberg MC et al (2000) Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. Fracture intervention trial research group. J Am Geriatr Soc 48(3):241–249

    PubMed  CAS  Google Scholar 

  • Ettinger B, Cooper C (1995) Clinical assessment of osteoporotic vertebral fractures. In: Genant HK, Jergas M, van Kuijk C (ed.) Vertebral fracture in osteoporosis. Radiology Research and Education Foundation Publishers, San Francisco, pp 15–20

    Google Scholar 

  • Ettinger B, Black DM, Nevitt MC, Rundle AC, Cauley JA, Cummings SR et al (1992) Contribution of vertebral deformities to chronic back pain and disability. The study of osteoporotic fractures research group. J Bone Miner Res 7(4):449–456

    Article  PubMed  CAS  Google Scholar 

  • Ferrar L, Jiang G, Barrington NA, Eastell R (2000) Identification of vertebral deformities in women: comparison of radiological assessment and quantitative morphometry using morphometric radiography and morphometric X-ray absorptiometry. J Bone Miner Res 15(3):575–585

    Article  PubMed  CAS  Google Scholar 

  • Ferrar L, Jiang G, Adams J, Eastell R (2005) Identification of vertebral fractures: an update. Osteoporos Int 16(7):717–728

    Article  PubMed  CAS  Google Scholar 

  • Ferrar L, Jiang G, Armbrecht G, Reid DM, Roux C, Gluer CC et al (2007) Is short vertebral height always an osteoporotic fracture? The osteoporosis and ultrasound study (OPUS). Bone 41(1):5–12

    Article  PubMed  CAS  Google Scholar 

  • Ferrar L, Roux C, Reid DM, Felsenberg D, Gluer CC, Eastell R (2012) Prevalence of non-fracture short vertebral height is similar in premenopausal and postmenopausal women: the osteoporosis and ultrasound study. Osteoporos Int 23(3):1035–1040

    Article  PubMed  CAS  Google Scholar 

  • Fink HA, Milavetz DL, Palermo L, Nevitt MC, Cauley JA, Genant HK et al (2005) What proportion of incident radiographic vertebral deformities is clinically diagnosed and vice versa? J Bone Miner Res 20(7):1216–1222

    Article  PubMed  Google Scholar 

  • Fornasier VL, Czitrom AA (1978) Collapsed vertebrae: a review of 659 autopsies. Clin Orthop Relat Res 131:261–265

    PubMed  Google Scholar 

  • Foundation NO (2010) Clinician’s guide to prevention and treatment of osteoporosis. National Osteoporosis Foundation, Washington

    Google Scholar 

  • Fuerst T, Wu C, Genant HK, von Ingersleben G, Chen Y, Johnston C et al (2009) Evaluation of vertebral fracture assessment by dual X-ray absorptiometry in a multicenter setting. Osteoporos Int 20(7):1199–1205

    Article  PubMed  CAS  Google Scholar 

  • Genant HK, Jergas M (2003) Assessment of prevalent and incident vertebral fractures in osteoporosis research. Osteoporos Int 14(Suppl 3):S43–S55

    PubMed  Google Scholar 

  • Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8(9):1137–1148

    Article  PubMed  CAS  Google Scholar 

  • Genant HK, Jergas M, Palermo L, Nevitt M, Valentin RS, Black D et al (1996) Comparison of semiquantitative visual and quantitative morphometric assessment of prevalent and incident vertebral fractures in osteoporosis. The study of osteoporotic fractures research group. J Bone Miner Res 11(7):984–996

    Article  PubMed  CAS  Google Scholar 

  • Gold DT (2001) The nonskeletal consequences of osteoporotic fractures. Psychologic and social outcomes. Rheum Dis Clin North Am 27(1):255–262

    Article  PubMed  CAS  Google Scholar 

  • Grados F, Roux C, de Vernejoul MC, Utard G, Sebert JL, Fardellone P (2001) Comparison of four morphometric definitions and a semiquantitative consensus reading for assessing prevalent vertebral fractures. Osteoporos Int 12(9):716–722

    Article  PubMed  CAS  Google Scholar 

  • Grados F, Fechtenbaum J, Flipon E, Kolta S, Roux C, Fardellone P (2009) Radiographic methods for evaluating osteoporotic vertebral fractures. Jt Bone Spine 76(3):241–247

    Article  Google Scholar 

  • Griffith JF, Guglielmi G (2010) Vertebral fracture. Radiol Clin North Am 48(3):519–529

    Article  PubMed  Google Scholar 

  • Griffith JF, Adams JE, Genant HK Diagnosis and classification of vertebral fracture. Primer metabolic bone disease and disorders of mineral metabolism, 8th edn. in press

    Google Scholar 

  • Grigoryan M, Guermazi A, Roemer FW, Delmas PD, Genant HK (2003) Recognizing and reporting osteoporotic vertebral fractures. Eur Spine J 12(Suppl 2):S104–S112

    Article  PubMed  Google Scholar 

  • Guermazi A, Mohr A, Grigorian M, Taouli B, Genant HK (2002) Identification of vertebral fractures in osteoporosis. Semin Musculoskelet Radiol 6(3):241–252

    Article  PubMed  Google Scholar 

  • Guglielmi G, Diacinti D, van Kuijk C, Aparisi F, Krestan C, Adams JE et al (2008) Vertebral morphometry: current methods and recent advances. Eur Radiol 18(7):1484–1496

    Article  PubMed  CAS  Google Scholar 

  • Harris ST, Watts NB, Genant HK, McKeever CD, Hangartner T, Keller M et al (1999) Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral efficacy with risedronate therapy (VERT) study group. JAMA 282(14):1344–1352

    Article  PubMed  CAS  Google Scholar 

  • Herss Nielsen VA, Podenphant J, Martens S, Gotfredsen A, Riis BJ (1991) Precision in assessment of osteoporosis from spine radiographs. Eur J Radiol 13(1):11–14

    Google Scholar 

  • Hurxthal LM (1968) Measurement of anterior vertebral compressions and biconcave vertebrae. Am J Roentgenol Radium Ther Nucl Med. 103(3):635–644

    Article  PubMed  CAS  Google Scholar 

  • Jager PL, Slart RH, Webber CL, Adachi JD, Papaioannou AL, Gulenchyn KY (2010) Combined vertebral fracture assessment and bone mineral density measurement: a patient-friendly new tool with an important impact on the Canadian risk fracture classification. Can Assoc Radiol J 61(4):194–200

    Article  PubMed  Google Scholar 

  • Jiang G, Eastell R, Barrington NA, Ferrar L (2004) Comparison of methods for the visual identification of prevalent vertebral fracture in osteoporosis. Osteoporos Int 15(11):887–896

    Article  PubMed  CAS  Google Scholar 

  • Johnell O, O’Neill T, Felsenberg D, Kanis J, Cooper C, Silman AJ (1997) Anthropometric measurements and vertebral deformities. European vertebral osteoporosis study (EVOS) group. Am J Epidemiol 146(4):287–293

    Article  PubMed  CAS  Google Scholar 

  • Kadowaki E, Tamaki J, Iki M, Sato Y, Chiba Y, Kajita E et al (2010) Prevalent vertebral deformity independently increases incident vertebral fracture risk in middle-aged and elderly Japanese women: the Japanese population-based osteoporosis (JPOS) cohort study. Osteoporos Int 21(9):1513–1522

    Article  PubMed  CAS  Google Scholar 

  • Kalidis L, Felsenberg D, Kalender WA, et al. (1992) Morphometric analysis of digitized radiographs: description of automatic evaluation. In: EFJ R (ed.) Current research in osteoporosis and bone mineral measurement II. British Institute of Radiology, London, pp 4–16

