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Gastrointestinal

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Book cover PET-CT and PET-MRI in Oncology

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

PET-CT combines in a single imaging session both anatomical and metabolic information. Depending on the strategy, the CT part of the study may yield only crude anatomical information and attenuation correction for the PET part, or it may offer full radiological diagnostic features. Regarding the radiotracers for gastrointestinal oncology, FDG remains the mainstay but alternative compounds aimed at more specific biological targets are actively tested. In particular Ga-68-labelled DOTA derivatives image somastostatin receptors with exquisite sensitivity and specificity. In clinical practice, several indications are well recognized for FDG PET-CT. These include the initial staging of esophageal, pancreatic and rectal cancers with a clinical impact in a significant proportion of patients. The metabolic activity, as recorded prior to any treatment, holds prognostic information in esophageal cancer and hepatocarcinomas. Furthermore, the metabolic response assessed early on during chemotherapy and/or radiotherapy may be very valuable in esophageal and rectal cancers, as well as in GISTs. Methodological issues remain to be solved, but the potential is clearly present so that an increased clinical role is highly likely in the near future. FDG PET-CT is a major clinical tool in the detection and staging of recurrent colorectal cancer, and for determining the resectability of liver metastases. Ongoing developments include technological advances, in particular the combined PET-MR devices, and alternative tracers, such as those imaging angiogenesis.

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References

  • Adams S, Baum R, Rink T, Schumm-Drager PM, Usadel KH, Hor G (1998) Limited value of fluorine-18 fluorodeoxyglucose positron emission tomography for the imaging of neuroendocrine tumours. Eur J Nucl Med 25(1):79–83

    Article  PubMed  CAS  Google Scholar 

  • Ambrosini V, Tomassetti P, Castellucci P, Campana D, Montini G, Rubello D, Nanni C, Rizzello A, Franchi R, Fanti S (2008) Comparison between 68Ga-DOTA-NOC and 18F-DOPA PET for the detection of gastro-entero-pancreatic and lung neuro-endocrine tumours. Eur J Nucl Med Mol Imaging 35(8):1431–1438

    Article  PubMed  CAS  Google Scholar 

  • American_Cancer_Society (2009) Cancer facts & figures. American Cancer Society, Atlanta

    Google Scholar 

  • Anderson CD, Rice MH, Pinson CW, Chapman WC, Chari RS, Delbeke D (2004) Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma. J Gastrointest Surg 8(1):90–97

    Article  PubMed  Google Scholar 

  • Antoch G, Kanja J, Bauer S, Kuehl H, Renzing-Koehler K, Schuette J, Bockisch A, Debatin JF, Freudenberg LS (2004a) Comparison of PET, CT, and dual-modality PET/CT imaging for monitoring of imatinib (STI571) therapy in patients with gastrointestinal stromal tumors. J Nucl Med 45(3):357–365

    PubMed  CAS  Google Scholar 

  • Antoch G, Saoudi N, Kuehl H, Dahmen G, Mueller SP, Beyer T, Bockisch A, Debatin JF, Freudenberg LS (2004b) Accuracy of whole-body dual-modality fluorine-18–2-fluoro-2-deoxy-d-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET. J Clin Oncol 22(21):4357–4368

    Article  PubMed  Google Scholar 

  • Antunes P, Ginj M, Zhang H, Waser B, Baum RP, Reubi JC, Maecke H (2007) Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? Eur J Nucl Med Mol Imaging 34(7):982–993

    Article  PubMed  CAS  Google Scholar 

  • Bassi MC, Turri L, Sacchetti G, Loi G, Cannillo B, La Mattina P, Brambilla M, Inglese E, Krengli M (2008) FDG-PET/CT imaging for staging and target volume delineation in preoperative conformal radiotherapy of rectal cancer. Int J Radiat Oncol Biol Phys 70(5):1423–1426

    Article  PubMed  Google Scholar 

  • Becherer A, Szabo M, Karanikas G, Wunderbaldinger P, Angelberger P, Raderer M, Kurtaran A, Dudczak R, Kletter K (2004) Imaging of advanced neuroendocrine tumors with (18)F-FDOPA PET. J Nucl Med 45(7):1161–1167

    PubMed  CAS  Google Scholar 

  • Beer AJ, Haubner R, Sarbia M, Goebel M, Luderschmidt S, Grosu AL, Schnell O, Niemeyer M, Kessler H, Wester HJ, Weber WA, Schwaiger M (2006) Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man. Clin Cancer Res 12(13):3942–39429

    Article  PubMed  CAS  Google Scholar 

  • Belhocine T, Foidart J, Rigo P, Najjar F, Thiry A, Quatresooz P, Hustinx R (2002) Fluorodeoxyglucose positron emission tomography and somatostatin receptor scintigraphy for diagnosing and staging carcinoid tumours: correlations with the pathological indexes p53 and Ki-67. Nucl Med Commun 23(8):727–734

    Article  PubMed  CAS  Google Scholar 

  • Berrisford RG, Wong WL, Day D, Toy E, Napier M, Mitchell K, Wajed S (2008) The decision to operate: role of integrated computed tomography positron emission tomography in staging oesophageal and oesophagogastric junction cancer by the multidisciplinary team. Eur J Cardiothorac Surg 33(6):1112–1116

    Article  PubMed  Google Scholar 

  • Binderup T, Knigge U, Loft A, Federspiel B, Kjaer A (2010) 18F-fluorodeoxyglucose positron emission tomography predicts survival of patients with neuroendocrine tumors. Clin Cancer Res 16(3):978–985

    Article  PubMed  CAS  Google Scholar 

  • Bipat S, Glas AS, Slors FJ, Zwinderman AH, Bossuyt PM, Stoker J (2004) Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging–a meta-analysis. Radiology 232(3):773–783

    Article  PubMed  Google Scholar 

  • Bipat S, Phoa SS, van Delden OM, Bossuyt PM, Gouma DJ, Lameris JS, Stoker J (2005a) Ultrasonography, computed tomography and magnetic resonance imaging for diagnosis and determining resectability of pancreatic adenocarcinoma: a meta-analysis. J Comput Assist Tomogr 29(4):438–445

    Article  PubMed  Google Scholar 

  • Bipat S, van Leeuwen MS, Comans EF, Pijl ME, Bossuyt PM, Zwinderman AH, Stoker J (2005b) Colorectal liver metastases: CT, MR imaging, and PET for diagnosis–meta-analysis. Radiology 237(1):123–131

    Article  PubMed  Google Scholar 

  • Blot WJ, McLaughlin JK (1999) The changing epidemiology of esophageal cancer. Semin Oncol 26 (5 Suppl 15):2–8

    Google Scholar 

  • Bystrom P, Berglund A, Garske U, Jacobsson H, Sundin A, Nygren P, Frodin JE, Glimelius B (2009) Early prediction of response to first-line chemotherapy by sequential [18F]-2-fluoro-2-deoxy-d-glucose positron emission tomography in patients with advanced colorectal cancer. Ann Oncol 20(6):1057–1061

    Article  PubMed  CAS  Google Scholar 

  • Chatterton BE, Ho Shon I, Baldey A, Lenzo N, Patrikeos A, Kelley B, Wong D, Ramshaw JE, Scott AM (2009) Positron emission tomography changes management and prognostic stratification in patients with oesophageal cancer: results of a multicentre prospective study. Eur J Nucl Med Mol Imaging 36(3):354–361

    Article  PubMed  CAS  Google Scholar 

  • Chen J, Cheong JH, Yun MJ, Kim J, Lim JS, Hyung WJ, Noh SH (2005a) Improvement in preoperative staging of gastric adenocarcinoma with positron emission tomography. Cancer 103(11):2383–2390

    Article  PubMed  Google Scholar 

  • Chen YK, Hsieh DS, Liao CS, Bai CH, Su CT, Shen YY, Hsieh JF, Liao AC, Kao CH (2005b) Utility of FDG-PET for investigating unexplained serum AFP elevation in patients with suspected hepatocellular carcinoma recurrence. Anticancer Res 25(6C):4719–4725

    Google Scholar 

  • Choi H, Charnsangavej C, de Castro Faria S, Tamm EP, Benjamin RS, Johnson MM, Macapinlac HA, Podoloff DA (2004) CT evaluation of the response of gastrointestinal stromal tumors after imatinib mesylate treatment: a quantitative analysis correlated with FDG PET findings. Am J Roentgenol 183(6):1619–1628

    Google Scholar 

  • Chua SC, Groves AM, Kayani I, Menezes L, Gacinovic S, Du Y, Bomanji JB, Ell PJ (2007) The impact of 18F-FDG PET/CT in patients with liver metastases. Eur J Nucl Med Mol Imaging 34(12):1906–1914

    Article  PubMed  Google Scholar 

  • Corless CL, Fletcher JA, Heinrich MC (2004) Biology of gastrointestinal stromal tumors. J Clin Oncol 22(18):3813–3825

    Article  PubMed  CAS  Google Scholar 

  • Corvera CU, Blumgart LH, Akhurst T, DeMatteo RP, D’Angelica M, Fong Y, Jarnagin WR (2008) 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer. J Am Coll Surg 206(1):57–65

    Article  PubMed  Google Scholar 

  • Dalah E, Bradley D, Nisbet A (2010) Simulation of tissue activity curves of (64)Cu-ATSM for sub-target volume delineation in radiotherapy. Phys Med Biol 55(3):681–694

    Article  PubMed  CAS  Google Scholar 

  • Davey K, Heriot AG, Mackay J, Drummond E, Hogg A, Ngan S, Milner AD, Hicks RJ (2008) The impact of 18-fluorodeoxyglucose positron emission tomography-computed tomography on the staging and management of primary rectal cancer. Dis Colon Rectum 51(7):997–1003

    Article  PubMed  CAS  Google Scholar 

  • de Geus-Oei LF, van Laarhoven HW, Visser EP, Hermsen R, van Hoorn BA, Kamm YJ, Krabbe PF, Corstens FH, Punt CJ, Oyen WJ (2008) Chemotherapy response evaluation with FDG-PET in patients with colorectal cancer. Ann Oncol 19(2):348–352

    Article  PubMed  Google Scholar 

  • de Geus-Oei LF, Vriens D, van Laarhoven HW, van der Graaf WT, Oyen, WJ (2009) Monitoring and predicting response to therapy with 18F-FDG PET in colorectal cancer: a systematic review. J Nucl Med 50 (Suppl 1):43S–54S

    Google Scholar 

  • Flamen P, Hoekstra OS, Homans F, Van Cutsem E, Maes A, Stroobants S, Peeters M, Penninckx F, Filez L, Bleichrodt RP, Mortelmans L (2001) Unexplained rising carcinoembryonic antigen (CEA) in the postoperative surveillance of colorectal cancer: the utility of positron emission tomography (PET). Eur J Cancer 37(7):862–869

    Article  PubMed  CAS  Google Scholar 

  • Floriani I, Torri V, Rulli E, Garavaglia D, Compagnoni A, Salvolini L, Giovagnoni A (2010) Performance of imaging modalities in diagnosis of liver metastases from colorectal cancer: a systematic review and meta-analysis. J Magn Reson Imaging 31(1):19–31

    Article  PubMed  Google Scholar 

  • Furukawa H, Ikuma H, Seki A, Yokoe K, Yuen S, Aramaki T, Yamagushi S (2006) Positron emission tomography scanning is not superior to whole body multidetector helical computed tomography in the preoperative staging of colorectal cancer. Gut 55(7):1007–1111

    Article  PubMed  CAS  Google Scholar 

  • Gabriel M, Decristoforo C, Kendler D, Dobrozemsky G, Heute D, Uprimny C, Kovacs P, Von Guggenberg E, Bale R, Virgolini IJ (2007) 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med 48(4):508–518

    Article  PubMed  CAS  Google Scholar 

  • Garin E, Le Jeune F, Devillers A, Cuggia M, de Lajarte-Thirouard AS, Bouriel C, Boucher E, Raoul JL (2009) Predictive value of 18F-FDG PET and somatostatin receptor scintigraphy in patients with metastatic endocrine tumors. J Nucl Med 50(6):858–864

    Article  PubMed  CAS  Google Scholar 

  • Gearhart SL, Frassica D, Rosen R, Choti M, Schulick R, Wahl R (2006) Improved staging with pretreatment positron emission tomography/computed tomography in low rectal cancer. Ann Surg Oncol 13(3):397–404

    Article  PubMed  Google Scholar 

  • Goerres GW, Stupp R, Barghouth G, Hany TF, Pestalozzi B, Dizendorf E, Schnyder P, Luthi F, von Schulthess GK, Leyvraz S (2005) The value of PET, CT and in-line PET/CT in patients with gastrointestinal stromal tumours: long-term outcome of treatment with imatinib mesylate. Eur J Nucl Med Mol Imaging 32(2):153–162

    Article  PubMed  CAS  Google Scholar 

  • Han AR, Gwak GY, Choi MS, Lee JH, Koh KC, Paik SW, Yoo BC (2009) The clinical value of 18F-FDG PET/CT for investigating unexplained serum AFP elevation following interventional therapy for hepatocellular carcinom. Hepatogastroenterology 56(93):1111–1116

