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Multislice-CT of the Abdomen pp 47–83Cite as

Imaging Findings of Cirrhotic Liver

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Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

The role of imaging in patients with cirrhosis is to characterize the morphologic manifestations of the disease, evaluate the hepatic and extrahepatic vasculature, assess the effects of portal hypertension, and detect and characterize hepatic tumors, especially differentiating hepatocellular caricnoma (HCC) from other tumors. CT plays a major role in the imaging of the liver. The recent development of multidetector row CT (MDCT) technology has helped CT to continue to excel in its currently established indications such as detection and characterization of hepatic lesions. HCC is the fifth most common tumor in the world and the incidence is expected to increase in the future due to hepatitis viral infections and increasing cirrhosis incidence. Approximately 90% of patients with HCC have cirrhosis. The imaging criteria of HCC are usually based on the vascular findings of HCC (e.g. arterial enhancement followed by washout in the portovenous and equilibrium phase). To understand the hemodynamics of HCC is important for the precise imaging diagnosis and treatment since there is a good correlation between their hemodynamics and pathophysiology. In this chapter, the most important and prevalent findings of HCC which can be evaluated by CT scans, and current diagnostic criteria were discussed. In addition, the imaging features of atypical HCC as well as frequent HCC mimickers in cirrhotic liver were also discussed.

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References

  • Addley HC, Griffin N et al (2011) Accuracy of hepatocellular carcinoma detection on multidetector CT in a transplant liver population with explant liver correlation. Clin Radiol 66(4):349–356

    Article  PubMed  CAS  Google Scholar 

  • Ahn IO, de Lange EE (1998) Early hyperenhancement of confluent hepatic fibrosis on dynamic MR imaging. AJR Am J Roentgenol 171(3):901–902

    PubMed  CAS  Google Scholar 

  • Ahn JH, Yu JS et al (2010) Nontumorous arterioportal shunts in the liver: CT and MRI findings considering mechanisms and fate. Eur Radiol 20(2):385–394

    Article  PubMed  Google Scholar 

  • Altenbernd J, Heusner TA et al (2011) Dual-energy-CT of hypervascular liver lesions in patients with HCC: investigation of image quality and sensitivity. Eur Radiol 21(4):738–743

    Article  PubMed  Google Scholar 

  • Ariizumi SI, Kotera Y et al (2011a) Combined hepatocellular-cholangiocarcinoma had poor outcomes after hepatectomy regardless of Allen and Lisa class or the predominance of intrahepatic cholangiocarcinoma cells within the tumor. Ann Surg Oncol

    Google Scholar 

  • Ariizumi S, Kotera Y et al (2011b) Mass-forming intrahepatic cholangiocarcinoma with marked enhancement on arterial-phase computed tomography reflects favorable surgical outcomes. J Surg Oncol 104(2):130–139

    Article  Google Scholar 

  • Asayama Y, Yoshimitsu K et al (2008) Arterial blood supply of hepatocellular carcinoma and histologic grading: radiologic-pathologic correlation. AJR Am J Roentgenol 190(1):W28–W34

    Article  PubMed  Google Scholar 

  • Awaya H, Mitchell DG et al (2002) Cirrhosis: modified caudate-right lobe ratio. Radiology 224(3):769–774

    Article  PubMed  Google Scholar 

  • Baron RL (1994) Understanding and optimizing use of contrast material for CT of the liver. AJR Am J Roentgenol 163(2):323–331

    PubMed  CAS  Google Scholar 

  • Baron RL, Peterson MS (2001) From the RSNA refresher courses: screening the cirrhotic liver for hepatocellular carcinoma with CT and MR imaging: opportunities and pitfalls. Radiographics 21 Spec No: S117–132

    Google Scholar 

  • Bartolozzi C, Crocetti L et al (2007) Biliary and reticuloendothelial impairment in hepatocarcinogenesis: the diagnostic role of tissue-specific MR contrast media. Eur Radiol 17(10):2519–2530

    Article  PubMed  Google Scholar 

  • Basaran C, Karcaaltincaba M et al (2005) Fat-containing lesions of the liver: cross-sectional imaging findings with emphasis on MRI. AJR Am J Roentgenol 184(4):1103–1110

    PubMed  Google Scholar 

  • Blachar A, Federle MP et al (2002) Hepatic capsular retraction: spectrum of benign and malignant etiologies. Abdom Imaging 27(6):690–699

    Article  PubMed  CAS  Google Scholar 

  • Bolog N, Andreisek G et al (2011) CT and MR imaging of hepatocellular carcinoma. J Gastrointestin Liver Dis 20(2):181–189

    PubMed  Google Scholar 

  • Borzio M, Fargion S et al (2003) Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 39(2):208–214

    Article  PubMed  Google Scholar 

  • Brancatelli G, Federle MP et al (2001) Hemangioma in the cirrhotic liver: diagnosis and natural history. Radiology 219(1):69–74

    PubMed  CAS  Google Scholar 

  • Brancatelli G, Federle MP et al (2002) Large regenerative nodules in Budd-Chiari syndrome and other vascular disorders of the liver: CT and MR imaging findings with clinicopathologic correlation. AJR Am J Roentgenol 178(4):877–883

    PubMed  Google Scholar 

  • Brancatelli G, Baron RL et al (2003) Helical CT screening for hepatocellular carcinoma in patients with cirrhosis: frequency and causes of false-positive interpretation. AJR Am J Roentgenol 180(4):1007–1014

    PubMed  Google Scholar 

  • Brancatelli G, Federle MP et al (2007) Cirrhosis: CT and MR imaging evaluation. Eur J Radiol 61(1):57–69

    Article  PubMed  Google Scholar 

  • Brancatelli G, Baron RL et al (2009) Focal confluent fibrosis in cirrhotic liver: natural history studied with serial CT. AJR Am J Roentgenol 192(5):1341–1347

    Article  PubMed  Google Scholar 

  • Bruix J, Sherman M (2005) Management of hepatocellular carcinoma. Hepatology 42(5):1208–1236

    Article  PubMed  Google Scholar 

  • Burrel M, Llovet JM et al (2003) MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: an explant correlation. Hepatology 38(4):1034–1042

    PubMed  Google Scholar 

  • Choi BI, Lee JM (2010) Advancement in HCC imaging: diagnosis, staging and treatment efficacy assessments: imaging diagnosis and staging of hepatocellular carcinoma. J Hepatobiliary Pancreat Sci 17(4):369–373