    Google Scholar 

  • Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19(4):385–397

    Article  PubMed  CAS  Google Scholar 

  • Kanis JA, Hans D, Cooper C, Baim S, Bilezikian JP, Binkley N et al (2011) Interpretation and use of FRAX in clinical practice. Osteoporos Int 22(9):2395–2411

    Article  PubMed  CAS  Google Scholar 

  • Kiel D (1995) Assessing vertebral fractures. national osteoporosis foundation working group on vertebral fractures. J Bone Miner Res 10(4):518–523

    PubMed  CAS  Google Scholar 

  • Kleerekoper M, Nelson DA (1992) Vertebral fracture or vertebral deformity. Calcif Tissue Int 50(1):5–6

    Article  PubMed  CAS  Google Scholar 

  • Krug R, Burghardt AJ, Majumdar S, Link TM (2010) High-resolution imaging techniques for the assessment of osteoporosis. Radiol Clin North Am 48(3):601–621

    Article  PubMed  Google Scholar 

  • Kwok AWL, Gong J-S, Wang Y-X J, Leung JCS, Kwok T, Griffith JF, Leung PC (2012) Prevalence and risk factors of radiographic vertebral fractures in elderly Chinese men and women: results of Mr. OS (Hong Kong) and Ms. OS (Hong Kong) studies. Osteoporos Int In press doi10.1007/s00198-012-2040-8

  • Lenchik L, Rogers LF, Delmas PD, Genant HK (2004) Diagnosis of osteoporotic vertebral fractures: importance of recognition and description by radiologists. AJR Am J Roentgenol 183(4):949–958

    Article  PubMed  Google Scholar 

  • Lindsay R, Silverman SL, Cooper C, Hanley DA, Barton I, Broy SB et al (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285(3):320–323

    Article  PubMed  CAS  Google Scholar 

  • Link TM, Guglielmi G, van Kuijk C, Adams JE (2005) Radiologic assessment of osteoporotic vertebral fractures: diagnostic and prognostic implications. Eur Radiol 15(8):1521–1532

    Article  PubMed  Google Scholar 

  • Masharawi Y, Salame K, Mirovsky Y, Peleg S, Dar G, Steinberg N et al (2008) Vertebral body shape variation in the thoracic and lumbar spine: characterization of its asymmetry and wedging. Clin Anat 21(1):46–54

    Article  PubMed  Google Scholar 

  • Matsumoto T, Hagino H, Shiraki M, Fukunaga M, Nakano T, Takaoka K et al (2009) Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis: a randomized placebo-controlled double-blind study. Osteoporos Int 20(8):1429–1437

    Article  PubMed  CAS  Google Scholar 

  • Mc Donnell P, Harrison N, Liebschner MA, Mc Hugh PE (2009) Simulation of vertebral trabecular bone loss using voxel finite element analysis. J Biomech 42(16):2789–2796

    Google Scholar 

  • Melton LJ 3rd, Lane AW, Cooper C, Eastell R, O’Fallon WM, Riggs BL (1993) Prevalence and incidence of vertebral deformities. Osteoporos Int 3(3):113–119

    Article  PubMed  Google Scholar 

  • Meunier P (1968) La dynamique du remaniement osseux humain, etudiee par lecture quantitative de la biopsie osseuse. Lyon

    Google Scholar 

  • Meunier PJ, Roux C, Ortolani S, Diaz-Curiel M, Compston J, Marquis P et al (2009) Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis. Osteoporos Int 20(10):1663–1673

    Article  PubMed  CAS  Google Scholar 

  • Nicholson PH, Haddaway MJ, Davie MW, Evans SF (1993) A computerized technique for vertebral morphometry. Physiol Meas 14(2):195–204

    Article  PubMed  CAS  Google Scholar 

  • Pfirrmann CW, Resnick D (2001) Schmorl nodes of the thoracic and lumbar spine: radiographic-pathologic study of prevalence, characterization, and correlation with degenerative changes of 1,650 spinal levels in 100 cadavers. Radiology 219(2):368–374