    PubMed  Google Scholar 

  • Haug A, Auernhammer CJ, Wangler B, Tiling R, Schmidt G, Goke B, Bartenstein P, Popperl G (2009) Intraindividual comparison of 68Ga-DOTA-TATE and 18F-DOPA PET in patients with well-differentiated metastatic neuroendocrine tumours. Eur J Nucl Med Mol Imaging 36(5):765–770

    Article  PubMed  CAS  Google Scholar 

  • Heinrich S, Goerres GW, Schafer M, Sagmeister M, Bauerfeind P, Pestalozzi BC, Hany TF, von Schulthess GK, Clavien PA (2005) Positron emission tomography/computed tomography influences on the management of resectable pancreatic cancer and its cost-effectiveness. Ann Surg 242(2):235–243

    Article  PubMed  Google Scholar 

  • Herrmann K, Ott K, Buck AK, Lordick F, Wilhelm D, Souvatzoglou M, Becker K, Schuster T, Wester HJ, Siewert JR, Schwaiger M, Krause BJ (2007) Imaging gastric cancer with PET and the radiotracers 18F-FLT and 18F-FDG: a comparative analysis. J Nucl Med 48(12):1945–1950

    Article  PubMed  CAS  Google Scholar 

  • Higashi T, Hatano E, Ikai I, Nishii R, Nakamoto Y, Ishizu K, Suga T, Kawashima H, Togashi K, Seo S, Kitamura K, Takada Y, Kamimoto S (2010) FDG PET as a prognostic predictor in the early post-therapeutic evaluation for unresectable hepatocellular carcinoma. Eur J Nucl Med Mol Imaging 37(3):468–482

    Article  PubMed  Google Scholar 

  • Jager PL, Gietema JA, van der Graaf WT (2004) Imatinib mesylate for the treatment of gastrointestinal stromal tumours: best monitored with FDG PET. Nucl Med Commun 25(5):433–438

    Article  PubMed  CAS  Google Scholar 

  • Kameyama R, Yamamoto Y, Izuishi K, Takebayashi R, Hagiike M, Murota M, Kaji M, Haba R, Nishiyama Y (2009) Detection of gastric cancer using 18F-FLT PET: comparison with 18F-FDG PET. Eur J Nucl Med Mol Imaging 36(3):382–388

    Article  PubMed  Google Scholar 

  • Kato H, Kimura H, Nakajima M, Sakai M, Sano A, Tanaka N, Inose T, Faried A, Saito K, Ieta K, Sohda M, Fukai Y, Miyazaki T, Masuda N, Fukuchi M, Ojima H, Tsukada K, Oriuchi N, Endo K, Kuwano H (2008) The additional value of integrated PET/CT over PET in initial lymph node staging of esophageal cancer. Oncol Rep 20(4):857–862

    PubMed  Google Scholar 

  • Kato H, Miyazaki T, Nakajima M, Takita J, Kimura H, Faried A, Sohda M, Fukai Y, Masuda N, Fukuchi M, Manda R, Ojima H, Tsukada K, Kuwano H, Oriuchi N, Endo K (2005) The incremental effect of positron emission tomography on diagnostic accuracy in the initial staging of esophageal carcinoma. Cancer 103(1):148–156

    Article  PubMed  Google Scholar 

  • Kato T, Tsukamoto E, Kuge Y, Katoh C, Nambu T, Nobuta A, Kondo S, Asaka M, Tamaki N (2002) Clinical role of (18)F-FDG PET for initial staging of patients with extrahepatic bile duct cancer. Eur J Nucl Med Mol Imaging 29(8):1047–1054

    Article  PubMed  CAS  Google Scholar 

  • Kawaoka T, Aikata H, Takaki S, Uka K, Azakami T, Saneto H, Jeong SC, Kawakami Y, Takahashi S, Toyota N, Ito K, Hirokawa Y, Chayama K (2009) FDG positron emission tomography/computed tomography for the detection of extrahepatic metastases from hepatocellular carcinoma. Hepatol Res 39(2):134–142

    Article  PubMed  Google Scholar 

  • Keswani RN, Early DS, Edmundowicz SA, Meyers BF, Sharma A, Govindan R, Chen J, Kohlmeier C, Azar RR (2009) Routine positron emission tomography does not alter nodal staging in patients undergoing EUS-guided FNA for esophageal cancer. Gastrointest Endosc 69(7):1210–1217