    Article  PubMed  Google Scholar 

  • Choi BI, Takayasu K et al (1993) Small hepatocellular carcinomas and associated nodular lesions of the liver: pathology, pathogenesis, and imaging findings. AJR Am J Roentgenol 160(6):1177–1187

    PubMed  CAS  Google Scholar 

  • Choi BI, Lee HJ et al (1997) Detection of hypervascular nodular hepatocellular carcinomas: value of triphasic helical CT compared with iodized-oil CT. AJR Am J Roentgenol 168(1):219–224

    PubMed  CAS  Google Scholar 

  • Choi BI, Lee KH et al (2002) Hepatic arterioportal shunts: dynamic CT and MR features. Korean J Radiol 3(1):1–15

    Article  PubMed  Google Scholar 

  • Chopra S, Dodd GD 3rd et al (1999) Mesenteric, omental, and retroperitoneal edema in cirrhosis: frequency and spectrum of CT findings. Radiology 211(3):737–742

    PubMed  CAS  Google Scholar 

  • Chou CT, Chen RC et al (2011) Prediction of microvascular invasion of hepatocellular carcinoma by pre-operative CT imaging. Br J Radiol [Epub ahead of print]

    Google Scholar 

  • Chung YE, Park MS et al (2009) Hepatocellular carcinoma variants: radiologic-pathologic correlation. AJR Am J Roentgenol 193(1):W7–W13

    Article  PubMed  Google Scholar 

  • Colagrande S, Centi N et al (2007a) Transient hepatic intensity differences: part 1, those associated with focal lesions. AJR Am J Roentgenol 188(1):154–159

    Article  PubMed  Google Scholar 

  • Colagrande S, Centi N et al (2007b) Transient hepatic intensity differences: part 2, those not associated with focal lesions. AJR Am J Roentgenol 188(1):160–166

    Article  PubMed  Google Scholar 

  • Da Ines D, Bailly A et al (2009) Hepatocellular carcinoma with sarcomatous change: prompt and fatal intraabdominal recurrence after liver transplantation. Gastroenterol Clin Biol 33(6–7):590–593

    Article  PubMed  Google Scholar 

  • Desmet VJ (2009) East-West pathology agreement on precancerous liver lesions and early hepatocellular carcinoma. Hepatology 49(2):355–357

    Article  PubMed  Google Scholar 

  • Desser TS (2009) Understanding transient hepatic attenuation differences. Semin Ultrasound CT MR 30(5):408–417

    Article  PubMed  Google Scholar 

  • Dodd GD 3rd, Baron RL et al (1999a) Spectrum of imaging findings of the liver in end-stage cirrhosis: part I, gross morphology and diffuse abnormalities. AJR Am J Roentgenol 173(4):1031–1036

    PubMed  Google Scholar 

  • Dodd GD 3rd, Baron RL et al (1999b) Spectrum of imaging findings of the liver in end-stage cirrhosis: part II, focal abnormalities. AJR Am J Roentgenol 173(5):1185–1192

    PubMed  Google Scholar 

  • Earls JP, Theise ND et al (1996) Dysplastic nodules and hepatocellular carcinoma: thin-section MR imaging of explanted cirrhotic livers with pathologic correlation. Radiology 201(1):207–214

    PubMed  CAS  Google Scholar 

  • Efremidis SC, Hytiroglou P et al (2007) Enhancement patterns and signal-intensity characteristics of small hepatocellular carcinoma in cirrhosis: pathologic basis and diagnostic challenges. Eur Radiol 17(11):2969–2982

    Article  PubMed  Google Scholar 

  • Fan R, Chen P et al (2011) Cooperation of deregulated Notch signaling and Ras pathway in human hepatocarcinogenesis. J Mol Histol 42(5):473–481

    Article  PubMed  CAS  Google Scholar 

  • Fernandez MP, Redvanly RD (1998) Primary hepatic malignant neoplasms. Radiol Clin N Am 36(2):333–348

    Article  PubMed  CAS  Google Scholar 

  • Ferrell LD, Crawford JM et al (1993) Proposal for standardized criteria for the diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver disease. Am J Surg Pathol 17(11):1113–1123

    Article  PubMed  CAS  Google Scholar 

  • Fisher MR, Gore RM (1985) Computed tomography in the evaluation of cirrhosis and portal hypertension. J Clin Gastroenterol 7(2):173–181

    Article  PubMed  CAS  Google Scholar 

  • Forner A, Vilana R et al (2008) Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology 47(1):97–104

    Article  PubMed  Google Scholar 

  • Fournier LS, Cuenod CA et al (2004) Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent. Eur Radiol 14(11):2125–2133

    Article  PubMed  Google Scholar 

  • Freeny PC, Baron RL et al (1992) Hepatocellular carcinoma: reduced frequency of typical findings with dynamic contrast-enhanced CT in a non-Asian population. Radiology 182(1):143–148

    PubMed  CAS  Google Scholar 

  • Fukukura Y, Taguchi J et al (1997) Combined hepatocellular and cholangiocarcinoma: correlation between CT findings and clinicopathological features. J Comput Assist Tomogr 21(1):52–58

    Article  PubMed  CAS  Google Scholar 

  • Furlan A, Marin D et al (2011) Hepatocellular carcinoma in cirrhotic patients at multidetector CT: hepatic venous phase versus delayed phase for the detection of tumour washout. Br J Radiol 84(1001):403–412

    Article  PubMed  CAS  Google Scholar 

  • Gibo M, Murata S et al (2001) Pericaval fat collection mimicking an intracaval lesion on CT in patients with chronic liver disease. Abdom Imaging 26(5):492–495

    Article  PubMed  CAS  Google Scholar 

  • Giorgio A, Amoroso P et al (1986) Cirrhosis: value of caudate to right lobe ratio in diagnosis with US. Radiology 161(2):443–445

    PubMed  CAS  Google Scholar 

  • Gomaa AI, Khan SA et al (2008) Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J Gastroenterol 14(27):4300–4308

    Article  PubMed  Google Scholar 

  • Gore RM (2008) Diffuse liver disease. In: Gore RM, Levine MS, Laufer I (eds) Textbook of gastrointestinal radiology, vol 2. Saunders, Philadelpia, pp 1685–1730

    Google Scholar 

  • Goshima S, Kanematsu M et al (2004) Nodule-in-nodule appearance of hepatocellular carcinomas: comparison of gadolinium-enhanced and ferumoxides-enhanced magnetic resonance imaging. J Magn Reson Imaging 20(2):250–255

    Article  PubMed  Google Scholar 

  • Grazioli L, Olivetti L et al (1999) The pseudocapsule in hepatocellular carcinoma: correlation between dynamic MR imaging and pathology. Eur Radiol 9(1):62–67

    Article  PubMed  CAS  Google Scholar 

  • Greenfield V, Cheung O et al (2008) Recent advances in nonalcholic fatty liver disease. Curr Opin Gastroenterol 24(3):320–327

    Article  PubMed  Google Scholar 

  • Hall TC, Garcea G et al (2011) Management of acute non-cirrhotic and non-malignant portal vein thrombosis: a systematic review. World J Surg 35(11):2510–2520

    Article  PubMed  CAS  Google Scholar 

  • Hammerstingl RM, Vogl TJ (2005) Abdominal MDCT: protocols and contrast considerations. Eur Radiol 15(Suppl 5):E78–E90

    PubMed  Google Scholar 

  • Harbin WP, Robert NJ et al (1980) Diagnosis of cirrhosis based on regional changes in hepatic morphology: a radiological and pathological analysis. Radiology 135(2):273–283

    PubMed  CAS  Google Scholar 

  • Hayashi M, Matsui O et al (1999) Correlation between the blood supply and grade of malignancy of hepatocellular nodules associated with liver cirrhosis: evaluation by CT during intraarterial injection of contrast medium. AJR Am J Roentgenol 172(4):969–976

    PubMed  CAS  Google Scholar 

  • Hayashi M, Matsui O et al (2002) Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material. Radiology 225(1):143–149

    Article  PubMed  Google Scholar 

  • Holland AE, Hecht EM et al (2005) Importance of small (< or = 20-mm) enhancing lesions seen only during the hepatic arterial phase at MR imaging of the cirrhotic liver: evaluation and comparison with whole explanted liver. Radiology 237(3):938–944

    Article  PubMed  Google Scholar 

  • Honda H, Ochiai K et al (1993) Hepatocellular carcinoma: correlation of CT, angiographic, and histopathologic findings. Radiology 189(3):857–862

    PubMed  CAS  Google Scholar 

  • Honda H, Hayashi T et al (1996) Hepatocellular carcinoma with sarcomatous change: characteristic findings of two-phased incremental CT. Abdom Imaging 21(1):37–40

    Article  PubMed  CAS  Google Scholar 

  • Hoshimoto S, Morise Z et al (2009) Hepatocellular carcinoma with extensive peliotic change. J Hepatobiliary Pancreat Surg 16(4):566–570

    Article  PubMed  Google Scholar 

  • Hwang GJ, Kim MJ et al (1997) Nodular hepatocellular carcinomas: detection with arterial-, portal-, and delayed-phase images at spiral CT. Radiology 202(2):383–388

    PubMed  CAS  Google Scholar 

  • Hytiroglou P (2004) Morphological changes of early human hepatocarcinogenesis. Semin Liver Dis 24(1):65–75

    Article  PubMed  Google Scholar 

  • Hytiroglou P, Park YN et al (2007) Hepatic precancerous lesions and small hepatocellular carcinoma. Gastroenterol Clin N Am 36(4):867–887, vii

    Google Scholar 

  • Iannaccone R, Laghi A et al (2005) Hepatocellular carcinoma: role of unenhanced and delayed phase multi-detector row helical CT in patients with cirrhosis. Radiology 234(2):460–467

    Article  PubMed  Google Scholar 

  • Ibarrola C, Castellano VM et al (2004) Focal hyperplastic hepatocellular nodules in hepatic venous outflow obstruction: a clinicopathological study of four patients and 24 nodules. Histopathology 44(2):172–179

    Article  PubMed  CAS  Google Scholar 

  • Ichikawa T, Federle MP et al (1999) Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology 213(2):352–361

    PubMed  CAS  Google Scholar 

  • Ikenaga N, Chijiiwa K et al (2009) Clinicopathologic characteristics of hepatocellular carcinoma with bile duct invasion. J Gastrointest Surg 13(3):492–497

    Article  PubMed  Google Scholar 

  • Imaeda T, Kanematsu M et al (1994) Extracapsular invasion of small hepatocellular carcinoma: MR and CT findings. J Comput Assist Tomogr 18(5):755–760

    Article  PubMed  CAS  Google Scholar 

  • International Consensus Group for Hepatocellular NeoplasiaThe International Consensus Group for Hepatocellular Neoplasia (2011) Perfusion measurement of the whole upper abdomen of patients with and without liver diseases: initial experience with 320-detector row CT. Eur J Radiol

    Google Scholar 

  • Ippolito D, Capraro C et al (2011) Quantitative assessment of tumour associated neovascularisation in patients with liver cirrhosis and hepatocellular carcinoma: role of dynamic-CT perfusion imaging. Eur Radiolo [Epub ahead of print]

    Google Scholar 

  • Ishida Y, Nagamatsu H et al (2008) Hepatocellular carcinoma with a “nodule-in-nodule” appearance reflecting an unusual dilated pseudoglandular structure. Intern Med 47(13):1215–1218

    Article  PubMed  Google Scholar 

  • Ishigami K, Yoshimitsu K et al (2009) Hepatocellular carcinoma with a pseudocapsule on gadolinium-enhanced MR images: correlation with histopathologic findings. Radiology 250(2):435–443

    Article  PubMed  Google Scholar 

  • Ito K, Honjo K et al (1996) Liver neoplasms: diagnostic pitfalls in cross-sectional imaging. Radiographics 16(2):273–293

    PubMed  CAS  Google Scholar 

  • Ito K, Mitchell DG et al (1999a) Expanded gallbladder fossa: simple MR imaging sign of cirrhosis. Radiology 211(3):723–726

    PubMed  CAS  Google Scholar 

  • Ito K, Mitchell DG et al (1999b) Primary sclerosing cholangitis: MR imaging features. AJR Am J Roentgenol 172(6):1527–1533

    PubMed  CAS  Google Scholar 

  • Ito K, Mitchell DG et al (2000) Enlargement of hilar periportal space: a sign of early cirrhosis at MR imaging. J Magn Reson Imaging 11(2):136–140

    Article  PubMed  CAS  Google Scholar 

  • Ito K, Mitchell DG et al (2003) Right posterior hepatic notch sign: a simple diagnostic MR finding of cirrhosis. J Magn Reson Imaging 18(5):561–566

    Article  PubMed  Google Scholar 

  • Ito K, Mitchell DG (2004) Imaging diagnosis of cirrhosis and chronic hepatitis. Intervirology 47(3–5):134–143

    Article  PubMed  Google Scholar 

  • Jang HJ, Choi BI et al (1998) Atypical small hemangiomas of the liver: “bright dot” sign at two-phase spiral CT. Radiology 208(2):543–548

    PubMed  CAS  Google Scholar 

  • Kadoya M, Matsui O et al (1992) Hepatocellular carcinoma: correlation of MR imaging and histopathologic findings. Radiology 183(3):819–825

    PubMed  CAS  Google Scholar 

  • Kamel IR, Liapi E et al (2005) Multidetector CT of hepatocellular carcinoma. Best Pract Res Clin Gastroenterol 19(1):63–89

    Article  PubMed  Google Scholar 

  • Kanematsu M, Semelka RC et al (2003) Hepatocellular carcinoma of diffuse type: MR imaging findings and clinical manifestations. J Magn Reson Imaging 18(2):189–195

    Article  PubMed  Google Scholar 

  • Kanematsu M, Goshima S et al (2005) Optimizing scan delays of fixed duration contrast injection in contrast-enhanced biphasic multidetector-row CT for the liver and the detection of hypervascular hepatocellular carcinoma. J Comput Assist Tomogr 29(2):195–201

    Article  PubMed  Google Scholar 

  • Kang SE, Lee JM et al (2011) Quantitative color mapping of the arterial enhancement fraction in patients with diffuse liver disease. AJR Am J Roentgenol 197(4):876–883

    Article  PubMed  Google Scholar 

  • Kawata S, Murakami T et al (2002) Multidetector CT: diagnostic impact of slice thickness on detection of hypervascular hepatocellular carcinoma. AJR Am J Roentgenol 179(1):61–66

    PubMed  Google Scholar 

  • Khalili K, Kyoung Kim T et al (2011) Indeterminate 1–2-cm nodules found on hepatocellular carcinoma surveillance: Biopsy for all, some, or none? Hepatology 54(6):2048–2054

    Article  PubMed  Google Scholar 

  • Khatri G, Merrick L et al (2010) MR imaging of hepatocellular carcinoma. Magn Reson Imaging Clin N Am 18(3):421–450 X

    Article  PubMed  Google Scholar 

  • Kim HJ, Kim AY et al (2005) Transient hepatic attenuation differences in focal hepatic lesions: dynamic CT features. AJR Am J Roentgenol 184(1):83–90

    PubMed  Google Scholar 

  • Kim SJ, Lee JM et al (2007a) Peripheral mass-forming cholangiocarcinoma in cirrhotic liver. AJR Am J Roentgenol 189(6):1428–1434

    Article  PubMed  Google Scholar 

  • Kim SR, Ikawa H et al (2007b) Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis. World J Gastroenterol 13(8):1271–1274

    PubMed  CAS  Google Scholar 

  • Kim BK, Han KH et al (2008a) Prediction of microvascular invasion before curative resection of hepatocellular carcinoma. J Surg Oncol 97(3):246–252

    Article  PubMed  Google Scholar 

  • Kim SR, Imoto S et al (2008b) Focal nodular hyperplasia-like lesion with venous washout in alcoholic liver cirrhosis. Intern Med 47(21):1899–1903

    Article  PubMed  Google Scholar 

  • Kim SH, Choi BI et al (2008c) Diagnostic accuracy of multi-/single-detector row CT and contrast-enhanced MRI in the detection of hepatocellular carcinomas meeting the milan criteria before liver transplantation. Intervirology 51(Suppl 1):52–60

    Google Scholar 

  • Kim KW, Lee JM et al (2009a) Quantitative CT color mapping of the arterial enhancement fraction of the liver to detect hepatocellular carcinoma. Radiology 250(2):425–434

    Article  PubMed  Google Scholar 

  • Kim SH, Lim HK et al (2009b) Scirrhous hepatocellular carcinoma: comparison with usual hepatocellular carcinoma based on CT-pathologic features and long-term results after curative resection. Eur J Radiol 69(1):123–130

    Article  PubMed  Google Scholar 

  • Kim YK, Han YM et al (2009c) Comparison of diffuse hepatocellular carcinoma and intrahepatic cholangiocarcinoma using sequentially acquired gadolinium-enhanced and Resovist-enhanced MRI. Eur J Radiol 70(1):94–100

    Article  PubMed  Google Scholar 

  • Kim KS, Lee JM et al (2010) Image fusion in dual energy computed tomography for detection of hypervascular liver hepatocellular carcinoma: phantom and preliminary studies. Invest Radiol 45(3):149–157

    Article  PubMed  Google Scholar 

  • Kim KW, Lee JM et al (2011a) Assessment of the treatment response of HCC. Abdom Imaging 36(3):300–314

    Article  PubMed  Google Scholar 

  • Kim SA, Lee JM et al (2011b) Intrahepatic mass-forming cholangiocarcinomas: enhancement patterns at multiphasic CT, with special emphasis on arterial enhancement pattern—correlation with clinicopathologic findings. Radiology 260(1):148–157

    Article  PubMed  Google Scholar 

  • Kim SE, Lee HC et al (2011c) Noninvasive diagnostic criteria for hepatocellular carcinoma in hepatic masses >2 cm in a hepatitis B virus-endemic area. Liver Int 31(10):1468–1476

    Article  PubMed  CAS  Google Scholar 

  • Kim KE, Park MS et al (2011d) Hepatocellular carcinoma: clinical and radiological findings in patients with chronic B viral hepatitis and chronic C viral hepatitis. Abdom Imaging [Epub ahead of print]

    Google Scholar 

  • Kitao A, Zen Y et al (2009) Hepatocarcinogenesis: multistep changes of drainage vessels at CT during arterial portography and hepatic arteriography–radiologic-pathologic correlation. Radiology 252(2):605–614

    Article  PubMed  Google Scholar 

  • Kobayashi S, Matsui O et al (2007) Imaging of benign hypervascular hepatocellular nodules in alcoholic liver cirrhosis: differentiation from hypervascular hepatocellular carcinoma. J Comput Assist Tomogr 31(4):557–563

    Article  PubMed  Google Scholar 

  • Kojiro M (1998) Pathology of early hepatocellular carcinoma: progression from early to advanced. Hepatogastroenterology 45(Suppl 3):1203–1205

    Google Scholar 

  • Kojiro M, Nakashima O (1999) Histopathologic evaluation of hepatocellular carcinoma with special reference to small early stage tumors. Semin Liver Dis 19(3):287–296

    Article  PubMed  CAS  Google Scholar 

  • Kojiro M, Roskams T (2005) Early hepatocellular carcinoma and dysplastic nodules. Semin Liver Dis 25(2):133–142

    Article  PubMed  Google Scholar 

  • Kondo F et al (2009) Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia. Hepatology 49(2):658–664

    Google Scholar 

  • Krinsky GA, Lee VS (2000) MR imaging of cirrhotic nodules. Abdom Imaging 25(5):471–482

    Article  PubMed  CAS  Google Scholar 

  • Krinsky GA, Lee VS et al (2001) Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: prospective diagnosis with MR imaging and explantation correlation. Radiology 219(2):445–454

    PubMed  CAS  Google Scholar 

  • Kudo M (2004) Atypical large well-differentiated hepatocellular carcinoma with benign nature: a new clinical entity. Intervirology 47(3–5):227–237

    Article  PubMed  Google Scholar 

  • Kudo M, Tochio H (2008) Intranodular blood supply correlates well with biological malignancy grade determined by tumor growth rate in pathologically proven hepatocellular carcinoma. Oncology 75(Suppl 1):55–64

    Google Scholar 

  • Kutami R, Nakashima Y et al (2000) Pathomorphologic study on the mechanism of fatty change in small hepatocellular carcinoma of humans. J Hepatol 33(2):282–289

    Article  PubMed  CAS  Google Scholar 

  • Lafortune M, Matricardi L et al (1998) Segment 4 (the quadrate lobe): a barometer of cirrhotic liver disease at US. Radiology 206(1):157–160

    PubMed  CAS  Google Scholar 

  • Lao XM, Chen DY et al (2007) Primary carcinosarcoma of the liver: clinicopathologic features of 5 cases and a review of the literature. Am J Surg Pathol 31(6):817–826

    Article  PubMed  Google Scholar 

  • Lee KH, Choi BI et al (2000) Nodular hepatocellular carcinoma: variation of tumor conspicuity on single-level dynamic scan and optimization of fixed delay times for two-phase helical CT. J Comput Assist Tomogr 24(2):212–218

    Article  PubMed  CAS  Google Scholar 

  • Lee YH, Kim SH et al (2007) Focal nodular hyperplasia-like nodules in alcoholic liver cirrhosis: radiologic-pathologic correlation. AJR Am J Roentgenol 188(5):W459–W463

    Article  PubMed  Google Scholar 

  • Lee HK, Park SJ et al (2008) Portal vein thrombosis: CT features. Abdom Imaging 33(1):72–79

    Article  PubMed  Google Scholar 

  • Lee DH, Kim SH et al (2009) Diagnostic performance of multidetector row computed tomography, superparamagnetic iron oxide-enhanced magnetic resonance imaging, and dual-contrast magnetic resonance imaging in predicting the appropriateness of a transplant recipient based on milan criteria: correlation with histopathological findings. Invest Radiol 44(6):311–321

    Article  PubMed  Google Scholar 

  • Lee JM, Trevisani F et al (2011) Imaging diagnosis and staging of hepatocellular carcinoma. Liver Transpl 17(Suppl 2): S34–43

    Google Scholar 

  • Libbrecht L, Desmet V et al (2005) Preneoplastic lesions in human hepatocarcinogenesis. Liver Int 25(1):16–27

    Article  PubMed  CAS  Google Scholar 

  • Lim JH, Kim MJ et al (2004) Dysplastic nodules in liver cirrhosis: detection with triple phase helical dynamic CT. Br J Radiol 77(923):911–916

    Article  PubMed  CAS  Google Scholar 

  • Lim YS, Kim WR (2008) The global impact of hepatic fibrosis and end-stage liver disease. Clin Liver Dis 12(4):733–746 Vii

    Article  PubMed  Google Scholar 

  • Liu QY, Huang SQ et al (2010) Small hepatocellular carcinoma with bile duct tumor thrombi: CT and MRI findings. Abdom Imaging 35(5):537–542

    Article  PubMed  Google Scholar 

  • Llovet JM, Chen Y et al (2006) A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology 131(6):1758–1767

    Article  PubMed  CAS  Google Scholar 

  • Llovet JM, Ricci S et al (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359(4):378–390

    Article  PubMed  CAS  Google Scholar 

  • Loyer EM, Chin H et al (1999) Hepatocellular carcinoma and intrahepatic peripheral cholangiocarcinoma: enhancement patterns with quadruple phase helical CT—a comparative study. Radiology 212(3):866–875

    PubMed  CAS  Google Scholar 

  • Luca A, Caruso S et al (2010) Multidetector-row computed tomography (MDCT) for the diagnosis of hepatocellular carcinoma in cirrhotic candidates for liver transplantation: prevalence of radiological vascular patterns and histological correlation with liver explants. Eur Radiol 20(4):898–907

    Article  PubMed  Google Scholar 

  • Maetani Y, Itoh K et al (2002) Benign hepatic nodules in Budd-Chiari syndrome: radiologic-pathologic correlation with emphasis on the central scar. AJR Am J Roentgenol 178(4):869–875

    PubMed  Google Scholar 

  • Maetani YS, Ueda M et al (2008) Hepatocellular carcinoma in patients undergoing living-donor liver transplantation. Accuracy of multidetector computed tomography by viewing images on digital monitors. Intervirology 51(Suppl 1):46–51

    Google Scholar 

  • Marin D, Nelson RC et al (2009) Hypervascular liver tumors: low tube voltage, high tube current multidetector CT during late hepatic arterial phase for detection—initial clinical experience. Radiology 251(3):771–779

    Article  PubMed  Google Scholar 

  • Martin J, Sentis M et al (1995) Fatty metamorphosis of hepatocellular carcinoma: detection with chemical shift gradient-echo MR imaging. Radiology 195(1):125–130

    PubMed  CAS  Google Scholar 

  • Martinsen AC, Saether HK et al (2011) Iterative reconstruction reduces abdominal CT dose. Eur J Radiol [Epub ahead of print]

    Google Scholar 

  • Mastropasqua M, Kanematsu M et al (2004) Cavernous hemangiomas in patients with chronic liver disease: MR imaging findings. Magn Reson Imaging 22(1):15–18

    Article  PubMed  Google Scholar 

  • Mathers CD, Lopez AD, Murray CJL (2006) The burden of disease and mortality by condition data, methods, and results for 2001. In: Mathers CD, Lopez AD, Ezzati M et al (eds) Global burden of disease and risk factors. Oxford University Press and the World Bank, Washington (DC), pp 45–93

    Google Scholar 

  • Matsui O (2004) Imaging of multistep human hepatocarcinogenesis by CT during intra-arterial contrast injection. Intervirology 47(3–5):271–276

    Article  PubMed  Google Scholar 

  • Matsui O, Kobayashi S et al (2011) Hepatocelluar nodules in liver cirrhosis: hemodynamic evaluation (angiography-assisted CT) with special reference to multi-step hepatocarcinogenesis. Abdom Imaging 36(3):264–272

    Article  PubMed  Google Scholar 

  • McLarney JK, Rucker PT et al (1999) Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics 19(2):453–471

    PubMed  CAS  Google Scholar 

  • Minagawa M, Ikai I et al (2007) Staging of hepatocellular carcinoma: assessment of the Japanese TNM and AJCC/UICC TNM systems in a cohort of 13,772 patients in Japan. Ann Surg 245(6):909–922

    Article  PubMed  Google Scholar 

  • Mitsumori LM, Shuman WP et al (2012) Adaptive statistical iterative reconstruction versus filtered back projection in the same patient: 64 channel liver CT image quality and patient radiation dose. Eur Radiol 22(1):138–143

    Article  PubMed  Google Scholar 

  • Monzawa S, Omata K et al (1999) Well-differentiated hepatocellular carcinoma: findings of US, CT, and MR imaging. Abdom Imaging 24(4):392–397

    Article  PubMed  CAS  Google Scholar 

  • Moubarak E, Bouvier A et al (2011) Portosystemic collateral vessels in liver cirrhosis: a three-dimensional MDCT pictorial review. Abdom Imaging [Epub ahead of print]

    Google Scholar 

  • Moucari R, Rautou PE et al (2008) Hepatocellular carcinoma in Budd-Chiari syndrome: characteristics and risk factors. Gut 57(6):828–835

    Article  PubMed  CAS  Google Scholar 

  • Murakami T, Kim T et al (1997) Combined hepatocellular and cholangiocellular carcinoma. Radiat Med 15(4):243–246

    PubMed  CAS  Google Scholar 

  • Nakashima O, Sugihara S et al (1995) Pathomorphologic characteristics of small hepatocellular carcinoma: a special reference to small hepatocellular carcinoma with indistinct margins. Hepatology 22(1):101–105

    PubMed  CAS  Google Scholar 

  • Nakashima Y, Nakashima O et al (1999) Vascularization of small hepatocellular carcinomas: correlation with differentiation. Liver 19(1):12–18

    Article  PubMed  CAS  Google Scholar 

  • Nakashima O, Kurogi M et al (2004) Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules? J Hepatol 41(6):992–998

    Article  PubMed  CAS  Google Scholar 

  • Nakamura K, Zen Y et al (2007) Vascular endothelial growth factor, its receptor Flk-1, and hypoxia inducible factor-1alpha are involved in malignant transformation in dysplastic nodules of the liver. Hum Pathol 38(10):1532–1546

    Article  PubMed  CAS  Google Scholar 

  • Namasivayam S, Salman K et al (2007) Hypervascular hepatic focal lesions: spectrum of imaging features. Curr Probl Diagn Radiol 36(3):107–123

    Article  PubMed  Google Scholar 

  • Ohtomo K, Baron RL et al (1993a) Confluent hepatic fibrosis in advanced cirrhosis: appearance at CT. Radiology 188(1):31–35

    PubMed  CAS  Google Scholar 

  • Ohtomo K, Baron RL et al (1993b) Confluent hepatic fibrosis in advanced cirrhosis: evaluation with MR imaging. Radiology 189(3):871–874

    PubMed  CAS  Google Scholar 

  • Okada M, Kim T et al (2011) Hepatocellular nodules in liver cirrhosis: state of the art CT evaluation (perfusion CT/volume helical shuttle scan/dual-energy CT, etc.). Abdom Imaging 36(3):273–281

    Article  PubMed  Google Scholar 

  • Okazaki H, Ito K et al (2000) Discrimination of alcoholic from virus-induced cirrhosis on MR imaging. AJR Am J Roentgenol 175(6):1677–1681

    PubMed  CAS  Google Scholar 

  • Okuda K (2002) Natural history of hepatocellular carcinoma including fibrolamellar and hepato-cholangiocarcinoma variants. J Gastroenterol Hepatol 17(4):401–405

    Article  PubMed  Google Scholar 

  • Onaya H, Itai Y et al (2000) Highly enhanced hepatic masses seen on CT during arterial portography: early hepatocellular carcinoma and adenomatous hyperplasia. Jpn J Clin Oncol 30(10):440–445

    Article  PubMed  CAS  Google Scholar 

  • Ozaki K, Matsui O et al (2010) Selective atrophy of the middle hepatic venous drainage area in hepatitis C-related cirrhotic liver: morphometric study by using multidetector CT. Radiology 257(3):705–714

    Article  PubMed  Google Scholar 

  • Park YN, Kim YB et al (2000) Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis. Arch Pathol Lab Med 124(7):1061–1065

    PubMed  CAS  Google Scholar 

  • Park YN, Kim MJ (2011) Hepatocarcinogenesis: imaging-pathologic correlation. Abdom Imaging 36(3):232–243

    Article  PubMed  Google Scholar 

  • Parkin DM, Bray F et al (2001) Estimating the world cancer burden: Globocan 2000. Int J Cancer 94(2):153–156

    Article  PubMed  CAS  Google Scholar 

  • Perez-Johnston R, Lenhart DK et al (2010) CT angiography of the hepatic and pancreatic circulation. Radiol Clin N Am 48(2):311–330 viii

    Article  PubMed  Google Scholar 

  • Piscaglia F, Gianstefani A et al (2010) Criteria for diagnosing benign portal vein thrombosis in the assessment of patients with cirrhosis and hepatocellular carcinoma for liver transplantation. Liver Transpl 16(5):658–667

    PubMed  Google Scholar 

  • Poddar N, Avezbakiyev B et al (2010) Hepatocellular carcinoma presenting as an incidental isolated malignant portal vein thrombosis. J Gastrointest Cancer [Epub ahead of print]

    Google Scholar 

  • Pomfret EA, Washburn K et al (2010) Report of a national conference on liver allocation in patients with hepatocellular carcinoma in the United States. Liver Transpl 16(3):262–278