    PubMed  CAS  Google Scholar 

  • Riggs BL, Melton III LJ, 3rd, Robb RA, Camp JJ, Atkinson EJ, Peterson JM et al. (2004) Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res 19(12):1945–1954

    Google Scholar 

  • Samelson EJ, Christiansen BA, Demissie S, Broe KE, Zhou Y, Meng CA et al (2011) Reliability of vertebral fracture assessment using multidetector CT lateral scout views: the framingham osteoporosis study. Osteoporos Int 22(4):1123–1131

    Article  PubMed  CAS  Google Scholar 

  • Sanders KM, Nicholson GC, Watts JJ, Pasco JA, Henry MJ, Kotowicz MA et al (2006) Half the burden of fragility fractures in the community occur in women without osteoporosis. When is fracture prevention cost-effective? Bone 38(5):694–700

    Article  PubMed  Google Scholar 

  • US Department of Health and Human Services (2004). Bone health and osteoporosis: a report of the surgeon general. In: Rockville MD (ed.)

    Google Scholar 

  • Siris ES, Miller PD, Barrett-Connor E, Faulkner KG, Wehren LE, Abbott TA et al (2001) Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the national osteoporosis risk assessment. JAMA 286(22):2815–2822

    Article  PubMed  CAS  Google Scholar 

  • Siris E, Adachi JD, Lu Y, Fuerst T, Crans GG, Wong M et al (2002) Effects of raloxifene on fracture severity in postmenopausal women with osteoporosis: results from the MORE study. multiple outcomes of raloxifene evaluation. Osteoporos Int 13(11):907–913

    Article  PubMed  CAS  Google Scholar 

  • Siris ES, Genant HK, Laster AJ, Chen P, Misurski DA, Krege JH (2007) Enhanced prediction of fracture risk combining vertebral fracture status and BMD. Osteoporos Int 18(6):761–770

    Article  PubMed  CAS  Google Scholar 

  • Siris ES, Boonen S, Mitchell PJ, Bilezikian J, Silverman S (2012) What’s in a name? What constitutes the clinical diagnosis of osteoporosis? Osteoporos Int In press doi:10.1007/s00198-012-1991-0

  • Smith RW, Eyler WR, Mellinger RC (1960) On the incidence of osteoporosis. Ann Intern Med 52:773–781

    Article  PubMed  Google Scholar 

  • Smith-Bindman R, Cummings SR, Steiger P, Genant HK (1991) A comparison of morphometric definitions of vertebral fracture. J Bone Miner Res 6(1):25–34

    Article  PubMed  CAS  Google Scholar 

  • Thomsen JS, Ebbesen EN, Mosekilde LI (2002) Age-related differences between thinning of horizontal and vertical trabeculae in human lumbar bone as assessed by a new computerized method. Bone 31(1):136–142

    Article  PubMed  CAS  Google Scholar 

  • Tsujio T, Nakamura H, Terai H, Hoshino M, Namikawa T, Matsumura A, et al. (2011) Characteristic radiographic or magnetic resonance images of fresh osteoporotic vertebral fractures predicting potential risk for nonunion: a prospective multicenter study. Spine (Phila Pa 1976) 36(15):1229–1235

    Google Scholar 

  • Williams AL, Al-Busaidi A, Sparrow PJ, Adams JE, Whitehouse RW (2009) Under-reporting of osteoporotic vertebral fractures on computed tomography. Eur J Radiol 69(1):179–183

    Article  PubMed  Google Scholar 

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Jarraya, M., Hayashi, D., Griffith, J.F., Guermazi, A., Genant, H.K. (2013). Identification of Vertebral Fractures. In: Guglielmi, G. (eds) Osteoporosis and Bone Densitometry Measurements. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_701

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