    Article  PubMed  Google Scholar 

  • Kinkel K, Lu Y, Both M, Warren RS, Thoeni RF (2002) Detection of hepatic metastases from cancers of the gastrointestinal tract by using noninvasive imaging methods (US, CT, MR imaging, PET): a meta-analysis. Radiology 224(3):748–756

    Article  PubMed  Google Scholar 

  • Kinner S, Antoch G, Bockisch A, Veit-Haibach P (2007) Whole-body PET/CT-colonography: a possible new concept for colorectal cancer staging. Abdom Imaging 32(5):606–612

    Article  PubMed  Google Scholar 

  • Kong G, Jackson C, Koh DM, Lewington V, Sharma B, Brown G, Cunningham D, Cook GJ (2008) The use of 18F-FDG PET/CT in colorectal liver metastases–comparison with CT and liver MRI. Eur J Nucl Med Mol Imaging 35(7):1323–1329

    Article  PubMed  CAS  Google Scholar 

  • Kornberg A, Kupper B, Thrum K, Katenkamp K, Steenbeck J, Sappler A, Habrecht O, Gottschild D (2009) Increased 18F-FDG uptake of hepatocellular carcinoma on positron emission tomography independently predicts tumor recurrence in liver transplant patients. Transplant Proc 41(6):2561–2563

    Article  PubMed  CAS  Google Scholar 

  • Krause BJ, Herrmann K, Wieder H, zum Buschenfelde CM (2009) 18F-FDG PET and 18F-FDG PET/CT for assessing response to therapy in esophageal cancer. J Nucl Med 50 (Suppl 1):89S–96S

    Google Scholar 

  • Kuehl H, Antoch G, Stergar H, Veit-Haibach P, Rosenbaum-Krumme S, Vogt F, Frilling A, Barkhausen J, Bockisch A (2008) Comparison of FDG-PET, PET/CT and MRI for follow-up of colorectal liver metastases treated with radiofrequency ablation: initial results. Eur J Radiol 67(2):362–371

    Article  PubMed  Google Scholar 

  • Kwekkeboom DJ, Kam BL, van Essen M, Teunissen JJ, van Eijck CH, Valkema R, de Jong M, de Herder WW, Krenning EP (2010) Somatostatin receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors. Endocr Relat Cancer 17(1):R53–73

    Article  PubMed  CAS  Google Scholar 

  • Lee JD, Yun M, Lee JM, Choi Y, Choi YH, Kim JS, Kim SJ, Kim KS, Yang WI, Park YN, Han KH, Lee WJ, Yoo N, Lim SM, Park JH (2004) Analysis of gene expression profiles of hepatocellular carcinomas with regard to 18F-fluorodeoxyglucose uptake pattern on positron emission tomography. Eur J Nucl Med Mol Imaging 31(12):1621–1630

    Article  PubMed  CAS  Google Scholar 

  • Lee JW, Paeng JC, Kang KW, Kwon HW, Suh KS, Chung JK, Lee MC, Lee DS (2009) Prediction of tumor recurrence by 18F-FDG PET in liver transplantation for hepatocellular carcinoma. J Nucl Med 50(5):682–7

    Article  PubMed  Google Scholar 

  • Lin M, Shon IH, Wilson R, D’Amours SK, Schlaphoff G, Lin P (2007) Treatment response in liver metastases following 90Y SIR-spheres: an evaluation with PET. Hepatogastroenterology 54(75):910–912

    PubMed  CAS  Google Scholar 

  • Llamas-Elvira JM, Rodriguez-Fernandez A, Gutierrez-Sainz J, Gomez-Rio M, Bellon-Guardia M, Ramos-Font C, Rebollo-Aguirre AC, Cabello-Garcia D, Ferron-Orihuela A (2007) Fluorine-18 fluorodeoxyglucose PET in the preoperative staging of colorectal cancer. Eur J Nucl Med Mol Imaging 34(6):859–867

    Article  PubMed  CAS  Google Scholar 

  • Lordick F, Ott K, Krause BJ, Weber WA, Becker K, Stein HJ, Lorenzen S, Schuster T, Wieder H, Herrmann K, Bredenkamp R, Hofler H, Fink U, Peschel C, Schwaiger M, Siewert JR (2007) PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial. Lancet Oncol 8(9):797–805

    Article  PubMed  Google Scholar 

  • Mabille M, Vanel D, Albiter M, Le Cesne A, Bonvalot S, Le Pechoux C, Terrier P, Shapeero LG, Dromain C (2009) Follow-up of hepatic and peritoneal metastases of gastrointestinal tumors (GIST) under Imatinib therapy requires different criteria of radiological evaluation (size is not everything!!!). Eur J Radiol 69(2):204–208

    Article  PubMed  Google Scholar 

  • Mees G, Dierckx R, Vangestel C, Van de Wiele C (2009) Molecular imaging of hypoxia with radiolabelled agents. Eur J Nucl Med Mol Imaging 36(10):1674–1686

    Article  PubMed  CAS  Google Scholar 

  • Meyers BF, Downey RJ, Decker PA, Keenan RJ, Siegel BA, Cerfolio RJ, Landreneau RJ, Reed CE, Balfe DM, Dehdashti F, Ballman KV, Rusch VW, Putnam JB Jr (2007) The utility of positron emission tomography in staging of potentially operable carcinoma of the thoracic esophagus: results of the American College of Surgeons Oncology Group Z0060 trial. J Thorac Cardiovasc Surg 133(3):738–745

    Article  PubMed  Google Scholar 

  • Miettinen M, Lasota J (2001) Gastrointestinal stromal tumors–definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 438(1):1–12

    Article  PubMed  CAS  Google Scholar 

  • Nagata K, Ota Y, Okawa T, Endo S, Kudo SE (2008) PET/CT colonography for the preoperative evaluation of the colon proximal to the obstructive colorectal cancer. Dis Colon Rectum 51(6):882–890

    Article  PubMed  Google Scholar 

  • Okada M, Murakami T, Kumano S, Kuwabara M, Shimono T, Hosono M, Shiozaki H (2009) Integrated FDG-PET/CT compared with intravenous contrast-enhanced CT for evaluation of metastatic regional lymph nodes in patients with resectable early stage esophageal cancer. Ann Nucl Med 23(1):73–80

    Article  PubMed  Google Scholar 

  • Orlando LA, Kulasingam SL, Matchar DB (2004) Meta-analysis: the detection of pancreatic malignancy with positron emission tomography. Aliment Pharmacol Ther 20(10):1063–1070

    Article  PubMed  CAS  Google Scholar 

  • Pan L, Gu P, Huang G, Xue H, Wu S (2009) Prognostic significance of SUV on PET/CT in patients with esophageal cancer: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol 21(9):1008–1015

    Article  PubMed  Google Scholar 

  • Park JW, Kim JH, Kim SK, Kang KW, Park KW, Choi JI, Lee WJ, Kim CM, Nam BH (2008) A prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinoma. J Nucl Med 49(12):1912–1921

    Article  PubMed  Google Scholar 

  • Pasquali C, Rubello D, Sperti C, Gasparoni P, Liessi G, Chierichetti F, Ferlin G, Pedrazzoli S (1998) Neuroendocrine tumor imaging: can 18F-fluorodeoxyglucose positron emission tomography detect tumors with poor prognosis and aggressive behavior? World J Surg 22(6):588–592

    Article  PubMed  CAS  Google Scholar 

  • Petrowsky H, Wildbrett P, Husarik DB, Hany TF, Tam S, Jochum W, Clavien PA (2006) Impact of integrated positron emission tomography and computed tomography on staging and management of gallbladder cancer and cholangiocarcinoma. J Hepatol 45(1):43–50

    Article  PubMed  Google Scholar 

  • Pfannenberg AC, Aschoff P, Brechtel K, Muller M, Klein M, Bares R, Claussen CD, Eschmann SM (2007) Value of contrast-enhanced multiphase CT in combined PET/CT protocols for oncological imaging. Br J Radiol 80(954):437–445

    Article  PubMed  CAS  Google Scholar 

  • Putzer D, Gabriel M, Kendler D, Henninger B, Knoflach M, Kroiss A, Vonguggenberg E, Warwitz B, Virgolini IJ (2010) Comparison of 68Ga-DOTA-Tyr3-octreotide and 18F-fluoro-L-dihydroxyphenylalanine positron emission tomography in neuroendocrine tumor patients. Q J Nucl Med Mol Imaging 54(1):68–75

    PubMed  CAS  Google Scholar 

  • Rodriguez-Moranta F, Salo J, Arcusa A, Boadas J, Pinol V, Bessa X, Batiste-Alentorn E, Lacy AM, Delgado S, Maurel J, Pique JM, Castells A (2006) Postoperative surveillance in patients with colorectal cancer who have undergone curative resection: a prospective, multicenter, randomized, controlled trial. J Clin Oncol 24(3):386–393

    Article  PubMed  Google Scholar 

  • Roedl JB, Halpern EF, Colen RR, Sahani DV, Fischman AJ, Blake MA (2009) Metabolic tumor width parameters as determined on PET/CT predict disease-free survival and treatment response in squamous cell carcinoma of the esophagus. Mol Imaging Biol 11(1):54–60

    Article  PubMed  Google Scholar 

  • Ruers TJ, Wiering B, van der Sijp JR, Roumen RM, de Jong KP, Comans EF, Pruim J, Dekker HM, Krabbe PF, Oyen WJ (2009) Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study. J Nucl Med 50(7):1036–1041

    Article  PubMed  Google Scholar 

  • Schnell O, Krebs B, Carlsen J, Miederer I, Goetz C, Goldbrunner RH, Wester HJ, Haubner R, Popperl G, Holtmannspotter M, Kretzschmar HA, Kessler H, Tonn JC, Schwaiger M, Beer AJ (2009) Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography. Neuro Oncol 11(6):861–870

    Article  PubMed  Google Scholar 

  • Schottelius M, Laufer B, Kessler H, Wester HJ (2009) Ligands for mapping alphavbeta3-integrin expression in vivo. Acc Chem Res 42(7):969–980

    Article  PubMed  CAS  Google Scholar 

  • Seo S, Hatano E, Higashi T, Hara T, Tada M, Tamaki N, Iwaisako K, Ikai I, Uemoto S (2007) Fluorine-18 fluorodeoxyglucose positron emission tomography predicts tumor differentiation, P-glycoprotein expression, and outcome after resection in hepatocellular carcinoma. Clin Cancer Res 13(2 Pt 1):427–433

    Google Scholar 

  • Shiomi S, Nishiguchi S, Ishizu H, Iwata Y, Sasaki N, Tamori A, Habu D, Takeda T, Kubo S, Ochi H (2001) Usefulness of positron emission tomography with fluorine-18-fluorodeoxyglucose for predicting outcome in patients with hepatocellular carcinoma. Am J Gastroenterol 96(6):1877–1880

    Article  PubMed  CAS  Google Scholar 

  • Shreve PD (1998) Focal fluorine-18 fluorodeoxyglucose accumulation in inflammatory pancreatic disease. Eur J Nucl Med 25(3):259–264

    Article  PubMed  CAS  Google Scholar 

  • Sobhani I, Tiret E, Lebtahi R, Aparicio T, Itti E, Montravers F, Vaylet C, Rougier P, Andre T, Gornet JM, Cherqui D, Delbaldo C, Panis Y, Talbot JN, Meignan M, Le Guludec D (2008) Early detection of recurrence by 18FDG-PET in the follow-up of patients with colorectal cancer. Br J Cancer 98(5):875–880

    Article  PubMed  CAS  Google Scholar 

  • Sorensen N, Jensen A, Wille-Jorgensen P, Friberg L, Rordam L, Ingeman L, Hennild V (2010) Strict follow-up programme including CT and F-FDG-PET after curative surgery for colorectal cancer. Colorectal Dis 12(10):e224–e228

    Article  PubMed  CAS  Google Scholar 

  • Soyka JD, Veit-Haibach P, Strobel K, Breitenstein S, Tschopp A, Mende KA, Lago MP, Hany TF (2008) Staging pathways in recurrent colorectal carcinoma: is contrast-enhanced 18F-FDG PET/CT the diagnostic tool of choice? J Nucl Med 49(3):354–361

    Article  PubMed  Google Scholar 

  • Stahl A, Ott K, Weber WA, Becker K, Link T, Siewert JR, Schwaiger M, Fink U (2003) FDG PET imaging of locally advanced gastric carcinomas: correlation with endoscopic and histopathological findings. Eur J Nucl Med Mol Imaging 30(2):288–295

    Article  PubMed  CAS  Google Scholar 

  • Strobel K, Heinrich S, Bhure U, Soyka J, Veit-Haibach P, Pestalozzi BC, Clavien PA, Hany TF (2008) Contrast-enhanced 18F-FDG PET/CT: 1-stop-shop imaging for assessing the resectability of pancreatic cancer. J Nucl Med 49(9):1408–1413

    Article  PubMed  Google Scholar 

  • Stroobants S, Goeminne J, Seegers M, Dimitrijevic S, Dupont P, Nuyts J, Martens M, van den Borne B, Cole P, Sciot R, Dumez H, Silberman S, Mortelmans L, van Oosterom A (2003) 18FDG-Positron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec). Eur J Cancer 39(14):2012–2020

    Article  PubMed  CAS  Google Scholar 

  • Tang S, Huang G, Liu J, Liu T, Treven L, Song S, Zhang C, Pan L, Zhang T (2009) Usefulness of (18)F-FDG PET, combined FDG-PET/CT and EUS in diagnosing primary pancreatic carcinoma: A meta-analysis. Eur J Radiol

    Google Scholar 

  • Taylor MD, Smith PW, Brix WK, Wick MR, Theodosakis N, Swenson BR, Kozower BD, Jones DR (2009) Correlations between selected tumor markers and fluorodeoxyglucose maximal standardized uptake values in esophageal cancer. Eur J Cardiothorac Surg 35(4):699–705

    Article  PubMed  Google Scholar 

  • Van Cutsem EJ, Oliveira J (2008) Colon cancer: ESMO clinical recommendations for diagnosis, adjuvant treatment and follow-up. Ann Oncol 19 (Suppl 2):ii29–30

    Google Scholar 

  • Van den Abbeele AD (2008) The lessons of GIST–PET and PET/CT: a new paradigm for imaging. Oncologist 13 (Suppl 2):8–13

    Google Scholar 

  • van Westreenen HL, Westerterp M, Bossuyt PM, Pruim J, Sloof GW, van Lanschot JJ, Groen H, Plukker JT (2004) Systematic review of the staging performance of 18F-fluorodeoxyglucose positron emission tomography in esophageal cancer. J Clin Oncol 22(18):3805–3812

    Article  PubMed  Google Scholar 

  • Veit-Haibach P, Kuehle CA, Beyer T, Stergar H, Kuehl H, Schmidt J, Borsch G, Dahmen G, Barkhausen J, Bockisch A, Antoch G (2006) Diagnostic accuracy of colorectal cancer staging with whole-body PET/CT colonography. JAMA 296(21):2590–2600

    Article  PubMed  CAS  Google Scholar 

  • Wiering B, Krabbe PF, Jager GJ, Oyen WJ, Ruers TJ (2005) The impact of fluor-18-deoxyglucose-positron emission tomography in the management of colorectal liver metastases. Cancer 104(12):2658–2670

    Article  PubMed  Google Scholar 

  • Yun M, Lim JS, Noh SH, Hyung WJ, Cheong JH, Bong JK, Cho A, Lee JD (2005) Lymph node staging of gastric cancer using (18)F-FDG PET: a comparison study with CT. J Nucl Med 46(10):1582–1588

    PubMed  Google Scholar 

  • Zhang C, Chen Y, Xue H, Zheng P, Tong J, Liu J, Sun X, Huang G (2009) Diagnostic value of FDG-PET in recurrent colorectal carcinoma: a meta-analysis. Int J Cancer 124(1):167–173

    Article  PubMed  CAS  Google Scholar 

  • Zhernosekov KP, Filosofov DV, Baum RP, Aschoff P, Bihl H, Razbash AA, Jahn M, Jennewein M, Rosch F (2007) Processing of generator-produced 68Ga for medical application. J Nucl Med 48(10):1741–1748

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Nuclear Medicine, University Hospital of Liège, Domaine Universitaire du Sart Tilman B35, 4000, Liège 1, Belgium

    Roland Hustinx

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  1. Roland Hustinx
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Correspondence to Roland Hustinx .

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Editors and Affiliations

  1. Rochester, 55901, Minnesota, USA

    Patrick Peller

  2. , Division of Neuroradiology, Boston University School of Medicine, Boston, 02493, Massachusetts, USA

    Rathan Subramaniam

  3. Dept. Radiology, Boston University Medical Center, E. Newton St. 88, Boston, 02118, Massachusetts, USA

    Ali Guermazi

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© 2011 Springer-Verlag Berlin Heidelberg

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Hustinx, R. (2011). Gastrointestinal. In: Peller, P., Subramaniam, R., Guermazi, A. (eds) PET-CT and PET-MRI in Oncology. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_432

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  • DOI: https://doi.org/10.1007/174_2011_432

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  • Print ISBN: 978-3-642-01138-2

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