    Article  PubMed  Google Scholar 

  • Popper H (1986) General pathology of the liver: light microscopic aspects serving diagnosis and interpretation. Semin Liver Dis 6(3):175–184

    Article  PubMed  CAS  Google Scholar 

  • Prasad SR, Wang H et al (2005) Fat-containing lesions of the liver: radiologic-pathologic correlation. Radiographics 25(2):321–331

    Article  PubMed  Google Scholar 

  • Qayyum A, Graser A et al (2004) CT of benign hypervascular liver nodules in autoimmune hepatitis. AJR Am J Roentgenol 183(6):1573–1576

    PubMed  Google Scholar 

  • Rimola J, Forner A et al (2009) Cholangiocarcinoma in cirrhosis: absence of contrast washout in delayed phases by magnetic resonance imaging avoids misdiagnosis of hepatocellular carcinoma. Hepatology 50(3):791–798

    Article  PubMed  Google Scholar 

  • Roncalli M, Terracciano L et al (2011) Liver precancerous lesions and hepatocellular carcinoma: the histology report. Dig Liver Dis 43(Suppl 4):S361–372

    Google Scholar 

  • Sadek AG, Mitchell DG et al (1995) Early hepatocellular carcinoma that develops within macroregenerative nodules: growth rate depicted at serial MR imaging. Radiology 195(3):753–756

    PubMed  CAS  Google Scholar 

  • Sakamoto M, Hirohashi S et al (1991) Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 22(2):172–178

    Article  PubMed  CAS  Google Scholar 

  • Sangiovanni A, Manini MA et al (2010) The diagnostic and economic impact of contrast imaging techniques in the diagnosis of small hepatocellular carcinoma in cirrhosis. Gut 59(5):638–644

    Article  PubMed  Google Scholar 

  • Sano K, Ichikawa T et al (2011) Imaging study of early hepatocellular carcinoma: usefulness of gadoxetic acid-enhanced MR Imaging. Radiology 261(3):834–844

    Article  PubMed  Google Scholar 

  • Saygili OB, Tarhan NC et al (2005) Value of computed tomography and magnetic resonance imaging for assessing severity of liver cirrhosis secondary to viral hepatitis. Eur J Radiol 54(3):400–407

    Article  PubMed  Google Scholar 

  • Schindera ST, Diedrichsen L et al (2011) Iterative reconstruction algorithm for abdominal multidetector CT at different tube voltages: assessment of diagnostic accuracy, image quality, and radiation dose in a phantom study. Radiology 260(2):454–462

    Article  PubMed  Google Scholar 

  • Schuppan D, Afdhal NH (2008) Liver cirrhosis. Lancet 371(9615):838–851

    Article  PubMed  CAS  Google Scholar 

  • Schutte K, Bornschein J et al (2009) Hepatocellular carcinoma—epidemiological trends and risk factors. Dig Dis 27(2):80–92

    Article  PubMed  Google Scholar 

  • Semelka RC, Brown ED et al (1994) Hepatic hemangiomas: a multi-institutional study of appearance on T2-weighted and serial gadolinium-enhanced gradient-echo MR images. Radiology 192(2):401–406

    PubMed  CAS  Google Scholar 

  • Serste T, Barrau V et al (2011) Accuracy and disagreement of CT and MRI for the diagnosis of small hepatocellular carcinoma and dysplastic nodules: role of biopsy. Hepatology

    Google Scholar 

  • Sherman M (2010) The radiological diagnosis of hepatocellular carcinoma. Am J Gastroenterol 105(3):610–612

    Article  PubMed  Google Scholar 

  • Shin CI, Lee JM et al (2007) Recurrence patterns of combined hepatocellular-cholangiocarcinoma on enhanced computed tomography. J Comput Assist Tomogr 31(1):109–115

    Article  PubMed  Google Scholar 

  • Stevens WR, Johnson CD et al (1994) CT findings in hepatocellular carcinoma: correlation of tumor characteristics with causative factors, tumor size, and histologic tumor grade. Radiology 191(2):531–537

    PubMed  CAS  Google Scholar 

  • Stevens WR, Gulino SP et al (1996) Mosaic pattern of hepatocellular carcinoma: histologic basis for a characteristic CT appearance. J Comput Assist Tomogr 20(3):337–342

    Article  PubMed  CAS  Google Scholar 

  • Sumie S, Kuromatsu R et al (2008) Microvascular invasion in patients with hepatocellular carcinoma and its predictable clinicopathological factors. Ann Surg Oncol 15(5):1375–1382

    Article  PubMed  Google Scholar 

  • Sun HY, Lee JM et al (2010) Gadoxetic acid-enhanced magnetic resonance imaging for differentiating small hepatocellular carcinomas (< or = 2 cm in diameter) from arterial enhancing pseudolesions: special emphasis on hepatobiliary phase imaging. Invest Radiol 45(2):96–103

    Article  PubMed  CAS  Google Scholar 

  • Taguchi K, Aishima S et al (2005) Significance of the relationship between irregular regeneration and two hepatocarcinogenic pathways: “de novo” and so-called “dysplastic nodule-hepatocellular carcinoma” sequence. J Surg Oncol 92(2):100–103

    Article  PubMed  CAS  Google Scholar 

  • Takahashi S, Miyanishi K et al (2008) Case report of a focal nodular hyperplasia-like nodule present in cirrhotic liver. Hepatol Res 38(5):521–528

    Article  PubMed  Google Scholar 

  • Takayasu K, Furukawa H et al (1995) CT diagnosis of early hepatocellular carcinoma: sensitivity, findings, and CT-pathologic correlation. AJR Am J Roentgenol 164(4):885–890

    PubMed  CAS  Google Scholar 

  • Takayasu K, Muramatsu Y et al (2007) CT Imaging of early hepatocellular carcinoma and the natural outcome of hypoattenuating nodular lesions in chronic liver disease. Oncology 72(Suppl 1):83–91

    Google Scholar 

  • Taouli B, Losada M et al (2004) Magnetic resonance imaging of hepatocellular carcinoma. Gastroenterology 127(5 Suppl 1):S144–S152

    Article  PubMed  Google Scholar 

  • Tarantino L, Francica G et al (2006) Diagnosis of benign and malignant portal vein thrombosis in cirrhotic patients with hepatocellular carcinoma: color Doppler US, contrast-enhanced US, and fine-needle biopsy. Abdom Imaging 31(5):537–544

    Article  PubMed  CAS  Google Scholar 

  • Terada T, Nakanuma Y (1989) Survey of iron-accumulative macroregenerative nodules in cirrhotic livers. Hepatology 10(5):851–854

    Article  PubMed  CAS  Google Scholar 

  • Terada T, Nakanuma Y et al (1989) Fatty macroregenerative nodule in non-steatotic liver cirrhosis. A morphologic study. Virchows Arch A Pathol Anat Histopathol 415(2):131–136

    Article  PubMed  CAS  Google Scholar 

  • Tsuchiyama T, Terasaki S et al (2002) Tiny staining spots in liver cirrhosis associated with HCV infection observed by computed tomographic hepatic arteriography: follow-up study. J Gastroenterol 37(10):807–814

    Article  PubMed  Google Scholar 

  • Tsunetomi S, Ohto M et al (1989) Diagnosis of small hepatocellular carcinoma by computed tomography: correlation of CT findings and histopathology. J Gastroenterol Hepatol 4(5):395–404

    Article  PubMed  CAS  Google Scholar 

  • Tublin ME, Dodd GD 3rd et al (1997) Benign and malignant portal vein thrombosis: differentiation by CT characteristics. AJR Am J Roentgenol 168(3):719–723

    PubMed  CAS  Google Scholar 

  • Ueda K, Terada T et al (1992) Vascular supply in adenomatous hyperplasia of the liver and hepatocellular carcinoma: a morphometric study. Hum Pathol 23(6):619–626

    Article  PubMed  CAS  Google Scholar 

  • Valls C, Andia E et al (2002) CT in hepatic cirrhosis and chronic hepatitis. Semin Ultrasound CT MR 23(1):37–61

    Article  PubMed  Google Scholar 

  • Valls C, Iannacconne R et al (2006) Fat in the liver: diagnosis and characterization. Eur Radiol 16(10):2292–2308

    Article  PubMed  Google Scholar 

  • van den Bos IC, Hussain SM et al (2007) MR imaging of hepatocellular carcinoma: relationship between lesion size and imaging findings, including signal intensity and dynamic enhancement patterns. J Magn Reson Imaging 26(6):1548–1555

    Article  PubMed  Google Scholar 

  • Vilgrain V, Lewin M et al (1999) Hepatic nodules in Budd-Chiari syndrome: imaging features. Radiology 210(2):443–450

    PubMed  CAS  Google Scholar 

  • Vilgrain V, Boulos L et al (2000) Imaging of atypical hemangiomas of the liver with pathologic correlation. Radiographics 20(2):379–397

    PubMed  CAS  Google Scholar 

  • Wanless IR (1995) Terminology of nodular hepatocellular lesions. International working party. Hepatology 22(3):983–993

    Google Scholar 

  • Wiesner RH, Freeman RB et al (2004) Liver transplantation for hepatocellular cancer: the impact of the MELD allocation policy. Gastroenterology 127(5 Suppl 1):S261–S267

    Article  PubMed  Google Scholar 

  • Willatt JM, Hussain HK et al (2008) MR Imaging of hepatocellular carcinoma in the cirrhotic liver: challenges and controversies. Radiology 247(2):311–330

    Article  PubMed  Google Scholar 

  • Yamashita Y, Fan ZM et al (1993) Sclerosing hepatocellular carcinoma: radiologic findings. Abdom Imaging 18(4):347–351

    Article  PubMed  CAS  Google Scholar 

  • Yang JD, Roberts LR (2010) Epidemiology and management of hepatocellular carcinoma. Infect Dis Clin N Am 24(4):899–919 viii

    Article  CAS  Google Scholar 

  • Yoon SH, Lee JM et al (2009) Multiphasic MDCT enhancement pattern of hepatocellular carcinoma smaller than 3 cm in diameter: tumor size and cellular differentiation. AJR Am J Roentgenol 193(6):W482–W489

    Article  PubMed  Google Scholar 

  • Yoshikawa J, Matsui O et al (1988) Fatty metamorphosis in hepatocellular carcinoma: radiologic features in 10 cases. AJR Am J Roentgenol 151(4):717–720

    PubMed  CAS  Google Scholar 

  • Yu JS, Kim KW et al (1997) Small arterial-portal venous shunts: a cause of pseudolesions at hepatic imaging. Radiology 203(3):737–742

    PubMed  CAS  Google Scholar 

  • Yu JS, Kim KW et al (2000a) Nontumorous hepatic arterial-portal venous shunts: MR imaging findings. Radiology 217(3):750–756

    PubMed  CAS  Google Scholar 

  • Yu JS, Kim KW et al (2000b) Hepatic cavernous hemangioma in cirrhotic liver: imaging findings. Korean J Radiol 1(4):185–190

    Article  PubMed  CAS  Google Scholar 

  • Zech CJ, Reiser MF et al (2009) Imaging of hepatocellular carcinoma by computed tomography and magnetic resonance imaging: state of the art. Dig Dis 27(2):114–124

    Article  PubMed  Google Scholar 

  • Zheng RQ, Zhou P et al (2004) Hepatocellular carcinoma with nodule-in-nodule appearance: demonstration by contrast-enhanced coded phase inversion harmonic imaging. Intervirology 47(3–5):184–190

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Seoul National University, College of Medicine, Yeon gon dong 28, Jongno gu, Seoul, South Korea

    Jeong Min Lee, Dong Ho Lee &  Jeong-Hee Yoon

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  1. Jeong Min Lee
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  2. Dong Ho Lee
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  3. Jeong-Hee Yoon
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  1. , Department of Clinical Radiology, Munich University Hospitals - Grosshader, Marchioninistraße 15, Munich, 81377, Germany

    Christoph Johannes Zech

  2. Department of Oncology, Dept. Transplants and Advanced Technolog, University of Pisa, Via Paradisa 2, Pisa, 56127, Italy

    Carlo Bartolozzi

  3. , Department of Radiology, The University of Chicago, 5841 S. Maryland Ave MC 2026, Chicago, 60611, USA

    Richard Baron

  4. , Department of Clinical Radiology, Munich University Hospitals - Grosshader, Marchioninistraße 15, Munich, 81377, Germany

    Maximilian F. Reiser

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Lee, J.M., Lee, D.H., Yoon, H. (2012). Imaging Findings of Cirrhotic Liver. In: Zech, C., Bartolozzi, C., Baron, R., Reiser, M. (eds) Multislice-CT of the Abdomen. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_538

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