Skip to main content

Rasmussen Encephalitis

  • Chapter
MRI in Epilepsy

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

  • 3318 Accesses

Abstract

Rasmussen encephalitis is typically a chronic inflammatory disease of a one brain hemisphere in children. A MRI course of initial swelling and progressive brain atrophy and tissue destruction later on reflects the inflammatory changes; however, many patients show some brain atrophy already at their initial MRI examination.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bauer J, Elger CE, Hans VH, Schramm J, Urbach H, Lassmann H et al (2007) Astrocytes are a specific immunological target in Rasmussen’s encephalitis. Ann Neurol 62:67–80

    Article  PubMed  Google Scholar 

  • Bien CG, Widman G, Urbach H et al (2002a) The natural history of Rasmussen’s encephalitis. Brain 125:1751–1759

    Article  PubMed  Google Scholar 

  • Bien CG, Bauer J, Deckwerth TL, Wiendl H, Deckert M, Wiestler OD et al (2002b) Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen’s encephalitis. Ann Neurol 51:311–318

    Article  PubMed  CAS  Google Scholar 

  • Bien CG, Urbach H, Deckert M, Schramm J, Wiestler OD, Lassmann H et al (2002c) Diagnosis and staging of Rasmussen’s encephalitis by serial MRI and histopathology. Neurology 58:250–257

    Article  PubMed  CAS  Google Scholar 

  • Bien CG, Elger CE (2008) Epilepsia partialis continua: semiology and differential diagnosis. Epileptic Disord 10:3–7

    PubMed  Google Scholar 

  • Bien CG, Gleissner U, Sassen R, Widman G, Urbach H, Elger CE (2004) An open study of tacrolimus therapy in Rasmussen’s encephalitis. Neurology 62:2106–2109

    Article  PubMed  CAS  Google Scholar 

  • Bien CG, Granata T, Antozzi C et al (2005) Pathogenesis, diagnosis, and treatment of Rasmussen encephalitis. A European consenus statement. Brain 128:454–471

    Article  PubMed  CAS  Google Scholar 

  • Bien CG, Tietmeier H, Sassen R, Kuczaty S, Urbach H, von Lehe M, Becker A, Bast T, Brückmann D, Diers A, Herkenrath P, Jansma C, Karenfort A, Kieslich M, Kruse B, Kurlemann G, Rona S, Schubet S, Vieker S, Wilken B, Elger CE Rasmussen encephalitis: a first randomized clinical trial for an orphan disease (submitted)

    Google Scholar 

  • Chiapparini L, Granata T, Farina L, Ciceri E, Erbetta A, Ragona F et al (2003) Diagnostic imaging in 13 cases of Rasmussen’s encephalitis: can early MRI suggest the diagnosis? Neuroradiology 45:171–183

    PubMed  CAS  Google Scholar 

  • Dyke CG, Davidoff LM, Masson CB (1933) Cerebral hemiatrophy with homolateral hypertrophy of the skull and sinuses. Surg Gynecol Obstet 57:588–600

    Google Scholar 

  • Granata T, Gobbi G, Spreafico R, Vigevano F, Capovilla G, Ragona F et al (2003) Rasmussen’s encephalitis: early characteristics allow diagnosis. Neurology 60:422–425

    Article  PubMed  CAS  Google Scholar 

  • Hart YM, Andermann F, Fish DR, Dubeau F, Robitaille Y, Rasmussen T et al (1997) Chronic encephalitis and epilepsy in adults and adolescents: a variant of Rasmussen’s syndrome? Neurology 48:418–424

    Article  PubMed  CAS  Google Scholar 

  • Honavar M, Janota I, Polkey CE (1992) Rasmussen’s encephalitis in surgery for epilepsy. Dev Med Child Neurol 34:3–14

    Article  PubMed  CAS  Google Scholar 

  • Larionov S, Koenig R, Urbach H, Sassen R, Elger CE, Bien CG (2005) MRI brain volumetry in Rasmussen encephalitis: the fate of affected and “unaffected” hemispheres. Neurology 64:885–887

    Article  PubMed  CAS  Google Scholar 

  • Oguni H, Andermann F, Rasmussen TB (1991) The natural history of the syndrome of chronic encephalitis and epilepsy: a study of the MNI series of fortyeight cases. In: Andermann F (ed) Chronic encephalitis and epilepsy. Rasmussen’s syndrome. Butterworth-Heinemann, Boston, pp 7–35

    Google Scholar 

  • Rasmussen T, Olszewski J, Lloyd-Smith D (1958) Focal seizures due to chronic localized encephalitis. Neurology 8:435–445

    Article  PubMed  CAS  Google Scholar 

  • Robitaille Y (1991) Neuropathologic aspects of chronic encephalitis. In: Andermann F (ed) Chronic encephalitis and epilepsy. Rasmussen’s syndrome. Butterworth-Heinemann, Boston, pp 79–110

    Google Scholar 

  • Rogers SW, Andrews PI, Gahring LC, Whisenand T, Cauley K, Crain B et al (1994) Autoantibodies to glutamate receptor GluR3 in Rasmussen’s encephalitis. Science 265:648–651

    Article  PubMed  CAS  Google Scholar 

  • Wagner J, Schöne-Barke C, Bien CG, Urbach H, Elger CE, Weber B (2012) Automated 3D MRI volumetry reveals regional atrophy differences in Rasmussen’s encephalitis. Epilepsia 2012 Apr 53(4):613−621. doi: 10.1111/j.1528-1167.2011.03396.x

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Horst Urbach .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Urbach, H., Bien, C.G. (2013). Rasmussen Encephalitis. In: Urbach, H. (eds) MRI in Epilepsy. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_573

Download citation

  • DOI: https://doi.org/10.1007/174_2012_573

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-25137-5

  • Online ISBN: 978-3-642-25138-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics